Article
Neurosciences
Alessandra Vergallito, Erica Varoli, Alberto Pisoni, Giulia Mattavelli, Lilia Del Mauro, Sarah Feroldi, Giuseppe Vallar, Leonor J. Romero Lauro
Summary: We studied the effects of transcranial direct current stimulation (tDCS) on cortical excitability using a combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG). Anodal tDCS over the right Posterior Parietal Cortex (rPPC) increased cortical excitability, while cathodal tDCS had no effect. However, when an endogenous task-induced activation was present during stimulation, cathodal tDCS effectively modulated cortical excitability.
Article
Multidisciplinary Sciences
Diego Milardovich, Victor H. Souza, Ivan Zubarev, Sergei Tugin, Jaakko O. Nieminen, Claudia Bigoni, Friedhelm C. Hummel, Juuso T. Korhonen, Dogu B. Aydogan, Pantelis Lioumis, Nima Taherinejad, Tibor Grasser, Risto J. Ilmoniemi
Summary: The study developed a deep learning-based algorithm, DELMEP, to automate the estimation of motor evoked potentials (MEPs) latency. The algorithm has low computational cost, allowing real-time MEP characterization, and shows high accuracy. This makes it a promising option for artificial intelligence-based personalized clinical applications.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Z. Cattaneo, C. Ferrari, A. Ciricugno, E. Heleven, D. J. L. G. Schutter, M. Manto, F. Van Overwalle
Summary: Research on the role of the posterior cerebellum in social and affective cognition using various brain stimulation methods has been reviewed. The functional role of the posterior cerebellum in processes such as mood regulation and social cognition may be explained by a generic prediction mechanism, and could involve different cortico-cerebellar and cerebellar limbic networks. Stimulation approaches such as paired-pulse TMS and frequency-tuned stimulation provide insights into cerebro-cerebellar circuits and potential clinical applications for improving social and affective skills associated with cerebellar abnormalities.
Article
Neurosciences
Aline Iannone, Irene Santiago, Silvia T. Ajao, Joaquim Brasil-Neto, John C. Rothwell, Danny A. Spampinato
Summary: Transcranial direct current stimulation (tDCS) is a promising intervention in clinical and behavioral neuroscience, but its impact is limited by response variability. Focal stimulation over the primary motor cortex (M1) enhances skill learning and activates distinct pathways to M1, suggesting that it may improve outcomes in future behavior enhancement studies.
NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Paolo A. Grasso, Elena Tonolli, Marta Bortoletto, Carlo Miniussi
Summary: The application of anodal transcranial direct current stimulation is associated with increased neuronal excitability and enhanced cognitive functioning, but may not always lead to desired behavioral outcomes. Electrophysiological and behavioral experiments revealed that AtDCS affects visuo-spatial contextual learning, increasing cortical response to stimuli but not improving learning performance.
Review
Behavioral Sciences
Pablo Solana, Julio Santiago
Summary: According to the embodied cognition view, comprehending action-related language requires the participation of sensorimotor processes. While most studies support this view, a significant portion of them lack statistical power and show signs of publication bias.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Adrianna Giuffre, Ephrem Zewdie, James G. Wrightson, Lauran Cole, Helen L. Carlson, Hsing-Ching Kuo, Ali Babwani, Adam Kirton
Summary: This study aimed to investigate the effects of tDCS and HD-tDCS on motor learning in children and assess motor cortex neurophysiology through robotic TMS mapping. While no significant effects were observed on map area and volume, changes in COG may occur.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Christian Nawroth, Katrina Rosenberger, Nina M. Keil, Jan Langbein
Summary: Artificial selection by humans has likely affected animals' ability to learn novel contingencies and their ability to adapt to changing environments, as evidenced by the slower learning performance of dairy goats compared to dwarf goats.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Leila Farnad, Ensiyeh Ghasemian-Shirvan, Mohsen Mosayebi-Samani, Min-Fang Kuo, Michael A. Nitsche
Summary: This study investigated the association between tDCS parameters and induced aftereffects on motor cortical excitability in older adults. The results showed that all active stimulation conditions significantly enhanced motor cortical excitability in both age groups, with no significant differences observed between the age groups. Prolonged plasticity was observed with higher stimulation intensities in the late-phase range.
Article
Psychiatry
Natasza D. Orlov, Syed Ali Muqtadir, Hooman Oroojeni, Bruno Averbeck, John Rothwell, Sukhi S. Shergill
Summary: This study investigated the effects of transcranial direct current stimulation (tDCS) of the medial prefrontal cortex (mPFC) on cognitive performance and underlying neurophysiological effects in individuals with schizophrenia. The results showed that tDCS significantly improved performance in the SSLT task, and was associated with increased insular activity and reduced amygdala activation.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Rebecca Herzog, Till M. Berger, Martje G. Pauly, Honghu Xue, Elmar Rueckert, Alexander Muenchau, Tobias Baeumer, Anne Weissbach
Summary: Transcranial current stimulation techniques can induce cortical plasticity. The cerebellum, an important relay in the motor system, is a promising target for plasticity induction. This study compared the effects of different tCS methods on cerebellar plasticity and found that 50 Hz tACS was the most effective in changing corticospinal excitability.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Andres Molero-Chamizo, Michael A. Nitsche, Rafael Tomas Andujar Barroso, Jose R. Alameda Bailen, Jesus Carlos Garcia Palomeque, Guadalupe Nathzidy Rivera-Urbina
Summary: Although fibromyalgia is primarily characterized by muscular pain, it also involves dysfunctions in various bodily systems. Neuromodulatory stimulation techniques have shown potential in treating the neurological symptoms of fibromyalgia. In this review, we discuss the use of non-invasive brain stimulation techniques as therapeutic strategies and their contribution to understanding the neurophysiological characteristics of fibromyalgia. While these approaches do not aim to cure the syndrome, they can significantly improve patients' quality of life by reducing key symptoms.
Article
Neurosciences
Chiara Ferrari, Andrea Ciricugno, Maria Arioli, Zaira Cattaneo
Summary: The medial sectors of the posterior cerebellum are involved in basic emotional recognition, while the lateral sectors are recruited for higher-level social inference. Moreover, the contribution of the cerebellum in these processes is limited to negative emotional stimuli.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Lijin Jose, Lais Bhering Martins, Thiago M. Cordeiro, Keya Lee, Alexandre Paim Diaz, Hyochol Ahn, Antonio L. Teixeira
Summary: This systematic review aims to investigate the effectiveness of noninvasive neuromodulation in HD-associated motor, cognitive, and behavioral symptoms. 19 studies were identified, exploring the use of ECT, TMS, and tDCS in the treatment of HD. The results showed improvement in HD symptoms, particularly depression and psychosis after ECT protocols, although the impact on cognitive and motor symptoms is more controversial.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Martina Vatrano, Idan Efim Nemirovsky, Paolo Tonin, Francesco Riganello
Summary: Neurofeedback is a non-invasive therapeutic approach that allows individuals to gain control over their own brainwaves and improve cognitive performance or alleviate symptoms. However, applying neurofeedback techniques in patients with disorders of consciousness presents unique challenges.
Article
Clinical Neurology
Edoardo Nicolo Aiello, Antonella Esposito, Chiara Gramegna, Valentina Gazzaniga, Stefano Zago, Teresa Difonzo, Ildebrando Marco Appollonio, Nadia Bolognini
Summary: This study provided updated normative data for the Italian FAB and found strong convergent validity with the MoCA. Age and education were predictive of all FAB measures, and no gender differences were detected.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Nadia Bolognini, Chiara Gramegna, Antonella Esposito, Edoardo Nicolo Aiello, Teresa Difonzo, Stefano Zago
Summary: This study provides normative data for using the TCAT as an adjuvant cognitive screening test in the neuropsychological evaluation of TC, demonstrating good convergent validity of the TCAT with respect to TC. These findings are relevant for the adoption of the TCAT in clinical practice.
NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Edoardo Nicolo Aiello, Sara Rimoldi, Nadia Bolognini, Ildebrando Appollonio, Giorgio Arcara
Summary: This study investigated the existing cognitive screening tests in Italy and found that while some met basic psychometric and diagnostic requirements, many tests still exhibited poor statistical properties that limit their recommendation for clinical applications.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Antonella Esposito, Ilaria Giannone, Lorenzo Diana, Ildebrando Appollonio, Nadia Bolognini
Summary: The study aimed at developing an Italian version of the TICS and assessing its psychometric and diagnostic properties. Results showed that the Italian TICS is a valid, reliable, and diagnostically accurate TBCS test.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Edoardo Nicolo Aiello, Antonella Esposito, Ilaria Giannone, Lorenzo Diana, Susan Woolley, Jennifer Murphy, Georgia Christodoulou, Lucio Tremolizzo, Nadia Bolognini, Ildebrando Appollonio
Summary: The study aimed to standardize the ALS-CBS (TM)-PhV for the Italian population, a telephone-based screening for frontotemporal dysfunction in MND patients. Results showed that the screening test was statistically reliable for assessing frontotemporal disorders and could improve tele-healthcare for MND patients, with epidemiological applications and effective assessments in decentralized clinical trials.
NEUROLOGICAL SCIENCES
(2022)
Correction
Clinical Neurology
Edoardo Nicolo Aiello, Antonella Esposito, Chiara Gramegna, Valentina Gazzaniga, Stefano Zago, Teresa Difonzo, Ildebrando Marco Appollonio, Nadia Bolognini
NEUROLOGICAL SCIENCES
(2023)
Correction
Clinical Neurology
Nadia Bolognini, Chiara Gramegna, Antonella Esposito, Edoardo Nicolo Aiello, Teresa Difonzo, Stefano Zago
NEUROLOGICAL SCIENCES
(2023)
Correction
Clinical Neurology
Edoardo Nicolo Aiello, Antonella Esposito, Ilaria Giannone, Lorenzo Diana, Susan Woolley, Jennifer Murphy, Georgia Christodoulou, Lucio Tremolizzo, Nadia Bolognini, Ildebrando Appollonio
NEUROLOGICAL SCIENCES
(2023)
Correction
Clinical Neurology
Edoardo Nicolo Aiello, Sara Rimoldi, Nadia Bolognini, Ildebrando Appollonio, Giorgio Arcara
NEUROLOGICAL SCIENCES
(2023)
Article
Food Science & Technology
Angelo Torrente, Laura Pilati, Salvatore Di Marco, Simona Maccora, Paolo Alonge, Lavinia Vassallo, Antonino Lupica, Serena Coppola, Cecilia Camarda, Nadia Bolognini, Filippo Brighina
Summary: This study found that multisensory integration is modified in chronic migraine, and onabotulinumtoxinA is effective in preventing chronic migraine and restoring multisensory processing.
Article
Clinical Neurology
Stefania Bianchi Marzoli, Lisa Melzi, Paola Ciasca, Alberto Raggi, Anna Bersano, Carlotta Casati, Nadia Bolognini
Summary: This study aimed to quantify the degree of ganglion cell degeneration using SD-OCT in adult patients with post-stroke homonymous visual field defect. The results showed that there were significant differences in pRNFL-AVG, GCC-AVG, GLV, and FLV between stroke patients and controls regardless of stroke type and involved vascular territories. Age and elapsed time from stroke had a significant effect on pRNFL-AVG and GCC-AVG, while visual field defect size was unrelated to SD-OCT measurements.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Simona Maccora, Nadia Bolognini, Carlo Mannina, Angelo Torrente, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Guido Sireci, Filippo Brighina
Summary: This study aimed to investigate the influence of estradiol on the sound-induced flash illusion (SIFI) and found that high estradiol levels during ovulation led to reduced perception of SIFI in women, indicating an enhanced excitability of the visual cortex. Additionally, migraine women perceived fewer flashes in the illusion compared to controls, independent of the menstrual cycle phase.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Luigi Tesio, Antonio Caronni, Cristina Russo, Giorgio Felisari, Elisabetta Banco, Anna Simone, Stefano Scarano, Nadia Bolognini
Summary: In mirror training (MIT), stroke patients move their hands while looking at the reflected image of the unaffected one, while reversed MIT (REMIT) requires moving hands while looking at the paretic one. This study compared the effects of MIT and REMIT on post-stroke upper-limb recovery and found that both were equally effective, challenging the exclusive role of mirror neurons in rehabilitation.
Article
Psychology, Experimental
Stefano Zago, Alice N. Preti, Teresa Difonzo, Annalisa D'Errico, Giuseppe Sartori, Andrea Zangrossi, Nadia Bolognini
Summary: Amnesia is common in major crimes, with both genuine and malingering cases. Various techniques such as polygraphs, event-related potentials, and facial analysis can assist in determining the credibility of crime-related amnesia. However, there is limited evidence on their usefulness in forensic practice.
TOPICS IN COGNITIVE SCIENCE
(2023)
Article
Geriatrics & Gerontology
Edoardo Nicolo Aiello, Chiara Gramegna, Antonella Esposito, Valentina Gazzaniga, Stefano Zago, Teresa Difonzo, Ottavia Maddaluno, Ildebrando Appollonio, Nadia Bolognini
Summary: This study aimed to update region-specific norms for the Italian MoCA and provide information on sensitivity and discriminative capability at the item level. Age and education significantly predicted all MoCA measures, while substantial disagreements with previous norms classifications were detected. Certain items in the MoCA were found to lack sensitivity, particularly in the orientation and memory tasks.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
