标题
Deconstructing and targeting the genomic architecture of human neurodegeneration
作者
关键词
-
出版物
NATURE NEUROSCIENCE
Volume 21, Issue 10, Pages 1310-1317
出版商
Springer Nature America, Inc
发表日期
2018-09-19
DOI
10.1038/s41593-018-0240-z
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases
- (2018) Mariet Allen et al. Alzheimers & Dementia
- Person-specific contribution of neuropathologies to cognitive loss in old age
- (2018) Patricia A. Boyle et al. ANNALS OF NEUROLOGY
- Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia
- (2018) Lei Yu et al. ANNALS OF NEUROLOGY
- Religious Orders Study and Rush Memory and Aging Project
- (2018) David A. Bennett et al. JOURNAL OF ALZHEIMERS DISEASE
- A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease
- (2018) Sara Mostafavi et al. NATURE NEUROSCIENCE
- Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study
- (2018) Hyun-Sik Yang et al. LANCET NEUROLOGY
- Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain
- (2018) Daniel Felsky et al. Molecular Neurodegeneration
- A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research
- (2018) Philip L. De Jager et al. Scientific Data
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome
- (2017) Bernard Ng et al. NATURE NEUROSCIENCE
- A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants
- (2017) Katie J. Ryan et al. Science Translational Medicine
- Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data
- (2017) Charles C. White et al. PLOS MEDICINE
- A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease
- (2017) Nicholas T. Seyfried et al. Cell Systems
- Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS
- (2017) E. Taskesen et al. Scientific Reports
- The epigenome in Alzheimer’s disease: current state and approaches for a new path to gene discovery and understanding disease mechanism
- (2016) Hans-Ulrich Klein et al. ACTA NEUROPATHOLOGICA
- Methylation profiles in peripheral blood CD4+ lymphocytes versus brain: The relation to Alzheimer's disease pathology
- (2016) Lei Yu et al. Alzheimers & Dementia
- TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia
- (2016) Bryan D. James et al. BRAIN
- Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study
- (2016) Zoe Arvanitakis et al. LANCET NEUROLOGY
- Relation of genomic variants for Alzheimer disease dementia to common neuropathologies
- (2016) Jose M. Farfel et al. NEUROLOGY
- Uncovering the Role of the Methylome in Dementia and Neurodegeneration
- (2016) Hans-Ulrich Klein et al. TRENDS IN MOLECULAR MEDICINE
- The BLUEPRINT Data Analysis Portal
- (2016) José María Fernández et al. Cell Systems
- The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease
- (2015) Christina M. Lill et al. Alzheimers & Dementia
- Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci
- (2015) Badri N. Vardarajan et al. ANNALS OF NEUROLOGY
- Association of DNA methylation in the brain with age in older persons is confounded by common neuropathologies
- (2015) Jingyun Yang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus
- (2015) R S Desikan et al. MOLECULAR PSYCHIATRY
- A novel Alzheimer disease locus located near the gene encoding tau protein
- (2015) G Jun et al. MOLECULAR PSYCHIATRY
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- CD33 modulates TREM2: convergence of Alzheimer loci
- (2015) Gail Chan et al. NATURE NEUROSCIENCE
- APOE and cerebral amyloid angiopathy in community-dwelling older persons
- (2015) Lei Yu et al. NEUROBIOLOGY OF AGING
- Residual decline in cognition after adjustment for common neuropathologic conditions.
- (2015) Lei Yu et al. NEUROPSYCHOLOGY
- TDP-43 is a key player in the clinical features associated with Alzheimer’s disease
- (2014) Keith A. Josephs et al. ACTA NEUROPATHOLOGICA
- Frontotemporal dementia and its subtypes: a genome-wide association study
- (2014) Raffaele Ferrari et al. LANCET NEUROLOGY
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
- (2014) Monica K Wetzel-Smith et al. NATURE MEDICINE
- Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
- (2014) Katie Lunnon et al. NATURE NEUROSCIENCE
- Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
- (2014) Philip L De Jager et al. NATURE NEUROSCIENCE
- Tau promotes neurodegeneration through global chromatin relaxation
- (2014) Bess Frost et al. NATURE NEUROSCIENCE
- Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
- (2014) T. Raj et al. SCIENCE
- Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
- (2014) M. N. Lee et al. SCIENCE
- Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression
- (2014) B. P. Fairfax et al. SCIENCE
- Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias
- (2014) Gary W. Beecham et al. PLoS Genetics
- Much of late life cognitive decline is not due to common neurodegenerative pathologies
- (2013) Patricia A. Boyle et al. ANNALS OF NEUROLOGY
- Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology
- (2013) Beatriz G. Perez-Nievas et al. BRAIN
- Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
- (2013) Bin Zhang et al. CELL
- Overview and Findings from the Religious Orders Study
- (2013) David A. Bennett et al. Current Alzheimer Research
- Overview and Findings from the Rush Memory and Aging Project
- (2013) David A. Bennett et al. Current Alzheimer Research
- Resilient Brain Aging: Characterization of Discordance between Alzheimer’s Disease Pathology and Cognition
- (2013) Selam Negash et al. Current Alzheimer Research
- Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
- (2013) S Hong Lee et al. NATURE GENETICS
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Disentangling the effects of age and APOE on neuropathology and late life cognitive decline
- (2013) Lei Yu et al. NEUROBIOLOGY OF AGING
- Brain reserve and cognitive reserve in multiple sclerosis: What you've got and how you use it
- (2013) J. F. Sumowski et al. NEUROLOGY
- Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus
- (2013) L. Ottoboni et al. NEUROLOGY
- Neural reserve, neuronal density in the locus ceruleus, and cognitive decline
- (2013) R. S. Wilson et al. NEUROLOGY
- U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease
- (2013) B. Bai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of Genetic Variants That Affect Histone Modifications in Human Cells
- (2013) G. McVicker et al. SCIENCE
- Relation of neuropathology with cognitive decline among older persons without dementia
- (2013) Patricia A. Boyle et al. Frontiers in Aging Neuroscience
- Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies
- (2012) J. A. Schneider et al. BRAIN
- Chromatin marks identify critical cell types for fine mapping complex trait variants
- (2012) Gosia Trynka et al. NATURE GENETICS
- Influence of late-life cognitive activity on cognitive health
- (2012) R. S. Wilson et al. NEUROLOGY
- Variant of TREM2 Associated with the Risk of Alzheimer's Disease
- (2012) Thorlakur Jonsson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
- (2012) M. T. Maurano et al. SCIENCE
- Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants
- (2012) Fanggeng Zou et al. PLoS Genetics
- Aging effects on DNA methylation modules in human brain and blood tissue
- (2012) Steve Horvath et al. GENOME BIOLOGY
- Cognitive reserve, presynaptic proteins and dementia in the elderly
- (2012) W G Honer et al. Translational Psychiatry
- Pervasive Sharing of Genetic Effects in Autoimmune Disease
- (2011) Chris Cotsapas et al. PLoS Genetics
- Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
- (2010) Taye H Hamza et al. NATURE GENETICS
- Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain
- (2010) J. Raphael Gibbs et al. PLoS Genetics
- Apolipoprotein E e4 Allele is Associated With More Rapid Motor Decline in Older Persons
- (2009) Aron S. Buchman et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease
- (2009) A D Roses et al. PHARMACOGENOMICS JOURNAL
- A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis
- (2008) Howard L. Weiner JOURNAL OF NEUROLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now