Article
Neurosciences
Jongryul Hong, Yeonji Jeong, Won Do Heo
Summary: In this study, researchers found that deletion of TrkB in neurons projecting from the medial entorhinal cortex to the mPFC led to reduced remote memory recall in male mice. The deletion of TrkB also attenuated the participation of mPFC cells in the recall of remote fear memory and was associated with reduced reactivation of cells in the mPFC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ramon Martinez-Marmol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong-Min Hong, Seon Beom Kim, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Elizabeth J. Coulson, Mi Kyeong Lee, Sun Yeou Kim, Frederic A. Meunier
Summary: The traditional medicinal mushroom Hericium erinaceus enhances peripheral nerve regeneration through neurotrophic activity. We identified N-de phenylethyl isohericerin (NDPIH) and hericene A as biologically active compounds from this mushroom that promote neurite outgrowth in hippocampal neurons. NDPIH acts through a neurotrophic pathway independent of TrkB with ERK1/2 activation, while hericene A acts through a novel pan-neurotrophic signaling pathway, leading to improved cognitive performance in mice.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Behavioral Sciences
Nishant Ranjan Chauhan, Rahul Kumar, Avinash Gupta, Ramesh Chand Meena, Sarita Nanda, Kamla Prasad Mishra, Shashi Bala Singh
Summary: This study investigated the effects of heat stress on the hippocampus and spatial memory in rats, revealing that heat exposure can lead to oxidative damage, neuronal apoptosis and spatial memory deficits in the hippocampus. Furthermore, the dysregulation of the BDNF/ERK1/2/CREB axis was found to be associated with cognitive decline under heat stress.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Dominik Fiedler, Manju Sasi, Robert Blum, Christopher M. Klinke, Marta Andreatta, Hans-Christian Pape, Maren D. Lange
Summary: Researchers have identified that the oval nucleus of the bed nucleus of the stria terminalis (ovBNST) is rich in brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) receptor, which interact to reduce neuronal excitability and mediate long-term depression (LTD) in ovBNST neurons. This suggests that BDNF/TrkB signaling is a critical regulator of synaptic activity in ovBNST, dampening excitability at short and long time scales, and providing a potential entry point for adaptation to stressful environmental encounters, particularly in mediating maladaptive behaviors associated with stress exposure.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Anna A. Cook, Sriram Jayabal, Jacky Sheng, Eviatar Fields, Tsz Chui Sophia Leung, Sabrina Quilez, Eileen McNicholas, Lois Lau, Shixia Huang, Alanna J. Watt
Summary: In a mouse model of SCA6, exercise and the TrkB agonist 7,8-DHF were found to increase cerebellar BDNF expression, improve motor coordination and cerebellar cell firing rate deficits, suggesting their potential as therapeutic interventions for SCA6.
Article
Clinical Neurology
Yuhuan Li, Nina Wang, Jie Pan, Xinrui Wang, Yanling Zhao, Zongjun Guo
Summary: Depression is a common mental disorder, and the mechanisms underlying it are still unclear. This study found that miR-144 expression was reduced in the hippocampus of CUMS rats, and by inhibiting PTP1B, miR-144 activated the TrkB/BDNF signaling pathway in the hippocampus, playing an antidepressant role.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Neurosciences
Gerardo Ramirez-Mejia, Elvi Gil-Lievana, Oscar Urrego-Morales, Ernesto Soto-Reyes, Federico Bermudez-Rattoni
Summary: The research demonstrates that inhibiting class I HDAC enhances long-term object recognition memory consolidation, coinciding with a peak of BDNF expression 4 hours after acquisition. Blocking the tyrosine kinase B (TrkB) receptor at 4 hours, but not at 8 hours, impairs ORM consolidation.
Article
Behavioral Sciences
Nader Asadian, Houman Parsaie, Abbas Ali Vafaei, Masoumeh Dadkhah, Samira Omoumi, Katayoun Sedaghat
Summary: Disruptions in light/dark cycle can affect memory formation and retrieval in human and animals. Chronic light deprivation disrupts the neural connections for hippocampal memory formation, impacting spatial and auditory fear memory in rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Sayna Bagheri, Kamyar Moradi, Elnaz Ehghaghi, Abolfazl Badripour, Mohammad Keykhaei, Amir Ashraf-Ganjouei, Mana Moassefi, Shahriar Faghani, Ahmad Reza Dehpour
Summary: Chronic social isolation stress can impair learning and memory-related behaviors, while melatonin treatment can alleviate memory impairment by modulating the BDNF/TrkB/CREB signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Pu Yang, Haiyan Chen, Tian Wang, Hong Su, Jing Li, Yujun He, Shengyong Su
Summary: This study aims to explore whether EA can relieve CIP and depression by regulating hippocampal synaptic plasticity, and provides foundational evidence for the efficacy of EA in treating CIP-related depression (CIPD).
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Yu-han Xie, Chun-ni Zhou, Xin Liang, Jing Tang, Chun-mao Yang, Yan-min Luo, Feng-lei Chao, Lin Jiang, Jin Wang, Ying-qiang Qi, Pei-lin Zhu, Yue Li, Kai Xiao, Yong Tang
Summary: Chronic stress can decrease the number of synapses in the hippocampus, while treatment with anti-Lingo-1 antibody can prevent this decline and improve spatial learning and memory abilities in stressed rats. The antibody also helps protect synapses and enhance the expression of postsynaptic density protein-95 (PSD-95) in specific regions of the hippocampus.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Vasilios Kafetzopoulos, Nikolaos Kokras, Nuno Sousa, Katerina Antoniou, Ioannis Sotiropoulos, Christina Dalla
Summary: The hippocampus-prefrontal cortex circuit plays a crucial role in stress and depression. Lesioning the thalamic nucleus reuniens (RE) can prevent the negative effects of chronic mild stress on prefrontal cortex neuroplasticity in male rats. This study demonstrates that pre-stress RE lesion can prevent hippocampal dendritic atrophy induced by chronic mild stress, similar to the effect of antidepressant treatment.
Article
Biochemistry & Molecular Biology
Maria Pina Serra, Francesco Sanna, Marianna Boi, Marcello Trucas, Alberto Fernandez-Teruel, Maria Giuseppa Corda, Osvaldo Giorgi, Marina Quartu
Summary: This study investigated the effects of a mild acute stressor, tail pinch, on the levels of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor B (trkB) proteins in the hippocampus of rats. The results showed that tail pinch induced distinct changes in BDNF and trkB levels in different regions of the hippocampus, with an upregulation in the dorsal area but a downregulation in the ventral area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Wenying Zhang, Tingyu Ding, Hong Zhang, Yuping Chen, Liping Liu, Jinjin Jiang, Siyuan Song, Hao Cheng, Changhao Wu, Jihu Sun, Qin Wu
Summary: This study demonstrates that the chronic stress-induced behavioral disorders can be improved by treatment with Clostridium butyricum RH2, possibly through regulating the balance of BDNF and proBDNF and inhibiting the expression of brain PAI-1.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xueyan Wang, Yueqi Yang, Aiai Xiao, Ning Zhang, Mingyong Miao, Zhengping Wang, Jun Han, Min Wen
Summary: This study investigated the prophylactic effects of medium-chain triglyceride-enriched and long-chain triglyceride-enriched ketogenic diets on cognitive deficiency in a chronic sleep deprivation model. The results showed that the medium-chain triglyceride-enriched ketogenic diet had stronger effects in improving cognitive deficiency by suppressing ferroptosis and improving synaptic plasticity. Mechanism results indicated that the medium-chain triglyceride-enriched ketogenic diet produced higher levels of Sirt3 protein, which may contribute to the synergistic effect of beta hydroxybutyric acid and decanoic acid.
Article
Multidisciplinary Sciences
Sook-Lei Liew, Julia M. Anglin, Nick W. Banks, Matt Sondag, Kaori L. Ito, Hosung Kim, Jennifer Chan, Joyce Ito, Connie Jung, Nima Khoshab, Stephanie Lefebvre, William Nakamura, David Saldana, Allie Schmiesing, Cathy Tran, Danny Vo, Tyler Ard, Panthea Heydari, Bokkyu Kim, Lisa Aziz-Zadeh, Steven C. Cramer, Jingchun Liu, Surjo Soekadar, Jan-Egil Nordvik, Lars T. Westlye, Junping Wang, Carolee Winstein, Chunshui Yu, Lei Ai, Bonhwang Koo, R. Cameron Craddock, Michael Milham, Matthew Lakich, Amy Pienta, Alison Stroud
Article
Genetics & Heredity
Michael C. Holter, Lauren T. Hewitt, Stephanie Koebele, Jessica M. Judd, Lei Xing, Heather A. Bimonte-Nelson, Cheryl D. Conrad, Toshiyuki Araki, Benjamin G. Neel, William D. Snider, Jason M. Newbern
Article
Behavioral Sciences
Tanya A. Gupta, Carter W. Daniels, J. Bryce Ortiz, McAllister Stephens, Paula Overby, Korinna Romero, Cheryl D. Conrad, Federico Sanabria
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Stephanie V. Koebele, Kenji J. Nishimura, Heather A. Bimonte-Nelson, Salma Kemmou, J. Bryce Ortiz, Jessica M. Judd, Cheryl D. Conra
HORMONES AND BEHAVIOR
(2020)
Article
Chemistry, Analytical
Julia M. Juliano, Ryan P. Spicer, Athanasios Vourvopoulos, Stephanie Lefebvre, Kay Jann, Tyler Ard, Emiliano Santarnecchi, David M. Krum, Sook-Lei Liew
Biographical-Item
Neurosciences
Liisa A. M. Galea, Roberta D. Brinton, Heather A. Cameron, Cheryl D. Conrad, Sonia J. Lupien, Rebecca M. Shansky, Catherine S. Woolley, Elizabeth Gould
TRENDS IN NEUROSCIENCES
(2020)
Article
Behavioral Sciences
Dylan N. Peay, Hovhannes M. Saribekyan, Priscilla A. Parada, Elizabeth M. Hanson, Bryce S. Badaruddin, Jessica M. Judd, Megan E. Donnay, Diego Padilla-Garcia, Cheryl D. Conrad
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Neurosciences
J. Bryce Ortiz, Jason Newbern, Cheryl D. Conrad
Summary: Chronic stress affects the inhibitory GABA circuitry in distinct hippocampal subregions without altering the total number of GABAergic neurons. It reduces the expression of CR+ in the CA3 region and DG region of the hippocampus, especially in males, but these changes reverse after a rest period. Chronic stress also decreases the proportion of hippocampal SOM+ neurons, and this reduction persists even with a rest period.
Article
Endocrinology & Metabolism
Camila de Avila, Sandrine Chometton, Juliane Calvez, Genevieve Guevremont, Alan Kania, Lola Torz, Christophe Lenglos, Anna Blasiak, Mette M. Rosenkilde, Birgitte Holst, Cheryl D. Conrad, John D. Fyer, Elena Timofeeva, Andrew L. Gundlach, Carlo Cifani
Summary: Food intake varies during the ovarian hormone/estrous cycle in humans and rodents, mediated mainly by estradiol. The RLN3/RXFP3 system is modulated by the estrous cycle, suggesting its involvement in food intake fluctuations observed in female rats. Further studies are needed to elucidate the cellular and molecular mechanisms of estradiol signaling.
NEUROENDOCRINOLOGY
(2021)
Editorial Material
Neurosciences
Cheryl D. Conrad
Summary: This study provides a descriptive analysis of biological, psychological, and socioemotional markers of stress in individuals who self-identify as being either 'very stressed out' or 'zen'.
NEUROBIOLOGY OF STRESS
(2022)
Article
Neurosciences
Jessica M. Judd, Elliot A. Smith, Jinah Kim, Vrishti Shah, Federico Sanabria, Cheryl D. Conrad
Article
Neuroimaging
Yanlu Wang, Julia M. Juliano, Sook-Lei Liew, Alexander M. McKinney, Seyedmehdi Payabvash
NEUROIMAGE-CLINICAL
(2019)
Article
Integrative & Complementary Medicine
Melanie Wathugala, David Saldana, Julia M. Juliano, Jennifer Chan, Sook-Lei Liew
JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE
(2019)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.