Article
Medicine, Research & Experimental
Shan Dongjie, R. Samuel Rajendran, Qing Xia, Gaimei She, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: The neuroprotective effects of Tongtian Oral Liquid (TTKFY) were evaluated in an animal model of Parkinson's disease. The results showed that TTKFY protected dopaminergic neurons, improved behavioral function, increased antioxidant activities, and regulated gene expression. This suggests that TTKFY has potential in preventing and treating Parkinson's disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Neurosciences
Yu Han, Mei Yuan, Yi-Sha Guo, Xin-Ya Shen, Zhen-Kun Gao, Xia Bi
Summary: In addition to genetic information, environmental factors play a crucial role in the structure and function of the nervous system and the development of nervous system diseases. Enriched environment promotes neural development and repair, enhances learning and memory capacity, but its effects may vary across different developmental stages.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sai Teja Meka, Sree Lalitha Bojja, Gautam Kumar, Sumit Raosaheb Birangal, Mallikarjuna Rao
Summary: Parkinson's Disease (PD) is a rapidly growing neurological disorder with high disability and mortality rates. Current treatments focus on symptomatic relief but there is a need for disease-modifying therapies. Recent research has identified histone deacetylase inhibitors (HDACi) as potential drug targets for neurodegenerative diseases like PD. A study found that a novel pan-HDACi showed neuroprotective effects in a PD rat model by reducing oxidative stress and inflammation, and restoring dopamine levels in the striatum.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sandro Huenchuguala, Juan Segura-Aguilar
Summary: Iron plays a fundamental role in various aspects of human life, but an imbalance in iron levels can lead to certain pathologies. Maintaining iron homeostasis is crucial in preventing these pathologies. While there is evidence suggesting iron's involvement in the degenerative process of Parkinson's disease, clinical studies have not shown positive effects of iron chelators in treating the disease.
Article
Biochemistry & Molecular Biology
Melissa Jasmin, Eun Hee Ahn, Merja H. Voutilainen, Joanna Fombonne, Catherine Guix, Tuulikki Viljakainen, Seong Su Kang, Li-ying Yu, Mart Saarma, Patrick Mehlen, Keqiang Ye
Summary: The netrin-1/DCC ligand/receptor pair plays key roles in CNS development, and although they are expressed in the adult brain, their function in mature neurons is not well understood. Research shows that netrin-1 plays a critical role in the fate of adult dopamine neurons, and targeting netrin-1 signaling may have therapeutic potential in Parkinson's disease. Studies in animal models suggest that overexpression of netrin-1 or administration of recombinant netrin-1 can be neuroprotective and neurorestorative in PD.
Review
Cell Biology
Reed Berlet, Dorothy Anne Galang Cabantan, Daniel Gonzales-Portillo, Cesar V. Borlongan
Summary: Stem cell therapy is a potential treatment for stroke, Parkinson's disease, and Huntington's disease. Enriched environment and exercise can enhance the reconstruction of neural circuitry in stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Manuj Ahuja, Navneet Ammal Kaidery, Otis C. Attucks, Erin McDade, Dmitry M. Hushpulian, Arsen Gaisin, Irina Gaisina, Young Hoon Ahn, Sergey Nikulin, Andrey Poloznikov, Irina Gazaryan, Masayuki Yamamoto, Mitsuyo Matsumoto, Kazuhiko Igarashi, Sudarshana M. Sharma, Bobby Thomas
Summary: Research suggests that genetic deletion or pharmacologic inhibition of Bach1 could be a promising therapeutic approach for Parkinson's disease, offering neuroprotection and reducing oxidative damage and neuroinflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Geriatrics & Gerontology
Taylor Russo, Markus Riessland
Summary: Immune responses are common in neurodegenerative diseases such as PD, AD, and ALS, but their role remains debated. This review discusses midbrain inflammation in PD patients and suggests that cellular senescence may be the cause for this immune response.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Plant Sciences
Ziying Wang, Jinshuai Cui, Dongni Li, Shuzhen Ran, Junqing Huang, Gang Chen
Summary: In this study, a natural compound called morin was found to promote mitophagy and have therapeutic effects on a Parkinson's disease mouse model. Morin acts by activating the AMPK-ULK1 pathway and promoting nuclear translocation of the mitophagy regulator TFEB. This research lays the foundation for the potential use of morin as a clinical drug for Parkinson's disease treatment.
Article
Behavioral Sciences
Soraya Lahlou, Ella Gabitov, Lucy Owen, Daphna Shohamy, Madeleine Sharp
Summary: Motor memory is preserved in Parkinson's patients and may be supported by compensatory non dopamine-sensitive mechanisms. Initial learning dopamine state does not influence motor memory. Parkinson's disease and aging may affect motor memory in similar ways.
Review
Cell Biology
P. A. Dionisio, J. D. Amaral, C. M. P. Rodrigues
Summary: Parkinson's disease is the second most common neurodegenerative disease globally, typically associated with dopaminergic damage. The main physiological characteristics that make the nigrostriatal circuit more susceptible to mitochondrial dysfunction and oxidative stress are related to several cell death mechanisms, including apoptosis, necrosis, and ferroptosis.
AGEING RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Yujeong Lee, Seonguk Yang, Dong Geun Hong, Dinakaran Thirumalai, Seung-Cheol Chang, Ki Wung Chung, Young-Suk Jung, Hyung Ryong Moon, Hae Young Chung, Jaewon Lee
Summary: This study investigated the neuroprotective effects of the barbiturate derivative, MHY2699, in a mouse model of Parkinson's disease. The results showed that MHY2699 ameliorated neuroinflammation, inhibited motor dysfunction, and prevented dopaminergic neuronal death in the MPTP-induced mouse model, suggesting its potential as a treatment for PD.
Review
Clinical Neurology
Kaitlyn M. L. Cramb, Dayne Beccano-Kelly, Stephanie J. Cragg, Richard Wade-Martins
Summary: Cramb et al. provide a review of evidence suggesting dopamine release deficits occur prior to neurodegeneration in Parkinson's disease. They also highlight the need for further investigation in understanding the mechanisms behind these deficits.
Article
Biochemistry & Molecular Biology
Min Hyung Seo, Sujung Yeo
Summary: Our study investigated the effects of knocking down serping1, a protein associated with smooth muscle contraction, relaxation, and inflammation responses, using serping1 siRNA in 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-induced Parkinson's disease (PD) mice. The results showed that serping1 siRNA decreased serping1 expression and reduced a-syn accumulation in the colon. In addition, the treatment also alleviated a-syn aggregation in the brain, suggesting that serping1 siRNA could potentially alleviate synucleinopathy in the gastrointestinal system and brain regions affected by PD.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.