Article
Biochemistry & Molecular Biology
Faiz Ali Khan, Gowhar Ali, Khista Rahman, Yahya Khan, Muhammad Ayaz, Osama F. Mosa, Asif Nawaz, Syed Shams ul Hassan, Simona Bungau
Summary: The study examined the pharmacological potential of a derived flavanone, 2-hydroxyflavanone, as a remedy for pain treatment. The results showed that 2-hydroxyflavanone exhibited considerable analgesic, anti-inflammatory, and anti-neuropathic effects, possibly mediated through opioidergic and GABAergic mechanisms.
Article
Anesthesiology
Puneet Rinwa, Laura Calvo-Enrique, Ming-Dong Zhang, Jens Randel Nyengaard, Pall Karlsson, Patrik Ernfors
Summary: Recent findings suggest that nociceptive nerves terminate in a specialized end-organ in mice, consisting of nociceptive nerves and specialized Schwann cells. Similarly, human skin contains nociceptive Schwann cells that contribute to neuropathy and pain hypersensitivity. Ablation of nociceptive Schwann cells in mice results in nerve retraction and hypersensitivity to mechanical, cold, and heat stimuli, while ablating the nociceptive nerves leads to changes in Schwann cell morphology and hypersensitivity. These results highlight the interdependence between nerves and nociceptive Schwann cells.
Article
Multidisciplinary Sciences
Dawn Jessup, Kareem Woods, Sach Thakker, M. Imad Damaj, Hamid I. Akbarali
Summary: Nociceptive hypersensitivity induced by chronic use of opioids and chemotherapeutics can be reversed by oral supplementation with the short-chain fatty acid sodium butyrate. The study also found that gut-derived mediators modulate neuronal hyperexcitability, which is involved in opioid and chemotherapy-induced hypersensitivity.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Haruka Itou, Ryou Toyota, Mamoru Takeda
Summary: The study found that quercetin can attenuate hyperexcitability and mechanical hyperalgesia of nociceptive neurons by inhibiting inflammatory signals and ion channels. These results support the potential use of quercetin as a therapeutic agent in treating trigeminal inflammatory mechanical hyperalgesia.
Article
Dentistry, Oral Surgery & Medicine
Yui Watanuki, Sora Yajima, Yukito Sashide, Mamoru Takeda
Summary: This in vivo study investigated the effects of systemic administration of theanine on the hyperexcitability of trigeminal spinal nucleus caudalis (SpVc) neurons associated with inflammation-induced hyperalgesia. The results showed that theanine attenuated hyperalgesia, reduced the discharge frequency and spontaneous discharge of the neurons, as well as restored the receptive field size. These findings support the potential therapeutic role of theanine in preventing inflammatory hyperalgesia.
EUROPEAN JOURNAL OF ORAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Che Aishah Nazariah Ismail, Anis Kausar Ghazali, Rapeah Suppian, Che Badariah Abd Aziz, Idris Long
Summary: The study showed that minocycline alleviates nociceptive responses in rats with diabetic neuropathic pain by suppressing NR2B activation, indicating its potential as a therapeutic antinociceptive drug for neuropathic pain management.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2021)
Article
Anesthesiology
Miriam M. Duell, Martina Stengel, Vivien Ries, Marion Strupf, Peter W. Reeh, Andreas E. Kremer, Barbara Namer
Summary: LPA can cause pain and itch in humans depending on the mode of application and activates afferent human C fibers.
Review
Physiology
Peter W. Reeh, Michael J. M. Fischer
Summary: This article reviews the discoveries of the Nobel laureates David Julius and Ardem Patapoutian in the field of temperature and touch receptors, TRPV1 and PIEZO1/2, and discusses topics such as mechanosensitivity and mechanical hyperalgesia.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Naila Rabbani
Summary: This article introduces the utility of AGEomics biomarkers and provides evidence for their closer association with disease phenotypes compared to other metabolites and metabolomic approaches. It also discusses how to train and test algorithms using machine learning methods for accurate and sensitive clinical diagnostic and screening applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Naila Rabbani, Paul J. Thornalley
Summary: The abnormal accumulation of methylglyoxal has been linked to aging and disease. Glyoxalase 1 plays a major role in the metabolism of methylglyoxal. Small molecule inducers of Glyoxalase 1 have been developed to alleviate dicarbonyl stress and treat type 2 diabetes. Moreover, cell permeable Glyoxalase 1 inhibitor prodrugs show potential as a treatment for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Physiology
Peter W. Reeh, Michael J. M. Fischer
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Physiology
Tal Hoffmann, Florian Klemm, Tatjana Kichko, Susanne K. Sauer, Katrin Kistner, Bernhard Riedl, Patrick Raboisson, Lei Luo, Alexandru Babes, Laurence Kocher, Giancarlo Carli, Michael J. M. Fischer, Peter W. Reeh
Summary: The formalin test, widely used to screen antinociceptive drug candidates, may not accurately target inflammatory pain. Formaldehyde can stimulate nerve fibers and induce pain-related behaviors. TRPA1 is identified as the primary transducer of formaldehyde effects on sensory neurons, but the actions of formaldehyde require further discussion and research.
PHYSIOLOGICAL REPORTS
(2022)
Editorial Material
Medicine, Research & Experimental
Naila Rabbani
Summary: The study found increased exposure of diabetic patients to methylglyoxal (MG), and the glyoxalase system plays an important role in the development of insulin resistance and vascular complications of diabetes. Other advances include the discovery of a new metabolic stress and therapeutic methods.
Article
Biochemistry & Molecular Biology
Naila Rabbani, Antonysunil Adaikalakoteswari, James R. R. Larkin, Sianna Panagiotopoulos, Richard J. J. MacIsaac, Dennis K. K. Yue, Gregory R. R. Fulcher, Matthew A. A. Roberts, Merlin A. Thomas, Elif Ekinci, Paul J. J. Thornalley
Summary: Accumulation of advanced glycation endproducts (AGEs) is associated with decline in renal function, particularly in diabetic patients. This study evaluated levels of AGEs in subjects with and without diabetes, with normal renal function and stages 2-4 chronic kidney disease (CKD), and identified a specific AGE, methylglyoxal-derived hydroimidazolone (MG-H1) free adduct, as the most responsive to CKD status and diabetes. The concentration of MG-H1 free adduct in serum was strongly related to CKD stage and increased in diabetes. This suggests that serum MG-H1 free adduct may serve as a potential AGE risk marker for diabetic and non-diabetic CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jinit Masania, Patrick Wijten, Susanne Keipert, Mario Ost, Susanne Klaus, Naila Rabbani, Paul J. Thornalley
Summary: Mice with ectopic expression of UCP1 in skeletal muscle show a healthy aging phenotype and increased resistance to metabolic health impairment. Decreased protein glycation and oxidative damage, along with increased expression of heat shock proteins and mechanoprotection, were observed in aged HSA-mUCP1 mice compared to wildtype controls. These findings suggest that the decreased formation and increased clearance of MG-derived AGEs may contribute to the healthy aging phenotype in HSA-mUCP1 mice.
Article
Biochemistry & Molecular Biology
Hanan Ehtewish, Areej Mesleh, Georgios Ponirakis, Alberto de la Fuente, Aijaz Parray, Ilham Bensmail, Houari Abdesselem, Marwan Ramadan, Shafi Khan, Mani Chandran, Raheem Ayadathil, Ahmed Elsotouhy, Ahmed Own, Hanadi Al Hamad, Essam M. Abdelalim, Julie Decock, Nehad M. Alajez, Omar Albagha, Paul J. Thornalley, Abdelilah Arredouani, Rayaz A. Malik, Omar M. A. El-Agnaf
Summary: Dementia is a progressive and debilitating neurological disease. Proteomic studies have revealed potential protein biomarkers for dementia. This pilot study used a high-throughput proximity extension immunoassay to quantify proteins in plasma and identified diagnostic biomarkers for dementia with high accuracy. Dysregulation of plasma proteins and correlation with cognitive performance suggest potential mechanisms and pathways in dementia pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Anna K. Becker, Alexandru Babes, Miriam M. Duell, Mohammad Khalil, Zoltan Kender, Jan Groener, Barbara Namer, Peter W. Reeh, Susanne K. Sauer
Summary: This study investigates the contribution of MGO to the development of pain and hyperalgesia in diabetic neuropathy. It found that TRPA1-expressing C-nociceptors play a crucial role in the development of spontaneous activity and sensitization in response to MGO.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Genetics & Heredity
Shadi Nejat, Kalhara R. Menikdiwela, Aliyah Efotte, Shane Scoggin, Bolormaa Vandanmagsar, Paul J. Thornalley, Mohammed Dehbi, Naima Moustaid-Moussa
Summary: This study confirms the findings in human studies using a mouse model and suggests that DNAJB3 may play a crucial role in metabolic functions and glucose homeostasis.
Article
Biochemistry & Molecular Biology
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: Transient ischemic attack (TIA) is a temporary neurologic deficit caused by ischemic insult to the brain, spinal cord, or retina. TIA is associated with a high risk of impending acute ischemic stroke (AIS), a condition characterized by focal infarction in the brain, spinal cord, or retina. This study investigated the differences in circulating microRNA profiles between AIS and TIA patients and identified a panel of differentially regulated microRNAs. Furthermore, a multivariate classifier was developed that could potentially be used as a biomarker to distinguish AIS and TIA patients. Understanding the molecular pathways in AIS compared to TIA may have important implications for therapeutic targeting in clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Monika Hollenhorst, Rajender Nandigama, Saskia B. Evers, Igor Gamayun, Noran Abdel Wadood, Alaa Salah, Mario Pieper, Amanda Wyatt, Alexey Stukalov, Anna Gebhardt, Wiebke Nadolni, Wera Burow, Christian Herr, Christoph Beisswenger, Soumya Kusumakshi, Fabien Ectors, Tatjana Kichko, Lisa Huebner, Peter Reeh, Antje Munder, Sandra-Maria Wienhold, Martin Witzenrath, Robert Bals, Veit Flockerzi, Thomas Gudermann, Markus Bischoff, Peter Lipp, Susanna Zierler, Vladimir Chubanov, Andreas Pichlmair, Peter Koenig, Ulrich Boehm, Gabriela Krasteva-Christ
Summary: This study reveals that tracheal brush cells express functional taste receptors and that bitter taste signaling induces neurogenic inflammation, which mediates secretion of immune mediators and defense against bacterial infections.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Substance Abuse
Lars Arendt-Nielsen, Earl Carstens, Gordon Proctor, Yves Boucher, Pere Clave, Kent Albin Nielsen, Thomas A. Nielsen, Peter W. Reeh
Summary: Nicotine provokes irritation, burning and pain in the oral cavity and throat. Managing these side effects will ensure better compliance to oral NRT products and hence increase the success of smoking cessation. A specific class of sensory receptors (TRP channels) are involved in mediating nicotine's sensory side effects, making them potential treatment targets. Many natural compounds are potentially beneficial modulators of TRP channels.
NICOTINE & TOBACCO RESEARCH
(2022)
