Article
Biochemistry & Molecular Biology
Hye Jin Kim, Hyun Joo Kim, Jin Ha Park, Hye Jung Shin, Sung Kyung Yu, Yun Ho Roh, Soo Yeon Jeon, So Yeon Kim
Summary: In patients undergoing major abdominal surgery with RBC transfusion, the administration of 20% albumin during surgery may impact kidney function. This study found that albumin administration was initially associated with an increased risk of AKI, prolonged hospitalization, and higher 30-day mortality. However, after adjusting for confounding factors, no significant association was found between albumin administration and AKI, although it remained associated with prolonged hospitalization. Albumin administration did not affect 30-day mortality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Ioana Tichil, Samara Rosenblum, Eldho Paul, Heather Cleland
Summary: Blood transfusions are crucial in the surgical management of major burn patients, with around half of transfusions related to surgical procedures and potentially influenced by blood conserving strategies. The trigger levels for transfusions in stable patients may be subject to review and reduction. Risk-adjusted analysis can support the use of blood transfusions as a valuable quality indicator in burn care.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mickael Vourc'h, Antoine Roquilly, Adrien Foucher, Christelle Retiere, Fanny Feuillet, Sapna Devi, Hamish E. G. McWilliam, Cecile Braudeau, Geraldine Bourreille, Abderrahman Hachani, Dermot O'Kane, Scott N. Mueller, Joseph Ischia, Jean-Christian Roussel, Jean-Christophe Rigal, Regis Josien, Bertrand Rozec, Jose A. Villadangos, Karim Asehnoune
Summary: This study found that transfusion of packed red blood cells with high levels of MRP_14 may increase the incidence of AKI after cardiac surgery. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Review
Medicine, General & Internal
Hyeon Ju Shin, Eunji Ko, Injae Jun, Hyun Jung Kim, Choon Hak Lim
Summary: This study evaluated the use of erythropoietin (EPO) in cardiac surgery and found that pre-operative administration of EPO can reduce the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI) and red blood cell transfusion. Additionally, pre-operative EPO treatment can also decrease intra-operative RBC transfusion and hospital length of stay.
Review
Medicine, General & Internal
Christina Massoth, Alexander Zarbock
Summary: Acute kidney injury after cardiac surgery presents specific patterns of damage and recovery, which are crucial for management and outcomes. The KDIGO classification only partially covers the conceptual framework and is insufficient for a comprehensive diagnosis. This review discusses the strengths and limitations of recent criteria for CSA-AKI and provides an overview of biomarkers. The evolving understanding of CSA-AKI as a time-sensitive condition has led to an increased demand for enhancing diagnostic criteria and implementing biomarkers in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shouqiang Zhu, Peng Lu, Zhenran Liu, Shaoyang Li, Peitong Li, Bingdi Wei, Jiayi Li, Yupei Wang
Summary: This study aimed to describe the longitudinal dynamic hemoglobin trajectories in patients undergoing cardiac surgery and explore their predictive value for AKI compared to traditional threshold values. The interaction of red blood cell transfusion was also investigated. The results showed three distinct hemoglobin trajectories, and patients in the highest and medium trajectory groups had significantly lower AKI risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Anesthesiology
Juan G. Ripoll, Mark M. Smith, Andrew C. Hanson, Phillip J. Schulte, Erica R. Portner, Daryl J. Kor, Matthew A. Warner
Summary: Preoperative anemia in cardiac surgery was found to be associated with adverse clinical outcomes, such as acute kidney injury, blood transfusions, reoperations, vascular complications, and longer hospital stays. These associations varied between men and women, with different hemoglobin thresholds identified for each sex. Further studies are needed to determine optimal preoperative hemoglobin values for different sexes to help improve outcomes in cardiac surgery.
ANESTHESIA AND ANALGESIA
(2021)
Article
Critical Care Medicine
Mira Kuellmar, Khaschayar Saadat-Gilani, Raphael Weiss, Christina Massoth, Anas Lagan, Manuel Nunez Cortes, Joachim Gerss, Lakhmir S. Chawla, Danilo Fliser, Melanie Meersch, Alexander Zarbock
Summary: Elevated renin concentrations are associated with cardiovascular instability and increased AKI after cardiac surgery. Elevated renin concentrations could be used to identify high-risk patients for cardiovascular instability and AKI who would benefit from timely intervention that could improve their outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Transplantation
Gregory L. Hundemer, Anand Srivastava, Kirolos A. Jacob, Neeraja Krishnasamudram, Salman Ahmed, Emily Boerger, Shreyak Sharma, Kapil K. Pokharel, Sameer A. Hirji, Marc Pelletier, Kassem Safa, Win Kulvichit, John A. Kellum, Leonardo Riella, David E. Leaf
Summary: Renal transplant recipients have a higher risk of acute kidney injury following cardiac surgery compared to non-RTRs, especially those with deceased donor status and higher preoperative calcineurin inhibitor trough levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Anesthesiology
Lihai Chen, Liang Hong, Aixia Ma, Yanfei Chen, Yue Xiao, Feng Jiang, Ruijian Huang, Cui Zhang, Xinyi Bu, Yali Ge, Jifang Zhou
Summary: This study found that venous congestion is associated with acute kidney injury and disease in patients undergoing cardiac surgery, while intraoperative hypotension is not associated with the development of acute kidney disease.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Cardiac & Cardiovascular Systems
Jin Sun Cho, Jae-Kwang Shim, Sak Lee, Jong-Wook Song, Nakcheol Choi, Sugeun Lee, Young-Lan Kwak
Summary: The study revealed that postoperative AKI in valvular heart surgery patients increases the risk of AKD and CKD development, with persistent AKI further escalating this risk. Additionally, heart failure and high right ventricular pressure postoperatively were identified as independent risk factors for CKD.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Physiology
Yugeesh R. Lankadeva, Clive N. May, Andrew D. Cochrane, Bruno Marino, Sally G. Hood, Peter R. McCall, Nobuki Okazaki, Rinaldo Bellomo, Roger G. Evans
Summary: Blood transfusion to increase hemoglobin concentration during experimental CPB did not improve renal tissue oxygenation, despite decreasing whole kidney oxygen extraction.
Review
Cardiac & Cardiovascular Systems
Roby Sebastian, M. Iqbal Ahmed
Summary: Pediatric cardiac surgery is often associated with significant blood loss requiring transfusion, which poses serious risks and challenges in management. Factors such as immaturity of the hemostatic system and metabolic differences in children contribute to the complexity of transfusion management in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Anesthesiology
Lisa Verwijmeren, Madeleen Bosma, Lisette M. Vernooij, Esther M. Linde, Ineke M. Dijkstra, Edgar J. Daeter, Eric P. A. Van Dongen, Wilton A. Van Klei, Peter G. Noordzij
Summary: Preoperative cardiac, inflammatory, renal, and metabolic biomarkers are associated with CSA-AKI and may improve identification of patients at risk. The use of a biomarker panel may enhance the identification of patients with CSA-AKI compared to using only clinical risk factors.
ANESTHESIA AND ANALGESIA
(2021)
Article
Medical Laboratory Technology
Hang Zhang, Hong Lang, Mengqing Ma, Min Yu, Hao Chai, Yuntao Hu, Wen Chen, Xin Chen
Summary: The study found that decreased preoperative uromodulin levels are independently associated with an increased risk of acute kidney injury (AKI) and perioperative kidney dysfunction after cardiac surgery.
CLINICA CHIMICA ACTA
(2022)
Article
Urology & Nephrology
Saban Elitok, Prasad Devarajan, Rinaldo Bellomo, Berend Isermann, Michael Haase, Anja Haase-Fielitz
Summary: The study aimed to investigate the prognostic value of AKI subtypes defined by the NGAL/hepcidin-25 ratio in higher-risk cardiac surgery patients. Results showed that subclinical and combined AKI patients had significantly higher in-hospital mortality rates, indicating a strong association between these biomarker-informed AKI subtypes and prognosis.
JOURNAL OF NEPHROLOGY
(2022)
Article
Mathematical & Computational Biology
Siegfried Kropf, Kai Antweiler, Ekkehard Glimm
Summary: This study investigates extensions to tests for superiority, equivalence, and non-inferiority in ecological studies using pairwise distance measures for multivariate sample vectors. It explores beyond the common two-sided tests for differences.
BIOMETRICAL JOURNAL
(2022)
Article
Urology & Nephrology
Michael Haase, Paul Lesny, Mark Anderson, Gavin Cloherty, Michael Stec, Anja Haase-Fielitz, Mathias Haarhaus, Carla Santos-Araujo, Pedro Mota Veiga, Fernando Macario
Summary: This study compares the immunogenicity and tolerability of different COVID-19 vaccination strategies in hemodialysis patients. The results suggest that heterologous vaccination with ChAd/BNT may induce stronger immune response, but with more frequent side effects.
JOURNAL OF NEPHROLOGY
(2022)
Editorial Material
Anesthesiology
L. F. Miles, D. A. Story
Article
Anesthesiology
A. Wu, M. T. Fahey, D. Cui, B. El-Behesy, D. A. Story
Summary: This study evaluated the effectiveness of the 'days alive and at home' metric in predicting the time for older adults to return home after hip fracture surgery. The results support the use of this metric as a useful patient-centered outcome measure and recommend its use in clinical trials.
Letter
Anesthesiology
Marissa T. Ferguson, Jeremy Fernando, Sean McManus, Ian Richardson, Jonathan Nicholson, David Story, Hilmy Ismail, Bernhard Riedel
ANAESTHESIA AND INTENSIVE CARE
(2022)
Article
Anesthesiology
Zoe M. Keon-Cohen, David A. Story, Juli A. Moran, Daryl A. Jones
Summary: The number of older, frail patients undergoing surgery is increasing, but there is a lack of discussion and documentation regarding their perioperative care.
ANAESTHESIA AND INTENSIVE CARE
(2022)
Article
Health Care Sciences & Services
Cassie E. McDonald, Camille Paynter, Jill J. Francis, Daevyd Rodda, Supreet Bajwa, Dwane Jackson, David Story
Summary: Short-stay care after arthroplasty was found to be acceptable to patients who had experienced this care pathway, although there were some limitations in acceptability. The findings of this study can guide the improvement of the short-stay care pathway.
HEALTH EXPECTATIONS
(2022)
Article
Psychology, Clinical
Camille Paynter, Cassie McDonald, David Story, Jill J. Francis
Summary: This study explores the applicability of the theoretical framework of acceptability (TFA) in surgical interventions and provides methodological guidance for its systematic use in research. Acceptability was assessed through theory-informed semi-structured interviews with 15 patients who had undergone joint replacement surgery at least 3 months ago. Results show that the TFA is sufficient for assessing acceptability but requires an additional construct to capture perceptions of risk and safety.
BRITISH JOURNAL OF HEALTH PSYCHOLOGY
(2023)
Article
Medical Laboratory Technology
Annemarie Albert, Sebastian Radtke, Louisa Blume, Rinaldo Bellomo, Michael Haase, Philipp Stieger, Ulrich Paul Hinkel, Ruediger C. Braun-Dullaeus, Christian Albert
Summary: This study investigated the impact of neutrophil gelatinase-associated lipocalin (NGAL) cutoff value selection and the acute kidney injury (AKI) classification system on the allocation of clinical AKI phenotypes and associated outcomes.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Ragna Iwers, Veronika Sliziuk, Michael Haase, Sophie Barabasch, Michael Zanker, Christian Butter, Anja Haase-Fielitz
Summary: This study evaluated the efficacy of an electronic alert system and care bundle for acute kidney injury. The results showed that the system improved process-related endpoints but did not have a significant impact on patient-related endpoints.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jonathan Nuebel, Charlotte Buhre, Meike Hoffmeister, Stefanie Oess, Oliver Labrenz, Kerstin Jost, Michael Hauptmann, Julika Schoen, Georg Fritz, Christian Butter, Anja Haase-Fielitz
Summary: This study found that changes in neuron-specific enolase (NSE) levels after TAVR did not significantly impair memory function, but patients with postoperative delirium (POD) had significantly higher levels of NSE.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Victoria Dworok, Valentin Haehnel, Marwin Bannehr, Vera Paar, Christoph Edlinger, Michael Lichtenauer, Christian Butter, Anja Haase-Fielitz
Summary: sST2 is correlated with the degree of peripheral edema and the diameter of inferior vena cava in patients with decompensated right heart failure, while other established markers show no correlation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Ebel, Alexander Kuehn, Abhinav Aggarwal, Benjamin Koehler, Benjamin Behrendt, Robin Gohmann, Boris Riekena, Christian Luecke, Juliane Ziegert, Charlotte Vogtmann, Bernhard Preim, Siegfried Kropf, Bernd Jung, Timm Denecke, Matthias Grothoff, Matthias Gutberlet
Summary: This study used 4D flow MRI to assess quantitative parameters of helical flow and obtained normal values in healthy volunteers. The results showed that wall shear stress and maximum forward velocity decreased with age, while other parameters were not correlated with age and gender.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, Research & Experimental
Fabian Schipmann, Marwin Bannehr, Valentin Haehnel, Victoria Dworok, Jonathan Nuebel, Christoph Edlinger, Michael Lichtenauer, Michael Haase, Michael Zaenker, Christian Butter, Anja Haase-Fielitz
Summary: This study investigates the impact of chronic kidney disease (CKD) progression on all-cause mortality in patients with tricuspid regurgitation (TR) and identifies potential risk factors for CKD progression. The results show that CKD progression, the grade of TR, and mitral regurgitation are independent risk factors for all-cause mortality. Anemia and diabetes are potential modifiers of CKD progression.