Review
Biochemistry & Molecular Biology
Matthew J. Payea, Carlos Anerillas, Ravi Tharakan, Myriam Gorospe
Summary: Senescence is a state of long-term cell cycle arrest caused by sublethal damage, leading to metabolic activity, production of inflammatory proteins, and inhibition of ribosome biogenesis. The translation process in senescent cells shows a paradoxical pattern with global repression triggered by DNA damage and selective increase in translation of specific proteins.
MOLECULAR AND CELLULAR BIOLOGY
(2021)
Article
Developmental Biology
Jaroslav Ferenc, Aissam Ikmi
Summary: This article discusses the important role of nutritional and metabolic cues in animal development, which not only support the developmental process as an energy source but also act as environmental indicators influencing decision-making. The modulation or driving of genetic programs by nutrition and metabolism to instruct developmental trajectories remains challenging.
Review
Multidisciplinary Sciences
Haithem Barbour, Nadine Sen Nkwe, Benjamin Estavoyer, Clemence Messmer, Mila Gushul-Leclaire, Romain Villot, Maxime Uriarte, Karine Boulay, Sari Hlayhel, Bassel Farhat, Eric Milot, Frederick A. Mallette, Salima Daou, El Bachir Affar
Summary: Ubiquitination is an important post-translational modification (PTM) that regulates various cellular processes in eukaryotes. Abnormalities in ubiquitin signaling play a role in human pathologies such as cancer and neurodegeneration. Progress has been made in understanding how ubiquitin ligases recognize their substrates and how ubiquitination is regulated. This study explores the coordination of E3 ligases and provides a comprehensive inventory of ubiquitination crosstalk with multiple PTMs, discussing the molecular mechanisms by which PTMs orchestrate ubiquitination to ensure cell homeostasis.
Article
Biochemistry & Molecular Biology
Tal Havkin-Solomon, Elad Itzhaki, Nir Joffe, Nina Reuven, Yosef Shaul, Rivka Dikstein
Summary: The study reveals that RPS3 mRNA-binding residues have multiple regulatory functions in translation and are exploited by SARS-CoV-2 to influence host and viral mRNA translation and stability.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Ion G. Motofei
Summary: Cancer research has primarily focused on investigating cells and molecular mechanisms. However, recent data suggests that the extracellular matrix also plays a significant role in cancer progression. The relationship between cells and the matrix creates a specific local microenvironment that supports malignant development. Cancer also involves systemic changes related to developmental processes and adaptation. There is currently a gap between the local investigation of cancer and the systemic approach to understanding it as a disease.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dan Li, Jihong Yang, Xin Huang, Hongwei Zhou, Jianlong Wang
Summary: Translational control is a fundamental regulatory layer that governs cellular identity and functions. Through an RNA interference screen, we identified eIF4A2 as a key translation initiation factor required for maintaining embryonic stem cell identity and defined its mechanistic action.
Article
Nanoscience & Nanotechnology
Themistoklis Zisis, Jan Schwarz, Miriam Balles, Maibritt Kretschmer, Maria Nemethova, Remy Chait, Robert Hauschild, Janina Lange, Calin Guet, Michael Sixt, Stefan Zahler
Summary: The study presents a versatile and high-throughput covalent photoimmobilization technique for generating sustainable patterns and gradients on cell culture surfaces, thereby restricting cell growth and migration. Additionally, by incorporating a switchable patterning step, spatial and temporal control was achieved, successfully reconstructing the dynamics of cell transformation during angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Shijie Ma, Zizheng Dong, Yanfei Huang, Jing-Yuan Liu, Jian-Ting Zhang
Summary: eIF3a regulates S6K1 activity by inhibiting mTORC1 kinase via regulating Raptor synthesis. Furthermore, mTORC1 may mediate eIF3a function in cellular response to cisplatin by regulating synthesis of NER proteins and NER activity.
Article
Multidisciplinary Sciences
Alexander Plong, Kevin Rodriguez, Mark Alber, Weitao Chen, G. Venugopala Reddy
Summary: WUSCHEL concentration regulation is crucial for stem cell homeostasis in Arabidopsis shoot apical meristems. CLAVATA3 not only represses WUSCHEL transcription, but also regulates WUSCHEL by controlling its nuclear export and diffusion between adjacent cells.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Scott D. Evans, Mary L. Droser, Douglas H. Erwin
Summary: Analysis of representative taxa from the Ediacaran White Sea assemblage suggests that early animals likely possessed genetic pathways for multicellularity, axial polarity, musculature, and a nervous system. The absence of major differentiation of macroscopic body units in these animals supports the hypothesis that features like heads with concentrated sensory machinery or ventral nerve cords evolved independently in disparate bilaterian clades.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Xiaojing Liu, Fengfeng Du, Linhe Sun, Jinfeng Li, Shaozhou Chen, Naiwei Li, Yajun Chang, Jian Cui, Wen Chen, Dongrui Yao
Summary: In this study, it was found that the natural mutant 'Da Sajin' in lotus may have originated from a red-flowered ancestor. Partial loss of anthocyanin pigments in white petals may result from metabolic disorder caused by light destruction. The translational and post-translational regulatory network plays an important role in anthocyanin metabolism in lotus.
Review
Pharmacology & Pharmacy
Anand Patwardhan, Norton Cheng, JoAnn Trejo
Summary: G protein-coupled receptors (GPCRs) are a large family of signaling receptors that regulate cellular and physiologic responses, implicated in various diseases. Although phosphorylation is a major regulator of GPCR signaling, other post-translational modifications (PTMs) such as ubiquitination, glycosylation, and palmitoylation play important roles in GPCR biology, yet understanding of these PTMs is limited. Comprehensive understanding of diverse PTMs is crucial for elucidating dysregulated mechanisms in disease and improving drug development for GPCRs.
PHARMACOLOGICAL REVIEWS
(2021)
Review
Multidisciplinary Sciences
Paula McSteen, Elizabeth A. Kellogg
Summary: Grasses have been cultivated by humans for various purposes for thousands of years. They have adapted and diversified into approximately 12,000 species, with different genes and traits selected in different crop species. Research on the molecular, cellular, and developmental bases of grain yield and dispersal in grasses is ongoing, and with increasing genomic resources, we expect to gain more insights into their ecological and economic success.
Review
Biochemistry & Molecular Biology
Annabelle Klein, Muriel Rhinn, William M. M. Keyes
Summary: Cellular senescence is a state induced by aging and stress, with both beneficial and harmful effects. Misregulation of senescence can lead to diseases and aging. The role of atypical senescence in the pathogenesis of developmental defects has not been well studied.
Review
Biochemistry & Molecular Biology
Montserrat Fernandez-Guarino, Maria Luisa Hernandez-Bule, Stefano Bacci
Summary: This review summarizes the recent knowledge of cellular and molecular processes in wound healing, explores pathological alterations and new therapies. Awareness of these scientific problems is crucial for experts dealing with these presentations on a daily basis.
Article
Oncology
Johannes Berlandi, Amel Chaouch, Nicolas De Jay, Isabel Tegeder, Katharina Thiel, Margret Shirinian, Claudia L. Kleinman, Astrid Jeibmann, Paul Lasko, Nada Jabado, Martin Hasselblatt
Article
Oncology
Brian Krug, Nicolas De Jay, Ashot S. Harutyunyan, Shriya Deshmukh, Dylan M. Marchione, Paul Guilhamon, Kelsey C. Bertrand, Leonie G. Mikael, Melissa K. McConechy, Carol C. L. Chen, Sima Khazaei, Robert F. Koncar, Sameer Agnihotri, Damien Faury, Benjamin Ellezam, Alexander G. Weil, Josie Ursini-Siegel, Daniel D. De Carvalho, Peter B. Dirks, Peter W. Lewis, Paolo Salomoni, Mathieu Lupien, Cheryl Arrowsmith, Paul F. Lasko, Benjamin A. Garcia, Claudia L. Kleinman, Nada Jabado, Stephen C. Mack
Correction
Oncology
Brian Krug, Nicolas De Jay, Ashot S. Harutyunyan, Shriya Deshmukh, Dylan M. Marchione, Paul Guilhamon, Kelsey C. Bertrand, Leonie G. Mikael, Melissa K. McConechy, Carol C. L. Chen, Sima Khazaei, Robert F. Koncar, Sameer Agnihotri, Damien Faury, Benjamin Ellezam, Alexander G. Weil, Josie Ursini-Siegel, Daniel D. De Carvalho, Peter B. Dirks, Peter W. Lewis, Paolo Salomoni, Mathieu Lupien, Cheryl Arrowsmith, Paul F. Lasko, Benjamin A. Garcia, Claudia L. Kleinman, Nada Jabado, Stephen C. Mack
Article
Multidisciplinary Sciences
Jian Kong, Hong Han, Julie Bergalet, Louis Philip Benoit Bouvrette, Greco Hernandez, Nam-Sung Moon, Hojatollah Vali, Eric Lecuyer, Paul Lasko
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
D. Taruscio, G. Baynam, H. Cederroth, S. C. Groft, E. W. Klee, K. Kosaki, P. Lasko, B. Melegh, O. Riess, M. Salvatore, W. A. Gahl
MOLECULAR GENETICS AND METABOLISM
(2020)
Article
Genetics & Heredity
Annabelle Dold, Hong Han, Niankun Liu, Andrea Hildebrandt, Mirko Brueggemann, Cornelia Rueckle, Heike Haenel, Anke Busch, Petra Beli, Kathi Zarnack, Julian Koenig, Jean-Yves Roignant, Paul Lasko
Review
Cell Biology
Paul Lasko
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2020)
Review
Biochemistry & Molecular Biology
Amel Chaouch, Paul Lasko
Summary: Drosophila melanogaster is a powerful genetic model for studying human disease, with many key factors and pathways conserved between fruit flies and humans. The study of fruit flies has contributed significantly to our understanding of genetics, developmental biology, and epigenetic research related to human disease. It has also led to important discoveries about chromatin regulators and their role in cancer progression, expanding our knowledge of how chromatin perturbations can lead to human cancer.
Review
Biochemistry & Molecular Biology
Greco Hernandez, Alejandra Garcia, Nahum Sonenberg, Paul Lasko
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Leily Kashkooli, David Rozema, Lina Espejo-Ramirez, Paul Lasko, Francois Fagotto
Summary: The differences in morphogenetic capabilities between ectoderm and mesoderm can be attributed to differences in Rho-kinases-dependent actomyosin contractility. The mobility in the mesoderm is regulated by Rnd1 and Shirin, which play essential roles in gastrulation. They contribute to decreasing cortical tension and conferring motility, with Shirin increasing tissue fluidity and dispersion and Rnd1 favoring more compact collective migration.
Article
Genetics & Heredity
Servi J. C. Stevens, Constance T. R. M. Stumpel, Karin E. M. Diderich, Marjon A. van Slegtenhorst, Mary-Alice Abbott, Courtney Manning, Jorune Balciuniene, Louise C. Pyle, Jacqueline Leonard, Jill R. Murrell, Romy van de Putte, Iris A. L. M. van Rooij, Alexander Hoischen, Paul Lasko, Han G. Brunner
Summary: Pathogenic variants in the CDX2 gene are rare genetic causes for a multiple congenital anomaly syndrome, with clinical features that overlap with caudal regression syndrome and VACTERL. The variability in phenotypes, even within unrelated patients carrying the same variant, highlights the essential role of CDX2 in caudal morphogenesis in humans.
Article
Biochemistry & Molecular Biology
Amel Chaouch, Johannes Berlandi, Carol C. L. Chen, Felice Frey, Shireen Badini, Ashot S. Harutyunyan, Xiao Chen, Brian Krug, Steven Hebert, Astrid Jeibmann, Chao Lu, Claudia L. Kleinman, Martin Hasselblatt, Paul Lasko, Margret Shirinian, Nada Jabado
Summary: Substitutions of lysine-to-methionine in Histone H3.3 impair the deposition of chromatin marks and result in abnormal eye development in Drosophila. These mutations affect transcriptional regulation of specific genes, showcasing the contribution of redistribution of antagonistic marks to disease pathogenesis.
Article
Multidisciplinary Sciences
Charles C. Y. Xu, Claire Ramsay, Mitra Cowan, Mehrnoush Dehghani, Paul Lasko, Rowan D. H. Barrett
Summary: The study demonstrates that simple and non-invasive environmental DNA (eDNA) methods can be used to detect transgenes of genetically modified (GM) animals in both terrestrial and aquatic environments. With the rapid advancement of genome-editing technologies like CRISPR, there will be a significant increase in the prevalence and diversity of GM animals, highlighting the importance of sensitive and cost-effective detection methods like eDNA.
Meeting Abstract
Oncology
Johannes Berlandi, Amel Chaouch, Isabel Tegeder, Katharina Thiel, Claudia L. Kleinman, Margret Shirinian, Nicolas De Jay, Astrid Jeibmann, Paul Lasko, Nada Jabado, Martin Hasselblatt
Review
Medicine, Research & Experimental
Hugh J. S. Dawkins, Ruxandra Draghia-Akli, Paul Lasko, Lilian P. L. Lau, Anneliene H. Jonker, Christine M. Cutillo, Ana Rath, Kym M. Boycott, Gareth Baynam, Hanns Lochmuller, Petra Kaufmann, Yann Le Cam, Virginie Hivert, Christopher P. Austin
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2018)