Article
Biochemistry & Molecular Biology
Xavier Ekolle Ndode-Ekane, Maria del Mar Puigferrat Perez, Rossella Di Sapia, Niina Lapinlampi, Asia Pitkanen
Summary: Traumatic brain injury disrupts the integrity of thalamic and cortical connections, leading to reorganization in the response to thalamic stimulation. TBI rats show decreased axon terminal density, altered orientation, and anisotropy of terminals in the perilesional cortex. Moreover, optical stimulation of the sensory thalamus induces different EEG responses in TBI rats compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Eppu Manninen, Karthik Chary, Niina Lapinlampi, Pedro Andrade, Tomi Paananen, Alejandra Sierra, Jussi Tohka, Olli Grohn, Asla Pitkanen
Summary: This study aimed to identify MRI biomarkers for post-traumatic epilepsy in Sprague-Dawley rats with traumatic brain injury. The researchers found that a combination of T-2 relaxation time and diffusion tensor data could distinguish rats with and without epilepsy, and even a single time-point measurement could significantly enrich the epilepsy rate within the study population.
Article
Clinical Neurology
Rebecca E. Woodrow, Stefan Winzeck, Andrea Luppi, Isaac R. Kelleher-Unger, Lennart R. B. Spindler, J. T. Lindsay Wilson, Virginia F. J. Newcombe, Jonathan P. Coles, David K. Menon, Emmanuel A. Stamatakis
Summary: Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. The study found acute thalamic hyperconnectivity in mTBI, even without structural changes. These acute changes in thalamic connectivity can serve as early markers for persistent symptoms and have associations with specific emotional and cognitive symptoms.
Article
Biochemistry & Molecular Biology
Jignesh D. Pandya, Sudeep Musyaju, Hiren R. Modi, Ying Cao, William J. Flerlage, Linda Huynh, Brittany Kociuba, Nishant P. Visavadiya, Firas Kobeissy, Kevin Wang, Janice S. Gilsdorf, Anke H. Scultetus, Deborah A. Shear
Summary: Traumatic Brain Injury (TBI) is a heterogeneous disorder caused by external physical assaults that damages the brain. Mitochondrial dysfunction plays a pivotal role in long-term injury progression through cellular excitotoxicity. This study provides an in-depth evaluation of mitochondrial endpoints with respect to redox and calcium homeostasis, and cell death responses following penetrating TBI (PTBI).
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Neurosciences
Gerben van Hameren, Jamil Muradov, Anna Minarik, Refat Aboghazleh, Sophie Orr, Shayna Cort, Keiran Andrews, Caitlin Mckenna, Nga Thy Pham, Mark A. Maclean, Alon Friedman
Summary: This study explored the association between mitochondrial function and vascular function after traumatic brain injury using a rodent model. The results showed that traumatic brain injury and cortical spreading depolarization resulted in mitochondrial dysfunction, impaired cortical blood flow, and neurobehavioral deficits.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Han Liu, Junchi He, Yue Wu, Yang Du, Yinghua Jiang, Chengzhi Chen, Zhanyang Yu, Jianjun Zhong, Zhigang Wang, Chongjie Cheng, Xiaochuan Sun, Zhijian Huang
Summary: The study showed that exogenous rANXA1 can improve BBB disruption and inflammatory response, leading to better functional outcomes following traumatic brain injury.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Lexin Zheng, Qiuyu Pang, Heng Xu, Hanmu Guo, Rong Liu, Tao Wang
Summary: Neurological dysfunctions often occur after mild or moderate traumatic brain injury (TBI), and stress may play a role in their recovery. However, there is limited research on the effects and mechanisms of stress on TBI-related neurological dysfunctions. This review investigates the effects of TBI and stress on neurological dysfunctions, explores the neurobiological links and mechanisms between stress and TBI, and summarizes the findings related to stress biomarkers and their potential diagnostic and therapeutic significance in mild or moderate TBI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neuroimaging
Abbie S. Taing, Matthew E. Mundy, Jennie L. Ponsford, Gershon Spitz
Summary: Impaired working memory is a common consequence of traumatic brain injury (TBI), with deficits in encoding and maintenance processes exhibited in both acute and chronic TBI patients. Functional MRI revealed interaction between task demands and specific working memory subcomponents in TBI patients, indicating a nuanced pattern of brain activation associated with working memory.
NEUROIMAGE-CLINICAL
(2021)
Article
Critical Care Medicine
Jesse T. Fischer, Paul T. Cirino, Dana DeMaster, Candice Alfano, Johanna Bick, Weihua Fan, Linda Ewing-Cobbs
Summary: This study looked at the impact of TBI on children's cool and hot self-regulation abilities, finding that children with cmsTBI had greater difficulties in both areas and lower FA in frontostriatal pathways. The results suggest that frontostriatal FA could serve as a biomarker for risk of SR difficulties and guide interventions in pediatric TBI and other neurodevelopmental populations.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Critical Care Medicine
Vijay Krishnamoorthy, Jordan M. Komisarow, Daniel T. Laskowitz, Monica S. Vavilala
Summary: Traumatic brain injury (TBI) is a significant global health issue with extracranial organ dysfunction being common after severe TBI, impacting clinical care and outcomes. However, extracranial organ dysfunction remains understudied compared to other critical care paradigms.
Article
Biochemistry & Molecular Biology
Yuhua Chen, Kai Gong, Quanhua Xu, Jiao Meng, Tianlin Long, Cuicui Chang, Zhanxiang Wang, Wei Liu
Summary: The study evaluated the effects of PGAM5 on neuronal injury and mitochondrial dysfunction in traumatic brain injury (TBI) models, showing that PGAM5 plays a critical role in TBI progression via Drp1 activation-mediated mitochondrial dysfunction.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Immunology
Xiang Liu, Zhuofan Lei, Dylan Gilhooly, Junyun He, Yun Li, Rodney M. Ritzel, Hui Li, Long-Jun Wu, Shaolin Liu, Junfang Wu
Summary: This study investigated the impact of traumatic brain injury (TBI) on olfactory deficits (OD) and identified the underlying mechanisms in mice. It was found that TBI caused inflammation and neuronal dysfunction in the olfactory bulb (OB), leading to OD. Targeting Hv1/NOX2 may be a potential intervention for improving post-traumatic anosmia.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Si-Wei Tan, Yan Zhao, Ping Li, Ya-Lei Ning, Zhi-Zhong Huang, Nan Yang, Dong Liu, Yuan-Guo Zhou
Summary: The study found that the continuous activation of the NLRP3 inflammasome and release of HMGB1 are closely related to cognitive impairment in the late stage of traumatic brain injury (TBI). Inhibition of HMGB1 improved long-term potentiation reduction and cognitive function by reducing NLRP3 inflammasome activation. This provides insights into the mechanism of cognitive dysfunction progression in TBI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Critical Care Medicine
Vijay Krishnamoorthy, Nancy Temkin, Jason Barber, Brandon Foreman, Jordan Komisarow, Fred K. Korley, Daniel T. Laskowitz, Joseph P. Mathew, Adrian Hernandez, John Sampson, Michael L. James, Raquel Bartz, Karthik Raghunathan, Benjamin A. Goldstein, Amy J. Markowitz, Monica S. Vavilala
Summary: In patients with traumatic brain injury, the development of early multiple organ dysfunction syndrome significantly impacts clinical outcomes and survival rates.
CRITICAL CARE MEDICINE
(2021)
Article
Neurosciences
Daniel J. King, Stefano Seri, Cathy Catroppa, Vicki A. Anderson, Amanda G. Wood
Summary: Pediatric traumatic brain injury can lead to inconsistent changes in brain morphology, with this study focusing on the relationship between cortical organization and long-term cognitive impairment post-pTBI. While specific reductions were found in structural covariance strength between controls and pTBI patients with executive function impairment, node-level differences were primarily in frontal regions. The study suggests that post-injury cortical thickness reductions in regions central to structural covariance topology may explain poor executive function outcomes in some patients.
Article
Computer Science, Information Systems
Joshua W. Joseph, David T. Chiu, Larry A. Nathanson, Steven Horng
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2016)
Article
Emergency Medicine
Joshua W. Joseph, Victor Novack, Matthew L. Wong, Larry A. Nathanson, Leon D. Sanchez
JOURNAL OF EMERGENCY MEDICINE
(2017)
Article
Emergency Medicine
Joshua W. Joseph, Samuel Davis, Elissa H. Wilker, Matthew L. Wong, Ori Litvak, Stephen J. Traub, Larry A. Nathanson, Leon D. Sanchez
EMERGENCY MEDICINE JOURNAL
(2018)
Article
Genetics & Heredity
Josh W. Joseph, Alon B. Neidich, Carole Ober, Lainie Friedman Ross
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2008)
Review
Neurosciences
Hedy Kober, Lisa Feldman Barrett, Josh Joseph, Eliza Bliss-Moreau, Kristen Lindquist, Tor D. Wager
Article
Neurosciences
Aifeng Zhang, Alex Leow, Olusola Ajilore, Melissa Lamar, Shaolin Yang, Josh Joseph, Jennifer Medina, Liang Zhan, Anand Kumar
NEUROPSYCHOPHARMACOLOGY
(2012)
Article
Critical Care Medicine
K. Sarah Hoehn, Kruti Acharya, Josh W. Joseph, Lainie Friedman
PEDIATRIC CRITICAL CARE MEDICINE
(2009)
Article
Health Care Sciences & Services
Gregory Andrew Peters, Matthew L. Wong, Joshua W. Joseph, Leon D. Sanchez
JMIR MHEALTH AND UHEALTH
(2019)
Article
Emergency Medicine
Peter S. Antkowiak, Terrance Lee, David T. Chiu, Bryan A. Stenson, Stephen J. Traub, Leon D. Sanchez, Joshua W. Joseph
Summary: This study retrospectively analyzed operational data from an urban academic hospital and identified three distinct groups of emergency physicians based on their ordering practices and resource utilization patterns. The findings validate the relationship between resource utilization and admission rates, and highlight the need for further investigation into the impact of physician characteristics and behavior on care quality and efficiency.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Emergency Medicine
Joshua W. Joseph, Leslie A. Bilello, Alden M. Landry, Mary C. O'Brien, Kenneth D. Marshall
Summary: There are compelling motivations for involving senior residents and attendings in high-risk intubations during the COVID-19 pandemic. Strategies should aim to preserve residents' role whenever possible, while maximizing supervision and providing alternative routes for intubation practice.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Emergency Medicine
Isha Agarwal, Joshua W. Joseph, Leon D. Sanchez
Summary: The study found that emergency physicians were more likely to prescribe opioids for conditions that are sometimes indicated as the shift hour progressed, while they were less likely to prescribe opioids for nonindicated conditions.
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE
(2022)
Article
Emergency Medicine
Joshua W. Joseph, Evan L. Leventhal, Anne V. Grossestreuer, Paul C. Chen, Benjamin A. White, Larry A. Nathanson, Noemie Elhadad, Leon D. Sanchez
Summary: This study examined the prediction of work relative value units (wRVUs) generated by patients at triage using deep-learning approaches. The results showed that deep-learning techniques can accurately predict wRVUs generated by patients. These algorithms have the potential to balance workload and compensation between emergency physicians, quantify crowding and mobilize resources, and reduce bias in the triage process.
JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Emergency Medicine
Joshua W. Joseph, Evan L. Leventhal, Anne Grossestreuer, Matthew L. Wong, Loren J. Joseph, Larry A. Nathanson, Michael W. Donnino, Noemie Elhadad, Leon D. Sanchez
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2020)
Article
Emergency Medicine
Joshua W. Joseph, Daniel J. Henning, Connie S. Strouse, David T. Chiu, Larry A. Nathanson, Leon D. Sanchez
ANNALS OF EMERGENCY MEDICINE
(2017)