Antiangiogenic therapy, hypoxia and metastasis: risky liaisons, or not?

In Vivo Antitumor and Antimetastatic Activity of Sunitinib in Preclinical Neuroblastoma Mouse Model

(2015) Libo Zhang et al.   NEOPLASIA

Metastasis in Melanoma Xenografts Is Associated with Tumor Microvascular Density Rather than Extent of Hypoxia

(2015) Einar K. Rofstad et al.   NEOPLASIA

HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

(2011) Charlotte Rolny et al.   CANCER CELL

Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of "Rebound" Revascularization as Mode of Escape

(2011) E. di Tomaso et al.   CANCER RESEARCH

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation

(2011) Sachie Hiratsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)

(2010) M. Reck et al.   ANNALS OF ONCOLOGY

Glioblastoma, Cancer Stem Cells and Hypoxia

(2010) Eli E. Bar   BRAIN PATHOLOGY

Bevacizumab in metastatic breast cancer: a meta-analysis of randomized controlled trials

(2010) A. Valachis et al.   BREAST CANCER RESEARCH AND TREATMENT

Hypoxia inducible factors in cancer stem cells

(2010) J M Heddleston et al.   BRITISH JOURNAL OF CANCER

PTEN suppression of YY1 induces HIF-2 activity in von hippel lindau null renal cell carcinoma

(2010) Brenda L. Petrella et al.   CANCER BIOLOGY & THERAPY

Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage

(2010) Young Jun Koh et al.   CANCER CELL

Anti-Placental Growth Factor Reduces Bone Metastasis by Blocking Tumor Cell Engraftment and Osteoclast Differentiation

(2010) L. Coenegrachts et al.   CANCER RESEARCH

Differential Effects of VEGFR-1 and VEGFR-2 Inhibition on Tumor Metastases Based on Host Organ Environment

(2010) Y.-J. Lee et al.   CANCER RESEARCH

Suppression of Tumor Growth and Metastasis by Simultaneously Blocking Vascular Endothelial Growth Factor (VEGF)-A and VEGF-C with a Receptor-Immunoglobulin Fusion Protein

(2010) D. Zhang et al.   CANCER RESEARCH

Cediranib/AZD2171 Inhibits Bone and Brain Metastasis in a Preclinical Model of Advanced Prostate Cancer

(2010) J. J. Yin et al.   CANCER RESEARCH

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

(2010) Carlos Bais et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α

(2010) Michal Manisterski et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

(2010) Ahmed Mohyeldin et al.   Cell Stem Cell

Effects of Anti-VEGF Treatment Duration on Tumor Growth, Tumor Regrowth, and Treatment Efficacy

(2010) A. Bagri et al.   CLINICAL CANCER RESEARCH

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

(2010) W. Zhang et al.   CLINICAL CANCER RESEARCH

Hypoxia and Hypoxia-Inducible Factors: Master Regulators of Metastasis

(2010) X. Lu et al.   CLINICAL CANCER RESEARCH

Cancer Dissemination—Lessons from Leukocytes

(2010) Chris D. Madsen et al.   DEVELOPMENTAL CELL

Retention of prolyl hydroxylase PHD2 in the cytoplasm prevents PHD2-induced anchorage-independent carcinoma cell growth

(2010) Terhi Jokilehto et al.   EXPERIMENTAL CELL RESEARCH

CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model

(2010) Saima Hassan et al.   INTERNATIONAL JOURNAL OF CANCER

Combination Therapy of Interleukin-2 and Sorafenib Improves Survival Benefits and Prevents Spontaneous Pulmonary Metastasis in Murine Renal Cell Carcinoma Models

(2010) Y. Amagai et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

The role of HIF prolyl hydroxylases in tumour growth

(2010) Terhi Jokilehto et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tumor-induced endothelial cell apoptosis: Roles of NAD(P)H oxidase-derived reactive oxygen species

(2010) Ruei-Zeng Lin et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase III Trial of Bevacizumab Plus Interferon Alfa-2a in Patients With Metastatic Renal Cell Carcinoma (AVOREN): Final Analysis of Overall Survival

(2010) Bernard Escudier et al.   JOURNAL OF CLINICAL ONCOLOGY

Disease Course Patterns After Discontinuation of Bevacizumab: Pooled Analysis of Randomized Phase III Trials

(2010) David Miles et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase III Trial Assessing Bevacizumab in Stages II and III Carcinoma of the Colon: Results of NSABP Protocol C-08

(2010) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

Anti-tumor effect of CT-322 as an Adnectin inhibitor of vascular endothelial growth factor receptor-2

(2010) Roni Mamluk et al.   mAbs

Mechanisms of Motility in Metastasizing Cells

(2010) Mahmut Yilmaz et al.   MOLECULAR CANCER RESEARCH

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells

(2010) S. Hiratsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malignant cells facilitate lung metastasis by bringing their own soil

(2010) D. G. Duda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the organ microenvironment in brain metastasis

(2010) Isaiah J. Fidler   SEMINARS IN CANCER BIOLOGY

Hypoxia: A Link between Fibrogenesis, Angiogenesis, and Carcinogenesis in Liver Disease

(2010) Olivier Rosmorduc et al.   SEMINARS IN LIVER DISEASE

The Tumor Microenvironment and DNA Repair

(2010) Thomas J. Klein et al.   SEMINARS IN RADIATION ONCOLOGY

Heterogeneity of the Tumor Vasculature

(2010) Janice Nagy et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Suppressive effect of bevacizumab on peritoneal dissemination from gastric cancer in a peritoneal metastasis model

(2010) Takuya Imaizumi et al.   SURGERY TODAY

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Sunitinib Prolongs Survival in Genetically Engineered Mouse Models of Multistep Lung Carcinogenesis

(2009) L. Gandhi et al.   Cancer Prevention Research

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1 , CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

(2009) L. Xu et al.   CANCER RESEARCH

Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis

(2009) Y. Huang et al.   CANCER RESEARCH

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Hypoxia Helps Glioma to Fight Therapy

(2009) Verena Amberger-Murphy   CURRENT CANCER DRUG TARGETS

The Angiogenic Switch: Implications in the Regulation of Tumor Dormancy

(2009) L. Moserle et al.   CURRENT MOLECULAR MEDICINE

Hypoxia inducible factor-2α: a critical mediator of aggressive tumor phenotypes

(2009) Guoliang Qing et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Kinases as Upstream Regulators of the HIF System: Their Emerging Potential as Anti-Cancer Drug Targets

(2009) Elitsa Dimova et al.   CURRENT PHARMACEUTICAL DESIGN

The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

(2009) Elisabetta Dejana et al.   DEVELOPMENTAL CELL

Regulation of Angiogenesis by Oxygen and Metabolism

(2009) Peter Fraisl et al.   DEVELOPMENTAL CELL

VEGF elicits epithelial-mesenchymal transition (EMT) in prostate intraepithelial neoplasia (PIN)-like cells via an autocrine loop

(2009) Oscar Gonzalez-Moreno et al.   EXPERIMENTAL CELL RESEARCH

Edema Control by Cediranib, a Vascular Endothelial Growth Factor Receptor–Targeted Kinase Inhibitor, Prolongs Survival Despite Persistent Brain Tumor Growth in Mice

(2009) Walid S. Kamoun et al.   JOURNAL OF CLINICAL ONCOLOGY

Hypoxia Increases Placenta Growth Factor Expression in Human Myocardium and Cultured Neonatal Rat Cardiomyocytes

(2009) Ronald J. Torry et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

New evidence for tumour embolism as a mode of metastasis

(2009) Ian R Hart   JOURNAL OF PATHOLOGY

Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression

(2009) Ulrike Maegdefrau et al.   JOURNAL OF PATHOLOGY

Oxygen regulates epithelial-to-mesenchymal transition: insights into molecular mechanisms and relevance to disease

(2009) Volker H. Haase   KIDNEY INTERNATIONAL

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

(2009) Ymera Pignochino et al.   Molecular Cancer

Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumor angiogenesis and tumor lymphangiogenesis

(2009) T. Schomber et al.   MOLECULAR CANCER THERAPEUTICS

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antiangiogenic therapies for high-grade glioma

(2009) Andrew D. Norden et al.   Nature Reviews Neurology

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Hyperoxic Treatment Induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model

(2009) Ingrid Moen et al.   PLoS One

The role of metastasis suppressor genes in metastatic dormancy 

(2008) CHRISTINE E. HORAK et al.   APMIS

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Targeting Angiogenesis Driven by Vascular Endothelial Growth Factors Using Antibody-Based Therapies

(2008) Axel Grothey et al.   CANCER JOURNAL

Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion

(2008) P. Friedl et al.   CANCER RESEARCH

Hypoxia-Inducible Factor 1  Mediates Anoikis Resistance via Suppression of  5 Integrin

(2008) N. Rohwer et al.   CANCER RESEARCH

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

VEGF inhibition: insights from preclinical and clinical studies

(2008) Yongping Crawford et al.   CELL AND TISSUE RESEARCH

Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis

(2008) M. P. Kim et al.   CELL AND TISSUE RESEARCH

Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase

(2008) J. Matsui et al.   CLINICAL CANCER RESEARCH

Hungry for Blood Vessels: Linking Metabolism and Angiogenesis

(2008) Peter Fraisl et al.   DEVELOPMENTAL CELL

Effect of Bevacizumab, a Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor, on Peritoneal Metastasis of MNK-45P Human Gastric Cancer in Mice

(2008) Shigeo Ninomiya et al.   JOURNAL OF SURGICAL RESEARCH

Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes

(2008) S. A. Lang et al.   MOLECULAR CANCER THERAPEUTICS

Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib

(2008) T. P. Padera et al.   MOLECULAR CANCER THERAPEUTICS

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

(2008) D. Gao et al.   SCIENCE