Article
Geriatrics & Gerontology
Ningtian Ma, Yuyang Liang, Lingyun Yue, Pu Liu, Yuxia Xu, Cuiqing Zhu
Summary: This study investigated the effects of Tau overexpression and Tau phosphorylation on the insulin signaling pathway (ISP) in Alzheimer's disease (AD). The results showed that Tau overexpression upregulated the basal activity of elements in the ISP, but suppressed the insulin-induced activation of the pathway. This dysfunction of the ISP was more pronounced in cells overexpressing phosphorylated Tau. The study also found that the effects of lonafarnib, an anti-aging drug, on the ISP differed between cells overexpressing wild-type Tau and phosphorylated Tau, suggesting that Tau phosphorylation mediates additional effects on the pathway. These findings provide insights into the link between abnormal Tau expression and phosphorylation and ISP dysfunction in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Chunyu Zhou, Cha-Gyun Jung, Mi-Jeong Kim, Atsushi Watanabe, Mona Abdelhamid, Ferdous Taslima, Makoto Michikawa
Summary: Insulin deficiency exacerbates Alzheimer's disease-like pathologies, with the involvement of Sirt2 protein.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Jian Bao, Zheng Liang, Xiaokang Gong, Jing Yu, Yifan Xiao, Wei Liu, Xiaochuan Wang, Jian-Zhi Wang, Xiji Shu
Summary: This study aimed to explore the underlying neurobiological mechanisms of high fat diet (HFD) influenced amyloid-beta (A beta) accumulation and cognitive performance during Alzheimer's disease (AD) pathology. The results showed that long-term HFD consumption aggravated A beta accumulation and cognitive impairments, mediated by the increased activity and stability of BACE1 enzyme.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Toshitaka Ochiai, Toshiharu Sano, Takeru Nagayama, Naoto Kubota, Takashi Kadowaki, Tomoko Wakabayashi, Takeshi Iwatsubo
Summary: The study found that IRS-2 plays a dominant role in brain IIS and supports the hypothesis that reduced IIS exerts anti-amyloid effects in the brain.
NEUROBIOLOGY OF DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Jinyi Yao, Zhijun He, Guanying You, Qiong Liu, Nan Li
Summary: Vanadium is an essential trace element with inhibitory effects on ATPase. Vanadium compounds have been applied in clinical trials for the treatment of diabetes due to their protective effects on beta cells and regulation of glucose metabolism. However, there is still a lack of efficient agents for treating Alzheimer's disease, which is characterized by senile plaques and neurofibrillary tangles in the brain, along with insulin deficiency and impaired insulin signaling. This review summarizes the advances in using vanadium compounds for AD treatment in experimental research and highlights current limitations.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Guanying You, Jinyi Yao, Qiong Liu, Nan Li
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by senile plaques and neurofibrillary tangles. Insulin deficiency and insulin resistance have been observed in AD brains. Insulin plays a critical role in learning and memory, as well as regulating tau phosphorylation. Recent studies revealed that microglia in AD brains transform into a disease-associated status to restrict Aβ toxicity and tau propagation. The risk of AD is increased in individuals with diabetes.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Clinical Neurology
Binita Rajbanshi, Anuj Guruacharya, James W. Mandell, George S. Bloom
Summary: Tau phosphorylation at T217 increases as Alzheimer's disease progresses and is associated with diseased neurons. Extracellular tau oligomers can induce an increase in tau(pT217). Phosphorylation reduces tau's affinity for microtubules.
ALZHEIMERS & DEMENTIA
(2023)
Review
Endocrinology & Metabolism
Haiyang Du, Xiaoyu Meng, Yu Yao, Jun Xu
Summary: GLP-1R agonists, a type of drug used to treat type 2 diabetes, have the potential to reduce inflammation and oxidative stress, provide neurotrophic effects, and decrease the progression of Alzheimer's disease. Further clinical trials are needed to validate their effectiveness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Jean-Pierre Bellier, Yuqi Cai, Sarah M. Alam, Thorsten Wiederhold, Arica Aiello, Jonathan S. Vogelgsang, Sabina Berretta, Jasmeer P. Chhatwal, Dennis J. Selkoe, Lei Liu
Summary: A wide array of post-translational modifications of the tau protein occurs in Alzheimer's disease (AD) and they are critical to pathogenesis and biomarker development. Several promising tau markers, pT181, pT217, and pT231, rely on increased phosphorylation within a common molecular motif threonine-proline-proline (TPP). The regional variability of pTPP tau suggests that examining different phosphorylation sites is essential for a comprehensive assessment of tau pathology.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Aashutosh U. Shetti, Abhirami Ramakrishnan, Liudmila Romanova, Wenping Li, Khanh Vo, Ipsita Volety, Ishara Ratnayake, Terilyn Stephen, Richard D. Minshall, Stephanie M. Cologna, Orly Lazarov
Summary: Patients with type 2 diabetes show impaired insulin signalling in the brain, which increases the risk of developing Alzheimer's disease. Reduced expression of Cav-1 in endothelial cells is found in a mouse model of type 2 diabetes and is correlated with alterations in insulin receptor expression and signalling in brain microvessels and brain parenchyma. Cav-1 plays a critical role in stabilizing insulin receptors in lipid rafts, and interacts with multiple proteins involved in insulin signalling in brain endothelial cells.
Review
Endocrinology & Metabolism
Joshua L. Milstein, Heather A. Ferris
Summary: The brain was once thought to be an insulin-insensitive organ, but now we know that insulin plays important roles in brain function and whole-body metabolism. Brain insulin resistance can lead to metabolic issues and contribute to conditions like obesity and neurodegeneration, such as Alzheimer's disease. Normal insulin signaling is crucial for brain health, affecting mitochondrial functioning and food intake.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Amy Woodfield, Tatiana Gonzales, Erik Helmerhorst, Simon Laws, Philip Newsholme, Tenielle Porter, Giuseppe Verdile
Summary: Alzheimer's disease and type 2 diabetes share similar pathological mechanisms, making drugs used to manage diabetes potential treatments for Alzheimer's. Insulin delivery has shown promise in improving cognition and reducing Alzheimer's-related neuropathology, but clinical trial outcomes have been inconsistent. Further investigation is needed to explore the use of insulin analogues for Alzheimer's treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Wang Liao, Jiaxin Xu, Bo Li, Yuting Ruan, Tian Li, Jun Liu
Summary: Alzheimer's disease is a prevalent neurodegenerative disease with no effective treatment. Metformin, a medication for Type 2 Diabetes Mellitus, has shown beneficial effects on cognitive function, but current evidence remains ambiguous and conflicting.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Laura Schnoeder, Inge Tomic, Laura Schwindt, Dominic Helm, Mandy Rettel, Walter Schulz-Schaeffer, Elmar Krause, Jens Rettig, Klaus Fassbender, Yang Liu
Summary: Deficiency of p38 alpha-MAPK in neurons leads to increased retrograde transportation of BACE1 in axons, shifting it from axonal terminals to lysosomes in the cell body, which exacerbates amyloid deposition in the brain of Alzheimer's disease.
Review
Pharmacology & Pharmacy
Mohammad Rafi Khezri, Keyvan Yousefi, Negin Mahboubi, Darya Hodaei, Morteza Ghasemnejad-Berenji
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder worldwide, and its association with diseases like diabetes has been well-studied. Metformin, a medication commonly used for type 2 diabetes, has shown potential disease-modifying effects on various aspects of AD pathophysiology.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biology
Akira Kuzuya, Katarzyna M. Zoltowska, Kathryn L. Post, Muriel Arimon, Xuejing Li, Sarah Svirsky, Masato Maesako, Alona Muzikansky, Vivek Gautam, Dora Kovacs, Bradley T. Hyman, Oksana Berezovska
Letter
Clinical Neurology
Ma Alma E. Carandang, Naoko Takamatsu, Hiroyuki Nodera, Atsuko Mori, Naoya Mimura, Nobuhisa Okada, Hisanori Kinoshita, Akira Kuzuya, Makoto Urushitani, Ryosuke Takahashi, Yuishin Izumi, Ryuji Kaji
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2017)
Article
Immunology
Madoka Sakai, Sakiho Ueda, Takuji Daito, Megumi Asada-Utsugi, Yumiko Komatsu, Ayae Kinoshita, Takakuni Maki, Akira Kuzuya, Ryosuke Takahashi, Akiko Makino, Keizo Tomonaga
MICROBIOLOGY AND IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Masato Maesako, Kengo Uemura, Masakazu Kubota, Akira Kuzuya, Kazuki Sasaki, Naoko Hayashida, Megumi Asada-Utsugi, Kiwamu Watanabe, Maiko Uemura, Takeshi Kihara, Ryosuke Takahashi, Shun Shimohama, Ayae Kinoshita
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Masato Maesako, Kengo Uemura, Akira Kuzuya, Kazuki Sasaki, Megumi Asada, Kiwamu Watanabe, Koichi Ando, Masakazu Kubota, Haruhiko Akiyama, Ryosuke Takahashi, Takeshi Kihara, Shun Shimohama, Ayae Kinoshita
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Geriatrics & Gerontology
Masato Maesako, Kengo Uemura, Masakazu Kubota, Akira Kuzuya, Kazuki Sasaki, Megumi Asada, Kiwamu Watanabe, Naoko Hayashida, Masafumi Ihara, Hidefumi Ito, Shun Shimohama, Takeshi Kihara, Ayae Kinoshita
NEUROBIOLOGY OF AGING
(2012)
Article
Geriatrics & Gerontology
Fangzhou Li, Hajime Takechi, Ryuji Saito, Takashi Ayaki, Atsuko Kokuryu, Akira Kuzuya, Ryosuke Takahashi
Article
Neurosciences
Yasuha Noda, Akira Kuzuya, Kyousuke Tanigawa, Mitsugu Araki, Ryoko Kawai, Biao Ma, Yoko Sasakura, Masato Maesako, Yoshitaka Tashiro, Masakazu Miyamoto, Kengo Uemura, Yasushi Okuno, Ayae Kinoshita
Article
Rheumatology
K. Kitagori, H. Yoshifuji, T. Oku, T. Ayaki, A. Kuzuya, T. Nakajima, S. Akizuki, R. Nakashima, K. Murakami, K. Ohmura, Y. Hirayama, R. Takahashi, T. Mimori
Article
Medicine, General & Internal
Masahiro Nagano, Katsuya Kobayashi, Mayumi Yamada-Otani, Akira Kuzuya, Riki Matsumoto, Jiro Oita, Makoto Yoneda, Akio Ikeda, Ryosuke Takahashi
Article
Geriatrics & Gerontology
Hajime Takechi, Atsuko Kokuryu, Akira Kuzuya, Shinji Matsunaga
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2019)
Article
Neurosciences
Naoto Jingami, Kengo Uemura, Megumi Asada-Utsugi, Akira Kuzuya, Shigeki Yamada, Masatsune Ishikawa, Takashi Kawahara, Takuya Iwasaki, Masamichi Atsuchi, Ryosuke Takahashi, Ayae Kinoshita
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Neurosciences
Masakazu Miyamoto, Akira Kuzuya, Yasuha Noda, Sakiho Ueda, Megumi Asada-Utsugi, Shinji Ito, Yoshiyasu Fukusumi, Hiroshi Kawachi, Ryosuke Takahashi, Ayae Kinoshita
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Letter
Clinical Neurology
Takafumi Wada, Atsushi Shima, Akira Kuzuya, Takakuni Maki, Hirofumi Yamashita, Ryosuke Takahashi
ACTA NEUROLOGICA BELGICA
(2023)
Letter
Dermatology
Yuki Honda, Atsushi Otsuka, Gyohei Egawa, Yutaka Inoue, Akira Kuzuya, Ryosuke Takahashi, Yoshiki Miyachi, Kenji Kabashinia
EUROPEAN JOURNAL OF DERMATOLOGY
(2015)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
