Article
Medicine, Research & Experimental
Yiru Wang, Xinyi Wang, Renfei Qi, Ying Lu, Yu Tao, Dongsheng Jiang, Yufang Sun, Xinghong Jiang, Chunfeng Liu, Yuan Zhang, Jin Tao
Summary: The study reveals a novel mechanism by which IL-33/ST2 suppresses A-type K+ currents in sensory neurons, leading to increased neuronal excitability and pain sensitivity. This mechanism involves the suppression of the tumorigenicity 2 (ST2) receptor and the activation of a Syk-dependent p38 beta signaling pathway. Targeting IL-33/ST2-mediated p38 beta signaling may represent a therapeutic approach to ameliorate pain behaviors.
Article
Biochemistry & Molecular Biology
Hung-Jen Wang, Chia-Hao Su, Yu-Ming Chen, Chun-Chieh Yu, Yao-Chi Chuang
Summary: Neurogenic inflammation and central sensitization play a role in chronic prostatitis/chronic pelvic pain syndrome. This study explores the molecular effects of low-intensity shock wave therapy (Li-ESWT) on central sensitization. The results indicate that Li-ESWT can downregulate the expression of inflammation-related proteins and neurons induced by intraprostatic capsaicin injection, and reduce the activity of pain-related brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yingqiao Wang, Raghav Garg, Jane E. Hartung, Adam Goad, Dipna A. Patel, Flavia Vitale, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: Utilizing nanomaterial-assisted photothermal stimulation, Ti3C2Tx (MXene) demonstrates excellent potential as a candidate for remote, non-genetic, optical modulation of neuronal electrical activity with high spatiotemporal resolution. The material's photothermal response, low cytotoxicity, and ease of large-scale synthesis make it a promising tool for modulating electrophysiology at various scales.
Article
Multidisciplinary Sciences
Haohao Wu, Charles Petitpre, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, Francois Lallemend
Summary: The study identified three main types of proprioceptive neurons (Ia, Ib and II PNs) and found that they segregate into eight distinct subgroups. Importantly, Ia-PN subtypes are plastic, suggesting a role in adaptive proprioception during motor behavior.
NATURE COMMUNICATIONS
(2021)
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Neurosciences
Andres de Leon, Julien Gibon, Philip A. Barker
Summary: NGF and BDNF are important trophic factors for sensory neurons during development, but the signaling pathways leading to their death differ, with BDNF-dependent sensory neuron degeneration potentially involving BAX and ROS.
Article
Medicine, General & Internal
Xu Liu, Jiang-Tao Zhang, Yue Hu, Wen-Qi Shan, Zhi-Hong Wang, Qing-Yue Fu, Dan-Ni Fu, Jiang Ji, Tong Liu
Summary: A new acute itch mouse model was established by injecting low-dose formalin into the neck or cheek of mice, revealing that activation of TRPA1 channel is a key factor in inducing itch in this model. This model may be effective for screening potential anti-itch drugs.
FRONTIERS IN MEDICINE
(2021)
Article
Physiology
Qin Li, Lu Qin, Jianhua Li
Summary: K(V)4 currents are decreased in muscle dorsal root ganglion neurons of PAD rats, particularly in IB4+ neurons. Stimulation of BK B1 and B2 receptors led to a greater inhibitory effect on KV4 currents in IB4+ neurons. Knockdown of K(V)4.3 decreased the activity of KV4 currents in IB4+ neurons.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Neurosciences
Kelsey G. Guenther, Zhili Xu, Julian Romero, Cecilia J. Hillard, Ken Mackie, Andrea G. Hohmann
Summary: CB2 agonists can suppress pathological pain in animal models without unwanted side effects associated with CB1 receptor activation. However, the specific types of pain responsive to CB2 agonists and the cell types underlying therapeutic efficacy are not fully understood.
Article
Neurosciences
Jianxiong Wei, Shuyang Chang, Siyi Liu, Lixia Tian, Xuan Zhu, Shuo Wang, Xiaoqiong Zhou, Yuying Wang, Linping Xu, Fu-Quan Huo, Lingli Liang
Summary: In this study, researchers investigated the role of LSD1, a histone demethylase and transcriptional co-repressor, in radicular pain. They found that LSD1 was upregulated in compressed and injured nerve ganglia, suggesting it may contribute to pain hypersensitivities. These findings suggest that LSD1 could serve as a potential target for the treatment of radicular pain and neuropathic pain.
BRAIN RESEARCH BULLETIN
(2022)
Article
Engineering, Biomedical
Yingqiao Wang, Jane E. Hartung, Adam Goad, Matias A. Preisegger, Benjamin Chacon, Michael S. Gold, Yury Gogotsi, Tzahi Cohen-Karni
Summary: This study investigates the biosafety of Ti3C2Tx-based photothermal modulation. It finds that culturing neurons on Ti3C2Tx films and illuminating them with laser pulses do not cause damage to the cell membrane, induce cellular stress, or generate oxidative stress. These findings provide important insights for the clinical translation of photothermal modulation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Gabriela I. Aparicio, Antonella Leon, Rocio Gutierrez Fuster, Baylen Ravenscraft, Paula V. Monje, Camila Scorticati
Summary: The peripheral nervous system can repair itself, and DRG neurons play a role in promoting axon regeneration after injury. The membrane glycoprotein GPM6a is present in DRG neurons and is required for neurite elongation. This suggests that GPM6a could contribute to axon regeneration in the peripheral nervous system.
Article
Plant Sciences
Dandan Yue, Zihan Zheng, Weiwei Fan, Lizhong Zhu, Dan Lin, Man Lu, Wenjing Ji, Peng Cao, Xiaoyan Sun, Chunping Hu
Summary: SXS may have an effect on inhibiting ectopic tissue growth, enhancing pain thresholds, reducing nerve fiber density and inflammatory factor expression, and alleviating inflammatory cell infiltration in the dorsal root ganglion of animals with endometriosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Wen Chen, Xiaotong Wang, Qingyu Sun, Yurui Zhang, Jing Liu, Tingting Hu, Weihua Wu, Chao Wei, Meng Liu, Yumeng Ding, Dianxin Liu, Yingzi Chong, Peipei Wang, Hongwei Zhu, Weihua Cui, Jiannan Zhang, Qian Li, Fei Yang
Summary: The NLRP3 pathway is activated in the DRG of the DNP model, and TET2 is involved in DNP hypersensitivity by upregulating the TXNIP/NLRP3 pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Lina Huang, Dilip Sharma, Xiaozhou Feng, Zhiqiang Pan, Shaogen Wu, Daisy Munoz, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Summary: The study found that RALY, an RNA-binding protein, plays a role in nerve trauma-induced nociceptive hypersensitivity by regulating the expression of translation initiation factor Eif4g2 in dorsal root ganglion neurons. Interventions targeting RALY expression levels could alleviate the development and maintenance of pain hypersensitivity.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.