Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond
出版年份 2011 全文链接
标题
Therapeutic Strategies in Fragile X Syndrome: Dysregulated mGluR Signaling and Beyond
作者
关键词
-
出版物
NEUROPSYCHOPHARMACOLOGY
Volume 37, Issue 1, Pages 178-195
出版商
Springer Nature
发表日期
2011-07-27
DOI
10.1038/npp.2011.137
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Behavioral profiles of mouse models for autism spectrum disorders
- (2011) Elodie Ey et al. Autism Research
- Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses
- (2011) Corinne M. Spencer et al. Autism Research
- Phosphatidylinositol 3-Kinase Isoforms as Novel Drug Targets
- (2011) Karolina Blajecka et al. CURRENT DRUG TARGETS
- Fragile X Mental Retardation Protein Regulates Protein Expression and mRNA Translation of the Potassium Channel Kv4.2
- (2011) C. Gross et al. JOURNAL OF NEUROSCIENCE
- Fragile X Mental Retardation Protein Regulates New Neuron Differentiation in the Adult Olfactory Bulb
- (2011) S. Scotto-Lomassese et al. JOURNAL OF NEUROSCIENCE
- Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse
- (2011) Laura K.K. Pacey et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling
- (2011) Ravi S. Muddashetty et al. MOLECULAR CELL
- Dendritic spine pathology in neuropsychiatric disorders
- (2011) Peter Penzes et al. NATURE NEUROSCIENCE
- The Physiology, Signaling, and Pharmacology of Dopamine Receptors
- (2011) J.-M. Beaulieu et al. PHARMACOLOGICAL REVIEWS
- Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome
- (2011) D. D. Krueger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A prospective open-label study of aripiprazole in fragile X syndrome
- (2011) Craig A. Erickson et al. PSYCHOPHARMACOLOGY
- Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
- (2011) S. Jacquemont et al. Science Translational Medicine
- Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome
- (2011) Inge Heulens et al. TheScientificWorldJOURNAL
- Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts
- (2010) Philip Awadalla et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males
- (2010) Stephen C. Collins et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells
- (2010) Yufeng Miao et al. BIOMEDICINE & PHARMACOTHERAPY
- Open-label add-on treatment trial of minocycline in fragile X syndrome
- (2010) Carlo Paribello et al. BMC Neurology
- Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice
- (2010) Aaron W. Grossman et al. BRAIN RESEARCH
- Open-label riluzole in fragile X syndrome
- (2010) Craig A. Erickson et al. BRAIN RESEARCH
- Treatment of epilepsy in children with developmental disabilities
- (2010) Dewi Frances T. Depositario-Cabacar et al. Developmental Disabilities Research Reviews
- Fragile X syndrome and model organisms: identifying potential routes of therapeutic intervention
- (2010) B. Bhogal et al. Disease Models & Mechanisms
- Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome
- (2010) Zhong-Hua Liu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Roles of Fragile X Mental Retardation Protein in Dopaminergic Stimulation-induced Synapse-associated Protein Synthesis and Subsequent α-Amino-3-hydroxyl-5-methyl-4-isoxazole-4-propionate (AMPA) Receptor Internalization
- (2010) Hansen Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss of the Fragile X Mental Retardation Protein Decouples Metabotropic Glutamate Receptor Dependent Priming of Long-Term Potentiation From Protein Synthesis
- (2010) Benjamin D. Auerbach et al. JOURNAL OF NEUROPHYSIOLOGY
- Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome
- (2010) C. Gross et al. JOURNAL OF NEUROSCIENCE
- Dysregulation of mTOR Signaling in Fragile X Syndrome
- (2010) A. Sharma et al. JOURNAL OF NEUROSCIENCE
- Fragile X Protein FMRP Is Required for Homeostatic Plasticity and Regulation of Synaptic Strength by Retinoic Acid
- (2010) M. E. Soden et al. JOURNAL OF NEUROSCIENCE
- Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome
- (2010) E. K. Osterweil et al. JOURNAL OF NEUROSCIENCE
- Fragile X Mental Retardation Protein Is Required for Rapid Experience-Dependent Regulation of the Potassium Channel Kv3.1b
- (2010) J. G. Strumbos et al. JOURNAL OF NEUROSCIENCE
- Defective GABAergic Neurotransmission and Pharmacological Rescue of Neuronal Hyperexcitability in the Amygdala in a Mouse Model of Fragile X Syndrome
- (2010) J. L. Olmos-Serrano et al. JOURNAL OF NEUROSCIENCE
- Enhanced Endocannabinoid Signaling Elevates Neuronal Excitability in Fragile X Syndrome
- (2010) L. Zhang et al. JOURNAL OF NEUROSCIENCE
- Delayed Stabilization of Dendritic Spines in Fragile X Mice
- (2010) A. Cruz-Martin et al. JOURNAL OF NEUROSCIENCE
- Physiological Activation of Synaptic Rac>PAK (p-21 Activated Kinase) Signaling Is Defective in a Mouse Model of Fragile X Syndrome
- (2010) L. Y. Chen et al. JOURNAL OF NEUROSCIENCE
- Fragile X mental retardation protein in learning-related synaptic plasticity
- (2010) Valentina Mercaldo et al. MOLECULES AND CELLS
- Functional impact of global rare copy number variation in autism spectrum disorders
- (2010) Dalila Pinto et al. NATURE
- Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack
- (2010) Maile R Brown et al. NATURE NEUROSCIENCE
- Behavioural phenotyping assays for mouse models of autism
- (2010) Jill L. Silverman et al. NATURE REVIEWS NEUROSCIENCE
- Genome Variation and Complexity in the Autism Spectrum
- (2010) L.N. van de Lagemaat et al. NEURON
- Critical Period Plasticity Is Disrupted in the Barrel Cortex of Fmr1 Knockout Mice
- (2010) Emily G. Harlow et al. NEURON
- Fragile X Mental Retardation Protein Is Required for Synapse Elimination by the Activity-Dependent Transcription Factor MEF2
- (2010) Brad E. Pfeiffer et al. NEURON
- Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
- (2010) Dieter Edbauer et al. NEURON
- Early developmental alterations in GABAergic protein expression in fragile X knockout mice
- (2010) Daniel C. Adusei et al. NEUROPHARMACOLOGY
- Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes
- (2010) K.L. Eagleson et al. NEUROSCIENCE
- Fragile X: Leading the way for targeted treatments in autism
- (2010) Lulu W. Wang et al. Neurotherapeutics
- GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism
- (2010) Marjelo A. Mines et al. PLoS One
- Array-Based FMR1 Sequencing and Deletion Analysis in Patients with a Fragile X Syndrome–Like Phenotype
- (2010) Stephen C. Collins et al. PLoS One
- Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome
- (2010) Feng Pan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arc-dependent synapse-specific homeostatic plasticity
- (2010) J.-C. Beique et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome
- (2010) A. Suvrathan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Arc regulates spine morphology and maintains network stability in vivo
- (2010) C. L. Peebles et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of local translation at the synapse by BDNF
- (2010) Ana Rita Santos et al. PROGRESS IN NEUROBIOLOGY
- A mutant form of PTEN linked to autism
- (2010) Roberta E. Redfern et al. PROTEIN SCIENCE
- Potential therapeutic interventions for fragile X syndrome
- (2010) Josien Levenga et al. TRENDS IN MOLECULAR MEDICINE
- Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of Fragile X syndrome
- (2009) Christopher J. Yuskaitis et al. BIOCHEMICAL PHARMACOLOGY
- Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue
- (2009) Catherine H. Choi et al. BIOGERONTOLOGY
- Protein translation in synaptic plasticity: mGluR-LTD, Fragile X
- (2009) Maggie W Waung et al. CURRENT OPINION IN NEUROBIOLOGY
- Autism-specific copy number variants further implicate the phosphatidylinositol signaling pathway and the glutamatergic synapse in the etiology of the disorder
- (2009) I. Cusco et al. HUMAN MOLECULAR GENETICS
- Ca2+/Calmodulin-dependent Protein Kinase IV Links Group I Metabotropic Glutamate Receptors to Fragile X Mental Retardation Protein in Cingulate Cortex
- (2009) Hansen Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fragile X Mental Retardation Protein Regulates the Levels of Scaffold Proteins and Glutamate Receptors in Postsynaptic Densities
- (2009) Janin Schütt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway
- (2009) Neetu Tyagi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The genetic and neurobiologic compass points toward common signaling dysfunctions in autism spectrum disorders
- (2009) Pat Levitt et al. JOURNAL OF CLINICAL INVESTIGATION
- A pilot open label, single dose trial of fenobam in adults with fragile X syndrome
- (2009) E Berry-Kravis et al. JOURNAL OF MEDICAL GENETICS
- Role of the metabotropic glutamate receptor subtype 1 in the Harmaline-induced tremor in rats
- (2009) Wacław Kolasiewicz et al. JOURNAL OF NEURAL TRANSMISSION
- Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice
- (2009) Yuze Shang et al. JOURNAL OF NEUROCHEMISTRY
- Metabotropic Glutamate Receptors in Median Preoptic Neurons Modulate Neuronal Excitability and Glutamatergic and GABAergic Inputs From the Subfornical Organ
- (2009) Miloslav Kolaj et al. JOURNAL OF NEUROPHYSIOLOGY
- Positive AMPA Receptor Modulation Rapidly Stimulates BDNF Release and Increases Dendritic mRNA Translation
- (2009) H. Jourdi et al. JOURNAL OF NEUROSCIENCE
- Fragile X mental retardation protein control of neuronal mRNA metabolism: Insights into mRNA stability
- (2009) Silvia De Rubeis et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- TrkB signalling pathways in LTP and learning
- (2009) Liliana Minichiello NATURE REVIEWS NEUROSCIENCE
- Dopamine D1 receptor activation induces tau phosphorylation via cdk5 and GSK3 signaling pathways
- (2009) Manon Lebel et al. NEUROPHARMACOLOGY
- The State of Synapses in Fragile X Syndrome
- (2009) Brad E. Pfeiffer et al. NEUROSCIENTIST
- Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms
- (2009) C. M. Gladding et al. PHARMACOLOGICAL REVIEWS
- Generation and Characterization of Fmr1 Knockout Zebrafish
- (2009) Marjo J. den Broeder et al. PLoS One
- Fragile X Mental Retardation Protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A
- (2009) Chanxia Li Frontiers in Neural Circuits
- A Novel Function for Fragile X Mental Retardation Protein in Translational Activation
- (2009) Elias G Bechara et al. PLOS BIOLOGY
- Early-phase ERK activation as a biomarker for metabolic status in fragile X syndrome
- (2008) Ning Weng et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Prepulse inhibition in fragile X syndrome: Feasibility, reliability, and implications for treatment
- (2008) David Hessl et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008).
- (2008) Edward S. Brodkin BEHAVIORAL NEUROSCIENCE
- The Autistic Neuron: Troubled Translation?
- (2008) Raymond J. Kelleher et al. CELL
- The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
- (2008) Ilaria Napoli et al. CELL
- Limbic Epileptogenesis in a Mouse Model of Fragile X Syndrome
- (2008) L.-F. Qiu et al. CEREBRAL CORTEX
- Dopaminergic Modulation of Auditory Cortex-Dependent Memory Consolidation through mTOR
- (2008) Horst Schicknick et al. CEREBRAL CORTEX
- Downregulation of Tonic GABAergic Inhibition in a Mouse Model of Fragile X Syndrome
- (2008) Giulia Curia et al. CEREBRAL CORTEX
- Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure
- (2008) C. L. Gatto et al. DEVELOPMENT
- Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning
- (2008) C. R. Tessier et al. DEVELOPMENT
- A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome
- (2008) Jason B. Dictenberg et al. DEVELOPMENTAL CELL
- Translational Regulation of the Human Achaete-scute Homologue-1 by Fragile X Mental Retardation Protein
- (2008) Michael Fähling et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome
- (2008) Elizabeth Berry-Kravis et al. JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
- Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome
- (2008) Jay R. Gibson et al. JOURNAL OF NEUROPHYSIOLOGY
- Roles of Calcium-Stimulated Adenylyl Cyclase and Calmodulin-Dependent Protein Kinase IV in the Regulation of FMRP by Group I Metabotropic Glutamate Receptors
- (2008) H. Wang et al. JOURNAL OF NEUROSCIENCE
- Circuit and Plasticity Defects in the Developing Somatosensory Cortex of Fmr1 Knock-Out Mice
- (2008) I. Bureau et al. JOURNAL OF NEUROSCIENCE
- Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation
- (2008) J. A. Ronesi et al. JOURNAL OF NEUROSCIENCE
- Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons
- (2008) Patricia S. Estes et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
- (2008) Shuang Chang et al. Nature Chemical Biology
- Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice
- (2008) Femke M.S. de Vrij et al. NEUROBIOLOGY OF DISEASE
- Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
- (2008) Gary J. Bassell et al. NEURON
- FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain
- (2008) Hansen Wang et al. NEURON
- Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
- (2008) Sungjin Park et al. NEURON
- Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate
- (2008) Maggie W. Waung et al. NEURON
- Elevated glycogen synthase kinase-3 activity in Fragile X mice: Key metabolic regulator with evidence for treatment potential
- (2008) Wenzhong William Min et al. NEUROPHARMACOLOGY
- Advances in the Treatment of Fragile X Syndrome
- (2008) R. J. Hagerman et al. PEDIATRICS
- Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome
- (2008) S. H. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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