X chromosome regulation: diverse patterns in development, tissues and disease

The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network

(2014) Edda G. Schulz et al.   Cell Stem Cell

Cellular Resolution Maps of X Chromosome Inactivation: Implications for Neural Development, Function, and Disease

(2014) Hao Wu et al.   NEURON

Neurocognitive variance and neurological underpinnings of the X and Y chromosomal variations

(2013) Andrea Gropman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

X Chromosome Inactivation and Epigenetic Responses to Cellular Reprogramming

(2013) Derek Lessing et al.   Annual Review of Genomics and Human Genetics

Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C

(2013) Daria Grafodatskaya et al.   BMC Medical Genomics

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

(2013) Jeannie T. Lee et al.   CELL

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

Mammalian X Upregulation Is Associated with Enhanced Transcription Initiation, RNA Half-Life, and MOF-Mediated H4K16 Acetylation

(2013) Xinxian Deng et al.   DEVELOPMENTAL CELL

Chromosome-wide profiling of X-chromosome inactivation and epigenetic states in fetal brain and placenta of the opossum, Monodelphis domestica

(2013) X. Wang et al.   GENOME RESEARCH

Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate

(2013) Amelia M. Lindgren et al.   HUMAN GENETICS

Epigenetic Functions of Smchd1 Repress Gene Clusters on the Inactive X Chromosome and on Autosomes

(2013) Anne-Valerie Gendrel et al.   MOLECULAR AND CELLULAR BIOLOGY

Tsix RNA and the Germline Factor, PRDM14, Link X Reactivation and Stem Cell Reprogramming

(2013) Bernhard Payer et al.   MOLECULAR CELL

XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells

(2013) Céline Vallot et al.   NATURE GENETICS

Independent specialization of the human and mouse X chromosomes for the male germ line

(2013) Jacob L Mueller et al.   NATURE GENETICS

Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration

(2013) Doris Bachtrog   NATURE REVIEWS GENETICS

Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway

(2013) Ryu-Suke Nozawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

(2013) J. M. Engreitz et al.   SCIENCE

Widespread sex differences in gene expression and splicing in the adult human brain

(2013) Daniah Trabzuni et al.   Nature Communications

Female Bias in Rhox6 and 9 Regulation by the Histone Demethylase KDM6A

(2013) Joel B. Berletch et al.   PLoS Genetics

Deletion of an X-Inactivation Boundary Disrupts Adjacent Gene Silencing

(2013) Lindsay M. Horvath et al.   PLoS Genetics

Age-dependent skewing of X chromosome inactivation appears delayed in centenarians’ offspring. Is there a role for allelic imbalance in Healthy Aging and Longevity?

(2012) Davide Gentilini et al.   AGING CELL

Dosage Compensation of the Sex Chromosomes

(2012) Christine M. Disteche   Annual Review of Genetics

Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor

(2012) H. S. Leong et al.   CANCER RESEARCH

Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation

(2012) J. Mauro Calabrese et al.   CELL

Reactivation of the inactive X chromosome in development and reprogramming

(2012) Tatsuya Ohhata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Recent advances in X-chromosome inactivation research

(2012) Tim Pollex et al.   CURRENT OPINION IN CELL BIOLOGY

Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation

(2012) J. W. Mugford et al.   DEVELOPMENT

Smchd1-Dependent and -Independent Pathways Determine Developmental Dynamics of CpG Island Methylation on the Inactive X Chromosome

(2012) Anne-Valerie Gendrel et al.   DEVELOPMENTAL CELL

Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes

(2012) J. T. Wolstenholme et al.   GENES BRAIN AND BEHAVIOR

Random X inactivation in the mule and horse placenta

(2012) X. Wang et al.   GENOME RESEARCH

KDM6A Point Mutations Cause Kabuki Syndrome

(2012) Noriko Miyake et al.   HUMAN MUTATION

Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation

(2012) Jennifer Grant et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Unravelling aetiology in male SLE—the X chromosome dose effect

(2012) Gisele Zandman-Goddard et al.   Nature Reviews Rheumatology

Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome

(2012) E. Pessia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and Evolutionary Patterns of Mammalian and Avian Dosage Compensation

(2012) Philippe Julien et al.   PLOS BIOLOGY

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

(2012) Karl B. Shpargel et al.   PLoS Genetics

The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

(2012) Xuqi Chen et al.   PLoS Genetics

Sex differences in microRNA regulation of gene expression: no smoke, just miRs

(2012) Christopher P Morgan et al.   Biology of Sex Differences

Expression of selected genes escaping from X inactivation in the 41, XXY* mouse model for Klinefelter’s syndrome

(2011) Steffi Werler et al.   ACTA PAEDIATRICA

Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome

(2011) Damien Lederer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

(2011) E. Splinter et al.   GENES & DEVELOPMENT

The origin and evolution of vertebrate sex chromosomes and dosage compensation

(2011) A M Livernois et al.   HEREDITY

Genes that escape from X inactivation

(2011) Joel B. Berletch et al.   HUMAN GENETICS

Evolutionary diversity and developmental regulation of X-chromosome inactivation

(2011) Martin Escamilla-Del-Arenal et al.   HUMAN GENETICS

Chromosome-wide DNA methylation analysis predicts human tissue-specific X inactivation

(2011) Allison M. Cotton et al.   HUMAN GENETICS

Sex Chromosome Complement Contributes to Sex Differences in Bradycardic Baroreflex Response

(2011) Ximena E. Caeiro et al.   HYPERTENSION

Clustered transcripts that escape X inactivation at mouse XqD

(2011) Alexandra M. Lopes et al.   MAMMALIAN GENOME

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

(2011) Ikuhiro Okamoto et al.   NATURE

Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis

(2011) Hong Lin et al.   NATURE GENETICS

Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster

(2011) Xinxian Deng et al.   NATURE GENETICS

X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription

(2011) Eda Yildirim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transcriptional sexual dimorphism during preimplantation embryo development and its consequences for developmental competence and adult health and disease

(2011) P Bermejo-Alvarez et al.   REPRODUCTION

The end of gonad-centric sex determination in mammals

(2011) Arthur P. Arnold   TRENDS IN GENETICS

Function of the Sex Chromosomes in Mammalian Fertility

(2011) E. Heard et al.   Cold Spring Harbor Perspectives in Biology

The Demoiselle of X-Inactivation: 50 Years Old and As Trendy and Mesmerising As Ever

(2011) Céline Morey et al.   PLoS Genetics

Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic

(2011) Shafagh Al Nadaf et al.   GENOME BIOLOGY

Genetics of Early Onset Cognitive Impairment

(2010) Hans Hilger Ropers   Annual Review of Genomics and Human Genetics

Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome

(2010) Alexandra M Lopes et al.   BMC GENOMICS

Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse

(2010) Björn Reinius et al.   BMC GENOMICS

Identification of regulatory elements flanking human XIST reveals species differences

(2010) Samuel C Chang et al.   BMC MOLECULAR BIOLOGY

Sexual Dimorphism in Mammalian Autosomal Gene Regulation Is Determined Not Only by Sry but by Sex Chromosome Complement As Well

(2010) Patrick J. Wijchers et al.   DEVELOPMENTAL CELL

Global survey of escape from X inactivation by RNA-sequencing in mouse

(2010) F. Yang et al.   GENOME RESEARCH

Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin

(2010) L. N. Changolkar et al.   MOLECULAR AND CELLULAR BIOLOGY

Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition

(2010) Daniel W. Bellott et al.   NATURE

The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos

(2010) Shin Kobayashi et al.   NUCLEIC ACIDS RESEARCH

Random X Inactivation and Extensive Mosaicism in Human Placenta Revealed by Analysis of Allele-Specific Gene Expression along the X Chromosome

(2010) Joana Carvalho Moreira de Mello et al.   PLoS One

Sex determines the expression level of one third of the actively expressed genes in bovine blastocysts

(2010) P. Bermejo-Alvarez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal Redistribution of Male-Biased Genes in Mammalian Evolution with Two Bursts of Gene Gain on the X Chromosome

(2010) Yong E. Zhang et al.   PLOS BIOLOGY

Genomic Responses to Abnormal Gene Dosage: The X Chromosome Improved on a Common Strategy

(2010) Xinxian Deng et al.   PLOS BIOLOGY

Expression in Aneuploid Drosophila S2 Cells

(2010) Yu Zhang et al.   PLOS BIOLOGY

Dosage compensation and the global re-balancing of aneuploid genomes

(2010) Matthias Prestel et al.   GENOME BIOLOGY

X Chromosome Inactivation Is Initiated in Human Preimplantation Embryos

(2009) Ilse M. van den Berg et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evidence that the nonsense-mediated mRNA decay pathway participates in X chromosome dosage compensation in mammals

(2009) Shanye Yin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mouse Models for Evaluating Sex Chromosome Effects that Cause Sex Differences in Non-Gonadal Tissues

(2009) Arthur P. Arnold   JOURNAL OF NEUROENDOCRINOLOGY

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice

(2009) C. Patrat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X Inactivation Counting and Choice Is a Stochastic Process: Evidence for Involvement of an X-Linked Activator

(2008) Kim Monkhorst et al.   CELL

Gene content evolution on the X chromosome

(2008) Tatiana A Gurbich et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

X chromosome in autoimmune diseases

(2008) Pietro Invernizzi et al.   Expert Review of Clinical Immunology

The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression

(2008) Jacob L Mueller et al.   NATURE GENETICS

Large-Scale Population Study of Human Cell Lines Indicates that Dosage Compensation Is Virtually Complete

(2008) Colette M. Johnston et al.   PLoS Genetics

Sex-Specific Expression of the X-Linked Histone Demethylase Gene Jarid1c in Brain

(2008) Jun Xu et al.   PLoS One