Innovative Drugs to Treat Depression: Did Animal Models Fail to Be Predictive or Did Clinical Trials Fail to Detect Effects?

50 years of hurdles and hope in anxiolytic drug discovery

(2013) Guy Griebel et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-depressive effect of polyphenols and omega-3 fatty acid from pomegranate peel and flax seed in mice exposed to chronic mild stress

(2013) Shivanna Naveen et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

The CRF1 receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: Comparison with paroxetine and d-cycloserine

(2013) J. Philbert et al.   PSYCHOPHARMACOLOGY

Increased corticosterone in peripubertal rats leads to long-lasting alterations in social exploration and aggression

(2013) Vandana Veenit et al.   Frontiers in Behavioral Neuroscience

Targeting the Glutamatergic System to Treat Major Depressive Disorder

(2012) Daniel C. Mathews et al.   DRUGS

The Vasopressin V1bReceptor Antagonist SSR149415 in the Treatment of Major Depressive and Generalized Anxiety Disorders

(2012) Guy Griebel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial

(2012) Kari R Nations et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?

(2012) Guy Griebel et al.   NATURE REVIEWS DRUG DISCOVERY

Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: A role for hippocampal cell proliferation

(2012) O.F. O’Leary et al.   NEUROSCIENCE

The neurobiology of depression and antidepressant action

(2012) Paul Willner et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Deep brain stimulation in treatment-resistant depression in mice: Comparison with the CRF1 antagonist, SSR125543

(2012) Carine Dournes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Depressive and cardiovascular disease comorbidity in a rat model of social stress: a putative role for corticotropin-releasing factor

(2012) Susan K. Wood et al.   PSYCHOPHARMACOLOGY

ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression

(2012) A B Singh et al.   Translational Psychiatry

A Double-Blind Placebo-Controlled Trial of Lamotrigine as an Antidepressant Augmentation Agent in Treatment-Refractory Unipolar Depression

(2011) James G. Barbee et al.   JOURNAL OF CLINICAL PSYCHIATRY

Discovering imaging endophenotypes for major depression

(2011) G Hasler et al.   MOLECULAR PSYCHIATRY

Antidepressants recruit new neurons to improve stress response regulation

(2011) A Surget et al.   MOLECULAR PSYCHIATRY

Is there still a future for neurokinin 3 receptor antagonists as potential drugs for the treatment of psychiatric diseases?

(2011) Guy Griebel et al.   PHARMACOLOGY & THERAPEUTICS

Results of a proof-of-concept, dose-finding, double-blind, placebo-controlled study of RX-10100 (Serdaxin®) in subjects with major depressive disorder

(2011) Robert Riesenberg et al.   PSYCHOPHARMACOLOGY

Chronic ω-3 fatty acids supplementation promotes beneficial effects on anxiety, cognitive and depressive-like behaviors in rats subjected to a restraint stress protocol

(2010) Anete Curte Ferraz et al.   BEHAVIOURAL BRAIN RESEARCH

Open questions in current models of antidepressant action

(2010) A Tanti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antidepressant Drug Effects and Depression Severity

(2010) Jay C. Fournier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: A randomized, double-blind placebo-controlled study

(2010) M. Bot et al.   JOURNAL OF AFFECTIVE DISORDERS

The Efficacy of Omega-3 Supplementation for Major Depression

(2010) François Lespérance et al.   JOURNAL OF CLINICAL PSYCHIATRY

Omega-3 fatty acids for major depressive disorder associated with the menopausal transition

(2010) Marlene P. Freeman et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Neuropsychiatric Disorders in Cushing’s Syndrome

(2010) Alberto M. Pereira et al.   NEUROENDOCRINOLOGY

ABCB1 (MDR1) polymorphisms and antidepressant response in geriatric depression

(2010) Jane E. Sarginson et al.   Pharmacogenetics and Genomics

CYP2C19 variation and citalopram response

(2010) David A. Mrazek et al.   Pharmacogenetics and Genomics

Therapeutic utility of non-peptidic CRF1 receptor antagonists in anxiety, depression, and stress-related disorders: Evidence from animal models

(2010) John H. Kehne et al.   PHARMACOLOGY & THERAPEUTICS

Association between Repeated Unpredictable Chronic Mild Stress (UCMS) Procedures with a High Fat Diet: A Model of Fluoxetine Resistance in Mice

(2010) Elsa Isingrini et al.   PLoS One

A Molecular Signature of Depression in the Amygdala

(2009) Etienne Sibille et al.   AMERICAN JOURNAL OF PSYCHIATRY

Tachykinin Receptors as Therapeutic Targets in Stress-Related Disorders

(2009) Karl Ebner et al.   CURRENT PHARMACEUTICAL DESIGN

Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression

(2009) Denis J. David et al.   NEURON

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke

(2009) Nicolas Blondeau et al.   NEUROPSYCHOPHARMACOLOGY

Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   BIOLOGICAL PSYCHIATRY

Chronic stress-induced alterations in amygdala responsiveness and behavior - modulation by trait anxiety and corticotropin-releasing factor systems

(2008) Carmen Sandi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Depression in Parkinson's disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

(2008) Ticyana Moralez da Silva et al.   JOURNAL OF AFFECTIVE DISORDERS

Humanized Mouse Lines and Their Application for Prediction of Human Drug Metabolism and Toxicological Risk Assessment

(2008) C. Cheung et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling

(2008) J M Bessa et al.   MOLECULAR PSYCHIATRY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

SSR149415, a non-peptide vasopressin V1b receptor antagonist, has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model

(2008) M. E. Breuer et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression

(2008) Manfred Uhr et al.   NEURON

Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

(2008) Athina Markou et al.   NEUROPSYCHOPHARMACOLOGY

Corticolimbic Transcriptome Changes are State-Dependent and Region-Specific in a Rodent Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   NEUROPSYCHOPHARMACOLOGY

PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus

(2008) Venugopal Reddy Venna et al.   PSYCHONEUROENDOCRINOLOGY

Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration

(2008) Irving Kirsch et al.   PLOS MEDICINE

Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms

(2007) Yvonne Freund-Levi et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Additional evidence for anxiolytic- and antidepressant-like activities of saredutant (SR48968), an antagonist at the neurokinin-2 receptor in various rodent-models

(2007) Caroline Louis et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder

(2007) Masaki Kato et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY