A Matter of Balance: Role of Neurexin and Neuroligin at the Synapse

Genome-Wide Association Study of Multiplex Schizophrenia Pedigrees

(2012) Douglas F. Levinson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Homodimerization and isoform-specific heterodimerization of neuroligins

(2012) Alexandros Poulopoulos et al.   BIOCHEMICAL JOURNAL

Phenotypic spectrum and genotype–phenotype correlations of NRXN1 exon deletions

(2012) Christian P Schaaf et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Neuroligin-1 induces neurite outgrowth through interaction with neurexin-1β and activation of fibroblast growth factor receptor-1

(2012) Michelle D. Gjørlund et al.   FASEB JOURNAL

GluR 2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation

(2012) S.-J. Lee et al.   JOURNAL OF NEUROSCIENCE

Mutation analysis of the NRXN1 gene in a Chinese autism cohort

(2012) Yalan Liu et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number

(2012) Hyung-Bae Kwon et al.   NATURE NEUROSCIENCE

Mutations affecting synaptic levels of neurexin-1β in autism and mental retardation

(2012) Rafael J. Camacho-Garcia et al.   NEUROBIOLOGY OF DISEASE

Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1

(2012) Rui T. Peixoto et al.   NEURON

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

A Subtype-Specific Function for the Extracellular Domain of Neuroligin 1 in Hippocampal LTP

(2012) Seth L. Shipman et al.   NEURON

Dimerization of postsynaptic neuroligin drives synaptic assembly via transsynaptic clustering of neurexin

(2012) S. L. Shipman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through extracellular coupling

(2012) E. C. Budreck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism

(2012) S. J. Baudouin et al.   SCIENCE

Neurexin and Neuroligin Mediate Retrograde Synaptic Inhibition in C. elegans

(2012) Z. Hu et al.   SCIENCE

Visualization of Subunit-Specific Delivery of Glutamate Receptors to Postsynaptic Membrane during Hippocampal Long-Term Potentiation

(2012) Hiromitsu Tanaka et al.   Cell Reports

Higher-Order Architecture of Cell Adhesion Mediated by Polymorphic Synaptic Adhesion Molecules Neurexin and Neuroligin

(2012) Hiroki Tanaka et al.   Cell Reports

Identification of rare X-linked neuroligin variants by massively parallel sequencing in males with autism spectrum disorder

(2012) Karyn Steinberg et al.   Molecular Autism

Rare Deletions at the Neurexin 3 Locus in Autism Spectrum Disorder

(2011) Andrea K. Vaags et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A case-control association study of NRXN1 polymorphisms with schizophrenia in Chinese Han population

(2011) Weihua Yue et al.   Behavioral and Brain Functions

Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons

(2011) Jae-Yeol Joo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SAM68 Regulates Neuronal Activity-Dependent Alternative Splicing of Neurexin-1

(2011) Takatoshi Iijima et al.   CELL

An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus

(2011) Mark R Etherton et al.   EMBO JOURNAL

Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions

(2011) Keiko Matsuda et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia

(2011) Julie Gauthier et al.   HUMAN GENETICS

Identification and functional characterization of rare mutations of the neuroligin-2 gene ( NLGN2 ) associated with schizophrenia

(2011) Chicheng Sun et al.   HUMAN MOLECULAR GENETICS

Gephyrin Regulates GABAergic and Glutamatergic Synaptic Transmission in Hippocampal Cell Cultures

(2011) Zeynep Kasap Varley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons

(2011) Jaewon Ko et al.   JOURNAL OF CELL BIOLOGY

Neurexin-Neuroligin Adhesions Capture Surface-Diffusing AMPA Receptors through PSD-95 Scaffolds

(2011) M. Mondin et al.   JOURNAL OF NEUROSCIENCE

Functional dependence of neuroligin on a new non-PDZ intracellular domain

(2011) Seth L Shipman et al.   NATURE NEUROSCIENCE

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

Structural Basis for Variant-Specific Neuroligin-Binding by α-Neurexin

(2011) Hiroki Tanaka et al.   PLoS One

Presenilin/γ-Secretase Regulates Neurexin Processing at Synapses

(2011) Carlos A. Saura et al.   PLoS One

The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo

(2011) G. J. Soler-Llavina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function

(2011) M. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of the α-Neurexin-1 Extracellular Region Reveals a Hinge Point for Mediating Synaptic Adhesion and Function

(2011) Meghan T. Miller et al.   STRUCTURE

The Structure of Neurexin 1α Reveals Features Promoting a Role as Synaptic Organizer

(2011) Fang Chen et al.   STRUCTURE

Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder

(2011) Yuka Yasuda et al.   Molecular Autism

Erratum: Genetic regulation of Nrnx1 expression: an integrative cross-species analysis of schizophrenia candidate genes

(2011) K Mozhui et al.   Translational Psychiatry

Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders

(2010) Michael S.L. Ching et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

RETRACTED: Imaging Activity-Dependent Regulation of Neurexin-Neuroligin Interactions Using trans-Synaptic Enzymatic Biotinylation

(2010) Amar Thyagarajan et al.   CELL

Trans-Synaptic Interaction of GluRδ2 and Neurexin through Cbln1 Mediates Synapse Formation in the Cerebellum

(2010) Takeshi Uemura et al.   CELL

Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder

(2010) John LR Rubenstein   CURRENT OPINION IN NEUROLOGY

Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus

(2010) Regina Dahlhaus et al.   HIPPOCAMPUS

N-cadherin and Neuroligins Cooperate to Regulate Synapse Formation in Hippocampal Cultures

(2010) Mytyl Aiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases

(2010) Nathalie Bot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRTMs and Neuroligins Bind Neurexins with a Differential Code to Cooperate in Glutamate Synapse Development

(2010) T. J. Siddiqui et al.   JOURNAL OF NEUROSCIENCE

Neurexin-Neuroligin Cell Adhesion Complexes Contribute to Synaptotropic Dendritogenesis via Growth Stabilization Mechanisms In Vivo

(2010) Simon Xuan Chen et al.   NEURON

Splice Form Dependence of β-Neurexin/Neuroligin Binding Interactions

(2010) Jesko Koehnke et al.   NEURON

Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions

(2010) Daniel Banovic et al.   NEURON

Neurexins Physically and Functionally Interact with GABAA Receptors

(2010) Chen Zhang et al.   NEURON

Differential dynamics and activity-dependent regulation of  - and  -neurexins at developing GABAergic synapses

(2010) Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Input-specific synaptic plasticity in the amygdala is regulated by neuroligin-1 via postsynaptic NMDA receptors

(2010) S.-Y. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation

(2010) A. Stan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism and Nonsyndromic Mental Retardation Associated with a De Novo Mutation in the NLGN4X Gene Promoter Causing an Increased Expression Level

(2009) Hussein Daoud et al.   BIOLOGICAL PSYCHIATRY

Copy Number Variation in Schizophrenia in the Japanese Population

(2009) Masashi Ikeda et al.   BIOLOGICAL PSYCHIATRY

Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation

(2009) Jaewon Ko et al.   EMBO JOURNAL

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn

(2009) So-Hee Lim et al.   EMBO JOURNAL

A Substitution Involving the NLGN4 Gene Associated with Autistic Behavior in the Greek Population

(2009) Andreas Pampanos et al.   Genetic Testing and Molecular Biomarkers

A Neuroligin-4 Missense Mutation Associated with Autism Impairs Neuroligin-4 Folding and Endoplasmic Reticulum Export

(2009) C. Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuroligin-2 accelerates GABAergic synapse maturation in cerebellar granule cells

(2009) Zhanyan Fu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroligin1: a cell adhesion molecule that recruits PSD-95 and NMDA receptors by distinct mechanisms during synaptogenesis

(2009) Stephanie L Barrow et al.   Neural Development

An Unbiased Expression Screen for Synaptogenic Proteins Identifies the LRRTM Protein Family as Synaptic Organizers

(2009) Michael W. Linhoff et al.   NEURON

Neuroligin 2 Drives Postsynaptic Assembly at Perisomatic Inhibitory Synapses through Gephyrin and Collybistin

(2009) Alexandros Poulopoulos et al.   NEURON

LRRTM2 Interacts with Neurexin1 and Regulates Excitatory Synapse Formation

(2009) Joris de Wit et al.   NEURON

LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation

(2009) Jaewon Ko et al.   NEURON

Altered synchrony and connectivity in neuronal networks expressing an autism-related mutation of neuroligin 3

(2009) R.C. Gutierrez et al.   NEUROSCIENCE

Postsynaptic scaffolding molecules modulate the localization of neuroligins

(2009) J.N. Levinson et al.   NEUROSCIENCE

Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: A preliminary study

(2009) Gabriela Novak et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

CASK Functions as a Mg2+-Independent Neurexin Kinase

(2008) Konark Mukherjee et al.   CELL

Expression of Neurexin, Neuroligin, and Their Cytoplasmic Binding Partners in the Pancreatic β-Cells and the Involvement of Neuroligin in Insulin Secretion

(2008) Arthur T. Suckow et al.   ENDOCRINOLOGY

Familial deletion within NLGN4 associated with autism and Tourette syndrome

(2008) Amy Lawson-Yuen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Disruption of the neurexin 1 gene is associated with schizophrenia

(2008) Dan Rujescu et al.   HUMAN MOLECULAR GENETICS

Frontal cortex subdivision patterning is coordinately regulated byFgf8,Fgf17, andEmx2

(2008) Jeremy A. Cholfin et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Synaptic Imbalance, Stereotypies, and Impaired Social Interactions in Mice with Altered Neuroligin 2 Expression

(2008) R. M. Hines et al.   JOURNAL OF NEUROSCIENCE

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Advances in autism genetics: on the threshold of a new neurobiology

(2008) Brett S. Abrahams et al.   NATURE REVIEWS GENETICS

Neurexin 1α structural variants associated with autism

(2008) Jin Yan et al.   NEUROSCIENCE LETTERS

Unusually rapid evolution of Neuroligin-4 in mice

(2008) M. F. Bolliger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals

(2008) Juhyun Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts

(2008) M. Heine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Neurexin 1β Tertiary Structure and Ligand Binding through Alternative Splicing

(2008) Kaiser C. Shen et al.   STRUCTURE

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES

Plasticity in the adult brain: lessons from the visual system

(2008) Maria Spolidoro et al.   EXPERIMENTAL BRAIN RESEARCH