Article
Multidisciplinary Sciences
Tara L. Henechowicz, Joyce L. Chen, Leonardo G. Cohen, Michael H. Thaut
Summary: The study compared the prevalence of the Val66Met BDNF polymorphism between musicians and the general population, finding no significant difference in distribution between the two groups.
Article
Multidisciplinary Sciences
Machhindra Garad, Elke Edelmann, Volkmar Lessmann
Summary: BDNF plays a crucial role in regulating synaptic plasticity, with studies showing a bidirectional mode of action involving different receptors. This study focused on the role of proBDNF/p75NTR signaling in MF-LTD and found that MF-LTD is not dependent on p75 neurotrophin receptors.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Madhusmita P. Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castren
Summary: Deleting the BDNF receptor TrkB from serotonergic neurons in the adult brain leads to increased levels of 5-HT and Tph2, with abnormal behavioral phenotype in transgenic mice. Despite increased food intake, the transgenic mice are significantly leaner than their wildtype littermates, possibly due to increased metabolic activity. Increased 5-HT levels are associated with significantly increased proliferation of hippocampal progenitors, while long-term survival of newborn cells remains unchanged.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Wenya Pei, Fanqi Meng, Qingwen Deng, Baobao Zhang, Yuan Gu, Boyu Jiao, Haoyu Xu, Jiuqing Tan, Xin Zhou, Zhiling Li, Guanheng He, Jingwen Ruan, Ying Ding
Summary: The study showed that electroacupuncture attenuated the loss of hippocampal neurons and synapses, stimulated hippocampal neurogenesis, and improved learning and memory in rats under sleep deprivation by upregulating BDNF and increasing the phosphorylation of TrkB and Erk. In cultured hippocampal neurons, exogenous BDNF enhanced synaptic plasticity through TrkB/Erk signaling, while this effect was reversed by treatment with the TrkB inhibitor K252a.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Neurosciences
Ronald S. Duman, Satoshi Deyama, Manoela Viar Fogaca
Summary: Depression is associated with neuronal atrophy and reduced synaptic connectivity in brain regions like the hippocampus and prefrontal cortex. Antidepressant treatments can reverse these deficits by up-regulating factors like BDNF, which plays a key role in synaptic plasticity. Rapid-acting antidepressants, such as ketamine, rely on the activity-dependent release of BDNF and other growth factors for their effects.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Daniel B. Dorman, Kim T. Blackwell
Summary: Synaptic plasticity, the experience-induced change in connections between neurons, plays a crucial role in learning and memory. This study investigates how spatiotemporal synaptic input patterns produce plasticity under in vivo-like conditions. The findings reveal the robustness of plasticity to trial-to-trial variability of spike timing and derive general rules describing the control of plasticity by spatiotemporal patterns of synaptic inputs.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Amirmohammad Khalaji, Amir Hossein Behnoush, Parnian Shobeiri, Behrad Saeedian, Antonio L. Teixeira, Nima Rezaei
Summary: The study found no significant difference in BDNF levels between patients with OSA and controls, as well as no statistically significant impact of CPAP treatment on BDNF levels. Therefore, BDNF peripheral levels are not significantly altered in OSA or by its related treatment, preventing its use as a biomarker.
SLEEP AND BREATHING
(2023)
Article
Oncology
Elena Diaz-Garcia, Sara Garcia-Tovar, Raquel Casitas, Ana Jaureguizar, Ester Zamarron, Begona Sanchez-Sanchez, Ana Sastre-Perona, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: The study shows that patients with obstructive sleep apnea (OSA) exhibit elevated levels of PSPC1, which is cleaved from monocytes by MMP2 and released into the plasma. Intermittent hypoxia (IH) promotes the expression of PSPC1, TGF beta, and MMP2 in monocytes, leading to increased expression of genes driving epithelial-to-mesenchymal transition. These findings suggest a mechanism by which hypoxemia contributes to tumor progression and aggressiveness in OSA patients.
Article
Physiology
Ming Deng, Yi-teng Huang, Jian-qing Xu, Xiao Ke, Yi-fei Dong, Xiao-shu Cheng
Summary: The study found that patients with severe OSAHS were more likely to have hypertension and higher LV mass and LV mass index. The association between intermittent hypoxia and left ventricular remodeling was significant, with oxygen desaturation index (ODI) being the most relevant parameter to LV remodeling among various intermittent hypoxia parameters.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-Pang Chuang, Huang-Pin Wu, Li-Ang Lee, Li-Chung Chiu, Shih-Wei Lin, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Jung-Wei Tsai, Jong-Hwei Su Pang
Summary: This study found that under intermittent hypoxia conditions, the expression of IL-8 was enhanced in monocytes of adult OSA patients, leading to an increase in the migration ability of monocytes towards IL-8.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Jing Wang, Yichen Cai, Jingyi Sun, Hua Feng, Xiaoyu Zhu, Qian Chen, Feng Gao, Qingbin Ni, Leilei Mao, Mingfeng Yang, Baoliang Sun
Summary: In this study, non-invasive treatment methods using AAV vectors carrying BDNF or TrkB genes were performed on stroke-injured rats. The combination therapy significantly improved upper limb motor functional recovery and neurotransmission efficiency, promoting axonal remodeling and restoration of synaptic structures.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Cell Biology
Md. Shamim Hossain, Shiro Mawatari, Takehiko Fujino
Summary: Plasmalogens (Pls) can enhance brain-derived neurotrophic factor expression, promote neurogenesis in the hippocampus, and improve learning and memory in mice. Pls regulates memory-related gene expression through signaling pathways and transcription factor recruitment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Clinical Neurology
Yang Ji, Yingmin Liang, Judith C. W. Mak, Mary S. M. Ip
Summary: Obesity is a strong risk factor for both obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD). Intermittent hypoxia plays an important role in the development of NAFLD in OSA. Understanding the roles of obesity and intermittent hypoxia in NAFLD is crucial for gaining more knowledge about the health consequences of OSA and devising effective therapeutic strategies.
Article
Psychology, Clinical
Joey W. Y. Chan, S. P. Lam, Shirley X. Li, Steven W. H. Chau, S. Y. Chan, N. Y. Chan, J. H. Zhang, Y. K. Wing
Summary: This study examines the efficacy of adjunctive bright light therapy with gradual timing advance in non-seasonal unipolar depression patients with evening chronotype. The results show that bright light therapy can accelerate the remission of depression and improve the remission rate in these patients.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Biology
Forrest Tin Wai Cheung, Amy Wing Yin Ho, Joey Wing Yan Chan, Xiao Li, Ngan Yin Chan, Jihui Zhang, Chung Shun Ho, Yun Kwok Wing, Shirley Xin Li
Summary: The study aimed to validate the Chinese version of the Munich Chronotype Questionnaire (MCTQ) in Chinese youth and explore its utility in individuals with insomnia. The results showed significant correlations between MCTQ parameters and circadian preference and insomnia symptoms. MCTQ was found to have good reliability and validity in Chinese youth and could be useful in assessing chronotype in individuals with insomnia.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Psychology, Developmental
Ngan Yan Chan, Siu Ping Lam, Jihui Zhang, Joey Wing Yan Chan, Mandy Man Wai Yu, Sooyeon Suh, Chien-Ming Yang, Isa Okajima, Albert Martin Li, Yun Kwok Wing, Shirley Xin Li
Summary: The study compared the efficacy of group-based therapy and email-delivered self-help cognitive behavioral therapy for insomnia in youths. The findings showed that both treatments were effective, but group-based therapy had superior effects on reducing maladaptive beliefs and mood symptoms.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Letter
Health Care Sciences & Services
Joshua Heng Tang, Yun Kwok Wing, Joey W. Y. Chan, Raymond S. K. Lo
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Clinical Neurology
Ilona Merikanto, Yves Dauvilliers, Frances Chung, Yun Kwok Wing, Luigi De Gennaro, Brigitte Holzinger, Bjorn Bjorvatn, Charles M. Morin, Thomas Penzel, Christian Benedict, Adrijana Koscec Bjelajac, Ngan Yin Chan, Colin A. Espie, Harald Hrubos-Strom, Yuichi Inoue, Maria Korman, Anne-Marie Landtblom, Damien Leger, Kentaro Matsui, Sergio Mota-Rolim, Michael R. Nadorff, Giuseppe Plazzi, Catia Reis, Juliana Yordanova, Markku Partinen
Summary: An international survey study reveals that post-acute sequelae of COVID-19 symptoms are more prevalent among severe cases and long-lasting sleep problems are at the core of these symptoms. Understanding the importance of sleep-related symptoms has clinical relevance in diagnosing and treating long-COVID.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Bei Huang, Jihui Zhang, Jing Wang, Steven Wai Ho Chau, Joey Wing Yan Chan, Mandy Wai Man Yu, Shirley Xin Li, Li Zhou, Vincent Mok, Yun Kwok Wing, Yaping Liu
Summary: This study found that family relatives of patients with RBD who have isolated recurrent dream-enactment behaviors have an increased risk of RBD and neurodegenerative features.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Hoi Man Yuen, Kate Ching-ching Chan, Winnie Chiu Wing Chu, Joey W. Y. Chan, Yun Kwok Wing, Albert Martin Li, Chun Ting Au
Summary: This study aimed to examine the craniofacial phenotype of Chinese prepubertal children with and without obstructive sleep apnea (OSA) using a quantitative photographic analysis technique and to develop a prediction model for OSA diagnosis based on the photogrammetric data. Potential ethnic differences in the association between OSA and photogrammetric data between Chinese and Caucasian children were also examined. The results showed significant differences in craniofacial features between different OSA groups in prepubertal children, and a prediction model based on clinical measurements and photogrammetric features achieved a good performance in OSA diagnosis.
Article
Clinical Neurology
Ngan Yin Chan, Wen Jie Wu, Joey Wing Yan Chan, Kate Ching Ching Chan, Albert Martin Li, Sandra Sau Man Chan, Kit Tai Hau, Yun Kwok Wing
Summary: This study explored the association between sleep and academic performance in a large and representative sample of school children and adolescents in Hong Kong. It found that there is an inverted U-shaped relationship between sleep duration and academic performance, with an optimal level of sleep associated with better academic performance. The findings highlight the importance of systematic sleep education and intervention to encourage optimal sleep patterns for students, which can have a positive effect on their academic performance.
Article
Cell Biology
Kin-Wai Tam, Cheuk-Yin Wong, Kenneth Lap-Kei Wu, Guy Lam, Xiaotong Liang, Wai-Ting Wong, Maximilian Tak-Sui Li, Wing-Yui Liu, Sa Cai, Graham Ka-Hon Shea, Daisy Kwok-Yan Shum, Ying-Shing Chan
Summary: The in vitro derivation of Schwann cells from human bone marrow stromal cells offers a potential therapy for neural regeneration. In experiments with rats, Schwann-cell-like cells derived from human induced pluripotent stem-cell-derived sensory neurons were used to bridge nerve injuries. This approach resulted in significant improvement in motor function and myelinated axons in both peripheral and central nervous systems.
Article
Public, Environmental & Occupational Health
Martin Chi-Sang Wong, Junjie Huang, Yuet-Yan Wong, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip, Rachel Ngan-Yin Chan, Steven Wai-Ho Chau, Siew-Chien Ng, Yun-Kwok Wing, Francis Ka-Leung Chan
Summary: This study investigated the prevalence and risk factors of long COVID symptoms among patients with COVID-19 in 4 major Chinese cities. The most common severe long COVID symptoms were fatigue, cough, sore throat, difficulty in concentrating, feeling of anxiety, myalgia, and arthralgia. Female gender, living with domestic workers, smoking, poor self-perceived health status, having >= 3 chronic diseases, chronic medication use, and critical severity of COVID-19 were associated with severe long COVID. Prior vaccination with >= 2 doses of COVID-19 vaccines was a protective factor.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Health Care Sciences & Services
Lulu Yang, Hongliang Feng, Sizhi Ai, Yue Liu, Binbin Lei, Jie Chen, Xiao Tan, Christian Benedict, Ningjian Wang, Yun Kwok Wing, Lu Qi, Jihui Zhang
Summary: Evidence suggests a potential relationship between circadian rhythm and atrial fibrillation (AF), however, it is largely unknown whether circadian disruption can predict the onset of AF in the general population. This study aimed to investigate the association between accelerometer-measured circadian rest-activity rhythm (CRAR) and the risk of AF, as well as examine the joint associations and potential interactions of CRAR and genetic susceptibility with AF incidence. The results indicate that low amplitude, delayed acrophase, and low mesor are significantly associated with a higher risk of AF.
NPJ DIGITAL MEDICINE
(2023)
Article
Clinical Neurology
Wanqi Sun, Forrest Tin Wai Cheung, Ngan Yin Chan, Jihui Zhang, Joey Wing Yan Chan, Kate Ching Ching Chan, Yun Kwok Wing, Shirley Xin Li
Summary: This study aimed to examine the impacts of experimentally induced sleep variability on sleepiness, mood, cognitive performance, and sleep architectures among young adults. The results showed that the variable sleep schedule group reported a higher level of sleepiness, especially in the mornings, and increased negative mood in the evenings. However, there were no significant differences in positive mood, cognitive performance, and sleep macro- and micro-structures.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychiatry
Vanessa W. S. Ng, Miriam T. Y. Leung, Esther W. Chan, Edwin H. M. Lee, Joseph F. Hayes, David P. J. Osborn, Yun Kwok Wing, Wallis C. Y. Lau, Kenneth K. C. Man, Ian C. K. Wong
Summary: This study used a self-controlled case series design to examine the association between mood stabilizing agents and suicide attempts in patients with bipolar disorder. The results showed an increased risk of suicide attempts before treatment initiation, and a smaller but still increased risk after treatment initiation. However, the use of lithium and antiepileptics was associated with a lower risk, while the risk decreased with antipsychotics. Therefore, the study suggests that mood stabilizing agents are not causally associated with an increased risk of suicide attempts, and lithium and antiepileptics may have potential protective effects. Assiduous monitoring of symptoms relapse and warning signs of suicide should be part of the management plan.
PSYCHIATRY RESEARCH
(2023)
Article
Health Care Sciences & Services
Si-Jing Chen, Shirley Xin Li, Ji-Hui Zhang, Siu Ping Lam, Mandy Wai Man Yu, Chi Ching Tsang, Alice Pik Shan Kong, Kate Ching Ching Chan, Albert Martin Li, Yun Kwok Wing, Ngan Yin Chan
Summary: Insufficient sleep negatively affects child development and neurocognitive abilities, highlighting the importance of interventions to promote sleep health in children. This study evaluated the effectiveness of a school-based sleep education program and found that while it improved parental sleep knowledge and behavioral outcomes in children, it did not significantly impact sleep-wake patterns and sleep problems.
Article
Clinical Neurology
Joey W. Y. Chan, Shirley Xin Li, Steven Wai Ho Chau, Ngan Yin Chan, Jihui Zhang, Yun Kwok Wing
Summary: This study examined the predictors of dropout during a five-week light treatment in patients with unipolar non-seasonal depression and evening chronotypes. Treatment non-adherence during the first week of treatment was found to significantly increase the risk of dropout.
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)
