Review
Biochemistry & Molecular Biology
Lokender Kumar, Monish Bisen, Azhar Khan, Pradeep Kumar, Sanjay Kumar Singh Patel
Summary: This review discusses the role of MMPs in skeletal muscle function, muscle injury and repair, as well as the potential applications of MMPs in the treatment of musculoskeletal disorders.
Article
Biochemistry & Molecular Biology
Juliane Meissner, Maryam Rezaei, Isabel Siepe, Doreen Ackermann, Simone Koenig, Johannes A. Eble
Summary: Proteomics studies have shown that adhesomes are made up of a variety of proteins at cellular contact sites with the extracellular matrix. The redox state of individual adhesome proteins in response to environmental signals adds a new aspect to adhesome complexity. This redox proteomic analysis revealed that sulfenylation and protein location at adhesomes mutually influence each other.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.
Article
Biochemistry & Molecular Biology
Wang Ding, Yuxiang Ge, Huiyi Sun, Jun Xu, Huijie Gu, Chong Bian, Haihong Chen, Libo Jiang, Xiaofan Yin
Summary: This study identified that intracellular Zn2+ concentration significantly increased in NPCs treated with inflammatory stimuli and excessive mechanical stress, with ZIP8 being the predominant Zn2+ importer. Knockdown of ZIP8 alleviated ECM degradation induced by these stimuli by inhibiting NF-kappa B signaling pathway activation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Preety Choudhary, Tapasi Roy, Abhishek Chatterjee, Vineet Kumar Mishra, Suyash Pant, Snehasikta Swarnakar
Summary: Forced swim stress induces gastric ulceration by promoting ROS overproduction, while melatonin provides gastroprotection by reducing inflammation burden, inhibiting MMP-3 activity, and other mechanisms.
Review
Chemistry, Medicinal
Usman Sabir, Hong-mei Gu, Da-Wei Zhang
Summary: MMPs have a complex role in liver fibrosis, with high expression in the early stage causing tissue damage and promoting fibrosis progression, and downregulation in the later stage facilitating ECM accumulation and disease progression. Phytochemicals can modulate MMP activity and ECM turnover, alleviating disease progression, but their effects depend on disease models, stages, and the dosage, timing, and duration of phytochemicals used.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yihe Wang, Christine Y. Chuang, Clare L. Hawkins, Michael J. Davies
Summary: Matrix metalloproteinase-9 (MMP9) plays a crucial role in the degradation of extracellular matrix (ECM) proteins. This study demonstrates that MMP9 can be activated by both chloramines and oxidation. The activation of MMP9 and ECM degradation are interdependent processes that may contribute to the progression of diseases.
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Gaofeng Zhang, Yuanmei Liao, Hanshi Yang, Jian Tao, Lin Ma, Xiaohua Zuo
Summary: Irigenin, an isoflavonoid from Belamcanda chinensis, shows potential in reducing intervertebral disc degeneration (IDD) by inhibiting apoptosis and extracellular matrix degradation through decreasing the expression of caspase-3 and MMPs in TNF-alpha-stimulated nucleus pulposus cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Chiara Compagnoni, Veronica Zelli, Andrea Bianchi, Antinisca Di Marco, Roberta Capelli, Davide Vecchiotti, Laura Brandolini, Anna Maria Cimini, Francesca Zazzeroni, Marcello Allegretti, Edoardo Alesse, Alessandra Tessitore
Summary: This study analyzed the regulation of microRNA levels in corneal cells in response to recombinant human NGF (rhNGF) treatment, and identified key genes and pathways involved in neurotrophin signaling and cell proliferation and apoptosis control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Ratajczak-Wielgomas, Alicja Kmiecik, Piotr Dziegiel
Summary: The expression of POSTN is significantly increased in NSCLC and may serve as an independent prognostic factor. POSTN knockdown inhibits the migration and invasion of lung cancer cells, potentially through modulating the expression of MMP-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Carlos Ramos, Rebeca Canedo-Mondragon, Carina Becerril, Georgina Gonzalez-Avila, Ana Laura Esquivel, Ana Lilia Torres-Machorro, Martha Montano
Summary: Exposure to short-term wood smoke was found to significantly increase total cells, macrophages, neutrophils, and collagen in the respiratory system of guinea pigs, leading to overexpression of pro-inflammatory cytokines, MMPs, and TIMPs in lung tissue.
Review
Chemistry, Multidisciplinary
Meihui Yi, Weiyi Tan, Jiaqi Guo, Bing Xu
Summary: Enzymatic noncovalent synthesis allows for the control of multimolecular crowding in cells, offering opportunities for modulating cellular functions and various biomedical applications.
CHEMICAL COMMUNICATIONS
(2021)
Article
Neurosciences
Yusuke Takeichi, Tatsuya Uebi, Naoyuki Miyazaki, Kazuyoshi Murata, Kouji Yasuyama, Kanako Inoue, Toshinobu Suzaki, Hideo Kubo, Naoko Kajimura, Jo Takano, Toshiaki Omori, Ryoichi Yoshimura, Yasuhisa Endo, Masaru K. Hojo, Eichi Takaya, Satoshi Kurihara, Kenta Tatsuta, Koichi Ozaki, Mamiko Ozaki
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Hirofumi Kuramoto, Ryoichi Yoshimura, Hiroshi Sakamoto, Makoto Kadowaki
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2019)
Article
Microscopy
T. Nishida, R. Yoshimura, R. Nishi, Y. Imoto, Y. Endo
JOURNAL OF MICROSCOPY
(2020)
Article
Biochemistry & Molecular Biology
Mutsuko Sakai, Takaaki Sumiyoshi, Takuma Aoyama, Kenji Urayama, Ryoichi Yoshimura
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Entomology
Ryoichi Yoshimura, Taeko Suetsugu, Ai Kawahara, Kana Nakata, Masato Shikata, Souma Tanaka, Tsutomu Ono, Daisuke Fushiki, Yasuhisa Endo
JOURNAL OF INSECT PHYSIOLOGY
(2020)
Article
Pharmacology & Pharmacy
Mutsuko Sakai, Ryoichi Yoshimura
Summary: This study suggests that certain compounds may interfere with HSC recognition of stiffness, reducing liver fibrosis. Focal adhesion proteins may be promising targets in the development of liver fibrosis drugs.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Cell Biology
Hirofumi Kuramoto, Ada Koo, Linda J. Fothergill, Billie Hunne, Ryoichi Yoshimura, Makoto Kadowaki, John B. Furness
Summary: The study identified different morphologies and localizations of serotonin-containing enteroendocrine cells in the mouse large intestine, with different cell types distributed in various regions of the intestine. These cell morphologies facilitate communication with mucosal epithelial cells and response to mechanical forces.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell Biology
Ryo Morishita, Ryoichi Yoshimura, Hiroshi Sakamoto, Hirofumi Kuramoto
Summary: This immunohistochemical study examined the distribution and coding of substance P (SP) neurons and nerve fibers in the esophagus and discussed their functional roles. SP neurons were mainly cholinergic and some were nitrergic. SP nerve fibers were found in the myenteric plexus, muscularis mucosa, lower esophageal sphincter, and around blood vessels. Most SP nerve endings were cholinergic, but a few were calcitonin gene-related peptide (CGRP)-positive. Sensory neurons in the dorsal root ganglia and nodose ganglion projected to the esophagus, and most of the labeled SP neurons were CGRP-positive.
HISTOCHEMISTRY AND CELL BIOLOGY
(2023)
Article
Immunology
Katsuhiro Torii, Shohei Takagi, Ryoichi Yoshimura, Seiji Miyata
Summary: This study shows that a transient increase in microglial population in the mouse brain during inflammation is beneficial in attenuating sickness responses.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Neurosciences
Akihiro Okamoto, Rena Fujii, Ryoichi Yoshimura, Seiji Miyata
Summary: Tanycytes, specialized ependymal cells lining the ventricular spaces of the adult brain, are found to have the capability of transporting macromolecules from the cerebrospinal fluid to brain neurons.
NEUROSCIENCE LETTERS
(2022)
Article
Psychology, Biological
Rika Kasuga, Chinatsu Shiraki, Ririka Horikawa, Ryoichi Yoshimura, Erkin Kurganov, Seiji Miyata
Summary: TRPM8 plays a crucial role in activating autonomic hypothalamic neuronal circuits under innocuous and nocuous cold stimuli, affecting sleep, behavior, and neuronal activation. The behaviors of TRPM8 KO mice in response to innocuous and nocuous cold stimuli differ significantly from those of WT mice.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Neurosciences
Mari Komura, Seiji Miyata, Ryoichi Yoshimura
Summary: This study found that the TRPM8 agonist icilin pretreatment can alleviate the symptoms of sepsis induced by lipopolysaccharide (LPS), including decreases in body temperature, locomotor activity, body weight, and food and water intakes.
NEUROSCIENCE LETTERS
(2023)