Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Neurosciences
Hanna Dumanska, Nikolai Veselovsky
Summary: The study found that hypoxia leads to long-term potentiation of NMDA neurotransmission, and the protein kinase C (PKC) signaling pathway plays an important role in this process. It was discovered that adding a PKC inhibitor can block the induction of long-term potentiation, but cannot reverse the shortening of current kinetics. These findings provide insights into the prevention and treatment of hypoxic injuries and the underlying mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Fouad Lemtiri-Chlieh, Eric S. Levine
Summary: It is widely accepted that exogenous cannabinoids can impair short-term memory and cognition. Conversely, the activation of endogenous cannabinoids may enhance synaptic plasticity. This study found that the simultaneous activation of CB1 receptors by 2-AG and anandamide enhances LTP by suppressing inhibition at GABAergic synapses.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Makoto Honda, Takahiro Shimizu, Shotaro Moriyasu, Takenobu Murakami, Hiroshi Takigawa, Yoshikazu Ugawa, Ritsuko Hanajima
Summary: This study investigates the characteristics of motor cortical LTP-like effects in PSP patients and finds that the degree of LTP is correlated with the severity of bradykinesia.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
D. Guo, G. Zhao, G. Li, C. Wang, H. Wang, Z. Liu, B. Xu, X. Guo
Summary: The study identified the AccMKK4 gene in Apis cerana cerana and showed its potential role in the honeybees' response to environmental stress, particularly in oxidative stress. AccMKK4 was found to interact with Accp38b through the p38 MAPK pathway, suggesting its involvement in oxidative stress response mechanisms.
INSECT MOLECULAR BIOLOGY
(2021)
Article
Behavioral Sciences
Santiago Ojea Ramos, Matias Andina, Arturo Romano, Mariana Feld
Summary: The study demonstrates that adjusting the inter-trial interval can induce long-term memory with intrinsic features in crabs after only two training trials. This new observation suggests that individual trials can have an impact on the formation of long-term memory.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Li-Xin Cao, Yan-Hua Bing, Yin-Hua Xu, Guang-Jian Zhang, Chun-Ping Chu, Lan Hong, De-Lai Qiu
Summary: Nicotine enhances synaptic plasticity in the mouse cerebellar cortex, improving working memory and motor learning function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
P. Robin, T. Emmerich, A. Ismail, A. Nigues, Y. You, G. -H. Nam, A. Keerthi, A. Siria, A. K. Geim, B. Radha, L. Bocquet
Summary: Experiments reveal the emergence of memory in the transport of electrolytes across nanoscale channels, which lays the foundation for biomimetic computations.
Review
Biochemistry & Molecular Biology
Hong-Beom Park, Kwang-Hyun Baek
Summary: This review summarizes the role and mechanisms of MAPK signaling pathways in cancer, as well as the functions of E3 ligases and DUBs targeting MAPK signaling components.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Deborah Pre, Alexander T. Wooten, Steven Biesmans, Sandy Hinckley, Haowen Zhou, Sean P. Sherman, Priyanka Kakad, Jeffrey Gearhart, Anne G. Bang
Summary: Impairment of long-term potentiation (LTP) is a common feature in neurological disorders. Researchers have developed a multi-electrode array-based assay to study chemically induced LTP (cLTP) in human induced pluripotent stem cells (hiPSCs) derived from midbrain dopaminergic (DA) and cortical neuronal populations. The cLTP-MEA assay platform allows for analysis of the late phases of LTP, detection of molecular changes, and discovery of phenotype on hiPSC-derived neurons.
Article
Oncology
Shumei Kato, Robert Porter, Ryosuke Okamura, Suzanna Lee, Ori Zelichov, Gabi Tarcic, Michael Vidne, Razelle Kurzrock
Summary: The study found that patients with tumors harboring RAS alterations with high MAPK activity had significantly longer median progression-free survival (PFS) and overall survival when treated with MEK inhibitors. This correlation between RAS-mutant cancers with greater MAPK signaling and PFS suggests potential clinical benefit of MEK inhibitor treatment.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Mengmeng Zhang, Shuqun Zhang
Summary: This review provides a historic and recent understanding of the role of mitogen-activated protein kinase (MAPK) cascades in plant immunity, response to environmental stresses, and normal growth and development. The signaling specificity of MAPKs in plants is an interesting topic of research and is influenced by factors such as activation kinetics, spatial and temporal expression patterns, and functional characterization of MAPK substrates.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Neurosciences
Lindsay R. Halladay, Hugh T. Blair
JOURNAL OF NEUROSCIENCE RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Ozge Gunduz-Cinar, Emma Brockway, Lauren Lederle, Troy Wilcox, Lindsay R. Halladay, Ying Ding, Hyunjung Oh, Erica F. Busch, Katie Kaugars, Shaun Flynn, Aaron Limoges, Olena Bukalo, Kathryn P. MacPherson, Sophie Masneuf, Courtney Pinard, Etienne Sibille, Elissa J. Chesler, Andrew Holmes
MOLECULAR PSYCHIATRY
(2019)
Article
Neurosciences
J. Andrew Hardaway, Lindsay R. Halladay, Christopher M. Mazzone, Dipanwita Pati, Daniel W. Bloodgood, Michelle Kim, Jennifer Jensen, Jeffrey F. DiBerto, Kristen M. Boyt, Ami Shiddapur, Ave Erfani, Olivia J. Hon, Sofia Neira, Christina M. Stanhope, Jonathan A. Sugam, Michael P. Saddoris, Greg Tipton, Zoe McElligott, Thomas C. Jhou, Garret D. Stuber, Michael R. Bruchas, Cynthia M. Bulik, Andrew Holmes, Thomas L. Kash
Correction
Neurosciences
J. Andrew Hardaway, Lindsay R. Halladay, Christopher M. Mazzone, Dipanwita Pati, Daniel W. Bloodgood, Michelle Kim, Jennifer Jensen, Jeffrey F. DiBerto, Kristen M. Boyt, Ami Shiddapur, Ava Erfani, Olivia J. Hon, Sofia Neira, Christina M. Stanhope, Jonathan A. Sugam, Michael P. Saddoris, Greg Tipton, Zoe McElligott, Thomas C. Jhou, Garret D. Stuber, Michael R. Bruchas, Cynthia M. Bulik, Andrew Holmes, Thomas L. Kash
Article
Neurosciences
Lindsay R. Halladay, Adrina Kocharian, Patrick T. Piantadosi, Michael E. Authement, Abby G. Lieberman, Nathen A. Spitz, Kendall Coden, Lucas R. Glover, Vincent D. Costa, Veronica A. Alvarez, Andrew Holmes
BIOLOGICAL PSYCHIATRY
(2020)
Article
Neurosciences
Randi Emmons, Tasneem Sadok, Natalie G. Rovero, Malia A. Belnap, Hannah J. M. Henderson, Alex J. Quan, Noel J. Del Toro, Lindsay R. Halladay
Summary: Trauma during critical periods of development can lead to long-lasting adverse effects, including behavioral deficits related to anxiety and social behavior. Studies using rodent maternal separation have shown that manipulation of the bed nucleus of the stria terminalis (BNST) may have different effects on social behavior in non-stressed versus early life stress (ELS) mice, suggesting BNST as a potential therapeutic target for social anxiety disorders stemming from childhood trauma.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Biology
Lucas R. Glover, Kerry M. McFadden, Max Bjorni, Sawyer R. Smith, Natalie G. Rovero, Sarvar Oreizi-Esfahani, Takayuki Yoshida, Abagail F. Postle, Mio Nonaka, Lindsay R. Halladay, Andrew Holmes
Article
Behavioral Sciences
Hannah J. M. Henderson, Gabrielle Etem, Max Bjorni, Malia A. Belnap, Bryce Rosellini, Lindsay R. Halladay
Summary: Early life stress, modeled by rodent maternal separation, can induce lifelong emotional and social behavioral deficits that vary by age and sex. The MSEW model shows universal effects of enhanced anxiety and despair behaviors, as well as deficits in social motivation. Ethanol can counteract or potentiate social habituation induced by MSEW in adolescent mice, with differential effects across age, sex, and stress levels.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Patrick T. Piantadosi, Lindsay R. Halladay, Anna K. Radke, Andrew Holmes
Summary: The risk of aversive consequences from reward-seeking behavior can significantly impact future actions, with individuals adapting differently to negative and positive punishment risks. Those with substance use disorders or behavioral addictions may struggle to reduce addictive behaviors despite aversive consequences. Dopamine signaling and interconnected ventral striatal, cortical, and amygdala regions play critical roles in punishment learning and risky reward seeking behavior.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Lindsay R. Halladay, Steven M. Herron
Summary: Nearly one percent of children in the US suffer from childhood neglect or abuse, leading to long-term emotional and behavioral disorders. Research has mainly focused on the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis as a result of early life stress. However, recent evidence suggests that early life stress can also affect neural development in extrahypothalamic areas such as the bed nucleus of the stria terminalis (BNST). Maternal separation (MS) in rodents, a commonly used approach, has shown to induce lasting effects including increased anxiety, hyper-responsiveness to stress, and deficits in social behavior. The BNST has been identified as a critical mediator of the consequences of MS, particularly in socioemotional behavioral deficits, due to its connections with hypothalamic and extra-hypothalamic systems.
Review
Behavioral Sciences
Janet Ronquillo, Michael T. Nguyen, Linnea Y. Rothi, Trung-Dan Bui-Tu, Jocelyn Yang, Lindsay R. Halladay
Summary: The classic anxiety tests may sufficiently differentiate differences among genetically defined groups, while the revised 3DR test may be more suitable for investigating nuanced behavioral differences caused by environmental factors. Additionally, exposure to multiple tests significantly affects sociability, highlighting the importance of careful design and interpretation of batteries of rodent behavioral tests.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Daniela Moura, Alekhya Parvathaneni, Atehsa Sahagun, Hirofumi Noguchi, Jesse Garcia, Emma Brennan, Robert Brock, Iris Tilton, Lindsay Halladay, Samuel Pleasure, Laura Cocas
Summary: This study investigates the significance of neuroglial connections in myelination during development and neuronal plasticity. The findings suggest that neuronal activity plays a crucial role in regulating OPC proliferation and activation, as well as the types of neuronal inputs to OPCs.
Article
Neurosciences
Max Bjorni, Natalie G. Rovero, Elissa R. Yang, Andrew Holmes, Lindsay R. Halladay
Article
Substance Abuse
Lindsay R. Halladay, Adrina Kocharian, Andrew Holmes
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.