Article
Neurosciences
Chenhui Mao, Longze Sha, Jie Li, Xinying Huang, Shanshan Chu, Dan Lei, Jie Wang, Liling Dong, Caiyan Liu, Qi Xu, Bin Peng, Jing Gao
Summary: CSF biomarkers play a significant role in the diagnosis of AD, but do not correlate well with clinical progression, and should be interpreted in conjunction with MRI and cognitive evaluation.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Eun Jin Yoon, Jun-Young Lee, Seyul Kwak, Yu Kyeong Kim
Summary: Mild behavioral impairment (MBI) is a neurobehavioral syndrome associated with a higher risk of progression to Alzheimer's disease (AD) in individuals with amnestic mild cognitive impairment (MCI). The presence of multiple MBI domains is also associated with cortical thinning in specific brain regions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, Alzheimer's Disease Neuroimaging Initiative Alzheimers Dis Neuroimaging Initiative
Summary: This study examined the associations of APOE alleles and polygenic profiles with cerebrospinal fluid and plasma biomarkers, revealing differential effects of specific alleles on different biomarkers.
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Yuetiva Deming, Eva Vasiljevic, Autumn Morrow, Jiacheng Miao, Carol Van Hulle, Erin Jonaitis, Yue Ma, Vanessa Whitenack, Gwendlyn Kollmorgen, Norbert Wild, Ivonne Suridjan, Leslie M. Shaw, Sanjay Asthana, Cynthia M. Carlsson, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Barbara B. Bendlin, Qiongshi Lu, Corinne D. Engelman
Summary: APOE epsilon 4-carrier status and epsilon 4 allele count are not sufficient to fully account for the effects of APOE on Alzheimer's disease. A weighted risk score (APOE-npscore) was developed to better explain the genetic effect on neuropathology and provide an improved method for analyzing APOE in relation to AD. This approach outperformed the traditional APOE epsilon 4-carrier status and epsilon 4 allele count in predicting CSF biomarker changes.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Keun You Kim, Junghee Ha, Minae Kim, So Yeon Cho, Hyunjeong Kim, Eosu Kim
Summary: This study investigated the association between blood adiponectin and leptin levels and future cognitive decline and cortical thinning. The results showed that higher plasma adiponectin levels were associated with faster cognitive decline and cortical thinning in individuals with Aβ(+) MCI. Plasma leptin levels were not predictive of cognition or cortical thickness regardless of Aβ status.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Catarina Bernardes, Marisa Lima, Diana Duro, Anuschka Silva-Spinola, Joao Duraes, Miguel Tabuas-Pereira, Ines Baldeiras, Sandra Freitas, Isabel Santana
Summary: This study confirms the role of cerebrospinal fluid Alzheimer's disease biomarkers in predicting conversion from mild cognitive impairment to dementia and suggests the utility of Montreal Cognitive Assessment in predicting conversion in highly educated subjects, supporting its use in the evaluation of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Xiaopei Xu, Luwei Hong, Jixuan Li, Xiaojun Guan, Xiaojun Xu, Peiyu Huang, Min-Ming Zhang
Summary: This study investigated the effect of the APOE epsilon 2 allele on basal forebrain cholinergic system functional connectivity in cognitively normal and mild cognitive impairment patients. The results showed an interaction effect between APOE epsilon 2 genotype and functional connectivity, and the functional connectivity was associated with cognitive performance. Therefore, the APOE epsilon 2 genotype may have a protective role in mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Zahinoor Ismail, Rebeca Leon, Byron Creese, Clive Ballard, Philippe Robert, Eric E. Smith
Summary: This study investigated the association between mild behavioral impairment (MBI) in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and found that adding MBI to MCI can better identify AD and improve dementia prognostication. Therefore, the addition of MBI is important for the detection of AD.
MOLECULAR NEURODEGENERATION
(2023)
Article
Geriatrics & Gerontology
Mark Sanderson-Cimino, Jeremy A. Elman, Xin M. Tu, Alden L. Gross, Matthew S. Panizzon, Daniel E. Gustavson, Mark W. Bondi, Emily C. Edmonds, Joel S. Eppig, Carol E. Franz, Amy J. Jak, Michael J. Lyons, Kelsey R. Thomas, McKenna E. Williams, William S. Kremen
Summary: Cognitive practice effects (PEs) can impact the diagnosis and progression prediction of MCI, increasing prevalence, reducing reversion rates, and increasing the risk of dementia. Accounting for PEs can improve diagnostic accuracy and the prediction ability of dementia in MCI diagnoses.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Elena Sagues-Sese, Jose Rioja, Francisco J. Garzon-Maldonado, Manuel Narvaez, Juan A. Garcia-Arnes, Natalia Garcia-Casares
Summary: This systematic review provides an overview of the state-of-the-art knowledge about insulin-related cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) and mild cognitive impairment (MCI). The results indicate decreased levels of CSF insulin and increased levels of insulin-related growth factors and their binding proteins.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Astrid Suchy-Dicey, Barbara Howard, W. T. Longstreth, Eric M. Reiman, Dedra Buchwald
Summary: This study found no evidence of an association between the APOE epsilon 4 allele and neurodegenerative risk in American Indians. Further research is needed to explore potential protective features.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Ayu Imai, Teruyuki Matsuoka, Jin Narumoto
Summary: This study investigated the relationship between mild behavioral impairment (MBI) and volume, cortical thickness, and surface area in the temporal and parietal lobes. The results showed that MBI, specifically in the emotional dysregulation domain, was associated with reduced cortical thickness in the right parahippocampal and supramarginal gyri. This suggests that MBI may serve as a predictor of early Alzheimer's disease (AD) below the diagnostic threshold.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Geriatrics & Gerontology
Mitzi M. Gonzales, Philip S. Insel, Craig Nelson, Duygu Tosun, Michael Schoell, Niklas Mattsson, Simona Sacuiu, David Bickford, Michael W. Weiner, R. Scott Mackin
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2018)
Article
Neurosciences
Fon Powell, Duygu Tosun, Roksana Sadeghi, Michael Weiner, Ashish Raj
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Clinical Neurology
Chin Hong Tan, Luke W. Bonham, Chun Chieh Fan, Elizabeth C. Mormino, Leo P. Sugrue, Iris J. Broce, Christopher P. Hess, Jennifer S. Yokoyama, Gil D. Rabinovici, Bruce L. Miller, Kristine Yaffe, Gerard D. Schellenberg, Karolina Kauppi, Dominic Holland, Linda K. McEvoy, Walter A. Kukull, Duygu Tosun, Michael W. Weiner, Reisa A. Sperling, David A. Bennett, Bradley T. Hyman, Ole A. Andreassen, Anders M. Dale, Rahul S. Desikan
Article
Clinical Neurology
Neha Prakash, Chelsea Caspell-Garcia, Christopher Coffey, Andrew Siderowf, Caroline M. Tanner, Karl Kieburtz, Brit Mollenhauer, Douglas Galasko, Kalpana Merchant, Tatiana Foroud, Lana M. Chahine, Daniel Weintraub, Cindy Casaceli, Ray Dorsey, Renee Wilson, Margaret Herzog, Nichole Daegele, Vanessa Arnedo, Mark Frasier, Todd Sherer, Ken Marek, Samuel Frank, Danna Jennings, Tanya Simuni, Kenneth Marek, Andrew Siderowf, John Seibyl, Christopher Coffey, Caroline Tanner, Duygu Tosun-Turgut, Tanya Simunir, Leslie Shaw, John Trojanowski, Andrew Singleton, Karl Kieburtz, Arthur Toga, Brit Mollenhauer, Douglas Galasko, Werner Poewe, Tatiana Foroud, Kathleen Poston, Todd Sherer, Sohini Chowdhury, Mark Frasier, Catherine Kopil, Vanessa Arnedo, Nichole Daegele, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Christina Salerno, Chelsea Caspell-Garcia, Arthur Toga, Karen Crawford, Tatiana Foroud, Paola Casalin, Giulia Malferrari, Mali Gani Weisz, Avi Orr-Urtreger, John Trojanowski, Leslie Shaw, Thomas Montine, David Russell, Tanya Simuni, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Susan Bressman, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Karen Williams, Whitney Richardson, Diana Willeke, Shawnees Peacock, Beatrice Heim, Anat Mirelman, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Lisbeth Carvajal, Stephanie Carvalho, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Buis Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
PARKINSONISM & RELATED DISORDERS
(2019)
Article
Clinical Neurology
Matthew J. Betts, Evgeniya Kirilina, Maria C. G. Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F. Callaghan, Christian Lambert, Arturo Cardenas-Blanco, Kerrin Pine, Luca Passamonti, Clare Loane, Max C. Keuken, Paula Trujillo, Falk Luesebrink, Hendrik Mattern, Kathy Y. Liu, Nikos Priovoulos, Klaus Fliessbach, Martin J. Dahl, Anne Maass, Christopher F. Madelung, David Meder, Alexander J. Ehrenberg, Oliver Speck, Nikolaus Weiskopf, Raymond Dolan, Ben Inglis, Duygu Tosun, Markus Morawski, Fabio A. Zucca, Hartwig R. Siebner, Mara Mather, Kamil Uludag, Helmut Heinsen, Benedikt A. Poser, Robert Howard, Luigi Zecca, James B. Rowe, Lea T. Grinberg, Heidi I. L. Jacobs, Emrah Duezel, Dorothea Haemmerer
Article
Geriatrics & Gerontology
Rachel L. Nosheny, Philip S. Insel, Niklas Mattsson, Duygu Tosun, Shannon Buckley, Diana Truran, N. Schuff, Paul S. Aisen, Michael W. Weiner
NEUROBIOLOGY OF AGING
(2019)
Article
Clinical Neurology
Tanya Simuni, Liz Uribe, Hyunkeun Ryan Cho, Chelsea Caspell-Garcia, Christopher S. Coffey, Andrew Siderowf, John Q. Trojanowski, Leslie M. Shaw, John Seibyl, Andrew Singleton, Arthur W. Toga, Doug Galasko, Tatiana Foroud, Duygu Tosun, Kathleen Poston, Daniel Weintraub, Brit Mollenhauer, Caroline M. Tanner, Karl Kieburtz, Lana M. Chahine, Alyssa Reimer, Samantha J. Hutten, Susan Bressman, Kenneth Marek, Vanessa Arnedo, Adrienne Clark, Mark Fraiser, Catherine Kopil, Sohini Chowdhury, Todd Sherer, Nichole Daegele, Christina Salerno, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Karen Crawford, Paola Casalin, Giulia Malferrari, Mali GaniWeisz, Avi Orr-Urtreger, Thomas Montine, Chris Baglieri, Amanda Christini, David Russell, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Karen Williams, Whitney Richardson, Diana Willeke, Shawnees Peacock, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Stephanie Carvalo, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Baris Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
Article
Clinical Neurology
Tanya Simuni, Michael C. Brumm, Liz Uribe, Chelsea Caspell-Garcia, Christopher S. Coffey, Andrew Siderowf, Roy Alcalay, John Q. Trojanowski, Leslie M. Shaw, John Seibyl, Andrew Singleton, Arthur W. Toga, Doug Galasko, Tatiana Foroud, Kelly Nudelman, Duygu Tosun-Turgut, Kathleen Poston, Daniel Weintraub, Brit Mollenhauer, Caroline M. Tanner, Karl Kieburtz, Lana M. Chahine, Alyssa Reimer, Samantha Hutten, Susan Bressman, Kenneth Marek, Christopher Coffey, Caroline Tanner, Arthur Toga, Douglas Galasko, Werner Poewe, Vanessa Arnedo, Adrienne Clark, Mark Frasier, Catherine Kopil, Sohini Chowdhury, Todd Sherer, Nichole Daegele, Cynthia Casaceli, Ray Dorsey, Renee Wilson, Sugi Mahes, Christina Salerno, Karen Crawford, Paola Casalin, Giulia Malferrari, Mali Gani Weisz, Avi Orr-Urtreger, John Trojanowski, Leslie Shaw, Thomas Montine, Chris Baglieri, Amanda Christini, David Russell, Nabila Dahodwala, Nir Giladi, Stewart Factor, Penelope Hogarth, David Standaert, Robert Hauser, Joseph Jankovic, Marie Saint-Hilaire, Irene Richard, David Shprecher, Hubert Fernandez, Katrina Brockmann, Liana Rosenthal, Paolo Barone, Alberto Espay, Dominic Rowe, Karen Marder, Anthony Santiago, Shu-Ching Hu, Stuart Isaacson, Jean-Christophe Corvol, Javiar Ruiz Martinez, Eduardo Tolosa, Yen Tai, Marios Politis, Debra Smejdir, Linda Rees, Karen Williams, Farah Kausar, Whitney Richardson, Diana Willeke, Shawnees Peacock, Barbara Sommerfeld, Alison Freed, Katrina Wakeman, Courtney Blair, Stephanie Guthrie, Leigh Harrell, Christine Hunter, Cathi-Ann Thomas, Raymond James, Grace Zimmerman, Victoria Brown, Jennifer Mule, Ella Hilt, Kori Ribb, Susan Ainscough, Misty Wethington, Madelaine Ranola, Helen Mejia Santana, Juliana Moreno, Deborah Raymond, Krista Speketer, Lisbeth Carvajal, Stephanie Carvalo, Ioana Croitoru, Alicia Garrido, Laura Marie Payne, Veena Viswanth, Lawrence Severt, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Kevin Biglan, Emily Vandenbroucke, Zulfiqar Haider Sheikh, Baris Bingol, Tanya Fischer, Pablo Sardi, Remi Forrat, Alastair Reith, Jan Egebjerg, Gabrielle Ahlberg Hillert, Barbara Saba, Chris Min, Robert Umek, Joe Mather, Susan De Santi, Anke Post, Frank Boess, Kirsten Taylor, Igor Grachev, Andreja Avbersek, Pierandrea Muglia, Kaplana Merchant, Johannes Tauscher
MOVEMENT DISORDERS
(2020)
Article
Biology
Ryan Ellis, Erik Ellestad, Brett Elicker, Michael D. Hope, Duygu Tosun
COMPUTERS IN BIOLOGY AND MEDICINE
(2020)
Article
Neurosciences
R. Scott Mackin, Philip S. Insel, Susan Landau, David Bickford, Ruth Morin, Emma Rhodes, Duygu Tosun, Howie J. Rosen, Meryl Butters, Paul Aisen, Rema Raman, Andrew Saykin, Arthur Toga, Clifford Jack, Robert Koeppe, Michael W. Weiner, Craig Nelson
Summary: The study evaluated the role of cortical amyloid deposition in memory dysfunction and dementia risk associated with late-life depression. Contrary to expectations, the late-life depression group showed less A13 deposition than the non-depressed group, and A13 deposition was not associated with depression history characteristics. However, A13 deposition was associated with memory performance.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Julie Lutz, R. Scott Mackin, Marcela C. Otero, Ruth Morin, David Bickford, Duygu Tosun, Derek D. Satre, Christine E. Gould, J. Craig Nelson, Sherry A. Beaudreau
Summary: The study revealed that decreased functional disability following psychotherapy for depression was associated with reduced suicide ideation among older adults, particularly in relation to feelings of worthlessness. Therefore, treatments aimed at reducing functional disability may help mitigate the risk of suicide in this population.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Duygu Tosun, Zeynep Demir, Dallas P. Veitch, Daniel Weintraub, Paul Aisen, Clifford R. Jack, William J. Jagust, Ronald C. Petersen, Andrew J. Saykin, Leslie M. Shaw, John Q. Trojanowski, Michael W. Weiner
Summary: Aβ, tau, and neurodegeneration have significant impacts on cognitive impairment and cognitive decline, while AD risk factors also play an important role in affecting disease progression.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Duygu Tosun, Pamela Thropp, Sudeepti Southekal, Bruce Spottiswoode, Rachid Fahmi
Summary: This study used an unsupervised data-driven whole-brain pattern analysis to identify distinct tau accumulation profiles and build baseline models predictive of tau-accumulation type. Screening for fast tau accumulation and A beta positivity in early Alzheimer's disease requires a lower sample size to achieve 80% power for a specific treatment.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Duygu Tosun, Ozlem Yardibi, Tammie L. S. Benzinger, Walter A. Kukull, Colin L. Masters, Richard J. Perrin, Michael W. Weiner, Arthur Simen, Adam J. Schwarz, lzheimers Dis Neuroimaging Initiative
Summary: In this study, a multilabel non-ADNC classifier using MRI signatures was developed for the identification of non-Alzheimer's disease neuropathological changes. The model showed high accuracy in distinguishing TDP-43, LBD, and CAA, outperforming reference models without MRI and ADNC biomarkers. Considering non-ADNC decreased the required sample size to detect cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Fon Powell, Duygu Tosun, Ashish Raj
Summary: Current methods for measuring the chronic rates of cognitive decline and degeneration in Alzheimer's disease rely on longitudinal neuropsychological batteries and clinical neuroimaging. Predicting future disease progression has proven challenging, with brain network diffusion models offering a potential solution to accurately estimate pathology transmission rates. Using machine learning, a new metric based on MRI-derived atrophy data was able to predict disease progression across different diagnostic groups and genetic risk factors.
BRAIN COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)