Article
Biochemistry & Molecular Biology
Kehong Zhang, Simona Pace, Paul M. Jordan, Lukas K. Peltner, Alexander Weber, Dagmar Fischer, Robert K. Hofstetter, Xinchun Chen, Oliver Werz
Summary: Tripterygium wilfordii glycosides modulate lipid mediator networks in human monocyte-derived macrophages, suppressing pro-inflammatory lipid mediators while inducing specialized pro-resolving mediators, contributing to its anti-rheumatic properties against rheumatoid arthritis.
Editorial Material
Immunology
Cecilia Garlanda, Domenico Supino
Summary: The researchers in this study designed a new drug to selectively inhibit IL-1 by analyzing an IL-1 receptor missense mutation associated with un-leashed IL-1-mediated inflammation.
Review
Microbiology
Amanda de Oliveira Matos, Pedro Henrique dos Santos Dantas, Marcelle Silva-Sales, Helioswilton Sales-Campos
Summary: TREM-1 is an innate immunity receptor associated with inflammation, with its two isoforms (mTREM-1 and sTREM-1) being extensively studied in bacterial diseases and sepsis. The inhibition of the receptor and the use of sTREM-1 as a biomarker have shown promise in treating and diagnosing bacterial infections.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Ann Hertzel, Jeongsik Yong, Xiaoli Chen, David A. Bernlohr
Summary: Immune cells infiltrate adipose tissue and play major roles in regulating fat cell mitochondrial function, affecting gene expression and cell death pathways.
Review
Immunology
Zachary J. J. Bernstein, Anjali Shenoy, Amy Chen, Nicola M. M. Heller, Jamie B. B. Spangler
Summary: IL-4 and IL-13 cytokines play important roles in immune activity, especially in T helper 2 cell-mediated inflammation, immune regulation, antibody production, and fibrosis. Manipulating the IL-4/IL-13 axis through cytokine engineering, fusion protein formulation, antagonist development, cell engineering, and biosensor design can lead to the discovery of new immunotherapies targeting allergy, autoimmune diseases, and cancer.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Dentistry, Oral Surgery & Medicine
C. Zhan, M. Huang, X. Yang, J. Hou
Summary: Dental nerves play crucial roles in tooth pain induction, sensitization, and maintenance, as well as regulating non-neuronal cells and immune responses. They are also involved in the repair of dental soft and hard tissues, highlighting their importance in pulpitis and potential implications for endodontic treatment.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Allergy
Alexandra Schroeder, Lars P. Lunding, Ulrich M. Zissler, Christina Vock, Sina Webering, Johanna C. Ehlers, Zane Orinska, Adam Chaker, Carsten B. Schmidt-Weber, Niklas J. Lang, Herbert B. Schiller, Marcus A. Mall, Heinz Fehrenbach, Charles A. Dinarello, Michael Wegmann
Summary: The study found that IL-37 downregulates allergic airway inflammation by counterbalancing the disease-amplifying effects of IL-1 beta and IL-33.
Article
Allergy
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Summary: IL-33 plays a crucial role in allergic diseases, and A20 is involved in regulating IL-33 signaling. In the absence of A20 in macrophages, IL-33-induced lung immune responses are altered, with reduced type 2 immune response and increased production of IFN-gamma. This study reveals a novel role for A20 in regulating IL-33-induced STAT1 signaling in macrophages.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Sara Siskind, Max Brenner, Ping Wang
Summary: TREM-1, an upregulated pattern recognition receptor in inflammatory diseases, can amplify immune responses. The excessive activation of TREM-1 and increased levels of circulating sTREM-1 have been found to be associated with increased mortality in sepsis patients. Therefore, targeting TREM-1 could be a promising strategy for sepsis treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Benjamin D. Andress, Rebecca M. Irwin, Ishaan Puranam, Brenton D. Hoffman, Amy L. McNulty
Summary: In this study, two models of physiologic mechanical stimulation were compared to determine the conserved responses to mechanical loading in meniscus tissue. The results showed significant modulation of inflammation-related pathways with mechanical stimulation. The anti-inflammatory effects of loading were well-conserved between the tissue compression and cell stretch models for the inner zone, but the cell stretch model resulted in a larger number of differentially regulated genes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Rheumatology
Aurelie Najm, Iain B. McInnes
Summary: IL-23, a pro-inflammatory cytokine secreted by dendritic cells and macrophages, plays a key role in the pathogenesis of rheumatic diseases by promoting T cell differentiation into Th17 cells. Therapeutic strategies targeting IL-23 have shown efficiency in PsA but not yet in RA.
Review
Medicine, General & Internal
Marwan Bouras, Karim Asehnoune, Antoine Roquilly
Summary: Traumatic brain injury (TBI) triggers an immediate immune response in brain tissue, followed by a systemic inflammatory response. This response aims to limit excessive systemic inflammation and promote healing, involving the regulation of the autonomic nervous system, hormonal systems, and immune cells. However, it also leads to immunosuppression and tolerance, which increases the risk of secondary infections.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Hanna Grasshoff, Sara Comduehr, Luisa R. Monne, Antje Mueller, Peter Lamprecht, Gabriela Riemekasten, Jens Y. Humrich
Summary: Regulatory T cells (Treg) are crucial for maintaining peripheral tolerance and controlling inflammation and autoimmunity, with the cytokine interleukin-2 (IL-2) playing a key role in their growth and survival. Many autoimmune and rheumatic diseases show disruptions in Treg biology, leading to an imbalance between protective and pathogenic immune cells. Low-dose IL-2 therapy aims to restore physiological balance by compensating for IL-2 deficiency and strengthening the Treg population to counteract inflammation effectively.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nian Wang, Runliu Wu, Paul B. Comish, Rui Kang, Daolin Tang
Summary: Sepsis 3.0 defines sepsis as life-threatening organ dysfunction caused by the host's uncontrolled response to infection, while the BET protein family is recognized as a significant regulator of inflammation and immune response in sepsis. BET inhibitors have shown promising therapeutic effects in experimental sepsis models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Kari Luotola
Summary: Low-grade inflammation plays a major role in obesity, metabolic syndrome, and the development of type 2 diabetes. The interleukin-1 receptor antagonist (IL-1Ra) is an important natural anti-inflammatory factor involved in glucose homeostasis disturbances. IL-1Ra levels can be used as a potential biomarker for metabolic dysregulation, particularly in prediabetes. Further research is needed to understand the role of IL-1Ra in metabolic abnormalities and its relationship with other lifestyle and metabolic parameters.