Article
Cell Biology
Lingyan Chen, Dejian Chen, Jiwei Li, Lipeng He, Ting Chen, Dandan Song, Shuang Shan, Jiaxin Wang, Xiaoang Lu, Bin Lu
Summary: Ciclopirox (CPX), an antifungal drug, has shown promising potential as a treatment for gastric cancer (GC). It inhibits GC growth through suppressing proliferation and stimulating autophagic cell death. Mechanistically, CPX regulates the phosphorylation of STAT3 at Tyr705 and Ser727 residues to regulate cell growth and autophagic cell death.
CELL DEATH & DISEASE
(2022)
Review
Medicine, Research & Experimental
Yushan Dong, Jingyu Chen, Yuhan Chen, Songjiang Liu
Summary: Immune effector cells in the tumor microenvironment can become depleted or remodeled, leading to the formation of immunosuppressive microenvironments. Targeting the STAT3 oncogenic pathway can regulate the immune microenvironment and improve cancer immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sultan Alhayyani, Louise McLeod, Alison C. West, Jesse J. Balic, Christopher Hodges, Liang Yu, Julian A. Smith, Zdenka Prodanovic, Steven Bozinovski, Beena Kumar, Saleela M. Ruwanpura, Mohamed I. Saad, Brendan J. Jenkins
Summary: The oncogenic potential of the STAT3 transcription factor in many human cancers, including lung cancer, is largely attributed to its nuclear activity as a tyrosine-phosphorylated transcription factor. However, an alternate pool of serine-phosphorylated STAT3 in mitochondria has been shown to promote tumorigenesis in a limited number of mutant RAS-addicted neoplasms. In mutant KRAS-driven lung adenocarcinoma, the transcriptional activity of pS(727)-STAT3 is essential for promoting a hyper-proliferative state in cancer cells through metabolic reprogramming.
Article
Biochemistry & Molecular Biology
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Jae-Ho Lee, Byoung Kuk Jang, Mi Kyung Kim
Summary: The study found that kahweol induces apoptosis in hepatocellular carcinoma cells by inhibiting the phosphorylation of specific signaling pathways, suggesting it as a potential inhibitor of HCC cell growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Seo Yun Moon, Heejin Lee, Seoree Kim, Ji Hyung Hong, Sang Hoon Chun, Hee Yeon Lee, Keunsoo Kang, Ho Shik Kim, Hye Sung Won, Yoon Ho Ko
Summary: The EGFR and Src-mediated STAT3 signaling pathway is activated in tamoxifen-resistant breast cancer cells, and inhibition of STAT3 may be a potential target for overcoming tamoxifen resistance. Increase in nuclear p21(Cip1) may play a key role in STAT3 inhibitor-induced cell death in tamoxifen-resistant cells.
Review
Pharmacology & Pharmacy
Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee
Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.
Article
Chemistry, Medicinal
Bo Deng, Xiao-Li Jiang, Zhang-Bin Tan, Min Cai, Sui-Hui Deng, Wen-Jun Ding, You-Cai Xu, Yu-Ting Wu, Shuang-Wei Zhang, Rui-Xue Chen, Jun Kan, En-Xin Zhang, Bin Liu, Jing-Zhi Zhang
Summary: This study demonstrated that Dauricine (Dau) inhibits proliferation and promotes cell death in melanoma cells by inhibiting the Src/STAT3 pathways. Molecular docking, dynamics simulations, and surface plasmon resonance imaging further supported the strong binding affinity of Dau to Src, and its effectiveness in suppressing melanoma growth in vivo.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Huang Chen, Aiwu Bian, Lian-fang Yang, Xuan Yin, Jie Wang, Chaowen Ti, Ying Miao, Shihong Peng, Shifen Xu, Mingyao Liu, Wen-Wei Qiu, Zhengfang Yi
Summary: A new small-molecule inhibitor N4 shows potent anti-tumor bioactivity in pancreatic cancer by targeting STAT3, effectively suppressing tumor growth and metastasis, and potentially offering clinical benefits for treatment.
Article
Oncology
Zhongqiu Zhou, Zhuojun Zhang, Han Chen, Wenhao Bao, Xiangqin Kuang, Ping Zhou, Zhiqing Gao, Difeng Li, Xiaoyi Xie, Chunxiao Yang, Xuhong Chen, Jinyuan Pan, Ruiming Tang, Zhengfu Feng, Lihuan Zhou, Lan Wang, Jianan Yang, Lili Jiang
Summary: This study demonstrates that SBSN and secreted SBSN promote bladder cancer metastasis through activation of the EGFR/SRC/STAT3 pathway, identifying SBSN as a potential diagnostic and therapeutic target for bladder cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Plant Sciences
Liru Tian, Chuan Li, Limin Xiang, Jia Zeng, Shuqing Chen, Weimin Guo, Shulin Chen, Yihai Wang, Xiangjiu He, Peiqiang Su, Caixia Xu
Summary: T52, a steroidal saponin extracted from Rohdea fargesii, has been found to possess strong anti-proliferative capabilities in human pharyngeal carcinoma cell lines. In this study, it was demonstrated that T52 also has strong anti-osteosarcoma properties through the inhibition of the STAT3 signaling pathway.
Article
Cell Biology
Fei Peng, Jie Xu, Bai Cui, Qilan Liang, Sai Zeng, Bin He, Hong Zou, Manman Li, Huan Zhao, Yuting Meng, Jin Chen, Bing Liu, Shasha Lv, Peng Chu, Fan An, Zifeng Wang, Junxiu Huang, Yajing Zhan, Yuwei Liao, Jinxin Lu, Lingzhi Xu, Jin Zhang, Zhaolin Sun, Zhiguang Li, Fangjun Wang, Eric W-F Lam, Quentin Liu
Summary: RNase III DROSHA is upregulated in various cancers and interacts with beta-Catenin to activate STC1 in a RNA cleavage-independent manner. The enhanced stability of DROSHA mRNA through m(6)A modification in BCSCs, activated by AURKA, plays a key role in promoting the BCSC phenotype. Inhibition of DROSHA m(6)A modification attenuates BCSC traits, highlighting the importance of AURKA-induced m(6)A modification in breast cancer progression.
Article
Cell Biology
Zhe Feng, Suho Lee, Bowen Jia, Tao Jian, Eunjoon Kim, Mingjie Zhang
Summary: The scaffold protein IRSp53 plays an important role in synapse development and synaptic plasticity. This study reveals that specific interactions between IRSp53 and its binding partners PSD-95 or Shank3 drive phase separation of complexes and promote synaptic enrichment of IRSp53 in mouse cortical neurons. The study also highlights the role of IRSp53 in actin filament formation and synaptic maturation. These findings provide mechanistic insights into the physiological roles of IRSp53 in synapse formation and function.
JOURNAL OF CELL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Mehrdokht Sadrkhanloo, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Rasoul Raesi, Motahhar Motahhary, Sam Saghari, Laleh Sharifi, Saied Bokaie, Sepideh Mirzaei, Maliheh Entezari, Amir Reza Aref, Shokooh Salimimoghadam, Mohsen Rashidi, Afshin Taheriazam, Kiavash Hushmandi
Summary: Prostate cancer is the most common malignancy in men, causing high death rates annually. Diagnosis of prostate cancer relies on biomarkers like the PSA test, and prognosis is usually poor. The cancer cells spread rapidly and metastasis is a major cause of death. Current therapies include chemotherapy, surgery, radiotherapy, and targeted therapy. The progression of prostate cancer cells involves factors like the STAT3 signaling pathway, which promotes malignant behavior, glycolysis, and drug resistance. Natural products and small molecules have been developed for targeting STAT3 signaling in prostate cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Nadav Wallis, Froma Oberman, Khriesto Shurrush, Nicolas Germain, Gila Greenwald, Tehila Gershon, Talia Pearl, Giancarlo Abis, Vikash Singh, Amandeep Singh, Arun K. Sharma, Haim M. Barr, Andres Ramos, Vladimir S. Spiegelman, Joel K. Yisraeli
Summary: The study identified a small molecule that inhibits the binding of Igf2bp1 to Kras RNA, leading to reduction in levels of Kras and other Igf2bp1 mRNA targets, inhibition of Kras protein and downstream signaling, and potential improvement in the prognosis of Igf2bp1-expressing tumors, such as lung cancer.
Article
Biochemistry & Molecular Biology
Sina Ahandoust, Kexin Li, Xun Sun, Bai-Yan Li, Hiroki Yokota, Sungsoo Na
Summary: This study reports the opposing roles of intracellular and extracellular Moesin (MSN) in pro-tumorigenic signaling in breast cancer cells. The inhibition of intracellular MSN decreases the activities of Src and FAK, while overexpression of intracellular MSN increases them. On the other hand, extracellular MSN decreases the activities of Src, FAK, and RhoA, as well as β-catenin translocation to the nucleus. These findings highlight the location-dependent effects of MSN on signaling pathways in breast cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)