Article
Medicine, General & Internal
Christopher C. Butler, F. D. Richard Hobbs, Oghenekome A. Gbinigie, Najib M. Rahman, Gail Hayward, Duncan B. Richards, Jienchi Dorward, David M. Lowe, Joseph F. Standing, Judith Breuer, Saye Khoo, Stavros Petrou, Kerenza Hood, Jonathan S. Nguyen-Van-Tam, Mahendra G. Patel, Benjamin R. Saville, Joe Marion, Emma Ogburn, Julie Allen, Heather Rutter, Nick Francis, Nicholas P. B. Thomas, Philip Evans, Melissa Dobson, Tracie-Ann Madden, Jane Holmes, Victoria Harris, May Ee Png, Mark Lown, Oliver van Hecke, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Lazaro Mwandigha, Ushma Galal, Sam Mort, Bhautesh D. Jani, Nigel D. Hart, Haroon Ahmed, Daniel Butler, Micheal McKenna, Jem Chalk, Layla Lavallee, Elizabeth Hadley, Lucy Cureton, Magdalena Benysek, Monique Andersson, Maria Coates, Sarah Barrett, Clare Bateman, Jennifer C. Davies, Ivy Raymundo-Wood, Andrew Ustianowski, Andrew Carson-Stevens, Ly-Mee Yu, Paul Little
Summary: This study aimed to determine the safety, effectiveness, and cost-effectiveness of molnupiravir in vaccinated high-risk patients in the community. The results showed that molnupiravir did not reduce hospital admissions or deaths associated with COVID-19 compared to usual care in this population.
Article
Medical Laboratory Technology
Philipp Schuetz
Summary: PCT can help differentiate bacterial from non-bacterial infections and inflammation states, particularly in respiratory illness. PCT-guided antibiotic stewardship has been shown to reduce antibiotic exposure and associated side-effects in patients with respiratory infection and sepsis. Patient-specific decisions regarding antibiotic usage should consider clinical situation, pretest probability for bacterial infection, severity of presentation, and PCT test results.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Virology
Ana B. Gorini da Veiga, Leticia G. Martins, Irina Riediger, Alix Mazetto, Maria do Carmo Debur, Tatiana S. Gregianini
Summary: Respiratory viral infections can be severe, especially for children, elderly, and patients with comorbidities. In Brazil, the official surveillance system investigates various viruses, but some cases with no identified pathogens remain. This study analyzed viruses in patients without underlying diseases, revealing the potential for coronaviruses to cause severe disease in healthy adults.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Critical Care Medicine
Cedric Daubin, Francois Fournel, Fabrice Thiolliere, Fabrice Daviaud, Michel Ramakers, Andrea Polito, Bernard Flocard, Xavier Valette, Damien Du Cheyron, Nicolas Terzi, Muriel Fartoukh, Stephane Allouche, Jean-Jacques Parienti
Summary: Procalcitonin levels showed limited accuracy in predicting bacterial infection in severe AECOPD patients, despite higher levels in those with bacterial infection. PCT may not be reliable as a standalone marker for initiating antibiotic treatment in this population.
ANNALS OF INTENSIVE CARE
(2021)
Article
Clinical Neurology
Robin Gens, Anissa Ourtani, Aurelie De Vos, Jacques De Keyser, Sylvie De Raedt
Summary: The Neutrophil-to-Lymphocyte ratio (NLR) within 24 h after acute ischemic stroke (AIS) does not predict post-stroke UTI, but weakly predicts high risk for post-stroke pneumonia (PSP). When combined with age, gender, NIHSS score, and dysphagia, NLR significantly improves in predicting PSP.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Guomei Shi, Minghao Li, Rujuan Zhou, Xiaorong Wang, Wu Xu, Feng Yang, Shouru Xue
Summary: This study showed that higher serum procalcitonin levels were associated with an increased risk of stroke-associated pneumonia, poor clinical outcomes, and mortality in patients with acute ischemic stroke. Procalcitonin was found to be a reliable diagnostic and prognostic biomarker for stroke-associated pneumonia and poor outcomes in Chinese patients receiving intravenous rt-PA treatment.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Clinical Neurology
Alessandro Pezzini, Mario Grassi, Giorgio Silvestrelli, Martina Locatelli, Nicola Rifino, Simone Beretta, Massimo Gamba, Elisa Raimondi, Giuditta Giussani, Federico Carimati, Davide Sangalli, Manuel Corato, Simonetta Gerevini, Stefano Masciocchi, Matteo Cortinovis, Sara La Gioia, Francesca Barbieri, Valentina Mazzoleni, Debora Pezzini, Sonia Bonacina, Andrea Pilotto, Alberto Benussi, Mauro Magoni, Enrico Premi, Alessandro Cesare Prelle, Elio Clemente Agostoni, Fernando Palluzzi, Valeria De Giuli, Anna Magherini, Daria Valeria Roccatagliata, Luisa Vinciguerra, Valentina Puglisi, Laura Fusi, Susanna Diamanti, Francesco Santangelo, Rubjona Xhani, Federico Pozzi, Giampiero Grampa, Maurizio Versino, Andrea Salmaggi, Simona Marcheselli, Anna Cavallini, Alessia Giossi, Bruno Censori, Carlo Ferrarese, Alfonso Ciccone, Maria Sessa, Alessandro Padovani
Summary: The study aimed to characterize acute ischemic stroke patients with SARS-CoV-2 infection and evaluate the prediction performance of clinical and laboratory parameters for in-hospital outcomes. Patients with COVID-19 had distinct risk factors, increased stroke severity, and higher in-hospital mortality rate compared to non-COVID-19 patients. A simple model based on clinical and routine laboratory parameters showed high accuracy in identifying ischemic stroke patients with SARS-CoV-2 infection with poor prognosis.
JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Mark Legacy, Dugald Seely, Ellen Conte, Athanasios Psihogios, Tim Ramsay, Dean A. Fergusson, Salmaan Kanji, John-Graydon Simmons, Kumanan Wilson
Summary: COVID-19 has caused worldwide morbidity and mortality, and effective treatments are still needed, especially for people in the community. This study aims to explore if nutrients such as vitamin C, vitamin D, vitamin, and zinc are effective treatment options for outpatients diagnosed with COVID-19.
Article
Infectious Diseases
Ildiko Gagyor, Alastair D. Hay
Summary: Clinical and antimicrobial stewardship outcomes are crucial in pragmatic primary care trials, but currently lack agreed standards for design. Recommendations for future research designs include specifying interpretation of conflicting results, ensuring prescriptions from external sources are included in AMS effectiveness measures, prioritizing antimicrobial resistance in outcomes, considering antibiotics used in interventions as part of the outcome, and involving patients in establishing principles for prioritizing AMS or clinical outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Medicine, General & Internal
Rajeel Imran, Ghada A. Mohamed, Fadi Nahab
Summary: The field of acute stroke treatment has seen significant progress, particularly in understanding the pathophysiology of acute ischemic injury and neuroimaging thrombolysis therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Hailun Yin, Songming Mo
Summary: Objective: This study aimed to explore the diagnostic value of combined detection of serum amyloid A (SAA), C-reactive protein (CRP) and procalcitonin (PCT) in children with bacterial or non-bacterial respiratory tract infection. Methods: 200 children with respiratory tract infection diagnosed in our hospital were included in the study. According to the results of the etiological examination, they were divided into bacterial infection group and non-bacterial infection group. At the same time, 100 healthy children admitted to the hospital for physical examination during the same period were selected as the healthy subjects control group. Changes in serum SAA, PCT, and CRP in three groups were compared. Comparison of a positive rate of the single index and combined detection were performed. Conclusion: The combined detection based on SAA, CRP, and PCT can effectively identify and diagnose respiratory tract infection in children, providing a certain reference for the promotion of the diagnostic scheme. Key messages: Serum SAA, PCT, and CRP were highly expressed in children with respiratory tract infection, and the expression level was the highest in children with bacterial pneumonia. The combined detection of serum SAA, CRP, and PCT indicators has higher diagnostic efficiency and can effectively make a differential diagnosis of respiratory tract infection in children.
ANNALS OF MEDICINE
(2022)
Article
Medicine, General & Internal
Tian Ming Tu, Christopher Ying Hao Seet, Jasmine Shimin Koh, Carol Huilian Tham, Hui Jin Chiew, Jasmyn Angon De Leon, Christopher Yuan Kit Chua, Andrew Che-Fai Hui, Shaun Shi Yan Tan, Shawn Sushilan Vasoo, Benjamin Yong-Qiang Tan, N. Thirugnanam Umapathi, Paul Anantharajah Tambyah, Leonard Leong Litt Yeo
Summary: This case series highlights the increased risk of acute ischemic stroke in male patients aged 50 years or younger during the convalescent phase of asymptomatic COVID-19 infection. The study suggests the importance of monitoring stroke risk and conducting serological testing in these patients to prevent potential complications.
Review
Pharmacology & Pharmacy
T. Marc Eastin, Justin A. Dye, Promod Pillai, Miguel A. Lopez-Gonzalez, Lei Huang, John H. Zhang, Warren W. Boling
Summary: Stroke is a significant cause of death and disability worldwide, with post-stroke cognitive impairment causing a decline in the quality of life. Currently, only pharmacological and mechanical thrombolysis interventions are advised for revascularization. However, these treatments are limited to the acute phase of stroke. Advances in neuroimaging and interventional devices have expanded the potential revascularization window, with delayed revascularization showing positive outcomes beyond the recommended therapeutic window. This review discusses the understanding of ischemic stroke, the latest revascularization doctrine, and evidence from clinical studies on effective delayed revascularization.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Hui-ling Wang, Ying-lei Li, Xiao-fang Li, Zhi-zun Wang
Summary: Dynamic monitoring of serum procalcitonin (PCT) in patients with acute stroke can accurately assess the severity of bacterial infection and guide the rational application of antibiotics.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Neurosciences
Rebecca Sadler, Julia V. Cramer, Steffanie Heindl, Sarantos Kostidis, Dene Betz, Kielen R. Zuurbier, Bernd H. Northoff, Marieke Heijink, Mark P. Goldberg, Erik J. Plautz, Stefan Roth, Rainer Malik, Martin Dichgans, Lesca M. Holdt, Corinne Benakis, Martin Giera, Ann M. Stowe, Arthur Liesz
JOURNAL OF NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Csaba Cserep, Balazs Posfai, Nikolett Lenart, Rebeka Fekete, Zsofia I. Laszlo, Zsolt Lele, Barbara Orsolits, Gabor Molnar, Steffanie Heindl, Anett D. Schwarcz, Katinka Ujvari, Zsuzsanna Kornyei, Krisztina Toth, Eszter Szabadits, Beata Sperlagh, Maria Baranyi, Laszlo Csiba, Tibor Hortobagyi, Zsofia Magloczky, Bernadett Martinecz, Gabor Szabo, Ferenc Erdelyi, Robert Szipocs, Michael M. Tamkun, Benno Gesierich, Marco Duering, Istvan Katona, Arthur Liesz, Gabor Tamas, Adam Denes
Review
Neurosciences
Corinne Benakis, Camille Martin-Gallausiaux, Jean-Pierre Trezzi, Philip Melton, Arthur Liesz, Paul Wilmes
CURRENT OPINION IN NEUROBIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Yaw Asare, Thomas A. Campbell-James, Yury Bokov, Lydia Luya Yu, Matthias Prestel, Omar El Bounkari, Stefan Roth, Remco T. A. Megens, Tobias Straub, Kyra Thomas, Guangyao Yan, Melanie Schneider, Natalie Ziesch, Steffen Tiedt, Carlos Silvestre-Roig, Quinte Braster, Yishu Huang, Manuela Schneider, Rainer Malik, Christof Haffner, Arthur Liesz, Oliver Soehnlein, Juergen Bernhagen, Martin Dichgans
CIRCULATION RESEARCH
(2020)
Article
Biology
Laura Sebastian Monasor, Stephan A. Mueller, Alessio Vittorio Colombo, Gaye Tanrioever, Jasmin Koenig, Stefan Roth, Arthur Liesz, Anna Berghofer, Anke Piechotta, Matthias Prestel, Takashi Saito, Takaomi C. Saido, Jochen Herms, Michael Willem, Christian Haass, Stefan F. Lichtenthaler, Sabina Tahirovic
Article
Immunology
Stefan Roth, Jun Yang, Julia Cramer, Rainer Malik, Arthur Liesz
Summary: This study demonstrates that neuropsychiatric symptoms can be differentiated and specifically modulated independent of treating the primary lesion in stroke. Neutralizing systemic cytokines specifically ameliorated neuropsychiatric symptoms, indicating the importance of analyzing these symptoms for anti-inflammatory therapies in stroke.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Stefan Roth, Jiayu Cao, Vikramjeet Singh, Steffen Tiedt, Gabriel Hundeshagen, Ting Li, Julia D. Boehme, Dhruv Chauhan, Jie Zhu, Alessio Ricci, Oliver Gorka, Yaw Asare, Jun Yang, Mary S. Lopez, Markus Rehberg, Dunja Bruder, Shengxiang Zhang, Olaf Gross, Martin Dichgans, Veit Hornung, Arthur Liesz
Summary: T cell death after acute injury is mainly driven by monocyte-T cell interaction, leading to extrinsic T cell apoptosis through IL-1 beta secretion after sensing extracellular DNA. Pharmacological inhibition of this pathway can improve T cell survival and reduce infections.
Article
Clinical Neurology
Andreas Hug, Tamara Spingler, Cornelia Hensel, Stefan Fichtner, Tiziana Daniel, Laura Heutehaus, Michel Wensing, Ruediger Rupp, Norbert Weidner
Summary: The NeuroMoves study aims to identify factors associated with changes in mobility after acute inpatient rehabilitation, focusing on participation. It is a national multicenter observational cohort study in Germany, recruiting 500 patients with mobility-restricting paralysis syndromes for an 8-month follow-up in the ambulatory setting. Daily distance covered and participation-oriented rehab interventions will be analyzed to inform healthcare decision-making regarding mobility-promoting interventions for these patients.
Article
Biology
Alessio Vittorio Colombo, Rebecca Katie Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastian Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Aguero, Andrew J. MacPherson, Edith Winkler, Jochen Herms, Corinne Benakis, Martin Dichgans, Harald Steiner, Martin Giera, Christian Haass, Sabina Tahirovic, Arthur Liesz
Summary: Microbiota-derived SCFA play a critical role in promoting A beta deposition in Alzheimer's disease by modulating the microglial phenotype along the gut-brain axis.
Article
Multidisciplinary Sciences
Gemma Llovera, Kelsey Pinkham, Arthur Liesz
Summary: Stroke is a major cause of death and acquired adult disability in developed countries. Limited therapeutic options for stroke patients highlight the need for further research, particularly on pathophysiological pathways such as post-stroke inflammation, angiogenesis, neuronal plasticity, and regeneration. Experimental stroke models are essential for analyzing and evaluating new drug targets, but detailed standardized models are urgently needed.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Immunology
Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger, Nikolett Lenart, Nicolai Franzmeier, Tibor Hortobagyi, Peter T. Nelson, Ann M. Stowe, Adam Denes, Dieter Edbauer, Arthur Liesz
Summary: Stroke is a major cause of death and permanent disability globally, with current therapies limited to vascular recanalization in the acute phase. Neuroinflammation has emerged as a key focus in translational research, playing a crucial role in post-stroke recovery and neurodegeneration.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Gemma Llovera, Alba Simats, Arthur Liesz
Summary: Stroke ranks as the third leading cause of death in developed countries and is the leading cause of acquired adult disability. Current therapeutic options are limited, prompting extensive research into novel strategies to extend the treatment window. Recent investigations have focused on key pathophysiological pathways post-stroke and the reproducibility of experimental results, with a standardized mouse model proposed to address these issues.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Rehabilitation
Tiziana Daniel, Tamara Spingler, Andreas Hug, Norbert Weidner, Michel Wensing, Charlotte Ullrich
Summary: This study aimed to explore the current practice of German outpatient neurorehabilitation services and identify associated factors. Semi-structured interviews were conducted with professionals and patients in outpatient neurorehabilitation services. The study found differences in satisfaction levels and perceived deficits in participation-oriented, evidence-based, and coordinated care. Factors associated with this practice included availability of specialized therapists, outpatient service catalogue, cost coverage, rehabilitation goal setting, and physician as care coordinator.
DISABILITY AND REHABILITATION
(2023)
Article
Neuroimaging
Andreas Hug, Adriano Bernini, Haili Wang, Antoine Lutti, Johann M. E. Jende, Markus Boettinger, Marc-Andre Weber, Norbert Weidner, Simone Lang
Summary: The study used MRI to analyze chronic complete SCI patients and healthy individuals, revealing a volume reduction in the dorsal aspect of the brain in SCI patients, which correlated with spinal cord atrophy, suggesting Wallerian degeneration as a main contributor to observed spinal cord atrophy. However, structural changes in other brain regions were not confirmed.
NEUROIMAGE-CLINICAL
(2021)
Correction
Endocrinology & Metabolism
C. Cserep, B. Posfai, B. Orsolits, G. Molnar, S. Heindl, N. Lenart, R. Fekete, Z. Laszlo, Z. Lele, A. D. Schwarcz, K. Ujvari, L. Csiba, T. Hortobagyi, Z. Magloczki, B. Martinecz, G. Szabo, F. Erdelyi, R. Szipocs, I. Katona, A. Liesz, G. Tamas, A. Denes, T. S. Ko, C. D. Mavroudis, R. W. Morgan, A. M. Marquez, W. Guo, T. W. Boorady, M. Devarajan, Y. Lin, W. P. Landis, A. J. Lautz, V. M. Nadkarni, R. A. Berg, R. M. Sutton, A. G. Yodh, D. J. Licht, T. J. Kilbaugh
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)