Review
Cell Biology
Stephanie Tye, George E. Ronson, Joanna R. Morris
Summary: The protection of stalled DNA replication forks requires the coordination of multiple recombination proteins and the utilization of nucleases in a different way than in homologous recombination. Despite similarities, the protection mechanism at stalled forks has unique features compared to the RAD51 loading step in homologous recombination.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Herve Techer, Philippe Pasero
Summary: The replication process in eukaryotic cells is crucial for generating two identical copies of the genome during the S phase, involving the action of replisomes at replication forks. New findings suggest a connection between stalled fork processing and the activation of the cGAS-STING pathway, potentially leading to an inflammatory response with both positive and negative impacts on stressed cells. These discoveries have significant implications for interferonopathies and cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Cecilia Tortajada, Hongzhou Zhang
Summary: This paper discusses China's construction of a "Food Silk Road" under the Belt and Road Initiative, exploring the driving factors, challenges, and potential implications for global food governance.
GLOBAL FOOD SECURITY-AGRICULTURE POLICY ECONOMICS AND ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Piero R. Bianco
Summary: The rescue of stalled DNA replication forks is crucial for cell viability. Both the bacterial helicase RecG and the eukaryotic enzyme SMARCAL1 can regress forks, but there are key differences between them, including their directionality and processivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xiaobao Xu, Anthony K. N. Chan, Mingli Li, Qiao Liu, Nicole Mattson, Sheela Pangeni Pokharel, Wen-Han Chang, Yate-Ching Yuan, Jinhui Wang, Roger E. Moore, Patrick Pirrotte, Jun Wu, Rui Su, Markus Muschen, Steven T. Rosen, Jianjun Chen, Lu Yang, Chun-Wei Chen
Summary: Epigenetic dysregulation of cell cycle is a characteristic of tumorigenesis in various cancers, including hepatocellular carcinoma. The study identified ACTR5 as an essential component for HCC tumor progression. Suppression of ACTR5 affected cell cycle signaling and inhibited HCC tumor growth. The study also revealed a distinct usage of ACTR5 and IES6 in HCC compared to other INO80 complex members, suggesting a unique mechanism for ACTR5/IES6 in supporting HCC proliferation. The findings suggest that targeting ACTR5/IES6 in combination with CDK inhibition may be a promising approach for HCC therapy.
Article
Chemistry, Analytical
Michal Hodon, Ondrej Karpis, Peter Sevcik, Andrea Kocianova
Summary: This study compares the suitability of available sensors for road traffic surveillance, focusing on factors such as efficiency and price of magnetometers. The results are summarized by scoring each sensor, providing the audience with information about the pros and cons of sensors. The study specifically looks at the use of magnetometers for road traffic monitoring placed at the roadside.
Article
Chemistry, Analytical
Sadra Karimzadeh, Masashi Matsuoka
Summary: This study measured the IRI for first-degree roads in East Azerbaijan Province, Iran, using QC, and developed new equations for constructing RQPM using discriminant analysis and multispectral information from high-resolution Sentinel-2 images. The developed equations provide a valuable tool for creating proxy maps and reducing road quality monitoring costs.
Article
Green & Sustainable Science & Technology
Chuanwei Zhang, Xibo Xue, Peilin Qin, Lingling Dong
Summary: This paper proposes a speed guidance strategy based on a vehicle-road cooperative environment to solve the traffic congestion problem of mining vehicles in the intersection area of three-fork roadways in coal mines. By optimizing and scheduling the operation of mining vehicles in a specific case, the vehicles can pass through the three-fork intersection quickly, improving transportation efficiency.
Article
Developmental Biology
Prabuddha Chakraborty, Terry Magnuson
Summary: INO80 is a catalytic subunit involved in DNA replication, repair, and transcription regulation. Its deficiency in murine spermatocytes leads to apoptosis and abnormal transcription. INO80 binding is primarily located near the promoter region and is necessary for the regulation of spermatogenic gene expression. In the absence of INO80, genes that were poised for activation become derepressed and show increased expression levels.
Article
Cell Biology
Shu Xian, Yan Zhang, Li Wang, Fang Yao, Jinli Ding, Yanqing Wang, Xiao Yang, Fangfang Dai, Tailang Yin, Yanxiang Cheng
Summary: The INO80 complex plays a crucial role in embryonic development, specifically regulating the viability, migration, and invasion of trophoblast cells, potentially influencing the occurrence of recurrent miscarriage (RM) through epigenetic regulation. These findings suggest that targeting INO80 and its associated gene expression changes could inform therapeutic strategies for RM.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Laura J. Hsieh, Muryam A. Gourdet, Camille M. Moore, Elise N. Munoz, Nathan Gamarra, Vijay Ramani, Geeta J. Narlikar
Summary: The INO80 chromatin remodeling complex plays a critical role in transcription by preferentially mobilizing hexasomes over nucleosomes. It does so by dislodging an H2A-H2B dimer, allowing nucleosomes to transiently resemble hexasomes. This versatile mechanism allows INO80 to regulate chromatin architecture during transcription, replication, and repair.
Article
Oncology
Yufeng Gu, Shengjun Xu, Zhengxin Wang, Jiayin Yang, Shusen Zheng, Qiang Wei, Zhikun Liu, Xiao Xu
Summary: Liver transplantation is an effective therapy for hepatocellular carcinoma, but the shortage of donor livers and the rapid progression of cancer often lead to patients being dropped from the waitlist. Immunotherapy has shown promise in advanced HCC treatment, but its use in transplantation is limited due to the increased risk of graft rejection.
CHINESE JOURNAL OF CANCER RESEARCH
(2023)
Article
Education & Educational Research
Jack T. Lee, William Yat Wai Lo, Dana Abdrasheva
Summary: Theoretical ideas about globalization and internationalization of higher education emphasize the tension among different ideologies of higher education. In this study, the focus is on how universities in Kazakhstan engage with China's Belt and Road Initiative, with findings showing a prioritization of economic gains, industry connections, and student opportunities rather than cultural connectivity and global cooperation highlighted in Chinese policy discourse.
Article
Biochemistry & Molecular Biology
Nicolas Luis Calzetta, Marina Alejandra Gonzalez Besteiro, Vanesa Gottifredi
Summary: This study found that PARP inhibition selectively alleviates reduced fork elongation rates in Chk1-depleted cells, but does not relieve fork asymmetry. PARPs not only affect fork movement, but also induce fork deceleration and increase DNA synthesis rates in Chk1-depleted cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Cell Biology
Maksym Shyian, David Shore
Summary: During nuclear DNA replication, the replisome needs to pass through and duplicate each chromosome's full length in each cell cycle. When encountering tight DNA-protein complexes, the replisomes slow down due to active fork pausing process with recognition of a protein barrier by an evolutionarily conserved Fork Pausing/Protection Complex (FPC). The FPC not only protects forks from collapse at protein barriers but also stimulates the DNA replication checkpoint and regulates topological transitions near the replication fork, contributing to genome integrity and various physiological functions in eukaryotic cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)