Article
Medicine, General & Internal
Fereshteh Javanmard, Morteza Koruji, Fatemeh Moradi, Mohammad Reza Kochakian, Seyed A. Moosavi, Hamid Reza Asgari
Summary: The study suggests that co-culturing with laminin and Schwann cells may be the most effective strategy for promoting neural differentiation in human umbilical cord mesenchymal stem cells (hUMSCs).
ARCHIVES OF IRANIAN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Arsinoe C. Thomaidou, Maria Goulielmaki, Antonis Tsintarakis, Panagiotis Zoumpourlis, Marialena Toya, Ioannis Christodoulou, Vassilis Zoumpourlis
Summary: The human body contains multipotent cells known as mesenchymal stem cells (MSCs) that have the potential to self-renew and differentiate into various cell types. MSCs are attractive candidates for therapeutic applications due to their ability to migrate to inflammation sites and their secretion of factors involved in tissue regeneration and immune regulation. MSCs derived from fetal, perinatal, or neonatal tissues possess additional advantages, such as increased proliferation potential, responsiveness to environmental cues, and low immunogenicity. MicroRNAs (miRNAs) play a crucial role in regulating MSC differentiation, and the identification of relevant miRNAs and miRNA signatures can enhance the understanding of MSC biology and aid in the development of regenerative and therapeutic protocols. This review focuses on umbilical cord-derived MSCs (UCMSCs) and discusses their miRNA-guided differentiation and regulatory mechanisms, highlighting their potential applications in treating various diseases and injuries while minimizing adverse events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Chemistry, Multidisciplinary
Yong Xie, Yi Sun, Yudong Liu, Jinyun Zhao, Quanbo Liu, Jiaqi Xu, Yiming Qin, Rundong He, Feifei Yuan, Tianding Wu, Chunyue Duan, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
Summary: This study explores a specific targeted treatment approach for spinal cord injury by identifying stable subpopulations of exosomes that can improve blood-spinal cord barrier integrity and promote neural function recovery.
Article
Biochemistry & Molecular Biology
Eun Ah Ye, Ho Seok Chung, Yoonkyung Park, Jeong Hye Sunwoo, Whanseo Lee, Jin Kim, Hungwon Tchah, Hun Lee, Jae Yong Kim
Summary: This study demonstrated the differentiation of human umbilical cord-derived mesenchymal stem cells (UC-MSCs) into corneal endothelial cells (CECs). The efficacy of MSC-induced CEC injection was investigated in a rabbit model of corneal endothelial dysfunction (CED). The results showed that MSC-induced CEC injection improved corneal opacity and neovascularization in the rabbit model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Xiao Zhai, Kai Chen, Huan Yang, Bo Li, Tianjunke Zhou, Haojue Wang, Huipeng Zhou, Shaofeng Chen, Xiaoyi Zhou, Xiaozhao Wei, Yushu Bai, Ming Li
Summary: CD73+ hucMSC-EVs ameliorated inflammation after spinal cord injury by reducing extracellular ATP, promoting A2bR/cAMP/PKA pathway and M2/M1 polarization. They may be promising nano drugs for clinical application in SCI therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Se-Hwa Jung, Ji-Eun You, Soon-Won Choi, Kyung-Sun Kang, Je-Yeol Cho, Jungmook Lyu, Pyung-Hwan Kim
Summary: The study investigated the biological function of the PKD1 gene in umbilical cord blood-derived mesenchymal stem cells (UCB-MSC), finding that it can enhance differentiation ability and maintain long-term stemness, providing new possibilities for stem cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Ziying Zhu, Yujun Zhang, Zhihua Huang, Haojie Hao, Muyang Yan
Summary: We found that small extracellular vesicles (sEVs) produced from umbilical cord mesenchymal stem cells (MSC-sEVs) cultured under hypoxia can promote repair and regeneration of peripheral nerve injury (PNI). These findings suggest that MSC-sEVs may be a promising therapeutic drug candidate for PNI treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell & Tissue Engineering
Yang Yang, Mao Pang, Cong Du, Zhong-Yu Liu, Zi-Hao Chen, Nan-Xiang Wang, Liang-Ming Zhang, Yu-Yong Chen, Jian Mo, Jian-Wen Dong, Pei-Gen Xie, Qi-You Wang, Bin Liu, Li-Min Rong
Summary: A prospective study was conducted to evaluate the safety and efficacy of allogeneic human umbilical cord mesenchymal stem cell transplantation in patients with spinal cord injury, and significant improvements in neurological functions and quality of life were observed.
Article
Immunology
XiaoJuan Lu, Hao Wang, Hongwei Wang, Fan Xie, Cuibao Jiang, Danpeng Shen, Hongpeng Zhang, Jie Yang, Youshu Lin
Summary: The study showed that both indirubin and human umbilical cord mesenchymal stem cells (hUC-MSCs) can effectively reduce psoriatic lesions in BALB/c mice, with the combined treatment showing the best results.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Yu-Hsun Chang, V. Bharath Kumar, Yao-Tseng Wen, Chih-Yang Huang, Rong-Kung Tsai, Dah-Ching Ding
Summary: This study demonstrates the successful differentiation of human umbilical cord mesenchymal stem cells (HUCMSCs) into retinal pigment epithelial (RPE)-like cells using a co-culture system. The induced cells showed the characteristic markers and functions of RPE cells, including engulfing photoreceptor outer segments and secreting neurotrophic factors. These findings provide fundamental information for the clinical-scale generation of RPE-like cells from HUCMSCs.
CELL TRANSPLANTATION
(2022)
Article
Neurosciences
Xu Zhu, Zhen Wang, Yi Eve Sun, Yuchen Liu, Zhourui Wu, Bei Ma, Liming Cheng
Summary: Spinal cord injury (SCI) can lead to severe dysfunction of the lower limbs, and the inflammatory response plays a crucial role in its prognosis. Transplanting human umbilical cord mesenchymal stem cells (hUCMSCs) can promote SCI repair by reducing inflammation. This study investigated the effects of hUCMSC transplantation on SCI mice and the underlying mechanisms, finding that the therapeutic effects of different hUCMSC lines were correlated with their ability to inhibit BV2 cell proliferation. The MSC_A line showed better improvement in motor function and reduced expression of glial fibrillary acidic protein (Gfap) and ionized calcium binding adaptor molecule 1 (Iba1), while increasing the expression of neuronal nuclei (NeuN).
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Xue-Cheng Sun, Hu Wang, Xu Ma, Hong-Fei Xia
Summary: In this study, a spinal cord injury model was established in female rats and the levels of proinflammatory factors in the blood were compared. The results showed that human umbilical cord mesenchymal stem cells transplantation improved the walking ability in rats with spinal cord injury by promoting nerve cell regeneration, neural gene expression, and inhibiting inflammatory reaction.
Review
Cell & Tissue Engineering
Oldouz Shareghi-oskoue, Leili Aghebati-Maleki, Mehdi Yousefi
Summary: Premature ovarian failure (POF) is a problem for women before the age of 40, characterized by symptoms such as amenorrhea and low estrogen levels. The current treatment approach involves stem cell therapy, particularly HUCMSC transplantation, which has shown to effectively improve ovarian function and treat infertility.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Neurosciences
Ji-Le Xie, Xing-Ran Wang, Mei-Mei Li, Zi-Han Tao, Wen-Wen Teng, Saijilafu
Summary: Spinal cord injury (SCI) causes motor, sensory, and autonomic dysfunction with significant economic costs. MSCs show promise as transplant cells for SCI treatment, due to their multipotency, trophic and immunomodulatory abilities, and ease of isolation. However, understanding the concept of MSCs is crucial for high-quality research in the field.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Hu Xiao, Min Li, Junbin Cai, Nanxiang Li, Ming Zhou, Peng Wen, Zhengyuan Xie, Qiang Wang, Jingyu Chang, Wangming Zhang
NEUROSCIENCE LETTERS
(2017)
Article
Neurosciences
Qiang Wang, Min Li, Zhengyuan Xie, Junbin Cai, Nanxiang Li, Hu Xiao, Ning Wang, Jinyan Wang, Fei Luo, Wangming Zhang
EXPERIMENTAL BRAIN RESEARCH
(2017)
Article
Medicine, Research & Experimental
Xie Zhengyuan, Xiao Hu, Wang Qiang, Li Nanxiang, Cai Junbin, Zhang Wangming
MEDICAL SCIENCE MONITOR
(2017)
Article
Clinical Neurology
Jiazhi Chen, Nanxiang Li, Dian He, Manfeng Wu, Hao Long, Kaijun Yang, Songtao Qi, Wangming Zhang, Jun Wang
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Neurosciences
Qiang Wang, Jiazhi Chen, Min Li, Siyuan Lv, Zhengyuan Xie, Nanxiang Li, Ning Wang, Jinyan Wang, Fei Luo, Wangming Zhang
Article
Multidisciplinary Sciences
Jiazhi Chen, Xinyu Chen, Siyuan Lv, Yuzhen Zhang, Hao Long, Kaijun Yang, Songtao Qi, Wangming Zhang, Jun Wang
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Neurosciences
Jiazhi Chen, Qiang Wang, Nanxiang Li, Shujie Huang, Min Li, Junbin Cai, Yuzheng Wang, Huantao Wen, Siyuan Lv, Ning Wang, Jinyan Wang, Fei Luo, Wangming Zhang
Summary: Excessive theta frequency oscillation and synchronization in the basal ganglia have been reported in elderly parkinsonian patients and LID animal models, especially during the off L-dopa state. Chronic L-dopa usage increases theta synchronization and information flow between SNr and M1 in LID rats, with a directionality from SNr to M1. Theta oscillational activity in M1 may result from abnormal synchronous discharges in the BG and may participate in the induction of dyskinesia.
NEUROSCIENCE BULLETIN
(2021)
Review
Oncology
Min Li, Yuhao Deng, Wangming Zhang
Summary: Medulloblastoma, the most common malignant brain cancer in pediatrics, is classified into four molecular subgroups. The identification of metastatic drivers has provided important insights into the treatment of medulloblastoma. The tumor microenvironment and signaling pathways play crucial roles in the spread and invasion of tumor cells.
MOLECULAR CANCER RESEARCH
(2021)
Article
Neurosciences
Jin Cong, Kangrong Lu, Wenjie Zou, Ziming Li, Zhipeng Guo, Xiangzhen Tong, Jiawei Zheng, Jianping Zhu, Shuji Li, Wangming Zhang, Yanwu Guo, Tian-Ming Gao, Rongqing Chen
Summary: The study found that the aversive effects of CP 55,940 in mice are mediated by astroglial CB1Rs, and can be eliminated by inhibiting COX-2. This suggests that selective COX-2 inhibition or precise isolation of astroglial CB1R activity may be a strategy for addressing aversive responses to medical and recreational marijuana use.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Huantao Wen, Zitao Chen, Min Li, Qiongzhen Huang, Yuhao Deng, Jiawei Zheng, Moliang Xiong, Pengfei Wang, Wangming Zhang
Summary: The study showed that PBK is highly expressed in most cancers, associated with poor prognosis and clinicopathologic stages, and correlates significantly with TMB and MSI. Additionally, PBK expression is related to immune cell infiltration levels and specific immune cell types.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Moliang Xiong, Yun Feng, Shujie Huang, Siyuan Lv, Yuhao Deng, Min Li, Pengfei Wang, Minjie Luo, Huangtao Wen, Wangming Zhang
Summary: Teriparatide is a commonly used drug for the treatment of osteoporosis in postmenopausal women. It has been shown to have neuroprotective effects through multiple mechanisms, including promoting angiogenesis, inhibiting oxidative stress and neuroinflammation, protecting the blood-brain barrier, and reducing brain edema.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Yuhao Deng, Huantao Wen, Hanjie Yang, Zhengqiang Zhu, Qiongzhen Huang, Yuewei Bi, Pengfei Wang, Ming Zhou, Jianwei Guan, Wangming Zhang, Min Li
Summary: Medulloblastoma (MB) is the most common malignant brain tumor in pediatrics. Current standard treatment often results in high morbidity, so there is a need for more effective and less toxic therapies. This study identified an upregulated gene (PDZ binding kinase) in MB and found its aberrant expression to be associated with poor clinical outcomes. Targeting this gene with an inhibitor impaired MB cell proliferation and induced apoptosis.
Article
Endocrinology & Metabolism
Jiale Liu, Minjie Luo, Siyuan Lv, Shaohua Tao, Zhu Wu, Lihua Yu, Danna Lin, Lulu Huang, Li Wu, Xu Liao, Juan Zi, Xiaorong Lai, Yuting Yuan, Wangming Zhang, Lihua Yang
Summary: High-dose rapamycin treatment prior to surgery effectively reduced the tumor volume and blood supply in an infant with atypical choroid plexus papilloma, leading to successful resection. However, the infant experienced hyperglycemia as a side effect, which was controlled by adjusting the dose and administering insulin.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Yuewei Bi, Pengfei Wang, Jianshen Yu, Zhuyong Wang, Hanjie Yang, Yuhao Deng, Jianwei Guan, Wangming Zhang
Summary: This study aimed to investigate the electrophysiological effects of chronic L-dopa administration and eltoprazine (a 5-HT1A/1B receptor agonist) on motor complications in rats. Neural electrophysiological analysis revealed the significant roles of both dopaminergic and serotonergic systems in the development of dyskinesia. Eltoprazine improved dyskinesia by reducing abnormal glutamate-GABA metabolism.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Zhuyong Wang, Anyang Liu, Jianshen Yu, Pengfei Wang, Yuewei Bi, Sha Xue, Jiajun Zhang, Hongbo Guo, Wangming Zhang
Summary: This study investigates the differences between Alzheimer's disease (AD) and frontotemporal dementia (FTD) using electroencephalography (EEG) and highlights the significance of aperiodic components in distinguishing between the two disorders.
