A Nanoformulation‐Mediated Multifunctional Stem Cell Therapy with Improved Beta‐Amyloid Clearance and Neural Regeneration for Alzheimer's Disease

Stable Polymer Nanoparticles with Exceptionally High Drug Loading by Sequential Nanoprecipitation

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MOF-encapsulated nanozyme enhanced siRNA combo: Control neural stem cell differentiation and ameliorate cognitive impairments in Alzheimer's disease model

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Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

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A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

(2019) Yu-Chen Chen et al.   MOLECULAR THERAPY

Early network dysfunction in Alzheimer's disease

(2019) Dennis J. Selkoe   SCIENCE

A vicious cycle of β amyloid–dependent neuronal hyperactivation

(2019) Benedikt Zott et al.   SCIENCE

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

The Regulatory Functionality of Exosomes Derived from hUMSCs in 3D Culture for Alzheimer's Disease Therapy

(2019) Lingyan Yang et al.   Small

Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2019) Ting Zhang et al.   Stem Cell Reports

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Challenges and Opportunities for Intravital Near-Infrared Fluorescence Imaging Technology in the Second Transparency Window

(2018) Chunyan Li et al.   ACS Nano

An NIR-II Fluorescence/Dual Bioluminescence Multiplexed Imaging for In Vivo Visualizing the Location, Survival, and Differentiation of Transplanted Stem Cells

(2018) Dehua Huang et al.   ADVANCED FUNCTIONAL MATERIALS

Manipulation of Transgene Expression in Fibroblast Cells by a Multifunctional Linear-Branched Hybrid Poly(β-Amino Ester) Synthesized through an Oligomer Combination Approach

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A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies

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A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

(2017) Jun Wang et al.   Nature Reviews Neurology

Near-infrared fluorophores for biomedical imaging

(2017) Guosong Hong et al.   Nature Biomedical Engineering

Cytosolic Extract of Human Adipose Stem Cells Reverses the Amyloid Beta-Induced Mitochondrial Apoptosis via P53/Foxo3a Pathway

(2017) Tian Liu et al.   PLoS One

Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy

(2016) Ran Zhang et al.   ADVANCED MATERIALS

Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain

(2016) Xiaowei Li et al.   BIOMATERIALS

Stem cell therapy for Alzheimer's disease: hope or hype?

(2016) Selina Wray et al.   LANCET NEUROLOGY

Accelerating stem cell trials for Alzheimer's disease

(2016) Joshua G Hunsberger et al.   LANCET NEUROLOGY

Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy

(2016) Juan Yang et al.   Molecular Neurodegeneration

Exosomes in Alzheimer's disease

(2016) Tarja Malm et al.   NEUROCHEMISTRY INTERNATIONAL

Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury

(2015) Zhe Wang et al.   ACS Nano

Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks

(2015) Annette Tennstaedt et al.   BIOMATERIALS

Potential of neural stem cell-based therapies for Alzheimer's disease

(2015) Xue-Yuan Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions

(2015) Sandrine Andrieu et al.   LANCET NEUROLOGY

Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons

(2015) K Nieweg et al.   Cell Death & Disease

Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

(2014) Mathew Blurton-Jones et al.   Stem Cell Research & Therapy

Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near-Infrared Ag2S Quantum Dots

(2013) Guangcun Chen et al.   ADVANCED FUNCTIONAL MATERIALS

Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation

(2013) Alex Crowe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Vehicular Delivery of siRNA and Small Molecules to Control Stem Cell Differentiation

(2013) Shreyas Shah et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

(2013) Nobuhisa Iwata et al.   Scientific Reports

Multifunctional core-shell polymeric nanoparticles for transdermal DNA delivery and epidermal Langerhans cells tracking

(2010) Po-Wei Lee et al.   BIOMATERIALS

The Wnt /β-catenin signaling pathway in the adult neurogenesis

(2010) Lin Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

(2010) Adi Shruster et al.   JOURNAL OF NEUROCHEMISTRY

Near-Infrared Photoluminescent Ag2S Quantum Dots from a Single Source Precursor

(2010) Yaping Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neurod1 is essential for the survival and maturation of adult-born neurons

(2009) Zhengliang Gao et al.   NATURE NEUROSCIENCE

Sox9 Inhibits Wnt Signaling by Promoting β-Catenin Phosphorylation in the Nucleus

(2008) Lilia Topol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY