Article
Fisheries
Ping Zhong, Zhongneng Xu, Wei Chen, Kai Peng, Yuping Sun, Xiaopeng Wu, Huiming Sun, Xiaoying Chen, Peng Luo, Chaozheng Li, Huo Li, Wen Huang
Summary: 9C-Jun NH2-terminal kinase (JNK)-interacting protein 4 (JIP4) is identified and characterized in Litopenaeus vannamei, serving as an essential component in organizing and linking the MAPK pathway. Lv-JIP4 is widely expressed in various tissues, with high levels in muscle, and plays a potential role in activating and phosphorylating Lv-p38(MAPK) in response to low-temperature stress.
AQUACULTURE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Serhii A. Liakhov, Igor A. Schepetkin, Olexander S. Karpenko, Hanna Duma, Nadiia M. Haidarzhy, Liliya N. Kirpotina, Anastasia R. Kovrizhina, Andrei Khlebnikov, Irina Y. Bagryanskaya, Mark T. Quinn
Summary: In this study, 13 derivatives of a JNK inhibitor were synthesized, with 8 compounds showing submicromolar binding affinity for at least one JNK isoform, and most of them exhibiting anti-inflammatory effects. Selected compounds also directly confirmed JNK inhibition, indicating their potential as lead compounds for anti-inflammatory drug development.
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Cardiac & Cardiovascular Systems
Jing Tan, Wei Gao, Wanchao Yang, Xianzhang Zeng, Linlin Wang, Xiaoguang Cui
Summary: JNK1 exacerbates ischemia-reperfusion injury in lung transplantation, while JNK2 alleviates it. JNK1 silencing attenuates lung graft dysfunction by inhibiting inflammation and apoptosis.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Keiko Tanimura, Tadaaki Yamada, Mano Horinaka, Yuki Katayama, Sarina Fukui, Kenji Morimoto, Takayuki Nakano, Shinsaku Tokuda, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Junji Uchino, Kazue Yoneda, Seiji Yano, Toshiyuki Sakai, Koichi Takayama
Summary: Through activation of the JNK/c-Jun signaling, novel adaptive resistance has been identified as a key factor leading to failure of ALK-TKIs treatment, suggesting that combination therapy targeting JNK and ALK-TKIs may significantly delay regrowth of lung cancer cells and potentially improve patient outcomes.
Article
Biochemistry & Molecular Biology
Masashi Okada, Yurika Nakagawa-Saito, Yuta Mitobe, Asuka Sugai, Keita Togashi, Shuhei Suzuki, Chifumi Kitanaka
Summary: Glioma stem cells (GSCs) play a critical role in the malignancy of glioblastoma multiforme (GBM) by resisting therapy and promoting tumor initiation. This study reveals that phospholipase C (PLC) epsilon is highly expressed in GSCs and maintains their stemness and survival capacity through the activation of JNK pathway. PLC epsilon may serve as a promising therapeutic target for GSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hyunwook Cho, Jung-Mi Hah
Summary: JNK3 plays a crucial role in neurodegenerative diseases, and this study summarizes the research on JNK3 inhibitors, focusing on structural and docking insights.
Article
Multidisciplinary Sciences
Jake W. Willows, Gilian Gunsch, Emma Paradie, Magdalena Blaszkiewicz, Jeffrey R. Tonniges, Maria F. Pino, Steven R. Smith, Lauren M. Sparks, Kristy L. Townsend
Summary: Peripheral neuropathy, including axonal degeneration and demyelination, affects adipose tissues in obesity, diabetes, and aging. This study investigated the presence of demyelinating neuropathy in adipose tissue and found that adipose tissue contains myelinated and unmyelinated nerves populated by Schwann cells (SCs), which play a role in nerve regeneration. The study also showed that SCs in adipose tissue become dysregulated in diabetic peripheral neuropathy.
Article
Biochemical Research Methods
Xinmeng Liao, Mehmet Ozcan, Mengnan Shi, Woonghee Kim, Han Jin, Xiangyu Li, Hasan Turkez, Adnane Achour, Mathias Uhlen, Adil Mardinoglu, Cheng Zhang
Summary: Many approaches in systems biology have been applied in drug repositioning due to the increased availability of the omics data and computational biology tools. Using a multi-omics integrated network, Open MoA computes confidence scores to edges that represent connections between genes/proteins in the integrated network, and identifies potential drug targets and underlying molecular mechanisms of action. Open MoA was validated using well-established targets and successfully revealed the MoA of a repositioned drug. It represents a first-generation tool for predicting potential MoA of repurposed drugs and identifying new targets for effective treatments.
Article
Gastroenterology & Hepatology
Zhigang Fang, Hyeong-Geug Kim, Menghao Huang, Kushan Chowdhury, Ming O. Li, Suthat Liangpunsakul, X. Charlie Dong
Summary: This study demonstrates the protective role of Sesn1/2/3 in hepatic lipotoxicity-induced oxidative stress by reducing JNK phosphorylation and activity, leading to decreased lipotoxicity and oxidative stress in liver cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Wan Wang, Cong Xu, Xuan Zhou, Le Zhang, Liya Gu, Zhijing Liu, Jiage Ma, Juncai Hou, Zhanmei Jiang
Summary: This study explored the effects of probiotics and prebiotics in alleviating neurodegenerative diseases. The combination of Lactobacillus plantarum and galactooligosaccharides was found to reduce oxidative stress and increase levels of nuclear factor erythroid 2-related factor 2 in the brain. Additionally, the combination regulated the gut microbiota metabolite butyrate, which inhibited expression of p-JNK, downregulated pro-apoptotic proteins and inflammatory mediators, and upregulated synaptic protein expression. This suggests that Lactobacillus plantarum combined with galactooligosaccharides may have potential in alleviating neurodegeneration and memory impairment induced by D-galactose.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Anna A. Zhdankina, Dmitry I. Tikhonov, Sergey V. Logvinov, Mark B. Plotnikov, Andrei I. Khlebnikov, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment worldwide. JNK inhibitor IQ-1S shows potential in preventing and treating AMD, as it improves histological abnormalities associated with retinopathy in the OXYS rat model, including improved blood circulation, increased functional activity of the retinal pigment epithelium, reduced VEGF expression, and increased PEDF expression.
Article
Biochemistry & Molecular Biology
Igor A. Schepetkin, Oleksander S. Karpenko, Anastasia R. Kovrizhina, Liliya N. Kirpotina, Andrei I. Khlebnikov, Stepan I. Chekal, Alevtyna V. Radudik, Maryna O. Shybinska, Mark T. Quinn
Summary: The JNK family, including JNK1-3 proteins, regulates various physiological processes. The study aimed to find JNK inhibitors with high selectivity for JNK3. 26 new tryptanthrin-6-oxime analogs were synthesized and evaluated, and compounds 4d and 4e showed high selectivity for JNK3 and inhibited inflammatory responses. The results suggest the potential for developing anti-inflammatory drugs with selectivity for JNK3.
Article
Biochemistry & Molecular Biology
Yujie Guo, Gayan Bamunuarachchi, Kishore Vaddadi, Zhengyu Zhu, Chaitanya Gandikota, Kainat Ahmed, Samuel Pushparaj, Sunil More, Xiao Xiao, Xiaoyun Yang, Yurong Liang, Sanjay Mukherjee, Pradyumna Baviskar, Chaoqun Huang, Shitao Li, Antonius G. P. Oomens, Jordan Patrick Metcalf, Lin Liu
Summary: Influenza virus infection leads to reduced levels of Axin1, while overexpression of Axin1 and the chemical stabilizer XAV939 can inhibit virus replication and enhance the type I interferon response. Axin1 also activates JNK/c-Jun and Smad3 signaling pathways. XAV939 protects mice from influenza virus infection. These findings provide new insights into the regulation of the type I interferon response and suggest Axin1 as a potential therapeutic target against influenza virus infection.
MOLECULAR MICROBIOLOGY
(2022)
Article
Physiology
Fan Yang, Elyce Ozols, Frank Y. Ma, Khai Gene Leong, Greg H. Tesch, Xiaoyun Jiang, David J. Nikolic-Paterson
Summary: The JNK signaling pathway plays a role in acute high dose AA-induced kidney injury, but is not essential in promoting chronic kidney disease caused by ongoing DNA damage from chronic low dose AA exposure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zachary Pickell, Aaron M. Williams, Hasan B. Alam, Cindy H. Hsu
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Cardiac & Cardiovascular Systems
Katherine M. Berg, Jasmeet Soar, Lars W. Andersen, Bernd W. Boettiger, Sofia Cacciola, Clifton W. Callaway, Keith Couper, Tobias Cronberg, Sonia D'Arrigo, Charles D. Deakin, Michael W. Donnino, Ian R. Drennan, Asger Granfeldt, Cornelia W. E. Hoedemaekers, Mathias J. Holmberg, Cindy H. Hsu, Marlijn Kamps, Szymon Musiol, Kevin J. Nation, Robert W. Neumar, Tonia Nicholson, Brian J. O'Neil, Quentin Otto, Edison Ferreira de Paiva, Michael J. A. Parr, Joshua C. Reynolds, Claudio Sandroni, Barnaby R. Scholefield, Markus B. Skrifvars, Tzong-Luen Wang, Wolfgang A. Wetsch, Joyce Yeung, Peter T. Morley, Laurie J. Morrison, Michelle Welsford, Mary Fran Hazinski, Jerry P. Nolan
Article
Medicine, General & Internal
David R. Flum, Giana H. Davidson, Sarah E. Monsell, Nathan I. Shapiro, Stephen R. Odom, Sabrina E. Sanchez, F. Thurston Drake, Katherine Fischkoff, Jeffrey Johnson, Joe H. Patton, Heather Evans, Joseph Cuschieri, Amber K. Sabbatini, Brett A. Faine, Dionne A. Skeete, Mike K. Liang, Vance Sohn, Karen McGrane, Matthew E. Kutcher, Bruce Chung, Damien W. Carter, Patricia Ayoung-Chee, William Chiang, Amy Rushing, Steven Steinberg, Careen S. Foster, Shaina M. Schaetzel, Thea P. Price, Katherine A. Mandell, Lisa Ferrigno, Matthew Salzberg, Daniel A. DeUgarte, Amy H. Kaji, Gregory J. Moran, Darin Saltzman, Hasan B. Alam, Pauline K. Park, Lillian S. Kao, Callie M. Thompson, Wesley H. Self, Julianna T. Yu, Abigail Wiebusch, Robert J. Winchell, Sunday Clark, Anusha Krishnadasan, Erin Fannon, Danielle C. Lavallee, Bryan A. Comstock, Bonnie Bizzell, Patrick J. Heagerty, Larry G. Kessler, David A. Talan
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Emergency Medicine
Brendan W. Munzer, Benjamin S. Bassin, William J. Peterson, Ryan Tucker, Jessica Doan, Carrie Harvey, Nana Sefa, Cindy H. Hsu
WESTERN JOURNAL OF EMERGENCY MEDICINE
(2020)
Article
Emergency Medicine
Cindy H. Hsu, William J. Meurer, Robert Domeier, Jennifer Fowler, Sage P. Whitmore, Benjamin S. Bassin, Kyle J. Gunnerson, Jonathan W. Haft, William R. Lynch, Brahmajee K. Nallamothu, Renee A. Havey, Kelley M. Kidwell, William C. Stacey, Robert Silbergleit, Robert H. Bartlett, Robert W. Neumar
Summary: The study aimed to select refractory out-of-hospital cardiac arrest patients for expedited transport and rapid initiation of ECPR in the ED, based on real-time estimates. However, the trial did not meet feasibility outcomes, highlighting the need for additional research to improve prediction accuracy and optimize patient selection for better outcomes.
ANNALS OF EMERGENCY MEDICINE
(2021)
Article
Critical Care Medicine
Cindy H. Hsu, Mohamad H. Tiba, Andre L. Boehman, Brendan M. McCracken, Danielle C. Leander, Stephanie C. Francalancia, Zachary Pickell, Thomas H. Sanderson, Kevin R. Ward, Robert W. Neumar
Summary: The study found that chest compressions alone did not cause significant aerosol generation in a swine model, but increased aerosol generation was detected during chest compressions immediately following defibrillation. Further research is needed to clarify the clinical significance and mechanisms by which aerosol generation during chest compression is modified by defibrillation.
Article
Emergency Medicine
Cindy H. Hsu, Jennifer Fowler, James A. Cranford, Michael P. Thomas, Robert W. Neumar
Summary: The study successfully utilized social media, targeted emails, and in-person outreach for community consultation. Results showed that social media and targeted emails were more cost-effective than an in-person-only strategy for community consultation.
ACADEMIC EMERGENCY MEDICINE
(2022)
Review
Medicine, General & Internal
D. Chan, H. -J. Suk, B. Jackson, N. P. Milman, D. Stark, S. D. Beach, L. -H. Tsai
Summary: Brain oscillations play a crucial role in the function of our brains, affecting cognition and pathology. Recent research has shown that neuromodulation, specifically stimulation generating 40-HZ gamma waves, has the potential to improve cognitive function and reduce AD-specific pathology, offering a promising avenue for developing new therapeutic interventions for dementia.
JOURNAL OF INTERNAL MEDICINE
(2021)
Editorial Material
Critical Care Medicine
Sharaf Khan, Cindy H. Hsu
Article
Cardiac & Cardiovascular Systems
James M. Horowitz, Clark Owyang, Sarah M. Perman, Oscar J. L. Mitchell, Eugene Yuriditsky, Kelly N. Sawyer, Audrey L. Blewer, Jon C. Rittenberger, Anna Ciullo, Cindy H. Hsu, Pavitra Kotini-Shah, Nicholas Johnson, Ryan W. Morgan, Ari Moskowitz, Katie N. Dainty, Jessica Fleitman, Anezi I. Uzendu, Benjamin S. Abella, Felipe Teran
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Brooke Bessen, Jason Coult, Jennifer Blackwood, Cindy H. Hsu, Peter Kudenchuk, Thomas Rea, Heemun Kwok
Summary: The study found that receiving bystander cardiopulmonary resuscitation (CPR) was associated with significantly higher survival rates among out-of-hospital cardiac arrest patients with ventricular fibrillation (VF) initial rhythm. Through multivariable analysis and causal mediation analysis, it was revealed that part of the survival benefit was mediated by VF waveform measures.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Critical Care Medicine
Cindy H. Hsu, Keith Couper, Tyler Nix, Ian Drennan, Joshua Reynolds, Monica Kleinman, Katherine M. Berg
Summary: This systematic review aimed to examine the use of calcium compared to no calcium during cardiac arrest. The review included 4 studies on adult out-of-hospital cardiac arrest patients, 8 observational studies on adult cardiac arrest patients, and 3 observational studies on pediatric in-hospital cardiac arrest patients. The findings suggest that routine calcium administration during cardiac arrest does not improve outcomes.
RESUSCITATION PLUS
(2023)
Meeting Abstract
Clinical Neurology
Diane Chan, Ho-Jun Suk, Brennan Jackson, Noah Milman, Danielle Stark, Vanesa Fernandez, Erin Kitchener, Arit Banerjee, Elizabeth B. Klerman, Edward S. Boyden, Emery N. Brown, Bradford Dickerson, Li-Huei Tsai
ANNALS OF NEUROLOGY
(2021)
Review
Emergency Medicine
Vivian Lam, Cindy H. Hsu
EMERGENCY MEDICINE CLINICS OF NORTH AMERICA
(2020)
Article
Critical Care Medicine
Cindy H. Hsu, Mohamad H. Tiba, Brendan M. McCracken, Carmen Colmenero, Zachary Pickell, Danielle C. Leander, Anne M. Weitzel, Sarita Raghunayakula, Jinhui Liao, Tulasi Jinka, Brandon C. Cummings, Manjunath P. Pai, Hasan B. Alam, Kevin R. Ward, Thomas H. Sanderson, Robert W. Neumar
RESUSCITATION PLUS
(2020)