期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 110, 期 2, 页码 725-730出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1214718110
关键词
synapse; neurotranmitter receptor; neurexin
资金
- National Research Service Award [MH083473]
- National Institutes of Health [NS045014]
- Biozentrum of the University of Basel
- European Autism Interventions: A Multicentre Study for Developing New Medications (EU-AIMS)
- Innovative Medicines Initiative Joint Undertaking
- Swiss National Science Foundation
- National Research Foundation of Korea [2009K001247, 2010-0029402, 2010-0007293]
- Ministry of Education, Science and Technology, Republic of Korea
- National Research Foundation of Korea [2010-0029402, 2010-0007293] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Grants-in-Aid for Scientific Research [24650183, 23390156, 23650180] Funding Source: KAKEN
Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit development and synaptic plasticity, the molecular mechanisms underlying the dynamics of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1 (NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity, but it is unclear whether NL1 controls synaptic accumulation or function of the receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1 subunit. Our work uncovers NL1 isoform-specific cis-interactions with ionotropic glutamate receptors as a key mechanism for controlling synaptic properties.
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