Crystal structure of human CDC7 kinase in complex with its activator DBF4

Cdc7-Dbf4 Kinase Overexpression in Multiple Cancers and Tumor Cell Lines Is Correlated with p53 Inactivation

(2015) Dorine Bonte et al.   NEOPLASIA

Discovery of XL413, a potent and selective CDC7 inhibitor

(2012) Elena S. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

Molecular Mechanism of Activation of Human Cdc7 Kinase

(2011) Ryo Kitamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress

(2010) Darryl R. Jones et al.   CELL CYCLE

Targeting Cell Division Cycle 7 Kinase: A New Approach for Cancer Therapy

(2010) A. Montagnoli et al.   CLINICAL CANCER RESEARCH

How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

(2010) K. Labib   GENES & DEVELOPMENT

Mec1 Is One of Multiple Kinases that Prime the Mcm2-7 Helicase for Phosphorylation by Cdc7

(2010) John C.W. Randell et al.   MOLECULAR CELL

The Dbf4–Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

(2010) Yi-Jun Sheu et al.   NATURE

cAMP-dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

(2010) Madhusudan et al.   PROTEIN SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Incorporation into the prereplicative complex activates the Mcm2-7 helicase for Cdc7-Dbf4 phosphorylation

(2009) L. I. Francis et al.   GENES & DEVELOPMENT

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Transcriptional Co-activator LEDGF Interacts with Cdc7-Activator of S-phase Kinase (ASK) and Stimulates Its Enzymatic Activity

(2009) Siobhan Hughes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc7p-Dbf4p Regulates Mitotic Exit by Inhibiting Polo Kinase

(2009) Charles T. Miller et al.   PLoS Genetics

Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I

(2008) Joao Matos et al.   CELL

Cdc7-Drf1 kinase links chromosome cohesion to the initiation of DNA replication in Xenopus egg extracts

(2008) T. S. Takahashi et al.   GENES & DEVELOPMENT

Cdc7-dependent phosphorylation of Mer2 facilitates initiation of yeast meiotic recombination

(2008) H. Sasanuma et al.   GENES & DEVELOPMENT

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity

(2008) Alessia Montagnoli et al.   Nature Chemical Biology

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols