Article
Chemistry, Multidisciplinary
Hongshuang Qin, Tingting Cui, Zhenqi Liu, Ya Zhou, Jingsheng Niu, Jinsong Ren, Xiaogang Qu
Summary: Recent research has shown that oligomeric Aβ1-42 and Aβ1-40 can suppress the viability of breast cancer stem cells by disrupting iron homeostasis, leading to iron accumulation in lysosomes, triggering ROS production, and inducing stem cell death. In vivo experiments demonstrate that pretreatment with OAβ1-42 inhibits tumor formation in breast cancer stem cells. These findings suggest that OAβ1-42 and OAβ1-40 have multifaceted capabilities in eliminating cancer stem cells.
Article
Clinical Neurology
Hyuk Sung Kwon, Ye Eun Kim, Hyun-Hee Park, Jeong-Woo Son, Hojin Choi, Young Joo Lee, Hyun Young Kim, Kyu-Yong Lee, Seong-Ho Koh
Summary: The study demonstrates the neuroprotective effects of GV1001 on neural cells and rat brain ischemia-reperfusion injury, achieved through inducing cellular proliferation, mitochondrial stabilization, and antioxidant effects.
Article
Chemistry, Multidisciplinary
Oxana V. Galzitskaya, Olga M. Selivanova, Elena Y. Gorbunova, Leila G. Mustaeva, Viacheslav N. Azev, Alexey K. Surin
Summary: Under certain conditions, proteins and peptides can self-assemble into various supramolecular structures with potential pathological or functional implications. Fibrils, films, and amyloid gels are promising objects for nanobiotechnology research. Understanding the mechanism of structure formation and its influencing factors is crucial for developing nanobiomaterials with desired properties.
Article
Biotechnology & Applied Microbiology
Akiko Amano, Nobuo Sanjo, Wataru Araki, Yasutaka Anraku, Makoto Nakakido, Etsuro Matsubara, Takami Tomiyama, Tetsuya Nagata, Kouhei Tsumoto, Kazunori Kataoka, Takanori Yokota
Summary: Researchers developed polymeric nanomicelles capable of passing through the blood-brain barrier to deliver specific antibodies to the brain. The administration of 6H4 antibody fragments in polymeric nanomicelles for 10 weeks significantly reduced the amounts of toxic A beta species in the brain and inhibited the formation of A beta plaques. Behavioral analysis also showed an improvement in spatial reference memory in mice with Alzheimer's disease.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Faraz Vosough, Andreas Barth
Summary: Soluble oligomers of the amyloid-beta(1-42) peptide, which are considered neurotoxic in Alzheimer's disease, were characterized using biochemical and biophysical methods. The size of the oligomers was found to correlate with the position of the main amide I' band in the IR spectra, with larger oligomers having lower wavenumbers. Time-resolved aggregation experiments showed a more homogeneous absorption of beta-sheets in the oligomers after several hours, due to the consumption of smaller oligomers.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiong Zhu, Xiaoxun Xu, Beibei Chen, Yiyi Liao, Xue Guan, Ying He, Hai Cui, Yani Rong, Zheng Liu, Yali Xu
Summary: This study explored the feasibility, efficacy, and safety of ultrasound-targeted microbubbles destruction-assisted dual delivery of beta-amyloid antibody and neural stem cells for Alzheimer's disease. The results showed that the dual delivery treatment improved memory and spatial learning, promoted Aβ plaques clearance, and increased BDNF expression, providing potential insight for AD treatment.
Article
Biochemistry & Molecular Biology
Young-Hwan Ban, Dongsun Park, Ehn-Kyoung Choi, Tae Myoung Kim, Seong Soo Joo, Yun-Bae Kim
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease characterized by degeneration of the cholinergic system. Cell-based therapeutic approaches, such as using human neural stem cells and microglial cells, show promise in restoring cognitive function and reducing A beta accumulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Qisheng Luo, Dehong Yu, Zichun Song, Jiuying Cui, Yuanxun Gong, Qianli Tang, Xianjiu Liao, Ning Xin, Fenglei Gao
Summary: We have developed a bipedal driven catalytic hairpin assembly for the electrochemical detection of highly sensitive amyloid-beta oligomers. Aptamers specifically recognize of amyloid-beta oligomers can activate catalytic hairpin assembly and form bipedal molecular machines, achieving amplification of the electrochemical signal. This enzyme-free detection method can realize high sensitivity and specificity detection of multiple target proteins, and has reference significance and application value in the field of biological detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Dehua Huang, Yuheng Cao, Xue Yang, Yongyang Liu, Yejun Zhang, Chunyan Li, Guangcun Chen, Qiangbin Wang
Summary: Alzheimer's disease is a common form of dementia that currently has no cure. Existing treatments can only moderately relieve symptoms and slow progression. Research on nanoformulation-mediated NSC therapy in a murine model shows potential for improving cognitive impairments by enhancing A beta degradation and neural regeneration.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Daijiro Yanagisawa, Tomoko Kato, Hiroyasu Taguchi, Nobuaki Shirai, Koichi Hirao, Takayuki Sogabe, Takami Tomiyama, Keizo Gamo, Yukie Hirahara, Masaaki Kitada, Ikuo Tooyama
Summary: The study found that the keto form of curcumin derivative Shiga-Y51 shows strong binding activity for A beta oligomers, but has scant affinity for A beta fibrils. Imaging mass spectrometry revealed the blood-brain barrier permeability of Shiga-Y51 and its accumulation in the brain, making it a promising seed compound for developing imaging probes and therapeutic agents targeting A beta oligomers in Alzheimer's disease.
Review
Biochemistry & Molecular Biology
Wenjun Cai, Tong Wu, Ning Chen
Summary: The deposition of amyloid-beta (A beta) plaques in the brain is a primary pathological characteristic of Alzheimer's disease (AD) and can occur decades before clinical symptoms appear. The imbalance between A beta production and clearance is a major cause of AD. Direct inhibition of A beta production and aggregation has not been effective in clinical trials, necessitating novel approaches to combat A beta deposition. Understanding the role of non-neuronal cells in AD and utilizing patient-derived pluripotent stem cells (PSCs) can provide valuable insights for developing AD disease models and identifying new therapeutic targets. This review provides an overview of the latest studies on A beta clearance and highlights the importance of cell interactions in response to A beta plaques.
Article
Biochemistry & Molecular Biology
Ming-Chang Chiang, Christopher J. B. Nicol
Summary: This study demonstrates that glutathione conjugated gold nanoparticles (GSH-AuNPs) have the potential therapeutic value for Alzheimer's disease (AD) by protecting neural stem cells (hNSCs) from A beta-induced oxidative stress, endoplasmic reticulum stress, and mitochondrial dysfunction. GSH-AuNPs restore the expression of key genes and maintain cellular homeostasis in A beta-treated hNSCs.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Elisabetta Clementi, Beatrice Sampaolese, Gabriele Di Sante, Francesco Ria, Rosa Di Liddo, Vincenzo Romano Spica, Fabrizio Michetti
Summary: The study demonstrated that the expression of S100B in astrocytoma cells plays a crucial role in the activation of reactive astrocytic processes, including cytotoxicity, ROS and NOS activation. Silencing S100B in astrocytoma cells effectively protected the cells from amyloid beta-peptide-induced damage, reducing cell death, oxygen radical generation and nitric oxide synthase activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Catalini, Diego R. Perinelli, Paola Sassi, Lucia Comez, Giovanni F. Palmieri, Assunta Morresi, Giulia Bonacucina, Paolo Foggi, Stefania Pucciarelli, Marco Paolantoni
Summary: A method for quickly forming protein hydrogels has been designed based on the self-assembly of highly concentrated lysozyme solutions in acidic conditions, with properties easily modulated by selecting the curing temperature. Molecular insights from in situ FTIR spectroscopy, calorimetric, and rheological results have provided a consistent picture on structure-property correlations, showing formation of interconnected amyloid oligomers.
Article
Oncology
Ying-Gui Yang, Young Wha Koh, Ita Novita Sari, Nayoung Jun, Sanghyun Lee, Lan Thi Hanh Phi, Kwang Seock Kim, Yoseph Toni Wijaya, Sang Hun Lee, Moo-Jun Baek, Dongjun Jeong, Hyog Young Kwon
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Biochemistry & Molecular Biology
Eun Ji Kang, Yu Mi Baek, Eunil Hahm, Sang Hun Lee, Xuan-Hung Pham, Mi Suk Noh, Dong-Eun Kim, Bong-Hyun Jun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Endocrinology & Metabolism
Yong-Seok Han, Sang Min Kim, Jun Hee Lee, Seo Kyung Jung, Hyunjin Noh, Sang Hun Lee
JOURNAL OF PINEAL RESEARCH
(2019)
Article
Telecommunications
Hyun-Ho Han, Seuc-Ho Ryu, Gyoo-Soo Chae, Sang-Hun Lee
WIRELESS PERSONAL COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Chul Won Yun, Sang Hun Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Physical
Xuan-Hung Pham, Eunil Hahm, Eunji Kang, Yu Na Ha, Sang Hun Lee, Won-Yeop Rho, Yoon-Sik Lee, Dae Hong Jeong, Bong-Hyun Jun
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Article
Oncology
Hyun Jin Roh, Eun Byeol Go, Kyung Bin Kim, Jong Hwa Lee, Sang Hun Lee
ANTICANCER RESEARCH
(2019)
Review
Medicine, General & Internal
Jong Hwa Lee, Hyun Jin Roh, Jun Woo Ahn, Jeong Sook Kim, Jin Young Choi, Soo-Jeong Lee, Sang Hun Lee
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Medicine, General & Internal
Jin-Young Choi, Song-Soo Yang, Jong-Hwa Lee, Hyun-Jin Roh, Jun-Woo Ahn, Jeong-Sook Kim, Soo-Jeong Lee, Sang-Hun Lee
Summary: Congenital diaphragmatic hernia, especially Bochdalek hernia, during pregnancy is rare but can lead to high morbidity and mortality. Early diagnosis and surgical intervention are crucial, with multidisciplinary care and individualized treatment being key to optimal results for both the mother and fetus.
Review
Medicine, General & Internal
Ok Ju Kang, Ji Hye Koh, Ji Eun Yoo, So Yeon Park, Jeong-Ik Park, Songsoo Yang, Sang-Hun Lee, Soo-Jeong Lee, Jun-Woo Ahn, Hyun-Jin Roh, Jeong Sook Kim
Summary: Non-tubal ectopic pregnancies with abdominal hemorrhaging have significantly higher mortality and morbidity rates compared to tubal pregnancies. Prompt diagnosis and management through laparoscopic surgery are crucial for improving prognosis in cases of primary diaphragmatic ectopic pregnancy with hemorrhage.
Review
Medicine, General & Internal
Hyoeun Kim, Ji Hye Koh, Jihee Lee, Yeongeun Sim, Sang-Hun Lee, Soo-Jeong Lee, Jun-Woo Ahn, Hyun-Jin Roh, Jeong Sook Kim
Summary: This case report presents a successful treatment for heterotopic cesarean scar pregnancy, using selective potassium chloride injection into the scar pregnancy and uterine cerclage to control vaginal bleeding, resulting in the preservation of the intrauterine pregnancy and full-term delivery.
Review
Medicine, General & Internal
Sang Hun Lee, Songsoo Yang, Inkyu Park, Yeong Cheol Im, Gyu Yeol Kim
Summary: This case report describes a 33-year-old pregnant woman who experienced a sudden onset of epigastric pain at 18 weeks of pregnancy due to a ruptured SAA. After emergent intervention and surgery, the woman recovered without complications and was discharged 15 days postoperatively, even though the fetus was found to be dead during resuscitation.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Urology & Nephrology
Seong Cheol Kim, Won Hyeok Lee, Song Hee Kim, Abdumadjidov Alisher Abdulkhayevich, Jeong Woo Park, Young Min Kim, Kyung Hyun Moon, Sang Hun Lee, Sungchan Park
Summary: This study confirms the association between DRG2 expression and docetaxel-induced apoptosis in prostate cancer cells. Knockdown of DRG2 increases docetaxel-induced apoptosis without G2/M arrest, showing potential to enhance treatment outcomes in castration-resistant prostate cancer.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Oncology
Jeong-Yeol Park, Sang-Hun Lee, Kyu-Rae Kim, Young-Tak Kim, Joo-Hyun Nam
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
