Review
Biochemistry & Molecular Biology
Farzin Zobdeh, Ivan I. Eremenko, Mikail A. Akan, Vadim V. Tarasov, Vladimir N. Chubarev, Helgi B. Schioeth, Jessica Mwinyi
Summary: Migraine is a complex neurological disorder and current drug treatments have limited success rates. Understanding the epigenetic changes associated with migraine may help to improve treatment strategies and identify new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Carla L. Sanchez-Lafuente, Brady S. Reive, Lisa E. Kalynchuk, Hector J. Caruncho
Summary: A healthy diet has been found to reduce the risk of mental health problems, such as major depression. The influence of diet on mood is mediated by epigenetic alterations in the brain. Animal studies have shown that diet can directly or indirectly affect depressive symptoms and epigenetic mechanisms in the brain, primarily through DNA methylation, histone acetylation, and microRNAs. Inadequate maternal diets can also increase the offspring's susceptibility to anxiety and depressive-like behavior, which is accompanied by changes in the epigenome. The systematic review highlights the importance of understanding the role of brain epigenetics in the effects of diet on mental health.
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin Song, Julia A. VanBuskirk, Shannath L. Merbs
Summary: This study reveals an important role of epigenetic regulation in controlling opsin expression, and demonstrates this through experiments using epigenetic modifiers in cell cultures and mouse retinal explants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bibiana Torok, Csilla Lea Fazekas, Adrienn Szabo, Dora Zelena
Summary: Vasopressin, acting through V2, V1a, and V1b receptors, regulates kidney water resorption, blood pressure, stress-axis, social behavior, and memory. Its implication in depression and schizophrenia may involve epigenetic changes such as DNA methylation, histone modification, and micro RNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Psychiatry
Anil Srivastava, Oluwagbenga Dada, Jessica Qian, Nzaar Al-Chalabi, Ali Bani Fatemi, Philip Gerretsen, Ariel Graff, Vincenzo De Luca
Summary: Schizophrenia is a chronic psychotic disorder that significantly impacts behavior, thought, and cognition, with possible contributions from both genetic and epigenetic factors. Current research focuses on DNA methylation, histone modification, and non-coding RNA, offering potential new avenues for diagnosis and treatment of schizophrenia. Limitations in current knowledge and potential future research directions are also discussed.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wei Wang, Xiaolong Du, Mingxing Chu, Xiaoyun He
Summary: This study investigated the effects of photoperiod on the expression and epigenetic changes of the GNAQ gene. The results showed that photoperiod can induce DNA methylation in the core promoter region and histone acetylation in the promoter region of the GNAQ gene. These findings are important for understanding the role of epigenetic modifications in reproduction in sheep.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Junying Lu, Yuanyuan Huang, Xiaohao Zhang, Yang Xu, Shu Nie
Summary: Diabetes, a metabolic disorder, leads to vascular complications, accelerated by mechanisms such as oxidative stress and inflammation caused by high blood glucose. Epigenetic modifications and non-coding RNAs play important roles in the pathogenesis of diabetic vascular complications.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alison C. Brewer
Summary: The epigenetic landscape plays a crucial role in gene transcription and cellular phenotype determination, with chromatin remodelling during cellular differentiation being a key factor. Redox-dependent molecular mechanisms, including NADPH oxidases generating ROS, are important in regulating epigenetic changes. The role of NADPH oxidases in redox-dependent chromatin remodelling and the impact of epigenetic changes on ROS-producing enzymes are discussed in relation to cellular differentiation and homeostasis, particularly focusing on Nox4.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Fayaz Ahmad Mir, Ayeman Amanullah, Buddhi Prakash Jain, Zeeshan Hyderi, Akash Gautam
Summary: Gene expression in the brain undergoes significant changes during memory acquisition, recall, and forgetfulness. Non-genetic factors such as environmental elements, epigenetic changes, and lifestyle have gained attention in understanding the causes of neurodegenerative diseases and age-related dementia. Epigenetic modifications play a crucial role in regulating gene expression in all living organisms. Genes associated with aging and memory disorders related to neurodegeneration are regulated by epigenetic processes including DNA methylation, histone acetylation, and mRNA editing. Understanding the mechanisms behind these epigenetic changes could lead to effective treatments for neurodegeneration and age-induced dementia.
AGEING RESEARCH REVIEWS
(2023)
Review
Immunology
Chao Yang, Dan Li, Dehong Teng, Yueru Zhou, Lei Zhang, Zhangfeng Zhong, Guan-Jun Yang
Summary: This review discusses the research on the pathogenesis of rheumatoid arthritis (RA) in the past five years based on epigenetic modifications, providing new methods and strategies for the diagnosis and treatment of this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Amanda L. Morin, Phyo W. Win, Angela Z. Lin, Christina A. Castellani
Summary: Bidirectional crosstalk between the nuclear and mitochondrial genomes is crucial for cell functioning. Mitochondrial DNA copy number and heteroplasmy can influence mitochondrial function, nuclear genome, and contribute to overall health and disease. Mitochondria act as environmental biosensors, conveying essential information about cell state to the nuclear genome. Cellular communication between mitochondrial variation and nuclear epigenome can occur through modifications of metabolites and intermediates, affecting epigenetic modifications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.