Review
Biochemistry & Molecular Biology
Yan Zhang, Chu-Yun Liu, Wei-Can Chen, Yan-Chuan Shi, Cong-Mei Wang, Shu Lin, He-Fan He
Summary: Neuropeptide Y plays a crucial role in maintaining body homeostasis by interacting with immune cells, BDNF, and promoting angiogenesis, impacting nutritional and inflammatory microenvironments. Its therapeutic potential, especially as an adjuvant therapy for stem cells, presents promising prospects for treating various diseases.
CELL AND BIOSCIENCE
(2021)
Article
Clinical Neurology
Leo Sher, Linda M. Bierer, Janine Flory, Iouri Makotkine, Rachel Yehuda
Summary: This study found that plasma BDNF levels were higher among combat veterans who made suicide attempts post-deployment compared to those who did not. BDNF may be involved in the pathophysiology of suicidal behavior in this population.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Hiroyuki Yajima, Izuki Amano, Sumiyasu Ishii, Tetsushi Sadakata, Wataru Miyazaki, Yusuke Takatsuru, Noriyuki Koibuchi
Summary: TH deficiency results in developmental delay in primary hippocampal neurons, likely caused by decreased Bdnf expression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Andonia Petkova-Tuffy, Nina Goedecke, Julio Viotti, Martin Korte, Thomas Dresbach
Summary: The study reveals that NL1 and BDNF act together to play a crucial role in synaptic maturation, including increasing the stability of active zones and recycling of synaptic vesicles, a process that relies on a transsynaptic pathway between them. Using BDNF can mimic the effects of NL1 overexpression on structural and functional maturation, while blocking BDNF signaling can prevent the effects of NL1 on presynaptic maturation.
Article
Multidisciplinary Sciences
Carlos Berlanga-Macias, Mairena Sanchez-Lopez, Montserrat Solera-Martinez, Ana Diez-Fernandez, Inmaculada Ballesteros-Yanez, Carlos A. Castillo-Sarmiento, Isabel A. Martinez-Ortega, Vicente Martinez-Vizcaino
Summary: This study found no significant positive association between exclusive breastfeeding and BDNF serum levels in Spanish schoolchildren aged eight to 11 years. Regardless of breastfeeding duration, age group, or sexual maturation, BDNF levels did not show significant differences, indicating that exclusive breastfeeding may not have a significant impact on BDNF levels in this age group.
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Article
Neurosciences
Shristi Khanal, Eugene Bok, Jaekwang Kim, Gyu Hwan Park, Dong-Young Choi
Summary: Parkinson's disease (PD) is a common neurodegenerative disease without known cure or therapy. Inosine, a purine nucleoside, can protect neuroblastoma cells and dopaminergic neurons through brain-derived neurotrophic factor (BDNF) upregulation and activation of its downstream signaling pathway. Adenosine receptors A1 and A2A play critical roles in mediating the neuroprotective effects of inosine. Inosine shows therapeutic potential in treating dopaminergic neurodegeneration in PD.
Article
Psychiatry
Otto Simonsson, Jose Carlos Bouso, Florian Kurth, Draulio B. Araujo, Christian Gaser, Jordi Riba, Eileen Luders
Summary: Research suggests potential benefits of ayahuasca in treating movement and neurodegenerative disorders, with preliminary evidence showing a thicker corpus callosum in ayahuasca users compared to controls. Further studies with larger samples and longitudinal designs are needed to confirm these findings and provide implications for future clinical research.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Anatomy & Morphology
Rene Westerhausen, Marietta Papadatou-Pastou
Summary: Recent research casts doubt on the long-held belief that left or mixed hand preference is associated with a larger corpus callosum, suggesting that this relationship may not be as strong as previously thought.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Jessica L. Fletcher, Larissa K. Dill, Rhiannon J. Wood, Sharon Wang, Kate Robertson, Simon S. Murray, Akram Zamani, Bridgette D. Semple
Summary: The study found that targeting TrkB immediately after early-life TBI can reduce brain tissue damage, preserve myelin integrity, provide neuroprotection, and lead to some improved neurobehavioral outcomes.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Psychiatry
Hayley Dingsdale, Samantha M. Garay, Hannah R. Tyson, Katrina A. Savory, Lorna A. Sumption, Jemima S. Kelleher, Kate Langley, Stephanie Van Goozen, Rosalind M. John
Summary: The study found a sex-specific association between cord serum BDNF levels at birth and attention development parameters in infants at one year old. This finding provides some support for the hypothesis that reduced serum BDNF levels at birth are linked to an increased risk for neurodevelopmental disorders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Jessica A. Harder, Raina N. Fichorova, Akanksha Srivastava, Aleta Wiley, Katherine E. Burdick, Joseph J. Locascio, Hadine Joffe
Summary: This study found that BDNF levels are positively correlated with the severity of mood symptoms in women with perimenopausal depression symptoms, resembling the pattern seen in hormonally-sensitive PMDD. This suggests the presence of a hormonally-sensitive mood disorder biomarker profile distinct from that of major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Entomology
Ryoichi Yoshimura, Taeko Suetsugu, Yasuhisa Endo
JOURNAL OF INSECT PHYSIOLOGY
(2017)
Article
Neurosciences
Yusuke Takeichi, Tatsuya Uebi, Naoyuki Miyazaki, Kazuyoshi Murata, Kouji Yasuyama, Kanako Inoue, Toshinobu Suzaki, Hideo Kubo, Naoko Kajimura, Jo Takano, Toshiaki Omori, Ryoichi Yoshimura, Yasuhisa Endo, Masaru K. Hojo, Eichi Takaya, Satoshi Kurihara, Kenta Tatsuta, Koichi Ozaki, Mamiko Ozaki
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Hirofumi Kuramoto, Ryoichi Yoshimura, Hiroshi Sakamoto, Makoto Kadowaki
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2019)
Article
Biochemistry & Molecular Biology
Yuka Matsuzaki, Rina Maruta, Keiko Takaki, Eiji Kotani, Yasuko Kato, Ryoichi Yoshimura, Yasuhisa Endo, Ciara Whitty, Christian Pernstich, Raj Gandhi, Michael Jones, Hajime Mori
Article
Microscopy
T. Nishida, R. Yoshimura, R. Nishi, Y. Imoto, Y. Endo
JOURNAL OF MICROSCOPY
(2020)
Article
Biochemistry & Molecular Biology
Mutsuko Sakai, Takaaki Sumiyoshi, Takuma Aoyama, Kenji Urayama, Ryoichi Yoshimura
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Entomology
Ryoichi Yoshimura, Taeko Suetsugu, Ai Kawahara, Kana Nakata, Masato Shikata, Souma Tanaka, Tsutomu Ono, Daisuke Fushiki, Yasuhisa Endo
JOURNAL OF INSECT PHYSIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mutsuko Sakai, Ryoichi Yoshimura
Summary: This study suggests that certain compounds may interfere with HSC recognition of stiffness, reducing liver fibrosis. Focal adhesion proteins may be promising targets in the development of liver fibrosis drugs.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Cell Biology
Hirofumi Kuramoto, Ada Koo, Linda J. Fothergill, Billie Hunne, Ryoichi Yoshimura, Makoto Kadowaki, John B. Furness
Summary: The study identified different morphologies and localizations of serotonin-containing enteroendocrine cells in the mouse large intestine, with different cell types distributed in various regions of the intestine. These cell morphologies facilitate communication with mucosal epithelial cells and response to mechanical forces.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell Biology
Ryo Morishita, Ryoichi Yoshimura, Hiroshi Sakamoto, Hirofumi Kuramoto
Summary: This immunohistochemical study examined the distribution and coding of substance P (SP) neurons and nerve fibers in the esophagus and discussed their functional roles. SP neurons were mainly cholinergic and some were nitrergic. SP nerve fibers were found in the myenteric plexus, muscularis mucosa, lower esophageal sphincter, and around blood vessels. Most SP nerve endings were cholinergic, but a few were calcitonin gene-related peptide (CGRP)-positive. Sensory neurons in the dorsal root ganglia and nodose ganglion projected to the esophagus, and most of the labeled SP neurons were CGRP-positive.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Immunology
Katsuhiro Torii, Shohei Takagi, Ryoichi Yoshimura, Seiji Miyata
Summary: This study shows that a transient increase in microglial population in the mouse brain during inflammation is beneficial in attenuating sickness responses.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Neurosciences
Akihiro Okamoto, Rena Fujii, Ryoichi Yoshimura, Seiji Miyata
Summary: Tanycytes, specialized ependymal cells lining the ventricular spaces of the adult brain, are found to have the capability of transporting macromolecules from the cerebrospinal fluid to brain neurons.
NEUROSCIENCE LETTERS
(2022)
Article
Psychology, Biological
Rika Kasuga, Chinatsu Shiraki, Ririka Horikawa, Ryoichi Yoshimura, Erkin Kurganov, Seiji Miyata
Summary: TRPM8 plays a crucial role in activating autonomic hypothalamic neuronal circuits under innocuous and nocuous cold stimuli, affecting sleep, behavior, and neuronal activation. The behaviors of TRPM8 KO mice in response to innocuous and nocuous cold stimuli differ significantly from those of WT mice.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Mari Komura, Seiji Miyata, Ryoichi Yoshimura
Summary: This study found that the TRPM8 agonist icilin pretreatment can alleviate the symptoms of sepsis induced by lipopolysaccharide (LPS), including decreases in body temperature, locomotor activity, body weight, and food and water intakes.
NEUROSCIENCE LETTERS
(2023)
Article
Cell Biology
Tomoki Nishida, Ryoichi Yoshimura, Yasuhisa Endo
CELL AND TISSUE RESEARCH
(2017)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)