Article
Urology & Nephrology
Sidharth Kumar Sethi, Rajesh Sharma, Aditi Gupta, Abhishek Tibrewal, Romel Akole, Rohan Dhir, Kritika Soni, Shyam Bihari Bansal, Pranaw Kumar Jha, Anil Bhan, Vijay Kher, Rupesh Raina
Summary: This study aimed to establish long-term renal outcomes for pediatric patients after cardiac surgery, focusing on urinary biomarker abnormalities that persist years after surgery and may contribute to a low glomerular filtration rate during follow-up. The presence of AKI, AKI stage, and younger age were not associated with low GFR at follow-up, while children with a higher surgical complexity score tended to have lower GFR.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Anesthesiology
Yi Shun Wang, Dong Xu Chen, Min Yan, Zhong Wu, Ying Qiang Guo, Qian Li, Lei Du
Summary: This study developed and validated a model to predict the severity of acute kidney injury (AKI) after on-pump cardiac surgery using 10 predictors. The model showed good accuracy in predicting AKI severity and may be useful in clinical practice.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Multidisciplinary Sciences
Yichuan Wang, Xuliang Huang, Shanshan Xia, Qingqing Huang, Jue Wang, Maochao Ding, Yunchang Mo, Jianping Yang
Summary: There is no gender gap in AKI frequency for cardiac surgery patients below and above 60 years old. However, women exhibit increased AKI severity and extended intubation duration.
Article
Critical Care Medicine
Christina Massoth, Alexander Zarbock, Melanie Meersch
Summary: The incidence of acute kidney injury (AKI) after cardiac surgery is high, with about 3% of patients requiring renal replacement therapy. According to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria, AKI is defined as a sudden deterioration of renal function, developing within a period of hours to days.
CRITICAL CARE CLINICS
(2021)
Article
Cardiac & Cardiovascular Systems
Shouqiang Zhu, Peng Lu, Zhenran Liu, Shaoyang Li, Peitong Li, Bingdi Wei, Jiayi Li, Yupei Wang
Summary: This study aimed to describe the longitudinal dynamic hemoglobin trajectories in patients undergoing cardiac surgery and explore their predictive value for AKI compared to traditional threshold values. The interaction of red blood cell transfusion was also investigated. The results showed three distinct hemoglobin trajectories, and patients in the highest and medium trajectory groups had significantly lower AKI risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Hsun-Yi Fu, Nai-Kuan Chou, Yih-Sharng Chen, Hsi-Yu Yu
Summary: This study found a high incidence of postoperative AKI in patients with pre-existing impaired renal function, which was associated with high preoperative serum creatinine levels and decreased CPB target temperature. AKI patients had higher hospital mortality and a worse two-year renal function evolution compared to non-AKI patients.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Nikolay O. Kamenshchikov, Yana J. Anfinogenova, Boris N. Kozlov, Yulia S. Svirko, Stanislav E. Pekarskiy, Vladimir V. Evtushenko, Vladimir A. Lugovsky, Vladimir M. Shipulin, Vladimir V. Lomivorotov, Yuriy K. Podoksenov
Summary: This study evaluated the effects of nitric oxide (NO) supplementation on the development of acute kidney injury (AKI) after cardiac surgery. The results showed that NO treatment during cardiopulmonary bypass (CPB) was associated with a lower incidence of AKI and higher urine output. There was also a decrease in urinary neutrophil gelatinase-associated lipocalin levels in the NO treatment group. Concentrations of NO metabolites were significantly increased in this group.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Benjamin R. Griffin, J. Pedro Teixeira, Sophia Ambruso, Michael Bronsert, Jay D. Pal, Joseph C. Cleveland, T. Brett Reece, David A. Fullerton, Sarah Faubel, Muhammad Aftab
Summary: This study aimed to investigate the association between stage 1 AKI after surgery and postoperative infection and mortality. The results showed that stage 1 AKI was independently associated with increased infection, ICU LOS, and hospital LOS. Treatment strategies focusing on AKI prevention, early recognition, and optimal medical management may reduce significant postoperative morbidity.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Anesthesiology
Lisa Verwijmeren, Madeleen Bosma, Lisette M. Vernooij, Esther M. Linde, Ineke M. Dijkstra, Edgar J. Daeter, Eric P. A. Van Dongen, Wilton A. Van Klei, Peter G. Noordzij
Summary: Preoperative cardiac, inflammatory, renal, and metabolic biomarkers are associated with CSA-AKI and may improve identification of patients at risk. The use of a biomarker panel may enhance the identification of patients with CSA-AKI compared to using only clinical risk factors.
ANESTHESIA AND ANALGESIA
(2021)
Article
Medicine, General & Internal
Sairah Sharif, Bohan Chen, Pamela Brewster, Tian Chen, Lance Dworkin, Rujun Gong
Summary: This study aims to investigate the efficacy of short term low dose lithium on CSA-AKI in human patients through renal function evaluation using creatinine and AKI biomarkers. The study compares the effects of lithium treatment and placebo treatment on kidney injury and renal function.
FRONTIERS IN MEDICINE
(2021)
Article
Pediatrics
Daniella Levy Erez, Shah Lokesh, Kathryn D. Howarth, Sherin Meloni, Lance Ballester, Benjamin Laskin, Kathleen E. Sullivan, Joshua Blinder
Summary: Acute kidney injury (AKI) is common after infant cardiac surgery and is associated with poor outcomes. Dysregulated immune activation may contribute to the development of AKI. This study aimed to identify immune-mediated AKI biomarkers after infant cardiopulmonary bypass (CPB)-assisted cardiac surgery.
PEDIATRIC NEPHROLOGY
(2023)
Review
Anesthesiology
Yu-qin Long, Xiao-mei Feng, Xi-sheng Shan, Qing-cal Chen, Zhengyuan Xia, Fu-hai Ji, Hong Liu, Ke Peng
Summary: This meta-analysis demonstrates that RIPC reduces the incidence of AKI after cardiac surgery. This renoprotective effect of RIPC is mainly evident during volatile only anesthesia, in non-high-risk patients, and when AKIN or KDIGO criteria used for AKI diagnosis.
ANESTHESIA AND ANALGESIA
(2022)
Article
Anesthesiology
Mikael Barbu, Anders Hjarpe, Andreas Martinsson, Goran Dellgren, Sven-Erik Ricksten, Lukas Lannemyr, Aldina Pivodic, Amar Taha, Anders Jeppsson
Summary: This study found that longer CPB time and aortic clamp time, periods of compromised blood flow during aortic clamp time, and lower hematocrit were associated with the risk of postoperative AKI. These findings suggest that efforts should be made to minimize CPB and aortic clamp time and avoid compromised blood flow and low hematocrit during surgery.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Pediatrics
Arushi Nautiyal, Sidharth Kumar Sethi, Rajesh Sharma, Rupesh Raina, Abhishek Tibrewal, Romel Akole, Aditi Gupta, Anil Bhan, Shyam Bihari Bansal
Summary: This study demonstrates the feasibility of using albuminuria as a biomarker for predicting AKI in children following cardiac surgery, especially when combined with a clinical model. Different age groups may have varying predictive values for AKI based on urinary albumin:creatinine ratio.
PEDIATRIC NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Peng Gao, Yu Jin, Peiyao Zhang, Wenting Wang, Jinxiao Hu, Jinping Liu
Summary: This study investigated the association between nadir DO(2)i during cardiopulmonary bypass (CPB) and postoperative acute kidney injury (AKI) in low-weight infants undergoing cardiac surgery. The results suggested that in low-weight infants undergoing mild hypothermia during CPB, the critical DO(2)i for preventing AKI was 258 mL/min/m(2) in the hypothermia phase and 281 mL/min/m(2) for rewarming. It was also recommended to use an individualized critical DO(2)i threshold during CPB.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
