Candesartan, an Angiotensin II AT1-Receptor Blocker and PPAR-γ Agonist, Reduces Lesion Volume and Improves Motor and Memory Function After Traumatic Brain Injury in Mice

ARE ACE-INHIBITORS OR ARB’S STILL NEEDED FOR CARDIOVASCULAR PREVENTION IN HIGH RISK PATIENTS? INSIGHTS FROM PROFESS AND TRANSCEND

(2014) W. Van Mieghem et al.   ACTA CLINICA BELGICA

Renin-angiotensin System Blockers and Modulation of Radiation-Induced Brain Injury

(2012) M. E. Robbins et al.   CURRENT DRUG TARGETS

Delayed inhibition of angiotensin II receptor type 1 reduces secondary brain damage and improves functional recovery after experimental brain trauma*

(2011) Ralph Timaru-Kast et al.   CRITICAL CARE MEDICINE

Telmisartan ameliorates lipopolysaccharide-induced innate immune response through peroxisome proliferator-activated receptor-γ activation in human monocytes

(2011) Tao Pang et al.   JOURNAL OF HYPERTENSION

Smad proteins differentially regulate transforming growth factor-β-mediated induction of chondroitin sulfate proteoglycans

(2011) Bala T. S. Susarla et al.   JOURNAL OF NEUROCHEMISTRY

Activation of cerebral peroxisome proliferator-activated receptors γ (PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat

(2011) M. Zuhayra et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Animal models of traumatic brain injury: A critical evaluation

(2011) William T. O'Connor et al.   PHARMACOLOGY & THERAPEUTICS

Valsartan attenuated oxidative stress, decreased MCP-1 and TGF-β1 expression in glomerular mesangial and epithelial cells induced by high-glucose levels

(2011) Bo Jiao et al.   BioScience Trends

Acute Treatment with Candesartan Reduces Early Injury After Permanent Middle Cerebral Artery Occlusion

(2011) Weihua Guan et al.   Translational Stroke Research

The Association between Hypertension and Dementia in the Elderly

(2011) Michiya Igase et al.   International Journal of Hypertension

Telmisartan suppresses cerebral injury in a murine model of transient focal ischemia

(2010) Yukiko Kasahara et al.   BRAIN RESEARCH

Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?

(2010) Niklas Marklund et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Molecular Pathophysiology of Concussive Brain Injury

(2010) Garni Barkhoudarian et al.   CLINICS IN SPORTS MEDICINE

Angiotensin II revisited: new roles in inflammation, immunology and aging

(2010) Ariela Benigni et al.   EMBO Molecular Medicine

Losartan inhibits LPS-induced inflammatory signaling through a PPARγ-dependent mechanism in human THP-1 macrophages

(2010) Jianbo An et al.   HYPERTENSION RESEARCH

Angiotensin II sustains brain inflammation in mice via TGF-β

(2010) Tobias V. Lanz et al.   JOURNAL OF CLINICAL INVESTIGATION

Amlodipine suppressed cardiac gene expression of brain natriuretic peptide, transforming growth factor-β1and fibronectin mediated by aldosterone in male stroke-prone spontaneously hypertensive rats

(2010) Shinsuke Harasawa et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Effect of Combined Treatment With Curcumin and Candesartan on Ischemic Brain Damage in Mice

(2010) Azza S. Awad   Journal of Stroke & Cerebrovascular Diseases

Vasopressor Use and Effect on Blood Pressure After Severe Adult Traumatic Brain Injury

(2010) Pimwan Sookplung et al.   Neurocritical Care

Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation

(2010) Julius Benicky et al.   NEUROPSYCHOPHARMACOLOGY

Melatonin Promotes Myelination by Decreasing White Matter Inflammation After Neonatal Stroke

(2010) Sonia Villapol et al.   PEDIATRIC RESEARCH

PPAR Modulation of Kinase-Linked Receptor Signaling in Physiology and Disease

(2010) Nicolas Rotman et al.   PHYSIOLOGY

Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications

(2010) Juan M. Saavedra et al.   PSYCHONEUROENDOCRINOLOGY

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

(2010) David J. Loane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Crosstalk between peroxisome proliferator-activated receptor-γ and angiotensin II in renal tubular epithelial cells in IgA nephropathy

(2009) Jing Xiao et al.   CLINICAL IMMUNOLOGY

Postischemic administration of angiotensin II type 1 receptor blocker reduces cerebral infarction size in hypertensive rats

(2009) Emi Omura-Matsuoka et al.   HYPERTENSION RESEARCH

Immunosuppressive effect of angiotensin receptor blocker on stimulation of mice CTLs by angiotensin II

(2009) Akihiko Maeda et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes

(2009) Ignacio M Larrayoz et al.   JOURNAL OF HYPERTENSION

PPARγ agonist, rosiglitazone, regulates angiotensin II-induced vascular inflammation through the TLR4-dependent signaling pathway

(2009) Yuanyuan Ji et al.   LABORATORY INVESTIGATION

PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms

(2008) Jae-Hyuk Yi et al.   BRAIN RESEARCH

Prevention and reduction of scarring in the skin by Transforming Growth Factor beta 3 (TGFβ3): from laboratory discovery to clinical pharmaceutical

(2008) Nick L. Occleston et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Protective mechanisms of the angiotensin II type 1 receptor blocker candesartan against cerebral ischemia: in-vivo and in-vitro studies

(2008) Hao Liu et al.   JOURNAL OF HYPERTENSION

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

(2008) J. Rodriguez-Pallares et al.   NEUROBIOLOGY OF DISEASE

Effects of Antihypertensive Drug Treatment on the Risk of Dementia and Cognitive Impairment

(2008) Ivy O Poon   PHARMACOTHERAPY

Temporary Pretreatment With the Angiotensin II Type 1 Receptor Blocker, Valsartan, Prevents Ischemic Brain Damage Through an Increase in Capillary Density

(2008) Jian-Mei Li et al.   STROKE

PPAR-, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches

(2008) Fiorella Malchiodi-Albedi et al.   PPAR Research