Article
Biology
Peilin Zhao, Tao Jiang, Huading Wang, Xueyan Jia, Anan Li, Hui Gong, Xiangning Li
Summary: By studying the detailed morphology of pontine-tegmental cholinergic neurons (PTCNs), we found that these neurons have abundant axons and collaterals, and can project to multiple brain regions in both the ascending and descending circuits, including the thalamus and cortex. Based on labeling in different circuits, PTCNs can be classified into four subtypes. These findings provide important organizational characteristics of cholinergic neurons in the upper brainstem to understand their connexional logic.
Article
Neurosciences
Stephano J. Chang, Iahn Cajigas, James D. Guest, Brian R. Noga, Eva Widerstrom-Noga, Ihtsham Haq, Letitia Fisher, Corneliu C. Luca, Jonathan R. Jagid
Summary: A new deep brain stimulation method targeting the CnF region has been proposed to alleviate freezing of gait in Parkinson's Disease patients. Clinical studies have shown that DTI-based targeting and intraoperative stimulation can help accurately and safely apply this method.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Pedro A. Pereira, Joana Coelho, Ana Silva, M. Dulce Madeira
Summary: Studies have shown that with age, there is no significant change in the number and size of dopamine neurons in the VTA of rats, but the cholinergic input decreases, while the cholinergic neurons in the PPT and LDT nuclei increase in size. These results suggest that dysfunction of the cholinergic system may contribute to the age-related deterioration of the brain reward system.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cell Biology
Daniel Dautan, Adrienn Kovacs, Tsogbadrakh Bayasgalan, Miguel A. Diaz-Acevedo, Balazs Pal, Juan Mena-Segovia
Summary: CnF and PPN neurons in the MLR demonstrate distinct physiological properties and connectivity patterns, contributing to short-lasting muscle activation and long-lasting muscle tone increase in motor behavior, respectively.
Article
Anatomy & Morphology
Peilin Zhao, Huading Wang, Anan Li, Qingtao Sun, Tao Jiang, Xiangning Li, Hui Gong
Summary: In this study, the input and output circuits of two cholinergic subregions in the midbrain were comprehensively investigated using viral tracing and fluorescent micro-optical sectional tomography. The results revealed similar spatial distributions of input and neuromodulatory afferents, as well as different quantitative measures, in these cholinergic nuclei. Additionally, the cholinergic nuclei showed similar targeting areas across multiple brain regions, but had different spatial preferences in 3D. Some cholinergic connections were found to be unidirectional and had different impacts on locomotion and anxiety. Overall, this study provides a better understanding of the organizational structure and functional modulation of the pontine-tegmental cholinergic system.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Nicole E. Chambers, Michael Coyle, Jordan Sergio, Kathryn Lanza, Carolyn Saito, Brent Topping, Stewart D. Clark, Christopher Bishop
Summary: This study found that cholinergic neurons in the pedunculopontine nucleus (PPN) affect gait parameters related to postural stability, potentially serving as a target for reducing intractable postural instability in patients with Parkinson's disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Ganghua He, Yang Li, Hua Deng, Hongyan Zuo
Summary: This article summarizes the function and regulatory mechanism of cholinergic neural circuits and their roles in neurodegenerative diseases. Cholinergic circuits regulate multiple nuclei in the brain through neurotransmission and are involved in learning and memory, attention, emotion, and movement. Dysfunction or loss of cholinergic circuits may lead to cognitive disorders such as Alzheimer's disease.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neurosciences
Rene Molina, Chris J. Hass, Stephanie Cernera, Kristen Sowalsky, Abigail C. Schmitt, Jaimie A. Roper, Daniel Martinez-Ramirez, Enrico Opri, Christopher W. Hess, Robert S. Eisinger, Kelly D. Foote, Aysegul Gunduz, Michael S. Okun
Summary: This study investigated the feasibility and effectiveness of PPN CL-DBS in treating medication-refractory FoG, showing high recruitment feasibility but suboptimal safety and heterogeneous clinical outcomes.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Nicola J. Ray, Rachael A. Lawson, Sarah L. Martin, Hilmar P. Sigurdsson, Joanna Wilson, Brook Galna, Sue Lord, Lisa Alcock, Gordon W. Duncan, Tien K. Khoo, John T. O'Brien, David J. Burn, John-Paul Taylor, River C. Rea, Maurizio Bergamino, Lynn Rochester, Alison J. Yarnall
Summary: Free-water imaging can predict dopamine system degeneration in Parkinson's disease and enhance the sensitivity of traditional DTI metrics. However, it has not been applied to investigate cholinergic system degeneration. Free-water imaging, free-water-corrected DTI, and volumetry were used to extract structural metrics from the cholinergic basal forebrain and pedunculopontine nucleus in people with Parkinson's disease.
Article
Geriatrics & Gerontology
Stephen Joza, Richard Camicioli, W. R. Wayne Martin, Marguerite Wieler, Myrlene Gee, Fang Ba
Summary: The study found that there may be a correlation between gait dysfunction in Parkinson's disease and connectivity deficits in the PPN network involving the right caudate nucleus and amygdala, which could be investigated in future larger studies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Angelo Insola, Paolo Mazzone, Giacomo Della Marca, Annamaria Capozzo, Flora Vitale, Eugenio Scarnati
Summary: The study showed that stimulation of the pedunculopontine tegmental nucleus (PPTg) can increase latency and decrease duration, amplitude, and area of the R2 component of blink reflex, regardless of the side of supraorbital nerve (SON) stimulation. The effects were stable for interstimulus intervals (ISI) between PPTg prepulse and SON stimulus.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Altair B. Dos Santos, Line K. Skaanning, Siganya Thaneshwaran, Eyd Mikkelsen, Cesar R. Romero-Leguizamon, Thomas Skamris, Morten P. Kristensen, Annette E. Langkilde, Kristi A. Kohlmeier
Summary: Parkinson's disease, Multiple System Atrophy, and Lewy Body Dementia are incurable diseases mechanistically linked to the protein alpha-synuclein. Sleep disorders are common in the early stages of these diseases, indicating the involvement of alpha-synuclein in sleep regulation. This study found that different forms of alpha-synuclein can affect sleep-controlling neurons in a structure-independent manner, suggesting that these neurons could be potential targets for future neuroprotective therapies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Behavioral Sciences
V. M. DeAngelo, J. D. Hilliard, G. C. McConnell
Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by gait dysfunction and degeneration of dopamine and acetylcholine. The study found significant gait deficits in P1KO rats at 5 months, improving by 8 months. Dopaminergic cell loss may contribute to gait deficits in the P1KO model, with variability within the model. Further analysis is needed to determine the suitability of the P1KO rat as a progressive model of gait abnormalities in PD.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Lina Wang, Min Ji, Huimin Sun, Caiting Gan, Heng Zhang, Xingyue Cao, Yongsheng Yuan, Kezhong Zhang
Summary: This study found that reduced cortical sensorimotor inhibition (SAI) is associated with severe freezing of gait (FOG) manifestations, impaired gait characteristics, and variability in PD patients with L-dopa-unresponsive FOG. This suggests the involvement of impaired thalamocortical cholinergic-GABAergic SAI pathways in ONOFF-FOG.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Neurosciences
V. S. Witzig, F. Alosaimi, Y. Temel, J. B. Schulz, A. Jahanshahi, S. K. H. Tan
Summary: This study investigated the effects of long-term intermittent bilateral STN-DBS on PPN cholinergic neurons in the MPTP Parkinsonian mouse model. The results showed that STN-DBS improved gait impairments but did not alter the expression or activation of PPN acetylcholine neurons. Therefore, the motor and gait effects of STN-DBS are less likely to be mediated by the STN-PPN connection and PPN cholinergic system.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Qiang Wang, Min Li, Zhengyuan Xie, Junbin Cai, Nanxiang Li, Hu Xiao, Ning Wang, Jinyan Wang, Fei Luo, Wangming Zhang
EXPERIMENTAL BRAIN RESEARCH
(2017)
Article
Clinical Neurology
Jiazhi Chen, Nanxiang Li, Dian He, Manfeng Wu, Hao Long, Kaijun Yang, Songtao Qi, Wangming Zhang, Jun Wang
JOURNAL OF CLINICAL NEUROSCIENCE
(2018)
Article
Neurosciences
Qiang Wang, Jiazhi Chen, Min Li, Siyuan Lv, Zhengyuan Xie, Nanxiang Li, Ning Wang, Jinyan Wang, Fei Luo, Wangming Zhang
Article
Multidisciplinary Sciences
Jiazhi Chen, Xinyu Chen, Siyuan Lv, Yuzhen Zhang, Hao Long, Kaijun Yang, Songtao Qi, Wangming Zhang, Jun Wang
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Neurosciences
Jiazhi Chen, Qiang Wang, Nanxiang Li, Shujie Huang, Min Li, Junbin Cai, Yuzheng Wang, Huantao Wen, Siyuan Lv, Ning Wang, Jinyan Wang, Fei Luo, Wangming Zhang
Summary: Excessive theta frequency oscillation and synchronization in the basal ganglia have been reported in elderly parkinsonian patients and LID animal models, especially during the off L-dopa state. Chronic L-dopa usage increases theta synchronization and information flow between SNr and M1 in LID rats, with a directionality from SNr to M1. Theta oscillational activity in M1 may result from abnormal synchronous discharges in the BG and may participate in the induction of dyskinesia.
NEUROSCIENCE BULLETIN
(2021)
Review
Oncology
Min Li, Yuhao Deng, Wangming Zhang
Summary: Medulloblastoma, the most common malignant brain cancer in pediatrics, is classified into four molecular subgroups. The identification of metastatic drivers has provided important insights into the treatment of medulloblastoma. The tumor microenvironment and signaling pathways play crucial roles in the spread and invasion of tumor cells.
MOLECULAR CANCER RESEARCH
(2021)
Article
Neurosciences
Jin Cong, Kangrong Lu, Wenjie Zou, Ziming Li, Zhipeng Guo, Xiangzhen Tong, Jiawei Zheng, Jianping Zhu, Shuji Li, Wangming Zhang, Yanwu Guo, Tian-Ming Gao, Rongqing Chen
Summary: The study found that the aversive effects of CP 55,940 in mice are mediated by astroglial CB1Rs, and can be eliminated by inhibiting COX-2. This suggests that selective COX-2 inhibition or precise isolation of astroglial CB1R activity may be a strategy for addressing aversive responses to medical and recreational marijuana use.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Huantao Wen, Zitao Chen, Min Li, Qiongzhen Huang, Yuhao Deng, Jiawei Zheng, Moliang Xiong, Pengfei Wang, Wangming Zhang
Summary: The study showed that PBK is highly expressed in most cancers, associated with poor prognosis and clinicopathologic stages, and correlates significantly with TMB and MSI. Additionally, PBK expression is related to immune cell infiltration levels and specific immune cell types.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Moliang Xiong, Yun Feng, Shujie Huang, Siyuan Lv, Yuhao Deng, Min Li, Pengfei Wang, Minjie Luo, Huangtao Wen, Wangming Zhang
Summary: Teriparatide is a commonly used drug for the treatment of osteoporosis in postmenopausal women. It has been shown to have neuroprotective effects through multiple mechanisms, including promoting angiogenesis, inhibiting oxidative stress and neuroinflammation, protecting the blood-brain barrier, and reducing brain edema.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Yuhao Deng, Huantao Wen, Hanjie Yang, Zhengqiang Zhu, Qiongzhen Huang, Yuewei Bi, Pengfei Wang, Ming Zhou, Jianwei Guan, Wangming Zhang, Min Li
Summary: Medulloblastoma (MB) is the most common malignant brain tumor in pediatrics. Current standard treatment often results in high morbidity, so there is a need for more effective and less toxic therapies. This study identified an upregulated gene (PDZ binding kinase) in MB and found its aberrant expression to be associated with poor clinical outcomes. Targeting this gene with an inhibitor impaired MB cell proliferation and induced apoptosis.
Article
Endocrinology & Metabolism
Jiale Liu, Minjie Luo, Siyuan Lv, Shaohua Tao, Zhu Wu, Lihua Yu, Danna Lin, Lulu Huang, Li Wu, Xu Liao, Juan Zi, Xiaorong Lai, Yuting Yuan, Wangming Zhang, Lihua Yang
Summary: High-dose rapamycin treatment prior to surgery effectively reduced the tumor volume and blood supply in an infant with atypical choroid plexus papilloma, leading to successful resection. However, the infant experienced hyperglycemia as a side effect, which was controlled by adjusting the dose and administering insulin.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Yuewei Bi, Pengfei Wang, Jianshen Yu, Zhuyong Wang, Hanjie Yang, Yuhao Deng, Jianwei Guan, Wangming Zhang
Summary: This study aimed to investigate the electrophysiological effects of chronic L-dopa administration and eltoprazine (a 5-HT1A/1B receptor agonist) on motor complications in rats. Neural electrophysiological analysis revealed the significant roles of both dopaminergic and serotonergic systems in the development of dyskinesia. Eltoprazine improved dyskinesia by reducing abnormal glutamate-GABA metabolism.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Zhuyong Wang, Anyang Liu, Jianshen Yu, Pengfei Wang, Yuewei Bi, Sha Xue, Jiajun Zhang, Hongbo Guo, Wangming Zhang
Summary: This study investigates the differences between Alzheimer's disease (AD) and frontotemporal dementia (FTD) using electroencephalography (EEG) and highlights the significance of aperiodic components in distinguishing between the two disorders.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
