Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors

Glia Maturation Factor (GMF) Interacts with Arp2/3 Complex in a Nucleotide State-dependent Manner

(2013) Malgorzata Boczkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for regulation of Arp2/3 complex by GMF

(2013) Qing Luan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insulin Receptor Substrate protein 53kDa (IRSp53) is a negative regulator of myogenic differentiation

(2012) Ashish Misra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Synergistic BAR–NPF interactions in actin-driven membrane remodeling

(2012) Shiro Suetsugu et al.   TRENDS IN CELL BIOLOGY

The Pathogen-Actin Connection: A Platform for Defense Signaling in Plants

(2011) Brad Day et al.   Annual Review of Phytopathology

mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation

(2011) Wah Ing Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell–ECM signaling

(2011) David Cohen et al.   JOURNAL OF CELL BIOLOGY

Enterohaemorrhagic Escherichia coli requires the spectrin cytoskeleton for efficient attachment and pedestal formation on host cells

(2011) Tyson Joel Ruetz et al.   MICROBIAL PATHOGENESIS

Structural Basis for Complex Formation between Human IRSp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. coli

(2011) Jens C. de Groot et al.   STRUCTURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Phospholipids regulate localization and activity of mDia1 formin

(2010) Nagendran Ramalingam et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains

(2010) Roman Gorelik et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and control of the actin regulatory WAVE complex

(2010) Zhucheng Chen et al.   NATURE

ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

(2010) H. Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

The interplay between Eps8 and IRSp53 contributes to Src-mediated transformation

(2010) P-S Liu et al.   ONCOGENE

Molecular Basis for the Dual Function of Eps8 on Actin Dynamics: Bundling and Capping

(2010) Maud Hertzog et al.   PLOS BIOLOGY

The BAR Domain Superfamily: Membrane-Molding Macromolecules

(2009) Adam Frost et al.   CELL

Molecular Mechanisms of Membrane Deformation by I-BAR Domain Proteins

(2009) Juha Saarikangas et al.   CURRENT BIOLOGY

Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination

(2009) B. K. Chauhan et al.   DEVELOPMENT

Actin Dynamics at the Leading Edge: From Simple Machinery to Complex Networks

(2009) Robert H. Insall et al.   DEVELOPMENTAL CELL

Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism between 14-3-3 Binding and SH3-Mediated Localization

(2009) J. M. Robens et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of the WAVE Complex by Coincident Signals Controls Actin Assembly

(2009) Andres M. Lebensohn et al.   MOLECULAR CELL

Coordination of Membrane and Actin Cytoskeleton Dynamics during Filopodia Protrusion

(2009) Changsong Yang et al.   PLoS One

I-BAR domains, IRSp53 and filopodium formation

(2009) Sohail Ahmed et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The postsynaptic density protein, IQ-ArfGEF/BRAG1, can interact with IRSp53 through its proline-rich sequence

(2008) Masashi Sanda et al.   BRAIN RESEARCH

The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics

(2008) Kim Buay Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Rho GTPases: new insights into their functions from in vivo studies

(2008) Sarah J. Heasman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

(2008) Giorgio Scita et al.   TRENDS IN CELL BIOLOGY