Review
Biochemistry & Molecular Biology
Parveen Salahuddin, Munazza Tamkeen Fatima, Vladimir N. Uversky, Rizwan Hasan Khan, Zeyaul Islam, Mohammad Furkan
Summary: Neurodegenerative diseases are characterized by the abnormal loss of neurons, with common pathogenic mechanisms involving misfolding and aggregation of proteins. Accumulating evidence suggests that amyloid oligomers, not fibrils, are the most toxic species causing AD and PD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Neurosciences
Marco Greco, Anas Munir, Debora Musaro, Chiara Coppola, Michele Maffia
Summary: Parkinson's disease is a pathological condition characterized by protein aggregation, and type 2 diabetes may be one of its etiological factors as it alters biological processes such as autophagy and mitochondrial homeostasis.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Sohaib Nizami, Val Millar, Kanisa Arunasalam, Tryfon Zarganes-Tzitzikas, David Brough, Gary Tresadern, Paul E. Brennan, John B. Davis, Daniel Ebner, Elena Di Daniel
Summary: Inhibition of the NLRP3 inflammasome has emerged as a promising therapeutic target, with a screening assay successfully identifying inhibitors targeting HSP90, JAK, and IKK-beta. This study provides valuable insights for further research on the application of inflammasomes in disease models.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Leslie C. Norins
Summary: Substantial evidence supports the clinical testing of FDA-approved drugs for repurposing to treat Alzheimer's disease, including drug mechanisms of action, in vivo testing, and epidemiological data. Investigating already-approved compounds can be faster and more cost-effective than un-approved compounds in the drug pipeline. With the increasing prevalence of AD due to longer life expectancy, the lack of an effective drug for treatment is a pressing public health concern.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Oxana V. Galzitskaya, Sergei Y. Grishin, Anna V. Glyakina, Nikita V. Dovidchenko, Anastasiia V. Konstantinova, Sergey V. Kravchenko, Alexey K. Surin
Summary: In recent years, there has been an increase in the number of identified diseases associated with the accumulation of amyloid proteins, which are known to cause degenerative diseases in humans. Therefore, it is important to develop strategies for the search and development of effective inhibitors of amyloid formation. This review focuses on three amyloidogenic peptides and proteins - A beta, alpha-synuclein, and insulin - and analyzes existing and prospective strategies for the development of effective and non-toxic inhibitors of amyloid formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Samuel Pena-Diaz, Javier Garcia-Pardo, Salvador Ventura
Summary: Parkinson's disease is the second most common neurodegenerative disorder worldwide, characterized by protein deposits in dopaminergic neurons. Recent research has identified compounds primarily of an aromatic nature that target a-Syn aggregation. This study provides a historical overview of Parkinson's disease, its molecular aspects, and current trends in small compound development to address a-Syn aggregation. These compounds are promising for the development of effective therapies for Parkinson's disease.
Article
Biochemistry & Molecular Biology
Yanfei Xie, Jiani Lu, Tiantian Yang, Chao Chen, Yongjie Bao, Luying Jiang, Hua Wei, Xiang Wu, Li Zhao, Shan He, Dongdong Lin, Fufeng Liu, Hao Liu, Xiaojun Yan, Wei Cui
Summary: Phloroglucinol has the ability to degrade pre-formed amyloid aggregates, inhibit seeding during amyloid aggregation, and reduce neurotoxicity, indicating its potential as a novel drug for treating neurodegenerative disorders.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biology
Sumire Matsumoto, Tomomi Tsunematsu
Summary: Protein misfolding and aggregation are associated with various neurodegenerative diseases like AD and PD. Sleep impairments in these diseases can serve as both accompanying symptoms and potential biomarkers for early diagnosis. The relationship between sleep disturbances and neurodegenerative diseases is a topic of interest for future research and potential treatment strategies.
Review
Medicine, General & Internal
Patrycja Pawlik, Katarzyna Blochowiak
Summary: Neurodegenerative diseases result in progressive neuronal degeneration, emphasizing the need for early screening and diagnosis. Biomarkers show promise for early detection, with saliva being explored as a potential non-invasive diagnostic tool. Research on salivary biomarkers for Alzheimer's and Parkinson's diseases continues, aiming to identify correlations between specific biomarkers and early clinical symptoms for improved treatment strategies.
Article
Neurosciences
Daniel Kam Yin Chan, Nady Braidy, Ren Fen Chen, Ying Hua Xu, Steven Bentley, Michal Lubomski, Ryan L. Davis, Jack Chen, Carolyn M. Sue, George D. Mellick
Summary: This study investigated the correlation between plasma levels of alpha-synuclein, anti-alpha-synuclein, and their ratios to amyloid beta-40 in Parkinson's disease diagnosis. A diagnostic algorithm was built using promising biomarkers, and the results were verified in an independent sample. The study showed that the combination of these biomarkers demonstrated promising sensitivity and specificity.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yijing Tang, Dong Zhang, Jie Zheng
Summary: This study demonstrates a repurposing strategy for an antimicrobial peptide, PG-1, as an amyloid inhibitor in Alzheimer's disease. PG-1 inhibits Aβ aggregation, disassembles preformed Aβ fibrils, reduces cytotoxicity, and preserves antimicrobial activity against various strains. This work introduces a promising approach to target multiple pathological pathways in AD.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Analytical
Yu P. Zhang, Evgeniia Lobanova, Derya Emin, Sergey V. Lobanov, Antonina Kouli, Caroline H. Williams-Gray, David Klenerman
Summary: This study introduces a new method for the diagnosis of early Parkinson's disease. The results show that the proportion of soluble alpha-synuclein aggregates can distinguish between Parkinson's disease patients and control groups, with Parkinson's disease patients having a higher proportion of larger and rounder alpha-synuclein aggregates. By combining the number and morphology of the aggregates, a new biomarker with improved accuracy for early Parkinson's disease diagnosis was constructed.
ANALYTICAL CHEMISTRY
(2023)
Article
Neurosciences
Ross D. Markello, Golia Shafiei, Christina Tremblay, Ronald B. Postuma, Alain Dagher, Bratislav Misic
Summary: Individuals with Parkinson's disease exhibit a complex clinical phenotype, where data fusion can capture inter-dependencies among different modalities, with neuroimaging data playing a critical role.
NPJ PARKINSONS DISEASE
(2021)
Article
Neurosciences
Andre D. G. Leitao, Brian Spencer, Floyd Sarsoza, Jennifer Ngolab, Jessica Amalraj, Eliezer Masliah, Chengbiao Wu, Robert A. Rissman
Summary: The study demonstrates that selectively knocking down alpha-synuclein can significantly reduce the number of A beta plaques in AD mice and ameliorate pathological and behavioral phenotypes. This suggests a novel therapeutic approach for targeting Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Jia-Li Pu, Chong-Yao Jin, Zhong-Xuan Wang, Yi Fang, Yao-Lin Li, Nai-Jia Xue, Ran Zheng, Zhi-Hao Lin, Yi-Qun Yan, Xiao-Li Si, Ying Chen, Yi Liu, Zhe Song, Ya-Ping Yan, Jun Tian, Xin-Zhen Yin, Bao-Rong Zhang
Summary: The study indicates that patients with Parkinson's disease who carry the APOE ε4 allele may experience faster motor progression, especially in those with high amyloid beta burden. This suggests a potential link between APOE ε4 and rapid motor decline in PD.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Wojciech Danysz, Gunnar Flik, Andrew McCreary, Carsten Tober, Wilfried Dimpfel, Jean C. Bizot, Richard Kostrzewa, Russell W. Brown, Claudia C. Jatzke, Sergio Greco, Ann-Kristin Jenssen, Christopher G. Parsons
JOURNAL OF NEURAL TRANSMISSION
(2015)
Article
Neurosciences
Christopher G. Parsons, Maarten Ruitenberg, Christine E. Freitag, Kamila Sroka-Saidi, Hermann Russ, Gerhard Rammes
Article
Neurosciences
Gerhard Rammes, Andreas Gravius, Maarten Ruitenberg, Nico Wegener, Caroline Chambon, Kamila Sroka-Saidi, Ross Jeggo, Lydia Staniaszek, Dave Spanswick, Eugene O'Hare, Philip Palmer, Eun-Mee Kim, Wolfgang Bywalez, Veronica Egger, Christopher G. Parsons
Article
Pharmacology & Pharmacy
Jens Nagel, Sergio Greco, Chris G. Parsons, Gunnar Flik, Carsten Tober, Kai-Uwe Klein, Wojciech Danysz
PHARMACOLOGICAL REPORTS
(2015)
Review
Pharmacology & Pharmacy
Chris G. Parsons, Gerhard Rammes
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2017)
Article
Neurosciences
Gerhard Rammes, Corinna Mattusch, Matthias Wulff, Franziska Seeser, Matthias Kreuzer, Kaichuan Zhu, Jan M. Deussing, Jochen Herms, Chris G. Parsons
Article
Biochemistry & Molecular Biology
Wojciech Danysz, Yan Han, Fugang Li, Jim Nicoll, Philipp Buch, Thomas Hengl, Maarten Ruitenberg, Chris Parsons
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Omar S. Mabrouk, Flora Mela, Mariangela Calcagno, Mirco Budri, Riccardo Viaro, Andrzej Dekundy, Christopher G. Parsons, Yves P. Auberson, Michele Morari
ACS CHEMICAL NEUROSCIENCE
(2013)
Review
Pharmacology & Pharmacy
Wojciech Danysz, Chris G. Parsons
BRITISH JOURNAL OF PHARMACOLOGY
(2012)
Article
Clinical Neurology
Caroline Nothdurfter, Sascha Tanasic, Barbara Di Benedetto, Manfred Uhr, Eva-Maria Wagner, Kate E. Gilling, Chris G. Parsons, Theo Rein, Florian Holsboer, Rainer Rupprecht, Gerhard Rammes
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Chemistry, Medicinal
Anna S. Sklyarova, Vladimir N. Rodionov, Christopher G. Parsons, Guenter Quack, Peter R. Schreiner, Andrey A. Fokin
MEDICINAL CHEMISTRY RESEARCH
(2013)
Article
Neurosciences
Gerhard Rammes, Franziska Seeser, Korinna Mattusch, Kaichuan Zhu, Laura Haas, Markus Kummer, Michael Heneka, Jochen Herms, Chris G. Parsons
Review
Neurosciences
Chris G. Parsons, Wojciech Danysz, Andrzej Dekundy, Irena Pulte
NEUROTOXICITY RESEARCH
(2013)
Article
Neurosciences
Martina Buerge, Stephan Kratzer, Corinna Mattusch, Carolin Hofmann, Matthias Kreuzer, Christopher G. Parsons, Gerhard Rammes
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
