Article
Biochemistry & Molecular Biology
Amandine Jullienne, Ryan Quan, Jenny Szu, Michelle Trinh, Erik J. Behringer, Andre Obenaus
Summary: This study utilized the 3xTg-AD mouse model to examine the role of vascular dysfunction and structural abnormalities in the progression of Alzheimer's disease. The findings demonstrate progressive alterations in individual cortical vessels and the cortical vascular network, potentially identifying unique diagnostic signatures of AD progression.
Article
Geriatrics & Gerontology
Xixia Chu, Yujun Hou, Qiong Meng, Deborah L. Croteau, Yong Wei, Supriyo De, Kevin G. Becker, Vilhelm A. Bohr
Summary: The study suggests that gut dysbiosis and gut microbiota-host interactions play an important role in aging and neurodegenerative diseases such as Alzheimer's disease. Supplementation with the NAD(+) precursor, nicotinamide riboside, can improve the diversity and composition of the gut microbiota in AD mice, indicating its therapeutic potential in AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Yu-Ting Hu, Xin-Lu Chen, Ya-Nan Zhang, Hugo McGurran, Jochem Stormmesand, Nicole Breeuwsma, Arja Sluiter, Juan Zhao, Dick Swaab, Ai-Min Bao
Summary: Epidemiological studies have shown that women have a higher prevalence of Alzheimer's disease (AD) than men. This study aimed to investigate the role of estrogen and the transcription factor EGR1 in AD pathogenesis using the 3xTg-AD mouse model. The results showed sex differences in levels of Aβ in the hippocampus and suggested that local E2 may have protective effects on EGR1 and cholinergic functions in AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Xiaolin Zhang, Ning Shen, Minghua Li, Jianfeng Cai, Marcia Gordon, David Morgan, Qingyu Zhou, Chuanhai Cao
Summary: This study aimed to investigate the therapeutic effect of low-dose delta-9-tetrahydrocannabinol (THC) in Alzheimer's disease (AD). The results showed that low-dose THC can reduce amyloid-beta aggregation and improve spatial learning in aged AD mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sandrine Joly, Lea Rodriguez, Vincent Pernet
Summary: The study found that in aging mice, the amyloidogenic and nonamyloidogenic pathways are not involved in visual function decline, and retinal neurons do not have the capacity to secrete A beta like other cortical and hippocampal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Raquel Sanchez-Varo, Marina Mejias-Ortega, Juan Jose Fernandez-Valenzuela, Cristina Nunez-Diaz, Laura Caceres-Palomo, Laura Vegas-Gomez, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Juan Antonio Garcia-Leon, Ines Moreno-Gonzalez, Marisa Vizuete, Javier Vitorica, David Baglietto-Vargas, Antonia Gutierrez
Summary: This review provides an overview of the major pathological elements of Alzheimer's disease and discusses the insights provided by mouse models in understanding the underlying mechanisms. It highlights the pros and cons of current models and explores the potential benefits of combining transgenic mice with omics technologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Jenny Szu, Andre Obenaus
Summary: Alzheimer's disease is a devastating neurological disorder characterized by memory and cognitive decline, with two main hypotheses proposed regarding its underlying mechanisms. The amyloid hypothesis suggests A beta accumulation as the basis of AD, while the vascular hypothesis links early vascular damage to increased A beta deposits in the brain. Studies have shown significant morphological changes in the cerebrovasculature associated with AD progression, highlighting the need for further research in this area.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Behavioral Sciences
Austin T. Marckx, Katja E. Fritschle, Laurent Calvier, Joachim Herz
Summary: The study focused on the importance of the hippocampal formation in learning and memory, and found that Reelin deficiency combined with AD risk factors resulted in impairments in spatial memory tasks. The deficiency of Reelin exacerbated spatial impairments with age, further highlighting the importance of Reelin in HF homeostasis and AD pathogenesis.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Medicine, General & Internal
Aurelie Ledreux, Sarah Thomas, Eric D. Hamlett, Camille Trautman, Anah Gilmore, Emily Rickman Hager, Daniel A. Paredes, Martin Margittai, Juan Fortea, Ann-Charlotte Granholm
Summary: Individuals with Down syndrome exhibit Alzheimer's disease pathology at a young age, including amyloid plaques and neurofibrillary tangles. Tau pathology can spread via extracellular vesicles, and NDEVs from individuals with DS-AD have been found to contain p-Tau. Transferring NDEVs from DS-AD patients into wildtype mice resulted in the spread of Tau pathology in the brain, demonstrating that these vesicles have Tau seeding capacity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jean-Philippe Vit, Dieu-Trang Fuchs, Ariel Angel, Aharon Levy, Itschak Lamensdorf, Keith L. Black, Yosef Koronyo, Maya Koronyo-Hamaoui
Summary: The ViS4M maze is a novel tool for assessing color and contrast vision in mice based on innate exploratory behavior. It was used to evaluate visual impairments in AD(+) mice and aged WT mice, revealing early color and contrast deficits in AD(+) mice and transition deficits in aged WT mice.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Chrisandra L. Shufelt, JoAnn E. Manson
Summary: Menopausal hormone therapy has varying effects on cardiometabolic markers and cardiovascular disease risk depending on formulation, dose, and route of delivery. Oral estrogens without progestogens have positive effects on lipoprotein levels, glycemia, insulin, and CVD risk, while adding progestogens blunts the lipid-related effects. Transdermal estrogens have less impact on coagulation, inflammation, and lipids compared to oral estrogens, potentially posing a lower risk of venous thromboembolism and stroke.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Obstetrics & Gynecology
Wenting Hao, Chunying Fu, Caiyun Dong, Chunmiao Zhou, Huizi Sun, Ziwei Xie, Dongshan Zhu
Summary: This population-based cohort study involving 160,080 women from the UK Biobank study found that earlier natural menopause (≤40 and 41-45 years) was associated with a higher risk of all-cause dementia compared to a menopause age of 46-50 years, while a U-shaped relationship was observed between age at surgical menopause and dementia risk.
HUMAN REPRODUCTION
(2023)
Article
Cell Biology
Soumen Das, Narendrakumar Ramanan
Summary: Neurons in the mammalian brain exhibit diversity in nuclear morphology across different brain regions, with variations in area, perimeter, and circularity. These nuclear size parameters also change with age, showing decreases in some regions and increases in others. In an Alzheimer's disease mouse model, neuronal nuclear morphology varies with plaque size and distance from the plaque. These findings suggest that changes in nuclear size and shape may be related to transcriptional activity in different ages and Alzheimer's disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Plant Sciences
Veronica Amoah, Paul Atawuchugi, Yakubu Jibira, Augustine Tandoh, Paul Poku Sampene Ossei, George Sam, George Ainooson
Summary: The hydroethanolic leaf extract of Lantana camara (LCE) has a prophylactic effect on short-term memory deficit and neuroinflammation induced by scopolamine in zebrafish and mice. LCE improved cognitive impairment and reduced inflammatory response.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yongjie Xiong, Yi Qu, Zhe Min, Jun Wu, Suming Zhang, Zheng Xue
Summary: This study developed a novel MRI contrast agent by coupling ultrasmall superparamagnetic iron oxide nanoparticles with a functional protein. The contrast agent successfully penetrated biological membranes and bound to Aβ deposits, allowing for the visualization of Aβ deposits in Alzheimer's disease animal models by MRI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Immunology
Chao Ma, Jerry B. Hunt, Maj-Linda B. Selenica, Awa Sanneh, Leslie A. Sandusky-Beltran, Mallory Watler, Rana Daas, Andrii Kovalenko, Huimin Liang, Devon Placides, Chuanhai Cao, Xiaoyang Lin, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee
Summary: Arginase plays a crucial role in Alzheimer's disease, and its deficiency in myeloid cells may exacerbate amyloid-beta deposition, behavioral impairments, and autophagy. Proper function of Arginase and arginine metabolism in myeloid cells is essential in restricting amyloidosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Chao Ma, Jerry B. Hunt, Andrii Kovalenko, Huimin Liang, Maj-Linda B. Selenica, Michael B. Orr, Bei Zhang, John C. Gensel, David J. Feola, Marcia N. Gordon, Dave Morgan, Paula C. Bickford, Daniel C. Lee
Summary: Brain myeloid cells, including infiltrating macrophages and resident microglia, play a crucial role in responding to neurodegenerative diseases like Alzheimer's disease. Genome-wide studies have identified AD-related genes enriched in these cells. Coordinated arginine metabolism through Arg1 is critical for their function, with dysregulation disrupting them and potentially serving as a new biomarker pathway for AD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Delphine Boche, Marcia N. Gordon
Summary: The review explores the diversity of microglial phenotypes in healthy brains, aging, and Alzheimer's disease, identifies knowledge gaps, and suggests areas for further research. Comparisons between human samples and mouse models are made to understand the molecular complexity of microglial response repertoire, which could lead to new therapeutic avenues for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Dylan J. Finneran, Ikenna P. Njoku, Diego Flores-Pazarin, Meghana R. Ranabothu, Kevin R. Nash, David Morgan, Marcia N. Gordon
Summary: This study compares the strength and specificity of two neuron-specific promoters with a ubiquitous promoter in driving transgene expression in the brain, finding that neuron-specific promoters have comparable overall expression but significantly less expression in peripheral tissues.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Anjanet Loon, Frank Zamudio, Awa Sanneh, Breanna Brown, Shayna Smeltzer, Milene L. Brownlow, Zainuddin Quadri, Melinda Peters, Edwin Weeber, Kevin Nash, Daniel C. Lee, Marcia N. Gordon, Dave Morgan, Maj-Linda B. Selenica
Summary: The study demonstrates that overexpression of increment D421-tau protein in middle-aged mice leads to more severe cognitive impairments and neuronal loss compared to overexpression of FL-tau protein. Additionally, the increment D421-tau protein induces a distinct phosphorylation profile and increased tau oligomerization, suggesting its potential role in tau-associated pathologies.
Review
Clinical Neurology
Marcia N. Gordon, Michael T. Heneka, Lydia M. Le Page, Christian Limberger, David Morgan, Andrea J. Tenner, Niccolo Terrando, Auriel A. Willette, Sara A. Willette
Summary: COVID-19 infection may increase the risk of cognitive impairment, so further research is needed to study the symptoms, genetic polymorphisms, and treatment decisions associated with cognitive impairment risk, and to establish research consortia to monitor long-term consequences. Additionally, the lack of model systems to test hypotheses related to infection and cognition is a pending issue.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
John S. Beck, Zachary Madaj, Calvin T. Cheema, Betul Kara, David A. Bennett, Julie A. Schneider, Marcia N. Gordon, Stephen D. Ginsberg, Elliott J. Mufson, Scott E. Counts
Summary: The mechanisms of Alzheimer's disease and mild cognitive impairment involve dysregulation of multiple molecular pathways. This study analyzed gene expression patterns and found that insulin signaling was associated with clinical diagnosis, potentially playing a role in disease onset. Additionally, the platelet-endothelium-leucocyte cell adhesion pathways and hypoxia-oxidative stress were linked to neuropathological diagnostic criteria, potentially impacting disease progression and clinical presentation.
Article
Biochemistry & Molecular Biology
Oksana Fihurka, Yuzhu Hong, Jiyu Yan, Breanna Brown, Xiaoyang Lin, Ning Shen, Yanhong Wang, Haohan Zhao, Marcia N. Gordon, David Morgan, Qingyu Zhou, Ping Chang, Chuanhai Cao
Summary: The research found that low-dose THC treatment through intranasal delivery significantly slows memory decline, decreases the levels of Alzheimer's disease-related peptides, and promotes reductions in tau protein levels and changes in mitochondrial function markers. Blood biochemical parameters showed insignificant changes during treatment. Intranasal delivery is a non-invasive and convenient method that targets therapeutics to the brain, minimizing systemic exposure to avoid adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Neurosciences
David J. Braun, Erica M. Weekman, Marcia N. Gordon, Claudia B. Spani
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Betul Kara, Marcia N. Gordon, Mahsa Gifani, Anne M. Dorrance, Scott E. Counts
CLINICS IN GERIATRIC MEDICINE
(2023)
Article
Neurosciences
Dylan Finneran, Qingyou Li, Meena S. Subbarayan, Aurelie Joly-Amado, Siddharth Kamath, Daniela G. Dengler, Marcia N. Gordon, Michael R. Jackson, Dave Morgan, Paula C. Bickford, Layton H. Smith, Kevin R. Nash
Summary: This study investigates the function and pharmacology of two commonly used isoforms of Fractalkine (FKN) and finds differences in cell activity and binding affinity, as well as the ineffectiveness of high concentrations of FKN in reducing inflammation. These findings provide a better understanding of the selection and interpretation of FKN peptides for in vitro and in vivo studies.
Article
Neurosciences
Amber M. Tetlow, Brianna M. Jackman, Mohammed M. Alhadidy, Varshini Perumal, David G. Morgan, Marcia N. Gordon
Summary: Advanced age may accelerate the development of Alzheimer's disease, but its effect on tau protein aggregation is modest and similar to previous findings.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Amber M. Tetlow, Brianna M. Jackman, Mohammed M. Alhadidy, Patricia Muskus, David G. Morgan, Marcia N. Gordon
Summary: Animal models of tauopathy were used to investigate the effects of tau genetic variants. Green fluorescent protein-labeled adeno-associated viral (AAV) vectors were used to deliver tau wild-type, tau P301L, and tau R406W into mice. The different mutations produced varying phenotypes, with tau wild-type and tau P301L causing memory impairments and tau P301L leading to increased accumulation of tau. Only tau wild-type resulted in localized brain tissue atrophy. The findings suggest the potential use of AAV expressing tau wild-type to study neurodegeneration in Alzheimer's disease pathology.
NEUROBIOLOGY OF AGING
(2023)
Correction
Neurosciences
Ge Song, Haiqiang Yang, Ning Shen, Phillip Pham, Breanna Brown, Xiaoyang Lin, Yuzhu Hong, Paul Sinu, Jianfeng Cai, Xiaopeng Li, Michael Leon, Marcia N. Gordon, David Morgan, Sai Zhang, Chuanhai Cao
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Meeting Abstract
Cell & Tissue Engineering
M. N. Gordon, J. S. Beck, N. M. Kanaan, S. Kamath, K. Nash, S. D. Ginsberg, S. E. Counts
CELL TRANSPLANTATION
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
