☆ 4.3 Article

Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in IM

NEUROBIOLOGY OF LEARNING AND MEMORY (2008)

期刊

NEUROBIOLOGY OF LEARNING AND MEMORY

卷 89, 期 2, 页码 125-133

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE

DOI: 10.1016/j.nlm.2007.07.002

关键词

learning; hippocampus; afterhyperpolarization; I-M; sI(AHP); neuronal excitability; calcium-activated potassium currents

类别

Behavioral Sciences Neurosciences Psychology Psychology, Multidisciplinary

资金

NIA NIH HHS [R37 AG008796-12S1, R37 AG008796-16S2, R37 AG008796-12, R37 AG008796-16, R37 AG008796-14, R37 AG008796-09S1, R37 AG008796-11, R37 AG008796-17S1, R37 AG008796-13S1, R37 AG008796-15S1, R37 AG08796, R37 AG008796, R37 AG008796-10, R37 AG008796-13, R37 AG008796-10S1, R37 AG008796-09, R37 AG008796-17, R37 AG008796-15, R37 AG008796-16S1] Funding Source: Medline
NIMH NIH HHS [F31 MH012761, F31 MH012761-03, F31 MH012761-01A1, F31 MH12761, F31 MH012761-02] Funding Source: Medline

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摘要

Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. In the current study we have extended our findings in rabbits by showing a reduction in both the AHP and accommodation in F344 X BN rat CA1 pyramidal neurons following acquisition of trace eyeblink conditioning. A component current of the AHP, I-M, was evaluated with a specific blocker of this current, and showed no apparent contribution to the learning-related increase in neuronal excitability. Rather, a reduction in an isoproterenol-sensitive component of the AHP, presumably sI(AHP), was observed to underlie the learning-specific change. (C) 2007 Elsevier Inc. All rights reserved.

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