Emerging biomedical applications of synthetic biology

Conditional DNA-Protein Interactions Confer Stimulus-Sensing Properties to Biohybrid Materials

(2011) Erik H. Christen et al.   ADVANCED FUNCTIONAL MATERIALS

Network News: Innovations in 21st Century Systems Biology

(2011) Adam P. Arkin et al.   CELL

Informing Biological Design by Integration of Systems and Synthetic Biology

(2011) Christina D. Smolke et al.   CELL

Anti-Borrelia burgdorferi Antibody Profile in Post-Lyme Disease Syndrome

(2011) Abhishek Chandra et al.   Clinical and Vaccine Immunology

Molecular diversity—the toolbox for synthetic gene switches and networks

(2011) Wilfried Weber et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fighting bacterial infections—Future treatment options

(2011) Jenny Fernebro   DRUG RESISTANCE UPDATES

LIPS arrays for simultaneous detection of antibodies against partial and whole proteomes of HCV, HIV and EBV

(2011) Peter D. Burbelo et al.   Molecular BioSystems

Origin of bistability underlying mammalian cell cycle entry

(2011) G. Yao et al.   Molecular Systems Biology

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

(2011) Nikolai Windbichler et al.   NATURE

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Autoantigen discovery with a synthetic human peptidome

(2011) H Benjamin Larman et al.   NATURE BIOTECHNOLOGY

Parallel on-chip gene synthesis and application to optimization of protein expression

(2011) Jiayuan Quan et al.   NATURE BIOTECHNOLOGY

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

(2011) Feng Zhang et al.   NATURE BIOTECHNOLOGY

Genotype and SNP calling from next-generation sequencing data

(2011) Rasmus Nielsen et al.   NATURE REVIEWS GENETICS

The potential of synthetic biology: a view from the European Academies Science Advisory Council

(2011) Robin Fears et al.   NATURE REVIEWS MICROBIOLOGY

Genetic elimination of dengue vector mosquitoes

(2011) M. R. Wise de Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Celebration of the Genome, Part I

(2011) B. R. Jasny et al.   SCIENCE

Synthetic Biology: Integrated Gene Circuits

(2011) N. Nandagopal et al.   SCIENCE

Synthetic Biology Moving into the Clinic

(2011) W. C. Ruder et al.   SCIENCE

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

(2011) Z. Xie et al.   SCIENCE

A Gene Therapy Technology-Based Biomaterial for the Trigger-Inducible Release of Biopharmaceuticals in Mice

(2010) Michael M. Kämpf et al.   ADVANCED FUNCTIONAL MATERIALS

Mammalian synthetic biology - from tools to therapies

(2010) Dominique Aubel et al.   BIOESSAYS

Making Cellular Memories

(2010) Devin R. Burrill et al.   CELL

How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?

(2010) Yohannes Mebratu et al.   CELL CYCLE

Ligand-dependent regulatory RNA parts for Synthetic Biology in eukaryotes

(2010) Markus Wieland et al.   CURRENT OPINION IN BIOTECHNOLOGY

Watch the clock—engineering biological systems to be on time

(2010) Dominique Aubel et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Antibody-profiling technologies for studying humoral responses to infectious agents

(2010) Peter D Burbelo et al.   Expert Review of Vaccines

A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms

(2010) Christian Kemmer et al.   JOURNAL OF CONTROLLED RELEASE

Multichromatic Control of Gene Expression in Escherichia coli

(2010) Jeffrey J. Tabor et al.   JOURNAL OF MOLECULAR BIOLOGY

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

A tunable dual-promoter integrator for targeting of cancer cells

(2010) Lior Nissim et al.   Molecular Systems Biology

Synthetic metabolism goes green

(2010) Joseph P. Noel   NATURE

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Life after the synthetic cell

(2010)   NATURE

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

Oligomeric organization of the B-cell antigen receptor on resting cells

(2010) Jianying Yang et al.   NATURE

A synchronized quorum of genetic clocks

(2010) Tal Danino et al.   NATURE

High-fidelity gene synthesis by retrieval of sequence-verified DNA identified using high-throughput pyrosequencing

(2010) Mark Matzas et al.   NATURE BIOTECHNOLOGY

Scalable gene synthesis by selective amplification of DNA pools from high-fidelity microchips

(2010) Sriram Kosuri et al.   NATURE BIOTECHNOLOGY

Self-sufficient control of urate homeostasis in mice by a synthetic circuit

(2010) Christian Kemmer et al.   NATURE BIOTECHNOLOGY

From pond scum to pharmacy shelf

(2010) Amber Dance   NATURE MEDICINE

A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection

(2010) Wataru Akahata et al.   NATURE MEDICINE

Rationally designed logic integration of regulatory signals in mammalian cells

(2010) Madeleine Leisner et al.   Nature Nanotechnology

Synthetic biology: applications come of age

(2010) Ahmad S. Khalil et al.   NATURE REVIEWS GENETICS

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

(2010) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

A synthetic low-frequency mammalian oscillator

(2010) Marcel Tigges et al.   NUCLEIC ACIDS RESEARCH

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

(2010) Y. Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A synthetic-natural hybrid oscillator in human cells

(2010) J. E. Toettcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Female-specific flightless phenotype for mosquito control

(2010) G. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered bacterial communication prevents Vibrio cholerae virulence in an infant mouse model

(2010) F. Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein transduction from retroviral Gag precursors

(2010) Christine Voelkel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

(2010) S. J. Culler et al.   SCIENCE

Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome

(2010) D. G. Gibson et al.   SCIENCE

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

(2010) et al.   SCIENCE

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis

(2009) Dominik E. Dorer et al.   ADVANCED DRUG DELIVERY REVIEWS

Artificial Ribozyme Switches Containing Natural Riboswitch Aptamer Domains

(2009) Markus Wieland et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice

(2009) S Ganai et al.   BRITISH JOURNAL OF CANCER

Genetically Engineered Salmonella typhimurium as an Imageable Therapeutic Probe for Cancer

(2009) V. H. Nguyen et al.   CANCER RESEARCH

A Synthetic Genetic Edge Detection Program

(2009) Jeffrey J. Tabor et al.   CELL

Frameworks for Programming Biological Function through RNA Parts and Devices

(2009) Maung Nyan Win et al.   CHEMISTRY & BIOLOGY

RNA-based computation in live cells

(2009) Yaakov Benenson   CURRENT OPINION IN BIOTECHNOLOGY

Recent advances in mammalian synthetic biology—design of synthetic transgene control networks

(2009) Marcel Tigges et al.   CURRENT OPINION IN BIOTECHNOLOGY

The promise and potential pitfalls of chimeric antigen receptors

(2009) Michel Sadelain et al.   CURRENT OPINION IN IMMUNOLOGY

The impact of synthetic biology on drug discovery

(2009) Wilfried Weber et al.   DRUG DISCOVERY TODAY

Engineering ligand-responsive gene-control elements: lessons learned from natural riboswitches

(2009) K H Link et al.   GENE THERAPY

Heat-stable oral alga-based vaccine protects mice from Staphylococcus aureus infection

(2009) Imke A.J. Dreesen et al.   JOURNAL OF BIOTECHNOLOGY

Eukaryotic systems broaden the scope of synthetic biology

(2009) Karmella A. Haynes et al.   JOURNAL OF CELL BIOLOGY

Optimization and quantification of protein synthesis inside liposomes

(2009) Maryam Amidi et al.   JOURNAL OF LIPOSOME RESEARCH

Synthetic biology: exploring and exploiting genetic modularity through the design of novel biological networks

(2009) Christina M. Agapakis et al.   Molecular BioSystems

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

A tunable synthetic mammalian oscillator

(2009) Marcel Tigges et al.   NATURE

Diversity-based, model-guided construction of synthetic gene networks with predicted functions

(2009) Tom Ellis et al.   NATURE BIOTECHNOLOGY

Synthetic viruses: a new opportunity to understand and prevent viral disease

(2009) Eckard Wimmer et al.   NATURE BIOTECHNOLOGY

Induction of protein-protein interactions in live cells using light

(2009) Masayuki Yazawa et al.   NATURE BIOTECHNOLOGY

Next-generation synthetic gene networks

(2009) Timothy K Lu et al.   NATURE BIOTECHNOLOGY

Synthetic EthR inhibitors boost antituberculous activity of ethionamide

(2009) Nicolas Willand et al.   NATURE MEDICINE

The second wave of synthetic biology: from modules to systems

(2009) Priscilla E. M. Purnick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence for large diversity in the human transcriptome created by Alu RNA editing

(2009) Michal Barak et al.   NUCLEIC ACIDS RESEARCH

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

(2009) M. Gitzinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

(2009) C. Carpenito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

(2009) T. K. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

As Swine Flu Circles Globe, Scientists Grapple With Basic Questions

(2009) J. Cohen et al.   SCIENCE

Creating Bacterial Strains from Genomes That Have Been Cloned and Engineered in Yeast

(2009) C. Lartigue et al.   SCIENCE

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes

(2008) F. Duan et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Intron length increases oscillatory periods of gene expression in animal cells

(2008) I. A. Swinburne et al.   GENES & DEVELOPMENT

A novel system for trigger-controlled drug release from polymer capsules

(2008) David A. Fluri et al.   JOURNAL OF CONTROLLED RELEASE

A fast, robust and tunable synthetic gene oscillator

(2008) Jesse Stricker et al.   NATURE

Evolvability and hierarchy in rewired bacterial gene networks

(2008) Mark Isalan et al.   NATURE

Refinement and standardization of synthetic biological parts and devices

(2008) Barry Canton et al.   NATURE BIOTECHNOLOGY

Drug-sensing hydrogels for the inducible release of biopharmaceuticals

(2008) Martin Ehrbar et al.   NATURE MATERIALS

Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded

(2008) Roberto Cattaneo et al.   NATURE REVIEWS MICROBIOLOGY

Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

(2008) D. Greber et al.   NUCLEIC ACIDS RESEARCH

A synthetic mammalian gene circuit reveals antituberculosis compounds

(2008) W. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

(2008) M. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

(2008) J. R. Coleman et al.   SCIENCE

Complete Chemical Synthesis, Assembly, and Cloning of a Mycoplasma genitalium Genome

(2008) D. G. Gibson et al.   SCIENCE