Article
Pharmacology & Pharmacy
Shoichiro Maeda, Jun Yamada, Kyoko M. Iinuma, Satomi Nadanaka, Hiroshi Kitagawa, Shozo Jinno
Summary: The study found that memantine can improve cognitive function by regulating adult hippocampal neurogenesis and the biosynthesis and degradation of chondroitin sulfate proteoglycan (CSPG), making it a potential candidate for the treatment of ageing-related cognitive decline.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Masoud Rahmati, Maryam Keshvari, Wenqing Xie, Guang Yang, Hongfu Jin, Hengzhen Li, Farzaneh Chehelcheraghi, Yusheng Li
Summary: In this study, the combined effect of resistance training (RT) and Urtica dioica extract (Ud) was investigated in preventing memory disorders and hippocampal tissue changes caused by aging in rats. The results showed that RT and Ud supplementation alleviated karyopyknosis in hippocampal tissue and improved cognitive function. These interventions also increased the levels of antioxidant enzymes and neurotrophic factors in the hippocampus, while protecting against oxidative stress and hippocampal damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Lili Chen, Qin Qin, Panchuan Huang, Fangli Cao, Maojia Yin, Yachen Xie, Wuchao Wang
Summary: Chronic neuropathic pain may lead to cognitive impairment in elderly patients, possibly due to the inhibitory effect of CCL2/CCR2 signaling on hippocampal neurogenesis.
BRAIN RESEARCH BULLETIN
(2023)
Article
Immunology
Isabel M. Alonso Bellido, Mercedes Posada-Perez, Francisco Hernandez-Rasco, Sandra Vazquez-Reyes, Maria Cabanillas, Antonio J. Herrera, Sara Bachiller, Jesus Soldan-Hidalgo, Ana M. Espinosa-Oliva, Bertrand Joseph, Rocio M. de Pablos, Jose L. Venero, Rocio Ruiz
Summary: The study aims to investigate the role of Caspase-3 in neurogenesis-related microglial functions. Using Caspase-3 conditional knockout mice, it was found that the reduction of Caspase-3 led to decreased microglia and neurogenic neurons in the hippocampus, as well as a lower phagocytic capacity of microglia. Behavioral analysis also showed impaired memory and learning in the absence of Caspase-3. These findings highlight the essential role of Caspase-3 in microglial function and the importance of a specific microglial phenotype in the maintenance of adult hippocampal neurogenesis.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Chemistry, Multidisciplinary
Bei-ni Wang, Cheng-biao Wu, Zi-miao Chen, Pei-pei Zheng, Ya-qian Liu, Jun Xiong, Jing-yu Xu, Pei-feng Li, Abdullah Al Mamun, Li-bing Ye, Zhi-long Zheng, Yan-qing Wu, Jian Xiao, Jian Wang
Summary: DL-3-n-Butylphthalide (DL-NBP), extracted from Chinese celery seeds, shows neuroprotective effects by improving cognitive decline associated with diabetes, including enhancing learning and memory function, reducing morphological changes, increasing neuronal survival, and restoring synaptic protein levels and dendritic density in the hippocampus. Additionally, DL-NBP decreases oxidative stress through Nrf2/HO-1 signaling and boosts brain-derived neurotrophic factor (BDNF) expression via PI3K/Akt/CREB signaling, suggesting its potential as a pharmacologic treatment for DACD.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Yun-Tao Zhao, Lulu Zhang, Haowen Yin, Ling Shen, Wenjing Zheng, Kun Zhang, Jian Zeng, Chuanyin Hu, You Liu
Summary: In a mouse model of depressive-like behavior induced by chronic unpredictable mild stress (CUMS), Hydroxytyrosol (HT) significantly improved depressive symptoms by alleviating oxidative stress and neuroinflammation, and enhancing the BDNF/TrkB/CREB signaling pathway.
Review
Cell Biology
Maria Isabel Cuartero, Alicia Garcia-Culebras, Cristina Torres-Lopez, Violeta Medina, Enrique Fraga, Sandra Vazquez-Reyes, Tania Jareno-Flores, Juan M. Garcia-Segura, Ignacio Lizasoain, Maria angeles Moro
Summary: After stroke injury, there is ongoing neurogenesis in the adult mammalian brain which can contribute to recovery. However, the neurogenic response may lead to different functional consequences, suggesting a complex interplay between physiological and pathological regulation. More in-depth understanding is needed on the key cell types, cell-cell interactions, and molecular pathways involved in neurogenic response after brain damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Ahmad Mus'ab Ahmad Hariza, Mohd Heikal Mohd Yunus, Jaya Kumar Murthy, Suzaily Wahab
Summary: Electroconvulsive therapy (ECT) is a long-standing treatment choice for disorders such as depression when pharmacological treatments have failed, but it has cognitive side effects. The mechanism behind these cognitive side effects has received less research compared to the therapeutic effects of ECT. This review highlights studies related to ECT as well as those investigating the mechanism of its outcomes, which may involve BDNF and NMDA signaling, as well as edema in astrocytes mediated by metabotropic glutamate receptor 5 and protein Homer1a.
Article
Cell Biology
Maheedhar Kodali, Sahithi Attaluri, Leelavathi N. Madhu, Bing Shuai, Raghavendra Upadhya, Jenny Jaimes Gonzalez, Xiaolan Rao, Ashok K. Shetty
Summary: The study found that initiating metformin treatment in late middle age can improve cognitive function in old age, possibly through modulation of microglia, proinflammatory cytokines, and autophagy.
Article
Neurosciences
Enrique Fraga, Violeta Medina, Maria Isabel Cuartero, Alicia Garcia-Culebras, Isabel Bravo-Ferrer, Macarena Hernandez-Jimenez, Juan Manuel Garcia-Segura, Olivia Hurtado, Jesus Miguel Pradillo, Ignacio Lizasoain, Maria angeles Moro
Summary: This study aimed to investigate the implication of adult hippocampal neurogenesis in hypoperfusion-induced vascular cognitive impairment and dementia (VCID) in mice. The results demonstrated that hypoperfused mice exhibited spatial memory deficits and reduced newborn neuron numbers with aberrant morphology. These findings provide new insights into diagnostic and therapeutic targets for VCID.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Immunology
Laura J. Westacott, Niels Haan, Claudia Evison, Omar Marei, Jeremy Hall, Timothy R. Hughes, Malik Zaben, B. Paul Morgan, Trevor Humby, Lawrence S. Wilkinson, William P. Gray
Summary: The study found that the immune system plays an important role in neurodevelopment and cognition, impacting adult hippocampal neurogenesis through the C3 and C3aR pathways, thereby affecting cognitive behaviors.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Karin Lin, Gregor Bieri, Geraldine Gontier, Soren Muller, Lucas K. Smith, Cedric E. Snethlage, Charles W. White, Sun Y. Maybury-Lewis, Saul A. Villeda
Summary: The study revealed that the MHC I class protein H2-K-b plays a crucial role in negatively regulating the proliferation of neural stem and progenitor cells by modulating growth factor signaling pathways, impacting adult hippocampal neurogenesis.
Article
Environmental Sciences
Wenlan Yu, Xiaoyue Chang, Jianzhao Liao, Jinwen Quan, Siying Liu, Ting He, Gaolong Zhong, Jilei Huang, Zhonghua Liu, Zhaoxin Tang
Summary: Long-term ingestion of tribasic copper chloride may result in cognitive dysfunction and disrupt mitochondrial metabolism by inhibiting mitophagy.
ENVIRONMENTAL POLLUTION
(2023)
Article
Clinical Neurology
Manal T. T. Usmani, Robert P. P. Krattli, Sanad M. M. El-Khatib, Anh C. D. Le, Sarah M. M. Smith, Janet E. E. Baulch, Ding Quan Ng, Munjal M. M. Acharya, Alexandre Chan
Summary: Breast cancer patients treated with doxorubicin (ADR) experience reduced levels of BDNF, leading to cognitive impairments. The orally active BDNF-enhancing medication riluzole (RZ) improves hippocampal-dependent learning and memory function, reduces anxiety-like behavior, and protects against neuroinflammation. RZ also prevents chemotherapy-induced reductions in BDNF levels and promotes dentate neurogenesis.
Article
Multidisciplinary Sciences
Kelsie J. Anson, Giulia A. Corbet, Amy E. Palmer
Summary: In this study, the researchers investigated how changes in intracellular zinc ion levels affect kinase signaling pathways using fluorescent biosensors and cell perturbations. The results showed that zinc ion fluctuations are not toxic and do not activate stress-dependent kinase signaling. Additionally, the study demonstrated that while zinc ions can inhibit phosphatases, ERK and Akt are primarily activated through upstream signaling pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ling-Xiao Shao, Quan Jiang, Xiu-Xiu Liu, Dong-Mei Gong, Yi-Xuan Yin, Gang Wu, Ning-He Sun, Cheng-Kun Wang, Qiao-Zhen Chen, Chao Yu, Wei-Xing Shi, Heng-Yu Fan, Kohji Fukunaga, Zhong Chen, Ying-Mei Lu, Feng Han
MOLECULAR PSYCHIATRY
(2019)
Article
Neurosciences
Chao Tan, Nan-Nan Lu, Cheng-Kun Wang, Dan-Yang Chen, Ning-He Sun, Hang Lyu, Jakob Koerbelin, Wei-Xing Shi, Kohji Fukunaga, Ying-Mei Lu, Feng Han
Article
Immunology
Xiu-xiu Liu, Lin Yang, Ling-xiao Shao, Yang He, Gang Wu, Yu-huan Bao, Nan-nan Lu, Dong-mei Gong, Ya-ping Lu, Tian-tian Cui, Ning-he Sun, Dan-yang Chen, Wei-xing Shi, Kohji Fukunaga, Hong-shan Chen, Zhong Chen, Feng Han, Ying-mei Lu
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Nopparat Suthprasertporn, Nopparada Mingchinda, Kohji Fukunaga, Wipawan Thangnipon
Article
Neurosciences
Ryo Inagaki, Shigeki Moriguchi, Kohji Fukunaga
MOLECULAR NEUROBIOLOGY
(2020)
Article
Neurosciences
Hisanao Izumi, Keita Sato, Kazuhiro Kojima, Takashi Saito, Takaomi C. Saido, Kohji Fukunaga
Article
Biochemistry & Molecular Biology
Yasushi Yabuki, Kazuya Matsuo, Ichiro Kawahata, Naoya Fukui, Tomohiro Mizobata, Yasushi Kawata, Yuji Owada, Norifumi Shioda, Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Ichiro Kawahata, Kohji Fukunaga
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Kazuya Matsuo, Yasushi Yabuki, Kohji Fukunaga
Article
Behavioral Sciences
Hidaka Haga, Ryo Yamada, Hisanao Izumi, Yasuharu Shinoda, Ichiro Kawahata, Hiroyuki Miyachi, Kohji Fukunaga
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Dian Yuan, An Cheng, Ichiro Kawahata, Hisanao Izumi, Jing Xu, Kohji Fukunaga
Summary: SAK3, like donepezil, shows significant effects in improving cognitive and emotional behaviors, as well as reducing oxidative stress levels in OBX mice. The antioxidative effects of SAK3 are similar to those of donepezil, suggesting they are among the neuroprotective mechanisms in AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yifei Wang, Yasuharu Shinoda, An Cheng, Ichiro Kawahata, Kohji Fukunaga
Summary: The research revealed that the interaction between FABP5 and α Syn can lead to mitochondrial dysfunction in neuronal cells, increasing the risk of PD development.
Article
Biochemistry & Molecular Biology
Qingyun Guo, Ichiro Kawahata, Tomohide Degawa, Yuri Ikeda-Matsuo, Meiling Sun, Feng Han, Kohji Fukunaga
Summary: The study demonstrates that FABPs may exacerbate infarct volumes after ischemic stroke, and inhibiting FABPs can alleviate ischemic injury. MF6 inhibits FABPs and reduces inflammation-associated prostaglandin E-2 levels, potentially serving as a neuroprotective therapy for ischemic stroke.
Review
Biochemistry & Molecular Biology
Qingyun Guo, Ichiro Kawahata, An Cheng, Wenbin Jia, Haoyang Wang, Kohji Fukunaga
Summary: Stroke is a leading cause of death and disability worldwide, but effective neuroprotective therapies for ischemic stroke patients are lacking. Lipids play important roles in the pathogenesis of neurological diseases, and fatty acid-binding proteins (FABPs) have been found to be involved in neurodegenerative diseases. However, FABPs' roles in ischemic stroke have received comparatively little attention. In this review, we summarize the literature on the associations between FABPs and ischemia and propose potential therapeutic targets for ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wenbin Jia, Ichiro Kawahata, An Cheng, Takuya Sasaki, Toshikuni Sasaoka, Kohji Fukunaga
Summary: We confirmed that the FABP3 inhibitor, MF1, successfully reduces nicotine-induced conditioned place preference in mice. MF1 treatment decreased CPP scores in a dose-dependent manner by inhibiting the activation of CaMKII and ERK in the nucleus accumbens and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.