Editorial Material
Psychology, Biological
Janet M. Box-Steffensmeier, Jean Burgess, Maurizio Corbetta, Kate Crawford, Esther Duflo, Laurel Fogarty, Alison Gopnik, Sari Hanafi, Mario Herrero, Ying-yi Hong, Yasuko Kameyama, Tatia M. C. Lee, Gabriel M. Leung, Daniel S. Nagin, Anna C. Nobre, Merete Nordentoft, Aysu Okbay, Andrew Perfors, Laura M. Rival, Cassidy R. Sugimoto, Bertil Tungodden, Claudia Wagner
Summary: Human behavior is complex and requires interdisciplinary research to address societal challenges. Broadening the scope of disciplines and incorporating insights from others is crucial for making progress.
NATURE HUMAN BEHAVIOUR
(2022)
Editorial Material
Multidisciplinary Sciences
Zane Lombard, Guida Landoure
Summary: Funding for a major genomics programme in Africa will run out this year, highlighting the importance of seizing the opportunity to address global health-related genomics inequality by leveraging the success of this initiative.
Review
Chemistry, Analytical
Khawla Chouchene, Joao Pinto da Costa, Mohamed Chamkha, Mohamed Ksibi, Sami Sayadi
Summary: Microplastics pose a global threat to marine ecosystems, and their bioavailability is influenced by various factors. Microplastics can adsorb contaminants and serve as vectors for toxicants and pathogens. Addressing the physico-chemical properties, toxicological concerns, bioavailability, and environmental impact of microplastics is crucial. Furthermore, the relationship between the biological response to microplastics and their physical and chemical characteristics is complex and needs further investigation. Research on the interactions of microplastics with aquatic organisms and related chemicals, as well as identifying knowledge gaps and future research opportunities, is summarized in this article.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yanhui Hu, Ben Ewen-Campen, Aram Comjean, Jonathan Rodiger, Stephanie E. Mohr, Norbert Perrimon
Summary: Paralogs are genes that arise through gene duplication and pose a challenge to functional genetics research when they retain overlapping or redundant function. We have developed Paralog Explorer, an online resource that enables researchers to identify candidate paralogous genes in model organisms' genomes and provides access to relevant databases for gene co-expression, protein-protein and genetic interactions, as well as gene ontology and phenotype annotations. This tool expands the capabilities of current ortholog prediction resources for the identification and study of paralogous genes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Engineering, Civil
Jianzhu Li, Yunpeng Li, Ting Zhang, Ping Feng
Summary: Climate change has affected hydrological processes and redistributed water resources. This study used the SDSM model, BMA method, and QM method to downscale and correct climate data in the Yongding watershed. The results showed an upward trend in temperature, precipitation, and runoff under future climate scenarios, suggesting a potential alleviation of water shortage in the watershed. These findings are of great importance for decision-making in water resources management and protection.
JOURNAL OF HYDROLOGY
(2023)
Article
Genetics & Heredity
Feng Xu, Yifan Wang, Yunchao Ling, Chenfen Zhou, Haizhou Wang, Andrew E. Teschendorff, Yi Zhao, Haitao Zhao, Yungang He, Guoqing Zhang, Zhen Yang
Summary: MicroRNAs play important roles in gene expression regulation, and their dysregulation is widely reported in pathological cellular states. The dbDEMC database was constructed to store and query differentially expressed miRNAs (DEMs) in human cancers. The updated version, dbDEMC 3.0, contains more data entries and includes data from mice and rats. It provides a valuable resource for studying the molecular functions and regulatory mechanisms of DEMs in human cancers.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Psychology, Multidisciplinary
Mattia Pinardi, Nicola Di Stefano, Giovanni Di Pino, Charles Spence
Summary: Crossmodal correspondences are consistent mappings between perceptual dimensions or stimuli from different sensory domains. Human movement augmentation, which aims to enhance motor abilities through artificial devices, faces the challenge of relaying supplementary information to users. This article explores the potential role of crossmodal correspondences in human augmentation and discusses three ways in which they can impact motor control and embodiment.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Nutrition & Dietetics
Oliwia Stefaniak, Malgorzata Dobrzynska, Slawomira Drzymala-Czyz, Juliusz Przyslawski
Summary: Alzheimer's disease is a progressive brain disease that is becoming a major health issue due to the aging population. Nutrition plays a crucial role in preventing and delaying the development of the disease, with diets rich in neuroprotective nutrients such as antioxidants, B vitamins, and polyunsaturated fatty acids recommended. Studies have shown that healthy dietary patterns like the Mediterranean diet can reduce the risk of Alzheimer's disease.
Review
Microbiology
Imane Allali, Regina E. Abotsi, Lemese Ah. Tow, Lehana Thabane, Heather J. Zar, Nicola M. Mulder, Mark P. Nicol
Summary: There are significant gaps in microbiome research in Africa, especially those focusing on diseases of public health importance. Local leadership, capacity building, intra-continental collaboration, and national government investment are needed in microbiome research within Africa.
Review
Cell Biology
Jialin Wei, Wen Zhang, Jie Li, Ye Jin, Zhidong Qiu
Summary: The large animal model is crucial in preclinical research. Transgenic pigs, due to advancements in genetic engineering, have shown superiority in disease research, particularly in metabolic diseases, neurodegenerative diseases, and genetic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Pingping Luo, Manting Luo, Fengyue Li, Xiaogang Qi, Aidi Huo, Zhenhong Wang, Bin He, Kaoru Takara, Daniel Nover, Yihe Wang
Summary: This study reviews urban flood numerical simulations and identifies accuracy and computational efficiency as the two key areas hindering the improvement of model quality. The 1D-2D coupling model, finite volume method, unstructured meshing method, and hybrid parallel computing applications are found to be the most effective strategies. Furthermore, the complex coupling of models and the lack of validation data remain crucial challenges in the development of urban flood modeling.
ENVIRONMENTAL MODELLING & SOFTWARE
(2022)
Article
Psychology, Biological
James W. Madole, K. Paige Harden
Summary: The authors of the study received 23 lively commentaries from various disciplines and answered three overarching questions regarding causality, similarities and differences between randomized controlled trials and within-family genome-wide association studies, and whether behavior genetics is qualitatively different from other fields.
BEHAVIORAL AND BRAIN SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W. Mills, Kirstine Calloe, Ulrike Leurs, Johan Z. Ye, Christian Stolte, Morten B. Thomsen, Bo H. Bentzen, Pia R. Lundegaard, Morten S. Olesen, Lars J. Jensen, Jesper Olsen, Alicia Lundby
Summary: Analyzing protein profiles in human and model organisms' cardiac tissues allows for identification of similarities and differences, providing important insights for translational cardiac research across species.
Article
Multidisciplinary Sciences
Felipe J. Colon-Gonzalez, Rory Gibb, Kamran Khan, Alexander Watts, Rachel Lowe, Oliver J. Brady
Summary: The recent global expansion of dengue has been facilitated by changes in urbanisation, mobility, and climate. This study projects changes in future dengue incidence in Southeast Asia up to 2099, predicting a peak this century. Equatorial areas will see the biggest increases, Thailand and Cambodia will show the biggest decreases in incidence.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Shashank Pandey, Tomas Chmelir, Magdalena Chottova Dvorakova
Summary: Diabetes mellitus is a serious disease with increasing incidence worldwide. Animal models have been extensively used in diabetes research, but there are challenges in translating the findings to human clinical trials.
Article
Clinical Neurology
Brendan T. Keenan, Raymond J. Galante, Jie Lian, Petr Simecek, Daniel M. Gatti, Lin Zhang, Diane C. Lim, Karen L. Svenson, Gary A. Churchill, Allan Pack
Article
Genetics & Heredity
Danny Laurent, Fiona Semple, Philip J. Starkey Lewis, Elaine Rose, Holly A. Black, Jennifer Coe, Stuart J. Forbes, Mark J. Arends, James W. Dear, Timothy J. Aitman
BMC MEDICAL GENOMICS
(2020)
Article
Cardiac & Cardiovascular Systems
Alexander J. Fletcher, Maaz B. J. Syed, Timothy J. Aitman, David E. Newby, Niki L. Walker
Article
Multidisciplinary Sciences
James E. D. Thaventhiran, Hana Lango Allen, Oliver S. Burren, William Rae, Daniel Greene, Emily Staples, Zinan Zhang, James H. R. Farmery, Ilenia Simeoni, Elizabeth Rivers, Jesmeen Maimaris, Christopher J. Penkett, Jonathan Stephens, Sri V. V. Deevi, Alba Sanchis-Juan, Nicholas S. Gleadall, Moira J. Thomas, Ravishankar B. Sargur, Pavels Gordins, Helen E. Baxendale, Matthew Brown, Paul Tuijnenburg, Austen Worth, Steven Hanson, Rachel J. Linger, Matthew S. Buckland, Paula J. Rayner-Matthews, Kimberly C. Gilmour, Crina Samarghitean, Suranjith L. Seneviratne, David M. Sansom, Andy G. Lynch, Karyn Megy, Eva Ellinghaus, David Ellinghaus, Silje F. Jorgensen, Tom H. Karlsen, Kathleen E. Stirrups, Antony J. Cutler, Dinakantha S. Kumararatne, Anita Chandra, J. David M. Edgar, Archana Herwadkar, Nichola Cooper, Sofia Grigoriadou, Aarnoud P. Huissoon, Sarah Goddard, Stephen Jolles, Catharina Schuetz, Felix Boschann, Paul A. Lyons, Matthew E. Hurles, Sinisa Savic, Siobhan O. Burns, Taco W. Kuijpers, Ernest Turro, Willem H. Ouwehand, Adrian J. Thrasher, Kenneth G. C. Smith
Article
Multidisciplinary Sciences
Bianca Jupp, Silvia Pitzoi, Enrico Petretto, Adam C. Mar, Yolanda Pena Oliver, Emily R. Jordan, Stephanie Taylor, Santosh S. Atanur, Prashant K. Srivastava, Kathrin Saar, Norbert Hubner, Wolfgang H. Sommer, Oliver Staehlin, Rainer Spanagel, Emma S. Robinson, Gunter Schumann, Margarita Moreno, Barry J. Everitt, Trevor W. Robbins, Timothy J. Aitman, Jeffrey W. Dalley
SCIENTIFIC REPORTS
(2020)
Article
Biochemical Research Methods
Susan McClatchy, Kristin M. Bass, Daniel M. Gatti, Adam Moylan, Gary Churchill
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Katharina Dulias, M. George B. Foody, Pierre Justeau, Marina Silva, Rui Martiniano, Gonzalo Oteo-Garcia, Alessandro Fichera, Simao Rodrigues, Francesca Gandini, Alison Meynert, Kevin Donnelly, Timothy J. Aitman, Andrew Chamberlain, Olivia Lelong, George Kozikowski, Dominic Powlesland, Clive Waddington, Valeria Mattiangeli, Daniel G. Bradley, Jaroslaw Bryk, Pedro Soares, James F. Wilson, Graeme Wilson, Hazel Moore, Maria Pala, Ceiridwen J. Edwards, Martin B. Richards
Summary: During the Neolithic period, Orkney was a major cultural center with flourishing farming and long-range contacts. New genomic evidence shows significant inward migration during the Bronze Age, but most of the male lineages originated from the local Neolithic period. Meanwhile, there is evidence of continuity in the female line of descent from the Mesolithic period to the present day.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Sophie J. Warlow, Martyna Adamowicz, John P. Thomson, Robert A. Wescott, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Lucy Q. Li, Brendan Conn, Ashley Hay, Iain J. Nixon, Timothy J. Aitman
Summary: This study evaluated the utility of plasma cfDNA ddPCR as a method for characterizing and longitudinally monitoring OPSCC patients. The results showed high concordance between pre-treatment plasma cfDNA HPV analysis and tissue-based assays, and longitudinally monitoring post-treatment cfDNA-HPV was strongly associated with patient outcomes.
Article
Oncology
Maria Prendecki, Stephen P. McAdoo, Tabitha Turner-Stokes, Ana Garcia-Diaz, Isabel Orriss, Kevin J. Woollard, Jacques Behmoaras, H. Terence Cook, Robert Unwin, Charles D. Pusey, Timothy J. Aitman, Frederick W. K. Tam
Summary: P2RX7 is not involved in inflammation and autoimmunity in glomerulonephritis, and there is an alternative inflammasome pathway for IL-1β production in rat dendritic cells, independent of P2RX7.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Lucy Q. Li, Martyna Adamowicz, Robert A. Wescott, Sophie J. Warlow, John P. Thomson, Christelle Robert, Lara M. Carey, Helen Thain, Kate Cuschieri, Brendan Conn, Ashley Hay, Timothy J. Aitman, Iain J. Nixon
Summary: This study aimed to determine the potential of post-treatment HPV cell-free DNA (cfDNA) as a biomarker for salvage neck dissection in patients with oropharyngeal squamous cell carcinoma (OPSCC) showing a partial response in the neck on imaging. Results showed that the detection of HPV cfDNA had a high positive predictive value in identifying patients with positive disease on subsequent neck dissection. However, there were cases of regional disease recurrence in patients with undetectable HPV cfDNA, indicating the need for further validation and larger studies on the use of post-treatment HPV cfDNA in OPSCC management.
Article
Multidisciplinary Sciences
Peter H. Dixon, Adam P. Levine, Ines Cebola, Melanie M. Y. Chan, Aliya S. Amin, Anshul Aich, Monika Mozere, Hannah Maude, Alice L. Mitchell, Jun Zhang, Jenny Chambers, Argyro Syngelaki, Jennifer Donnelly, Sharon Cooley, Michael Geary, Kypros Nicolaides, Malin Thorsell, William M. Hague, Maria Cecilia Estiu, Hanns-Ulrich Marschall, Daniel P. Gale, Catherine Williamson
Summary: The study identified multiple genetic signals associated with intrahepatic cholestasis of pregnancy (ICP), shedding light on the disease which can lead to preterm birth and stillbirth. Common sequence variation in liver-enriched genes and liver-specific cis-regulatory elements were pinpointed as contributing mechanisms to ICP susceptibility.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Lynne Hocking, Claire Andrews, Christine Armstrong, Morad Ansari, David Baty, Jonathan Berg, Therese Bradley, Caroline Clark, Austin Diamond, Jill Doherty, Anne Lampe, Ruth McGowan, David Moore, Dawn O'Sullivan, Andrew Purvis, Javier Santoyo-Lopez, Paul Westwood, Michael Abbott, Nicola J. Williams, Zosia Scottish Genomes Partnership, Timothy Aitman, Zosia Miedzybrodzka
Summary: Scottish NHS genetics centres investigated the diagnostic utility of the Genomics England 100,000 Genomes Project for rare, inherited conditions. Genome sequencing with gene panel filtering and reporting showed improved diagnostic yield compared to previous testing, but not compared to routine trio-exome sequence tests. Re-interpretation of genomic data using updated gene panels modestly increased diagnostic yield. Efficient methods for analyzing structural variation or decreased costs are needed to justify the additional expense of genome sequencing over exome sequencing.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Clinical Neurology
Danielle Leighton, Morad Ansari, Judith Newton, David Parry, Elaine Cleary, Shuna Colville, Laura Stephenson, Juan Larraz, Micheala Johnson, Emily Beswick, Michael Wong, Jenna Gregory, Javier Carod Artal, Richard Davenport, Callum Duncan, Ian Morrison, Colin Smith, Robert Swingler, Ian Deary, Mary Porteous, Timothy Aitman, Siddharthan Chandran, George Gorrie, Suvankar Pal, Carolyn Lothian Birth Cohorts Grp, CARE-MND Consortium
Summary: This study investigated the phenotypes and genotypes of a cohort of long-surviving individuals with motor neuron disease (MND). The findings suggest that long survivors are characterized by younger age at onset, increased prevalence of primary lateral sclerosis (PLS), and longer diagnostic delay. Genetic analysis revealed potentially pathogenic variants in several MND-associated genes.
JOURNAL OF NEUROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Tian Zhang, Gregory R. Keele, Isabela Gerdes Gyuricza, Matthew Vincent, Catherine Brunton, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Steven C. Munger, Fernando Pardo-Manuel de Villena, Martin T. Ferris, Joao A. Paulo, Steven P. Gygi, Gary A. Churchill
Summary: This study quantified phosphopeptides, proteins, and transcripts in mouse tissue samples and identified key regulators of protein phosphorylation, including kinases, phosphatases, cytokines, and genes. The integrative multi-omics analysis provided a powerful tool for identifying regulators of protein phosphorylation.
Article
Biotechnology & Applied Microbiology
Kwangbom Choi, Yang Chen, Daniel A. Skelly, Gary A. Churchill
