Article
Immunology
Yueyi Yao, Changyan Li, Fusheng Qian, Yu Zhao, Xiaoyi Shi, Dan Hong, Qinglong Ai, Lianmei Zhong
Summary: Our study reveals that Rg1 effectively suppresses the expression of inflammasomes and microglia pyroptosis induced by LPS. Rg1 regulates microglia pyroptosis in neuroinflammation by targeting the STAT3 signaling pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Immunology
Alanna G. Spiteri, Duan Ni, Zheng Lung Ling, Laurence Macia, Iain L. Campbell, Markus J. Hofer, Nicholas J. C. King
Summary: PLX5622, a widely used inhibitor of CSF-1R, has been shown to not only deplete microglia, but also mature monocytes in a mouse model of severe neuroinflammation induced by WNE. Its protective effect is mediated by the inhibition of CSF-1R, and it also has potential therapeutic applications in CNS viral infection and other monocyte-mediated diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Shao-jie Yang, Jing-ji Wang, Ping Cheng, Li-xia Chen, Jia-min Hu, Guo-qi Zhu
Summary: Ginseng, a traditional Chinese medicinal herb, has been used for thousands of years to nourish the organs, promote mental calmness, and enhance wisdom. One of its active components, ginsenoside Rg1, has been extensively studied for its anti-inflammatory, antioxidant, and neuroprotective properties, particularly in the treatment of brain disorders such as dementia and depression. This review summarizes the research progress on the mechanisms by which Rg1 improves depression-like behaviors, including its inhibition of the hypothalamic-pituitary-adrenal axis, regulation of synaptic plasticity, and modulation of gut flora. The findings suggest that Rg1 may have potential therapeutic effects on Alzheimer's disease, and its ability to regulate memory states caused by different stimuli. Future in-depth investigations are needed to fully understand the mechanisms of Rg1, and clinical trials in specific neuropsychiatric disorders will contribute to the development of effective drugs.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Huiqin Wang, Yantao Yang, Songwei Yang, Siyu Ren, Juling Feng, Yangbo Liu, Haodong Chen, Naihong Chen
Summary: Depression is closely associated with inflammation, and ginsenoside Rg1 can ameliorate neuroinflammation and alleviate depression by suppressing the ubiquitination of Cx43, showing potential therapeutic effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhangbi Wu, Jialin Huang, Xiaojie Bai, Qunan Wang, Fen Wang, Jun Xu, Huiping Tang, Chunying Yin, Yu Wang, Feng Yu, Hong Zhang
Summary: Ginsenoside-Rg1 exerts its neuroprotective effects by ameliorating hippocampus-dependent neuroglia activation-mediated neuroinflammation and neuroplasticity deficits.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Zhipeng Li, Qingchen Wang, Zhonghong Zhang, Xiao Zhang, Xintong Wu, Li Li, Yi Zhang, Yihua Yu
Summary: Luteolin inhibits neuroinflammation and alleviates depression-like behavior by upregulating A20 and Nrf2.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Cell Biology
Mustafa N. Mithaiwala, Danielle Santana-Coelho, Grace A. Porter, Jason C. O'Connor
Summary: Diseases of the central nervous system (CNS) present significant global health, social, and economic challenges, with neuroinflammation potentially serving as a common link between various neurological disorders. Exploring the relationship between neuroinflammation, the kynurenine pathway, and CNS diseases can provide insights for developing effective treatment strategies.
Article
Pharmacology & Pharmacy
Hui He, Xiaofang Xie, Xixi Kang, Jinqiang Zhang, Lu Wang, Nan Hub, Lei Xie, Cheng Peng, Zili You
Summary: This study used a stress-induced depression mouse model and found that ginsenoside Rg1 could exert antidepressant effects by inhibiting the activation of NLRP3 inflammasome in microglia, promoting a proneurogenic phenotype, and increasing hippocampal neurogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Hui-Qin Wang, Song-Wei Yang, Yan Gao, Ying-Jiao Liu, Xun Li, Qi-Di Ai, Mei-Yu Lin, Yan-Tao Yang, Qi Zeng, Yi Zhang, Zhen-Zhen Wang, Nai-Hong Chen
Summary: Panax ginseng is a valuable herb for the prevention and treatment of depression, with its main bioactive constituent, ginsenoside Rg1, upregulating the level of Cx43 in astrocytes. The study aims to dissect the mechanisms of Rg1 controlling Cx43 levels in primary astrocytes, showing that Rg1 can reverse CORT-induced downregulation of Cx43 biosynthesis and acceleration of Cx43 degradation. The findings suggest that Rg1 increases Cx43 protein levels through the upregulation of Cx43 mRNA and downregulation of Cx43 degradation pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Zhixin Peng, Xiaoheng Li, Jun Li, Yuan Dong, Yuhao Gao, Yajin Liao, Meichen Yan, Zengqiang Yuan, Jinbo Cheng
Summary: This study unveiled the role of Dlg1 in microglia, showing that knocking down Dlg1 can reduce microglial activation and alleviate LPS-induced depression-like behavior. This discovery provides a new potential therapeutic target for the clinical treatment of depression.
NEUROSCIENCE BULLETIN
(2021)
Article
Clinical Neurology
Tianyuan Wang, Huandi Weng, Hongji Zhou, Zecheng Yang, Zhongyou Tian, Biao Xi, Yalan Li
Summary: This study aimed to investigate the protective effects and mechanisms of action of esketamine in postoperative depression (POD). The results showed that esketamine can significantly improve depression-like symptoms caused by anesthesia and surgery, and restore synaptogenesis in the medial prefrontal cortex (mPFC) that had been perturbed by inflammation. The anti-inflammatory effects of esketamine may be mediated by the BDNF/TrkB signaling pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Medicine, Research & Experimental
Ruisi Liu, Yueling Gong, Chenyi Xia, Yemin Cao, Cheng Zhao, Mingmei Zhou
Summary: Neuroinflammation plays a crucial role in the pathogenesis of depression, and itaconate, a metabolite secreted by macrophages, has potent anti-inflammatory and immunomodulatory effects that can improve depressive symptoms through various mechanisms. With the development of optimization and new delivery systems, itaconate has gained significantly improved application value and therapeutic potential. This article provides an overview of the immunomodulatory effects of itaconate and its promising application as a precursor of antidepressants in inflammatory depression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Yang Xu, Wei Li, Mengmeng Shi, Xiaofan Xu, Dongmin Guo, Zhenghai Liu, Ling Chen, Xiaolin Zhong, Wenyu Cao
Summary: Gonadotropin-releasing hormone (GnRH) mediates depression-like behaviors by modulating microglia function in the hippocampus. The antidepressant effect of GnRH depends on hippocampal GnRHR signaling, and peripheral GnRH treatment prevents microglia-mediated inflammation in the hippocampus. These findings provide insights into the function and cross-talk of GnRH in neuro-immune response.
Article
Neurosciences
Andrej Roczkowsky, Matthew A. L. Doan, Brittyne A. Hlavay, Manmeet K. Mamik, William G. Branton, Brienne A. McKenzie, Leina B. Saito, Laura Schmitt, Gary Eitzen, Francesca Di Cara, Melinda Wuest, Frank Wuest, Richard Rachubinski, Christopher Power
Summary: This study investigates the peroxisomal injury and the effects of peroxisome-restorative therapy on inflammatory demyelination in multiple sclerosis (MS) models. It reveals that peroxisomes play critical roles in CNS homeostasis and their dysfunction is associated with neuroinflammation and demyelination in MS. The therapeutic peroxisome proliferator, 4-phenylbutyrate (4-PBA), shows potential in mitigating neuroinflammation and promoting myelin repair in MS.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Shangmin Yu, Xinying Wang, Linlin Lv, Tongyan Liu, Qingxiang Guan
Summary: Depression is a chronic mental disorder that poses a threat to human health and well-being. The treatment of depression is challenging due to the blood brain barrier, which limits the distribution of antidepressant drugs in the brain. This study developed a brain-targeted drug delivery system using borneol-modified PEGylated graphene oxide, which showed promising potential for the treatment of depression by efficiently penetrating the blood brain barrier and exhibiting neuroprotective effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Han Xiao, Rui Zhang, Xiaobo Fan, Xinglu Jiang, Mingyuan Zou, Xuejiao Yan, Haiping Hao, Guoqiu Wu
Summary: The development of nanomedicine has made significant breakthroughs in cancer treatment, but the biocompatibility and targeted penetration of nanomaterials remain limitations. A bifunctional nanoparticle, synthesized through the self-assembly of intermediate filaments with RGD peptide and encapsulation of 7-AAD molecules, serves as a fluorescent imaging probe for tumor treatment visualization.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Cell Biology
Xiao Zheng, Xiaoying Cai, Haiping Hao
Summary: The interaction between microbial metabolites and host targets plays a crucial role in signal transmission and biological regulation. Understanding the interaction between microbial metabolites and host targets can provide new insights into host health and disease, expand the range of druggable targets, and inspire drug design and discovery.
Article
Food Science & Technology
Keisuke Hamada, Ping Wang, Yangliu Xia, Nana Yan, Shogo Takahashi, Kristopher W. Krausz, Haiping Hao, Tingting Yan, Frank J. Gonzalez
Summary: WA has therapeutic effects on alcoholic liver disease by inhibiting hepatic lipogenesis to reduce liver injury caused by alcohol.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Analytical
Yiting Shi, Fengjie Yu, Yi Wu, Lin Dai, Yutong Feng, Shilei Chen, Guoxiang Wang, Hongyu Ma, Xitong Li, Chen Dai
Summary: The study identified GLpGER as a potential bioactive peptide derived from natural proteins that may help reduce acute alcohol-induced liver injury by restoring liver ADH activity and decreasing alcohol concentration levels.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemical Research Methods
Rongfan Tang, Pengcheng Chen, Zhe Wang, Lingling Wang, Haiping Hao, Tingjun Hou, Huiyong Sun
Summary: “Drug design targeting protein-protein interactions associated with disease development is crucial. Besides interrupting interactions, stabilizing protein-protein interactions can also be beneficial for therapy. However, characterizing the stabilization effect of stabilizers is challenging, which highlights the importance of developing reliable computational strategies.”
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Gastroenterology & Hepatology
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez
Summary: Intestinal PPAR alpha signaling modulates fatty acid uptake through regulating FABP1 expression, contributing to NASH progression. Targeting this pathway could be a potential therapeutic strategy for NASH treatment.
Article
Chemistry, Medicinal
Yun Wang, Yuanyuan Xu, Xiaowei Xu, Hong Wang, Dong Wang, Wenchao Yan, Jiaying Zhu, Haiping Hao, Guangji Wang, Lijuan Cao, Jun Zhang
Summary: This study confirmed the beneficial effects of Ginkgo biloba leave extract (GbE) in alleviating hypercholesterolemia, inflammation, and atherosclerosis. GbE treatment reshaped the intestinal microbiota, downregulated proinflammatory cytokines, and enhanced the expression of tight junction proteins. It also reversed the dysfunction of microbial metabolic phenotypes and reduced atherosclerotic plaque areas. These findings provide important insights into the pharmacological mechanism underlying the antiatherogenic efficacy of GbE.
PHYTOTHERAPY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jiajia Shen, Huimin Guo, Shijia Liu, Wei Jin, Zhi-Wei Zhang, Yong Zhang, Keanqi Liu, Shuying Mao, Zhihao Zhou, Lin Xie, Guangji Wang, Haiping Hao, Yan Liang
Summary: This study identifies the crucial role of intestinal flora and microbiota metabolites in the occurrence and treatment of ischaemic stroke. The accumulation of branched-chain amino acids is closely associated with gut microflora dysbiosis and neuroinflammation. Lactobacillus helveticus and Lactobacillus brevis colonization exhibit neuroprotective activity and alleviate the accumulation of branched-chain amino acids.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tingting Yao, Heng Xiao, Hong Wang, Xiaowei Xu
Summary: Proteolysis-targeting chimera (PROTAC) is a promising molecule that degrades specific proteins through the ubiquitin-proteasome system. It has shown remarkable efficacy in various fields and opened up new avenues for biomedical research and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Qinghua Wang, Zhe Wang, Sheng Tian, Lingling Wang, Rongfan Tang, Yang Yu, Jingxuan Ge, Tingjun Hou, Haiping Hao, Huiyong Sun
Summary: The mechanism of transcriptional regulation in nuclear receptors involves two main conformations, active and inactive. It is challenging to determine the molecular type of a ligand bound to the receptor's ligand-binding pocket (LBP) because agonists and antagonists bind to the same position. Therefore, precise and efficient methods are needed to distinguish between agonists and antagonists targeting the LBP of nuclear receptors.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Pharmacology & Pharmacy
Shuang Cui, Huijian Hu, An Chen, Ming Cui, Xiaojie Pan, Pengfei Zhang, Guangji Wang, Hong Wang, Haiping Hao
Summary: The acetylation of FXR regulates its nucleocytoplasmic shuttling and degradation under conditions of liver injury, which limits the clinical benefits of FXR agonists. SIRT1 activators can reduce FXR acetylation and prevent its cytosolic degradation, and combining SIRT1 activators with FXR agonists shows promise in treating liver diseases.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Pharmacology & Pharmacy
Wenjie Lu, Lingfei Yu, Lujun Wang, Songlin Liu, Manman Li, Zijun Wu, Shengqi Chen, Rongfeng Hu, Haiping Hao
Summary: A metformin hydrochloride mucosal nanoparticles enteric-coated capsule (MH-MNPs-EC) was developed to improve the bioavailability and hypoglycemic effect duration of metformin hydrochloride for the treatment of type 2 diabetes. The capsule showed improved efficacy and prolonged residence time in the intestine compared to commercial metformin hydrochloride capsules.
Review
Chemistry, Medicinal
Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang
Summary: Nonalcoholic fatty liver disease is a common liver disease without approved pharmacotherapy. Farnesoid X receptor (FXR) is considered a promising therapeutic target, but currently developed drugs have shown limited efficacy in clinical trials. This review summarizes the development of the FXR agonist obeticholic acid and discusses its limitations in depth.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Psychology, Multidisciplinary
Haiping Hao, Xiaobao Li, Xi Shen, Hong Jiang, Haoyue Xiao, Houchao Lyu
Summary: This study examined the reciprocal relationship between future time perspective and self-control among adolescents. The results showed that future-negative and future-confusional were negatively related to self-control, while future-positive, future-perspicuity, future-perseverant, and future-planning were positively related to self-control. The study also found reciprocal relationships between future-confusional, future-planning, and self-control.
CURRENT PSYCHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jianbing Wu, Yihui Hu, Hui Ye, Sheng Zhang, Jie Zhu, Duorui Ji, Yihua Zhang, Ya Ding, Zhangjian Huang
Summary: This study presents the design and construction of novel coordinative nanoparticles that can achieve specific activation and cleavage reactions of two prodrugs in tumors, leading to improved therapeutic efficacy for triple-negative breast cancer.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.