Article
Pediatrics
Faidra Veligratli, Demitra Alexandrou, Sarit Shah, Rakesh Amin, Mehul Dattani, Hoong-Wei Gan, Adeola Famuboni, Camilo Lopez-Garcia, Richard Trompeter, Detlef Bockenhauer
Summary: This study retrospectively evaluated the efficacy and safety of tolvaptan and urea in treating pediatric SIADH. The results showed that both tolvaptan and urea were effective in normalizing plasma sodium concentration, and patients tolerated the treatment well without any unexpected side effects.
PEDIATRIC NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Mouhand F. H. Mohamed, Ashraf O. E. Ahmed, Mhd Baraa Habib, Mohamed Abdalla, Yazan Salah Almohtasib, Hamad F. H. Mohamed, Zeinab A. S. Mohamed, Lina Abdalla, Ahmed Osman Saleh
Summary: This paper aimed to systematically review the literature and found a relatively high prevalence of SIADH of 20% in patients with brucellosis. Therefore, hyponatremia in patients with chronic fever should prompt SIADH and brucellosis workup, and patients with brucellosis should receive hyponatremia screening.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Chemistry, Medicinal
Zsolt Szeleczky, Zoltan Szakacs, Eva Bozo, Ferenc Baska, Krisztina Vukics, Sandor Levai, Krisztina Temesvari, Elemer Vass, Zoltan Beni, Balazs Kramos, Ildiko Magdo, Csaba Szantay, Janos Koti, Katalin Domany-Kovacs, Istvan Greiner, Imre Bata
Summary: A new class of selective vasopressin receptor 1A (V-1A) antagonists has been identified, with the synthesis of four atropisomeric stereoisomers characterized by chiral axis and a stereogenic center. In vitro pharmacological profiles show that the human V-1A receptor strongly prefers the isomers with aR axial chirality, with the most active isomer being the aR,5S form. The structure-activity relationships for the isomers and newly synthesized analogues could be tentatively explained by an in silico study.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Pradeep Paudel, Dong Hyun Kim, Jieun Jeon, Se Eun Park, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi
Summary: Aurantio-obtusin in Cassia seeds showed specific neuroprotective effects by targeting V1AR receptors, reducing neuronal damage in a transient brain ischemia/reperfusion injury mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Urology & Nephrology
Priscila Villalvazo, Raul Fernandez-Prado, Maria Dolores Sanchez Nino, Sol Carriazo, Beatriz Fernandez-Fernandez, Alberto Ortiz, Maria Vanessa Perez-Gomez
Summary: Bruce Lee died from cerebral edema possibly caused by hyponatremia. He had multiple risk factors for hyponatremia.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Medicine, General & Internal
Ya Zhou, Wenru Yang, Guotao Liu, Weiyi Gao
Summary: The study found that the use of vaptans had higher risks of hypernatremia and serum sodium overcorrection compared to placebo. Patients with baseline hyponatremia had a lower risk of hypernatremia incidence, but the use of loop diuretics increased the risk. The risk of serum sodium overcorrection should be considered for patients with both hyponatremia and normal serum sodium levels, and using a low dose of vaptans can reduce these risks.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Health Care Sciences & Services
Hilda T. Maibach, Michael J. Brownstein, Steven M. Hersch, Karen E. Anderson, Debra E. Itzkowitz, Eve M. Damiano, Neal G. Simon
Summary: SRX246, an orally available V1a receptor antagonist, was found to reduce aggressive behavior in HD patients and was well tolerated.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Medicinal
Ferenc Baska, Eva Bozo, Tamas Patocs
Summary: This manuscript summarizes recent patent activity related to vasopressin receptor antagonists, focusing on selective V1a or V2 antagonists and dual-acting V1a/V2 antagonists. Despite unsuccessful clinical trials in many cases, there is still potential in the research of vasopressin receptor antagonists, as evidenced by several ongoing clinical trials.
EXPERT OPINION ON THERAPEUTIC PATENTS
(2023)
Review
Clinical Neurology
Mendel Castle-Kirszbaum, Mervyn Kyi, Christopher Wright, Tony Goldschlager, R. Andrew Danks, W. Geoffrey Parkin
Summary: Disorders of tonicity and volume are sensed and integrated in the hypothalamus to maintain water balance. Classification of hyponatraemia by volume state is imprecise, and renal responses to dysnatraemia can help determine the etiology. Treatment for dysnatraemia should be tailored based on individual clinical context.
NEUROSURGICAL REVIEW
(2021)
Review
Medicine, General & Internal
Pajaree Krisanapan, Supawit Tangpanithandee, Charat Thongprayoon, Pattharawin Pattharanitima, Andrea Kleindienst, Jing Miao, Iasmina M. Craici, Michael A. Mao, Wisit Cheungpasitporn
Summary: This meta-analysis evaluates the safety and efficacy of vaptans in treating chronic hyponatremia in adult SIADH patients. The results indicate that vaptans effectively raise serum sodium concentration in the short-term, but caution is needed due to the risk of overcorrection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Floor van der Bilt, Jelmer Alsma
Summary: This article reports three cases of hyponatraemia caused by urinary retention and bladder distention, possibly due to the syndrome of inappropriate antidiuresis (SIAD). Laboratory findings met the criteria for SIAD, but no specific cause was identified. Pain or sympathetic nerve system activation may have led to SIAD. Placement of an indwelling urinary catheter prompted brisk diuresis and overcorrection of sodium, requiring treatment.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Hiroyuki Fujiki, Masayuki Matsunaga, Masayuki Furukawa, Tatsuya Yamashita, Shigeki Nakamura, Toshiki Miyazaki, Hiroshi Mizuguchi, Yasuhiro Menjo, Takakuni Matsuda, Yoshihisa Yamada
Summary: OPC-61815 is a pro-drug of tolvaptan, which can be converted into tolvaptan after intravenous administration. It has good water solubility and diuretic effect.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Buster Mannheimer, Henrik Falhammar, Jan Calissendorff, Jonatan D. Lindh, Jakob Skov
Summary: The study found that long-term use of furosemide was inversely correlated with hospitalization due to hyponatremia, suggesting a protective effect. However, spironolactone and amiloride may contribute to hyponatremia, especially early in treatment.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Maryam Bayat Mokhtari, Moein Bayat Mokhtari, Blanca Z. Rodriguez, Ting Yu Yen, Ivan B. Rodriguez
Summary: Ayahuasca, a hallucinogenic blend originating from South America, has been used in ritualistic ceremonies by local tribes for hundreds of years. Its usage has expanded to North America in mindfulness retreats. This case report describes a patient who attended a satanic ritual and consumed large amounts of Ayahuasca, leading to demonic hallucinations, paranoid delusion, and physical symptoms. The patient developed suicidal ideations and was unresponsive upon arrival at the hospital. After evaluation and supportive care, the patient recovered within four days. The similarity in pharmacodynamics between Ayahuasca and other drugs may have contributed to the development of a syndrome of inappropriate antidiuretic hormone secretion (SIADH).
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Masahiko Tosaka, Rei Yamaguchi, Yutaro Itabashi, Naoto Mukada, Haruka Tsuneoka, Kentaro Takahashi, Shunsuke Nakamura, Takahiko Nakazawa, Yuhei Yoshimoto
Summary: Oral tolvaptan administration is effective in treating hyponatremia with SIAD in patients after pituitary surgery. It significantly increases serum sodium concentration, decreases urine osmolality and urinary sodium concentration, and increases urine output.
Article
Multidisciplinary Sciences
Boris L. Zybailov, Galina V. Glazko, Yasir Rahmatallah, Dmitri S. Andreyev, Taylor McElroy, Oleg Karaduta, Stephanie D. Byrum, Lisa Orr, Alan J. Tackett, Samuel G. Mackintosh, Ricky D. Edmondson, Dorothy A. Kieffer, R. J. Martin, Sean H. Adams, Nosratola D. Vaziri, John M. Arthur
Article
Pharmacology & Pharmacy
Maria F. Lopes-Virella, Nathaniel L. Baker, Kelly J. Hunt, Samar M. Hammad, John Arthur, Gabriel Virella, Richard L. Klein
JOURNAL OF CLINICAL LIPIDOLOGY
(2019)
Article
Urology & Nephrology
Christopher P. Larsen, Shree G. Sharma, Tiffany N. Caza, Daniel J. Kenan, Aaron J. Storey, Ricky D. Edmondson, Christian Herzog, John M. Arthur
KIDNEY INTERNATIONAL
(2020)
Article
Urology & Nephrology
Tiffany N. Caza, Samar I. Hassen, Zeljko Dvanajscak, Michael Kuperman, Rick Edmondson, Christian Herzog, Aaron Storey, John Arthur, L. Nicholas Cossey, Shree G. Sharma, Daniel J. Kenan, Christopher P. Larsen
Summary: Patients with membranous nephropathy associated with malignancy were found to have unique NELL1 immune complexes in kidney biopsy tissue, with characteristic histopathology of incomplete capillary loop staining and IgG1 predominance. These NELL1-positive cases also showed a higher association with concurrent malignancy compared to other known types of membranous nephropathy.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Tiffany N. Caza, Samar I. Hassen, Michael Kuperman, Shree G. Sharma, Zeljko Dvanajscak, John Arthur, Rick Edmondson, Aaron Storey, Christian Herzog, Daniel J. Kenan, Christopher P. Larsen
Summary: Research has identified neural cell adhesion molecule 1 (NCAM1) as a target antigen in some cases of membranous lupus nephritis and rare cases of primary membranous nephropathy, colocalizing with IgG in glomerular immune deposits. Circulating antibodies to NCAM1 have been detected in serum of patients with NCAM1-associated membranous nephropathy, suggesting diagnostic significance. Future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.
KIDNEY INTERNATIONAL
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Husam M. Salah, John M. Arthur, Jawahar L. Mehta
EUROPEAN HEART JOURNAL
(2020)
Article
Urology & Nephrology
Laith Farah Al-Rabadi, Tiffany Caza, Claire Trivin-Avillach, Aylin R. Rodan, Nicole Andeen, Norifumi Hayashi, Brandi Williams, Monica P. Revelo, Fred Clayton, Jo Abraham, Edwin Lin, Willisa Liou, Chang-Jiang Zou, Nirupama Ramkumar, Tim Cummins, Daniel W. Wilkey, Issa Kawalit, Christian Herzog, Aaron Storey, Rick Edmondson, Ronald Sjoberg, Tianxin Yang, Jeremy Chien, Michael Merchant, John Arthur, Jon Klein, Chris Larsen, Laurence H. Beck
Summary: The study identified serine protease HTRA1 as a novel podocyte antigen in primary membranous nephropathy (MN) patients. Anti-HTRA1 antibodies in patients with HTRA1-associated MN were predominantly IgG4 and seemed to correlate with clinical disease activity. Screening of 118 quadruple-negative patients revealed a 4.2% prevalence of HTRA1-associated MN.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Multidisciplinary Sciences
John M. Arthur, J. Craig Forrest, Karl W. Boehme, Joshua L. Kennedy, Shana Owens, Christian Herzog, Juan Liu, Terry O. Harville
Summary: Many patients with a history of SARS-CoV-2 infection have developed specific antibodies against ACE2, which may decrease the activity of soluble ACE2 in plasma and increase levels of Ang II, potentially triggering symptoms of PASC.
Article
Urology & Nephrology
Christopher P. Larsen, Terrance J. Wickman, Juarez R. Braga, Luis A. Matute-Trochez, Anna E. Hasty, Lyndsey R. Buckner, John M. Arthur, Randy S. Haun, Juan Carlos Q. Velez
Summary: APOL1 high-risk alleles are associated with greater odds of AKI in Black American patients with COVID-19.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Adam Corken, Jerry Ware, Junqiang Dai, John M. Arthur, Susan Smyth, Clayton L. Davis, Juan Liu, Terry O. Harville, Milind A. Phadnis, Jawahar L. Mehta, Yasir Rahmatallah, Nishank Jain
Summary: The interaction between platelets and leukocytes is attenuated in CKD patients, without changes in platelet activation status. Monocyte differentiation state is altered and inflammatory markers are elevated. Platelet-derived cytokines are tightly correlated with others.
Article
Urology & Nephrology
Julia Hopkins, Juan Carlos Q. Velez, John M. Arthur, Michael G. Janech
Summary: This study surveyed undergraduate students to assess their recognition of the medical specialty of nephrology. The findings revealed that nephrology is one of the least recognized specialties among undergraduates. The lack of awareness extends even to premedical students, highlighting a gap in name recognition at an early career stage.
Article
Urology & Nephrology
Tiffany N. Caza, Samar Hassen, Daniel J. Kenan, Aaron Storey, John M. Arthur, Christian Herzog, Rick D. Edmondson, T. David Bourne, Laurence H. Beck, Christopher P. Larsen
Summary: A novel biomarker, TGFBR3, expressed in a subset of patients with MLN, was found to be a distinct form of MN significantly enriched in MLN. Diagnosis of TGFBR3-associated MN can alert clinicians to search for underlying autoimmune diseases and guide treatment decisions to improve patient prognosis.
Article
Physiology
Oleg Karaduta, Galina Glazko, Zeljko Dvanajscak, John Arthur, Samuel Mackintosh, Lisa Orr, Yasir Rahmatallah, Laxmi Yeruva, Alan Tackett, Boris Zybailov
PHYSIOLOGICAL REPORTS
(2020)
Review
Physiology
Gerren P. Hobby, Oleg Karaduta, Giuseppina F. Dusio, Manisha Singh, Boris L. Zybailov, John M. Arthur
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Review
Urology & Nephrology
John M. Arthur, Nithin Karakala, Ricky D. Edmondson