Group III Metabotropic Glutamate Receptors: Pharmacology, Physiology and Therapeutic Potential

Blocking Metabotropic Glutamate Receptor Subtype 7 (mGlu7) via the Venus Flytrap Domain (VFTD) Inhibits Amygdala Plasticity, Stress, and Anxiety-related Behavior

(2014) Christine E. Gee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Actions of Novel Allosteric Modulators Reveal Functional Heteromers of Metabotropic Glutamate Receptors in the CNS

(2014) S. Yin et al.   JOURNAL OF NEUROSCIENCE

Modulation of Short-Term Plasticity in the Corticothalamic Circuit by Group III Metabotropic Glutamate Receptors

(2014) C. L. Kyuyoung et al.   JOURNAL OF NEUROSCIENCE

Group III mGlu Receptor Agonist, ACPT-I, Exerts Potential Neuroprotective Effects In Vitro and In Vivo

(2014) Helena Domin et al.   NEUROTOXICITY RESEARCH

Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice

(2013) E. Iscru et al.   GENES BRAIN AND BEHAVIOR

Effects of a Metabotropic Glutamate Receptor Subtype 7 Negative Allosteric Modulator in the Periaqueductal Grey on Pain Responses and Rostral Ventromedial Medulla Cell Activity in Rat

(2013) Enza Palazzo et al.   Molecular Pain

Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors

(2013) David Lodge et al.   NEUROPHARMACOLOGY

Differential roles of mGlu7 and mGlu8 in amygdala-dependent behavior and physiology

(2013) Markus Fendt et al.   NEUROPHARMACOLOGY

Related functions of mGlu4 and mGlu8

(2013) Matthew J. Davis et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Group III metabotropic glutamate receptors and drug addiction

(2013) Limin Mao et al.   Frontiers of Medicine

Orthosteric versus allosteric GPCR activation: The great challenge of group-III mGluRs

(2012) Peter J. Flor et al.   BIOCHEMICAL PHARMACOLOGY

Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson's disease

(2012) Matthew J Betts et al.   BRITISH JOURNAL OF PHARMACOLOGY

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

(2012) Cyril Goudet et al.   FASEB JOURNAL

Activation of group III metabotropic glutamate receptors by endogenous glutamate protects against glutamate-mediated excitotoxicity in the hippocampus in vivo

(2012) Gabriela Vera et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Antiparkinsonian action of a selective group III mGlu receptor agonist is associated with reversal of subthalamonigral overactivity

(2012) S. Lopez et al.   NEUROBIOLOGY OF DISEASE

Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus

(2012) Marion S. Mercier et al.   NEUROPHARMACOLOGY

Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease

(2012) M. Amalric et al.   NEUROPHARMACOLOGY

Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning

(2012) Sreedeep Mukherjee et al.   NEUROPHARMACOLOGY

Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia

(2012) Khaled-Ezaheir Bennouar et al.   NEUROPHARMACOLOGY

Viral-Mediated Knockdown of mGluR7 in the Nucleus Accumbens Mediates Excessive Alcohol Drinking and Increased Ethanol-Elicited Conditioned Place Preference in Rats

(2012) Amine Bahi   NEUROPSYCHOPHARMACOLOGY

G-protein-mediated inhibition of the Trp channel TRPM1 requires the G   dimer

(2012) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological modulation of mGluR7 with AMN082 and MMPIP exerts specific influences on alcohol consumption and preference in rats

(2011) Amine Bahi et al.   ADDICTION BIOLOGY

Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges

(2011) Robert M. Duvoisin et al.   BEHAVIOURAL BRAIN RESEARCH

Depression of Release by mGluR8 Alters Ca2+ Dependence of Release Machinery

(2011) Evelyn Erdmann et al.   CEREBRAL CORTEX

Metabotropic Glutamate Receptor Subtype 8 in the Amygdala Modulates Thermal Threshold, Neurotransmitter Release, and Rostral Ventromedial Medulla Cell Activity in Inflammatory Pain

(2011) E. Palazzo et al.   JOURNAL OF NEUROSCIENCE

The Metabotropic Glutamate Receptor 7 Allosteric Modulator AMN082: A Monoaminergic Agent in Disguise?

(2011) S. J. Sukoff Rizzo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Differential effects of mGluR7 and mGluR8 activation on pain-related synaptic activity in the amygdala

(2011) Wenjie Ren et al.   NEUROPHARMACOLOGY

mGluR8 Modulates Excitatory Transmission in the Bed Nucleus of the Stria Terminalis in a Stress-Dependent Manner

(2011) Heather B Gosnell et al.   NEUROPSYCHOPHARMACOLOGY

Exciting Times beyond the Brain: Metabotropic Glutamate Receptors in Peripheral and Non-Neural Tissues

(2011) M. Julio-Pieper et al.   PHARMACOLOGICAL REVIEWS

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

(2010) Colleen M. Niswender et al.   Annual Review of Pharmacology and Toxicology

Acute pharmacological modulation of mGluR8 reduces measures of anxiety

(2010) Robert M. Duvoisin et al.   BEHAVIOURAL BRAIN RESEARCH

TRPM1: The endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells

(2010) Catherine W. Morgans et al.   BIOESSAYS

A novel role for the metabotropic glutamate receptor-7: modulation of faecal water content and colonic electrolyte transport in the mouse

(2010) M Julio-Pieper et al.   BRITISH JOURNAL OF PHARMACOLOGY

Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease

(2010) PJ Austin et al.   BRITISH JOURNAL OF PHARMACOLOGY

A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors

(2010) Etienne Doumazane et al.   FASEB JOURNAL

High affinity group III mGluRs regulate mossy fiber input to CA3 interneurons

(2010) Kathleen E. Cosgrove et al.   HIPPOCAMPUS

The Metabotropic Glutamate Receptor mGlu7 Activates Phospholipase C, Translocates Munc-13-1 Protein, and Potentiates Glutamate Release at Cerebrocortical Nerve Terminals

(2010) Ricardo Martín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Virtual Screening Hit Reveals New Possibilities for Developing Group III Metabotropic Glutamate Receptor Agonists

(2010) Chelliah Selvam et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Frontiers in Gut Nutrient Sensor Research: Luminal Glutamate–Sensing Cells in Rat Gastric Mucosa

(2010) Eiji Nakamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation

(2010) Francesca Fallarino et al.   NATURE MEDICINE

Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems

(2010) Joanna M. Wierońska et al.   NEUROPHARMACOLOGY

Metabotropic glutamate receptors: From the workbench to the bedside

(2010) F. Nicoletti et al.   NEUROPHARMACOLOGY

Luminal l-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats

(2009) Yasutada Akiba et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Selective activation of metabotropic G-protein-coupled glutamate 7 receptor elicits anxiolytic-like effects in mice by modulating GABAergic neurotransmission

(2009) Katarzyna Stachowicz et al.   BEHAVIOURAL PHARMACOLOGY

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism

(2009) Corinne Beurrier et al.   FASEB JOURNAL

mGluR4-positive allosteric modulation as potential treatment for Parkinson’s disease

(2009) Corey R Hopkins et al.   Future Medicinal Chemistry

The effect of mGlu8deficiency in animal models of psychiatric diseases

(2009) M. Fendt et al.   GENES BRAIN AND BEHAVIOR

Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson’s disease treatment

(2009) Dario Cuomo et al.   JOURNAL OF NEUROCHEMISTRY

Altered G-Protein Coupling in an mGluR6 Point Mutant Associated with Congenital Stationary Night Blindness

(2009) D. Beqollari et al.   MOLECULAR PHARMACOLOGY

The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems

(2009) K. Stachowicz et al.   NEUROPHARMACOLOGY

Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism

(2009) Xia Li et al.   NEUROPSYCHOPHARMACOLOGY

TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade

(2009) C. Koike et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabotropic receptors for glutamate and GABA in pain

(2008) Cyril Goudet et al.   BRAIN RESEARCH REVIEWS

Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

(2008) C. Bellone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Therapeutic Potential of Group III Metabotropic Glutamate Receptors

(2008) Hilde Lavreysen et al.   CURRENT MEDICINAL CHEMISTRY

GRM7 variants confer susceptibility to age-related hearing impairment

(2008) Rick A. Friedman et al.   HUMAN MOLECULAR GENETICS

Depression of excitatory transmission at PF-PC synapse by group III metabotropic glutamate receptors is provided exclusively by mGluR4 in the rodent cerebellar cortex

(2008) Karine Abitbol et al.   JOURNAL OF NEUROCHEMISTRY

A Novel Assay of Gi/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors

(2008) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

(2008) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

Identification of a serotonin/glutamate receptor complex implicated in psychosis

(2008) Javier González-Maeso et al.   NATURE

Presynaptic glutamate receptors: physiological functions and mechanisms of action

(2008) Paulo S. Pinheiro et al.   NATURE REVIEWS NEUROSCIENCE

AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala

(2008) Annarosa Ugolini et al.   NEUROPHARMACOLOGY

Metabotropic glutamate receptors mGluR4 and mGluR8 regulate transmission in the lateral olfactory tract–piriform cortex synapse

(2008) Paulianda J. Jones et al.   NEUROPHARMACOLOGY

Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors

(2008) Enza Palazzo et al.   NEUROPHARMACOLOGY

Upregulation of metabotropic glutamate receptor 8 mRNA expression in the rat forebrain after repeated amphetamine administration

(2008) Nikhil K. Parelkar et al.   NEUROSCIENCE LETTERS

Acute administration of cocaine reduces metabotropic glutamate receptor 8 protein expression in the rat striatum in vivo

(2008) Guo-Chi Zhang et al.   NEUROSCIENCE LETTERS

Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo

(2007) Nicholas MacInnes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

mGlu4 potentiation of K2P2.1 is dependant on C-terminal dephosphorylation

(2007) Stuart M. Cain et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats

(2007) Xia Li et al.   NEUROPHARMACOLOGY

Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid

(2007) Jaroslava Folbergrová et al.   NEUROPHARMACOLOGY

Group III mGluR regulation of synaptic transmission at the SC-CA1 synapse is developmentally regulated

(2007) Jennifer E. Ayala et al.   NEUROPHARMACOLOGY

Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures

(2007) R.T. Ngomba et al.   NEUROPHARMACOLOGY

Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain

(2007) Cyril Goudet et al.   PAIN