Review
Neurosciences
Sherif M. Elbasiouny
Summary: Excitability dysfunction of motoneurons in ALS is a disputed topic in the field due to conflicting reports in the literature on its nature, role, and underlying mechanisms. The form and role of excitability dysfunction in the disease are currently unclear, hindering a comprehensive understanding of ALS.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Wei Dong, Yuanwu Ma, Feifei Guan, Xu Zhang, Wei Chen, Li Zhang, Lianfeng Zhang
Summary: The study investigated the impact of C9orf72 protein deficiency on a rat ALS model, showing that C9orf72 protein loss alone is not enough to cause ALS, but it sensitizes MNs to other risk factors such as excitotoxicity, synergistically leading to ALS pathogenesis.
Article
Biochemistry & Molecular Biology
Fei Yao, Jingjie Peng, Endong Zhang, Dan Ji, Zhaolin Gao, Yixiong Tang, Xueyan Yao, Xiaobo Xia
Summary: This study reveals the role of NCOA4-FTH1-mediated disturbance of iron metabolism and ferroptosis in retinal ganglion cells (RGCs) during glaucoma. The protective effect of Deferiprone on RGCs via inhibition of ferroptosis is demonstrated, providing a research direction to understand and treat glaucoma via the iron homeostasis and ferroptosis pathways.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Biochemistry & Molecular Biology
Liaisan Arslanbaeva, Marco Bisaglia
Summary: This review discusses the role of the Nrf2 pathway in the pathogenesis of ALS and the modulation of this protective pathway by astrocytes. It also introduces the currently developed Nrf2 activators, including their potentials and limitations in both preclinical animal models and clinical studies.
Article
Medicine, Research & Experimental
Jialei Song, Natalie Dikwella, Daniela Sinske, Francesco Roselli, Bernd Knoell
Summary: Changes in neuronal activity affect the vulnerability of motoneurons in neurodegenerative diseases. The impact of neuronal activity on amyotrophic lateral sclerosis (ALS) and the role of the transcription factor serum response factor (SRF) were investigated in this study. Deletion of SRF in motoneurons resulted in earlier disease onset, neuroinflammation, and neuromuscular synapse degeneration in ALS mice. SRF was found to regulate autophagy-encoding genes, and its constitutively active form enhanced autophagy and reduced aggregate formation in ALS cells.
Review
Plant Sciences
Houqing Zeng, Haicheng Wu, Feng Yan, Keke Yi, Yiyong Zhu
Summary: Zinc (Zn) is an essential micronutrient for plants and animals, but its low availability in arable soils worldwide has led to serious agricultural problems. Plants have evolved multiple responses to adapt to Zn deficiency, involving biochemical and physiological changes to improve Zn acquisition and utilization, and defend against Zn deficiency stress. Studies on the regulatory mechanisms underlying Zn deficiency responses are important for improving Zn deficiency tolerance, use efficiency, and biofortification in plants.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Article
Cell & Tissue Engineering
Seema C. Namboori, Patricia Thomas, Ryan Ames, Sophie Hawkins, Lawrence O. Garrett, Craig R. G. Willis, Alessandro Rosa, Lawrence W. Stanton, Akshay Bhinge
Summary: Using single-cell transcriptomics, researchers identified activation of developmental pathways and core transcriptional factors in motor neurons of ALS patients, leading to gene dysregulation. The activation of TGFβ signaling may be a common mechanism shared by various types of ALS.
Article
Biochemistry & Molecular Biology
Oliver J. Ziff, Benjamin E. Clarke, Doaa M. Taha, Hamish Crerar, Nicholas M. Luscombe, Rickie Patani
Summary: This study reveals that astrocytes in amyotrophic lateral sclerosis (ALS) exhibit inflammatory reactive features and suppress neuronal support mechanisms. These findings offer potential therapeutic targets for ALS.
Article
Chemistry, Physical
Youzhi Li, Michel Nguyen, Laure Vendier, Anne Robert, Yan Liu, Bernard Meunier
Summary: TDMQ chelators have been designed as drug-candidates for regulating copper homeostasis and reducing oxidative stress in the brain of Alzheimer's patients. By studying the correlation between the structures and physicochemical properties of Cu- and Zn-TDMQ complexes, it helps to select the most promising drug-candidates for further biological studies.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Pharmacology & Pharmacy
Handong Qiao, Yuta Morioka, Dengli Wang, Keyue Liu, Shangze Gao, Hidenori Wake, Daiki Ousaka, Kiyoshi Teshigawara, Shuji Mori, Masahiro Nishibori
Summary: In this study, researchers report the production of a specific monoclonal antibody for 4-HNE adducts and demonstrate its effectiveness in ameliorating endotoxemia and liver injury in mice. The antibody treatment can suppress inflammatory responses and liver damage caused by endotoxemia. The study reveals the important role of exogenous 4-HNE adducts in hypercytokinemia and liver injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dae Ki Hong, Jae-Won Eom, A. Ra Kho, Song Hee Lee, Beom Seok Kang, Si Hyun Lee, Jae-Young Koh, Yang-Hee Kim, Bo Young Choi, Sang Won Suh
Summary: The compound 2G11 has been found to have neuroprotective effects by blocking zinc translocation and AMPK phosphorylation, thus protecting hippocampal neurons from ischemia-induced damage.
Article
Chemistry, Multidisciplinary
Tyler A. Bailey, Veronika Mocko, Katherine M. Shield, Dahlia D. An, Andrew C. Akin, Eva R. Birnbaum, Mark Brugh, Jason C. Cooley, Jonathan W. Engle, Michael E. Fassbender, Stacey S. Gauny, Andrew L. Lakes, Francois M. Nortier, Ellen M. O'Brien, Sara L. Thiemann, Frankie D. White, Christiaan Vermeulen, Stosh A. Kozimor, Rebecca J. Abergel
Summary: The development of targeted alpha therapies can potentially revolutionize disease treatment by delivering destructive radiation to diseased cells while sparing healthy tissue. Despite challenges with incompatible isotopes, researchers successfully produced Ce-134 for PET imaging, demonstrating its potential as a candidate for imaging Ac-225 or Th-227. Rigorous control of the Ce-III/Ce-IV redox couple was crucial for success in these experiments.
Review
Biochemistry & Molecular Biology
Yen-Chien Lee, Chi-Tai Yen, Yen-Ling Lee, Rong-Jane Chen
Summary: Thalassemia is a common genetic disorder, and Thalassemia intermedia is a non-transfusion-dependent type. Iron overload is a common issue in Thalassemia intermedia patients. The effectiveness of iron chelation therapy in improving patient outcomes is still debated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Juan P. Cabeza, Juan Camera, Olinda Briski, Minerva Yauri Felipe, Daniel F. Salamone, Andres Gambini
Summary: This study investigates the use of a novel zinc chelator for activating bovine and porcine oocytes. The results show that the zinc chelator can successfully induce blastocyst development in both species, although developmental rates and embryo quality are compromised in bovine compared to calcium-induced embryos. On the contrary, the new concentration and incubation time of the zinc chelator improve developmental rates in porcine without affecting embryo quality. These findings contribute to understanding the role of zinc in oocyte activation and preimplantation embryo development across different mammalian species.
Article
Chemistry, Physical
Paulius Kantakevicius, Calvin Mathiah, Linus O. Johannissen, Sam Hay
Summary: Metal ions play critical roles in biochemical processes by interacting with proteins. By modifying the AMBER molecular mechanics forcefield, better descriptions of nonbonded terms and improved computed binding energies can be achieved. The new parameters show significant improvements in computed binding energies and are in good agreement with experimental values, demonstrating the potential for this method to be applied to a range of systems.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2022)
Article
Neurosciences
Sang Eun Park, Ji Hoon Song, Chansik Hong, Dong Eun Kim, Jee-Won Sul, Tae-Youn Kim, Bo-Ra Seo, Insuk So, Sang-Yeob Kim, Dong-Jun Bae, Mi-Ha Park, Hye Min Lim, In-Jeoung Baek, Antonio Riccio, Joo-Yong Lee, Woo Hyun Shim, Bumwoo Park, Jae-Young Koh, Jung Jin Hwang
MOLECULAR NEUROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jae-Won Eom, Tae-Youn Kim, Bo-Ra Seo, Hwangseo Park, Jae-Young Koh, Yang-Hee Kim
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Cell Biology
Ji Hyun Shin, So Jung Park, Doo Sin Jo, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Yoon Kyung Jo, Jung Jin Hwang, Jin-A Lee, Dong-Gyu Jo, Jin Cheon Kim, Yong Keun Jung, Jae-Young Koh, Dong-Hyung Cho
Review
Neurosciences
Jae-Young Koh, Ha Na Kim, Jung Jin Hwang, Yang-Hee Kim, Sang Eun Park
Article
Multidisciplinary Sciences
YoungSoo Kim, Yong Kyoung Yoo, Hye Yun Kim, Jee Hoon Roh, Jinsik Kim, Seungyeop Baek, Jinny Claire Lee, Hye Jin Kim, Myung-Sic Chae, Dahye Jeong, Dongsung Park, Sejin Lee, HoChung Jang, Kyeonghwan Kim, Jeong Hoon Lee, Byung Hyun Byun, Su Yeon Park, Jeong Ho Ha, Kyo Chul Lee, Won Woo Cho, Jae-Seung Kim, Jae-Young Koh, Sang Moo Lim, Kyo Seon Hwang
Article
Cell Biology
Doo Sin Jo, So Jung Park, Ae-Kyeong Kim, Na Yeon Park, Joon Bum Kim, Ji-Eun Bae, Hyun Jun Park, Ji Hyun Shin, Jong Wook Chang, Peter K. Kim, Yong-Keun Jung, Jae-Young Koh, Seong-Kyu Choe, Kyu-Sun Lee, Dong-Hyung Cho
Article
Multidisciplinary Sciences
Young Hyun Cho, Seung-Hwan Lee, Sook-Jeong Lee, Ha Na Kim, Jae-Young Koh
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Bo Young Choi, Jeong Hyun Jeong, Jae-Won Eom, Jae-Young Koh, Yang-Hee Kim, Sang Won Suh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Hyun-Seo Park, Min Heui Yoo, Jae-Young Koh
NEUROBIOLOGY OF DISEASE
(2020)
Article
Cell & Tissue Engineering
Bo Young Choi, Dae Ki Hong, Jeong Hyun Jeong, Bo Eun Lee, Jae-Young Koh, Sang Won Suh
Review
Neurosciences
Jae-Young Koh, Sook-Jeong Lee
Review
Neurosciences
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Eoi Jong Seo, Jeong A. Choi, Jae-Young Koh, Young Hee Yoon
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Neurosciences
Huikyong Lee, Jae-Young Koh
Summary: The study revealed that cAMP can reverse lysosomal acidification defects through the activation of protein kinase A, and increase autophagy flux. Moreover, in the presence of v-ATPase inhibition, H+/K+-ATPase may act as an alternative route for lysosomal acidification.
Article
Pharmacology & Pharmacy
Jun-Sub Jung, A. Ra Kho, Song Hee Lee, Bo Young Choi, Shin-Hae Kang, Jae-Young Koh, Sang Won Suh, Dong-Keun Song
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2020)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)