Review
Biochemistry & Molecular Biology
Cong Li, Wu Xiong, Bowen Wan, Guang Kong, Siming Wang, Yingying Wang, Jin Fan
Summary: Secondary spinal cord injury is caused by an irreversible inflammatory response cascade, and the immune system plays a crucial role in mediating inflammation. Investigating the mechanisms and functions of peripheral immune cells at the site of injury is significant for identifying clinical therapeutic targets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Immunology
Jiansong Chen, Yiguo Shen, Xiaobo Shao, Weiliang Wu
Summary: Spinal cord injury (SCI) and spinal cord tumor cause significant damage to the spinal cord, leading to multiple impairments and high morbidity and mortality. The treatment options for these conditions are limited and the underlying molecular mechanisms remain unclear. In the review, the role of inflammasomes in SCI and spinal cord tumors is highlighted, and targeting inflammasomes is suggested as a potential therapeutic strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Huaguo Tang, Yuanjie Gu, Lei Jiang, Gang Zheng, Zhuoer Pan, Xiugui Jiang
Summary: Spinal cord injury (SCI) is a devastating neurological condition worldwide. The immune response plays a crucial role in tissue regeneration and functional recovery from SCI. New biological technologies have allowed for more precise classification of the heterogeneity of immune components. This review focuses on the roles of various immune cells and chemicals in SCI and summarizes clinical trials of immunomodulatory therapies and promising therapeutic drugs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Xu Gao, Zhifeng You, Yue Li, Xinyi Kang, Wen Yang, Huiru Wang, Ting Zhang, Xinhao Zhao, Yifu Sun, He Shen, Jianwu Dai
Summary: In this study, a functional hybrid gelatin and hyaluronic acid hydrogel (F-G/H) modified with cationic polymers and anti-inflammatory cytokines was developed to regulate the immune microenvironment after aSCT implantation. The hydrogel exhibited DAMP scavenging capacity, sustained release of anti-inflammatory cytokines, and reduced lymphocyte accumulation, thereby enhancing the survival and function of aSCTs. When combined with systemic immunosuppressive drug treatment, a significant improvement in locomotor functions of SCI rats was observed after aSCTs and F-G/H transplantation.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Sriharsha Gonuguntla, Jasmin Herz
Summary: The lymphatic vasculature plays a crucial role in peripheral organ clearance and immune responses. However, our understanding of spinal cord meningeal lymphatics and immunity is limited. This review provides a comprehensive overview of the state of spinal cord meningeal immunity, highlighting its unique anatomy, immune cells, lymphatic vasculature, and the potential impact of injuries and inflammatory disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Immunology
Jianfeng Li, Xizhe Liu, Jianmin Wang, Fuan Wang, Zhengya Zhu, Tao Tang, Jun Wang, Zhiyu Zhou, Manman Gao, Shaoyu Liu
Summary: Blood immune changes after spinal cord injury (SCI) have important implications for diagnosis and treatment of SCI. In this study, a human blood transcriptome dataset was analyzed to identify immune-related genes and biomarkers of SCI and its different grades. The results revealed alterations in immune cell contents, signaling pathways, and identified specific biomarkers for SCI. The correlation analysis between immune cells and biomarkers provided insights into the severity of SCI. These findings contribute to predicting and understanding SCI progression and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yongjin Li, Baobao Wang, Wenzhi Sun, Chao Kong, Guowang Li, Xiaolong Chen, Shibao Lu
Summary: This study investigates the expression and regulatory patterns of circular RNAs (circRNAs) and mRNA in the subacute stage of spinal cord injury (SCI) through RNA-sequencing and bioinformatics analysis. The findings contribute to understanding the pathophysiology of SCI and identifying potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Yuan Feng, Yong Peng, Jing Jie, Yumin Yang, Pengxiang Yang
Summary: Regeneration of neural tissue following spinal cord injury is limited due to damage in the local microenvironment. The immune microenvironment, formed by immune cells and cytokines, plays a crucial role in both inflammation and regeneration. However, there is limited research on the role of the immune microenvironment in spinal cord regeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Hengyi Wang, Yuanliang Xia, Baoqin Li, Yuehong Li, Changfeng Fu
Summary: Spinal cord injury (SCI) is a severe and traumatic disorder that leads to the loss of motor, sensory, and autonomic nervous function. The persistence of local immune inflammatory response after SCI poses challenges to its repair. Immune remodeling significantly affects stem cell survival and differentiation after transplantation and the prognosis of SCI. Immunological reconstruction strategies based on biomaterials have shown promising results and offer potential for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Erliang Li, Rongbao Yan, Kang Yan, Rui Zhang, Qian Zhang, Peng Zou, Huimei Wang, Huan Qiao, Shuang Li, Qiong Ma, Bo Liao
Summary: We used single-cell RNA sequencing to study the cell types and signaling pathways related to immune autophagy in the site of spinal cord injury. Our data set provides valuable insights into the pathobiology of spinal cord injury and other traumatic diseases of the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Neurosciences
Jonathon Chon Teng Chio, Katherine Jiaxi Xu, Phillip Popovich, Samuel David, Michael G. Fehlings
Summary: Spinal cord injury has complex pathophysiology, with neuroinflammation playing a major role in secondary injury. The use of systemic immunosuppressants is the primary pharmacological treatment, but its impact is complex, prompting the need for a superior approach. Comprehensive understanding of neuroinflammation and systemic immune responses is crucial for improving treatment methods.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Peng Peng, Hao Yu, Cong Xing, Bo Tao, Chao Li, Jingyuan Huang, Guangzhi Ning, Bin Zhang, Shiqing Feng
Summary: The study demonstrates that macrophages-derived exosomes can regulate macrophage polarization in the immune microenvironment of SCI, potentially through the miRNA-mRNA network. This suggests that M2 macrophages-derived exosomes may be a promising therapeutic agent for SCI repair by modulating polarization.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Angelica Alvarez Reyes, R. John Hurlbert, Travis M. Dumont, Wyatt L. Ramey
Summary: The study revealed that an increased number of organ system injuries is associated with greater intrahospital mortality in polytrauma patients with complete cSCI.
WORLD NEUROSURGERY
(2022)
Review
Immunology
Robert C. Sterner, Rosalie M. Sterner
Summary: Traumatic spinal cord injury (SCI) is a devastating condition that leads to loss of function and disability. The pathophysiology involves immediate cell dysfunction and death followed by secondary injury mechanisms, with inflammation playing a key role. Targeting the immune response after SCI could effectively reduce secondary injury and improve outcomes. Recent studies have provided molecular insights into the timing of the immune response and potential therapies such as pharmaceutical interventions, stem cell therapy, and extracellular vesicle therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Meeting Abstract
Clinical Neurology
J. Lerch, N. Hashi, A. Zawerton, T. Quach, P. Popovich
Article
Neurosciences
Jamie S. Church, Kristina A. Kigerl, Jessica K. Lerch, Phillip G. Popovich, Dana M. McTigue
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Camila M. Freria, Jodie C. E. Hall, Ping Wei, Zhen Guan, Dana M. McTigue, Phillip G. Popovich
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
John C. Gensel, Satoshi Nakamura, Zhen Guan, Nico van Rooijen, Daniel P. Ankeny, Phillip G. Popovich
JOURNAL OF NEUROSCIENCE
(2009)
Article
Multidisciplinary Sciences
Randall S. Carpenter, Roselyn R. Jiang, Faith H. Brennan, Jodie C. E. Hall, Manoj K. Gottipati, Stefan Niewiesk, Phillip G. Popovich
SCIENTIFIC REPORTS
(2019)
Article
Clinical Neurology
Karim Fouad, Phillip G. Popovich, Marcel A. Kopp, Jan M. Schwab
Summary: Lesion size is considered a reliable predictor of outcome after central nervous system injury, but lesions of comparable size can lead to different levels of functional impairment and recovery, contributing to failed replication in animal models. A clinical-radiological paradox may explain why individuals with similar injuries respond differently to rehabilitation in humans.
NATURE REVIEWS NEUROLOGY
(2021)
Article
Microbiology
Jingjie Du, Ahmed A. Zayed, Kristina A. Kigerl, Kylie Zane, Matthew B. Sullivan, Phillip G. Popovich
Summary: Metagenomic analysis revealed changes in gut microbial population dynamics after SCI, with decreases in beneficial bacteria and increases in potentially pathogenic bacteria. The study also identified reductions in microbial genes related to essential pathways for central nervous system function and an expansion of known murine gut viral species sequence space after SCI.
Article
Neurosciences
Yixing Du, Faith H. Brennan, Phillip G. Popovich, Min Zhou
Summary: This study investigates the role of microglia in regulating the structure and function of astrocytes in the mouse hippocampus, revealing that depletion of microglia disrupts astrocyte syncytial isopotentiality and dye coupling, leading to reduced synaptic transmission in neurons. Activation of microglia enhances synaptic transmission, while leaving astrocyte network function unaffected.
Article
Neurosciences
Nicole Pukos, Christina M. Marion, W. David Arnold, Benjamin T. Noble, Phillip G. Popovich, Dana M. McTigue
Summary: Our previous study found that a large number of new oligodendrocytes (OLs) are generated in the injured spinal cord of mice, with peak oligodendrogenesis occurring between 4 and 7 weeks post-injury. We also observed new myelin formation up to 2 months post-injury. Our current research expands on these findings, quantifying new myelin formation up to 6 months post-injury and investigating indices of demyelination. We discovered that remyelination reaches its peak during the third month post-injury and continues for at least 6 months. Additionally, we observed chronic demyelination through the expression of Nav1.2 and nodal protein disorganization. Our study also revealed a potential mechanism for initiating post-injury myelination, showing that oligodendrocyte progenitor cells (OPCs) make contact with glutamatergic axons in an activity-dependent manner. Increasing OPC/axon contacts through chemogenetic activation of axons may serve as a therapeutic target for enhancing post-spinal cord injury myelin repair.
Correction
Clinical Neurology
Karim Fouad, Phillip G. Popovich, Marcel A. Kopp, Jan M. Schwab
NATURE REVIEWS NEUROLOGY
(2023)
Article
Immunology
Katherine A. Mifflin, Faith H. Brennan, Zhen Guan, Kristina A. Kigerl, Angela R. Filous, Xiaokui Mo, Jan M. Schwab, Phillip G. Popovich
Summary: Pulmonary infection is a common and serious complication after spinal cord injury (SCI). This study shows that SCI not only impairs the immune system in the lung, but also decreases the tissue-specific defense mechanisms against infection. Moreover, the current drug AMD3100 is only partially effective in overcoming this immune suppression. Novel strategies are needed to prevent lung infection after SCI.
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Critical Care Medicine
Kristina G. Witcher, Chelsea E. Bray, Julia E. Dziabis, Daniel B. Mckim, Brooke N. Benner, Rachel K. Rowe, Olga N. Kokiko-Cochran, Philip G. Popovich, Jonathan Lifshitz, Daniel S. Eiferman, Jonathan P. Godbout
JOURNAL OF NEUROTRAUMA
(2018)
Meeting Abstract
Critical Care Medicine
A. V. Callahan, K. Sakurai, S. W. Abeyruwan, A. R. Ferguson, P. G. Popovich, U. Visser, J. L. Bixby, V. P. Lemmon
JOURNAL OF NEUROTRAUMA
(2014)
Meeting Abstract
Critical Care Medicine
A. M. Fenn, J. Skendelas, D. Moussa, M. Muccigrosso, P. G. Popovich, J. Lifshitz, D. S. Eiferman, J. P. Godbout
JOURNAL OF NEUROTRAUMA
(2014)
Meeting Abstract
Critical Care Medicine
Jessica L. Nielson, Darlene A. Burke, A. Todd Lash, Karen-Amanda Irvine, John C. Gensel, David S. Magnuson, Scott R. Whittemore, Dana M. McTigue, Philip G. Popovich, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson
JOURNAL OF NEUROTRAUMA
(2011)
