Article
Chemistry, Multidisciplinary
Tianze Xie, Qiang Zhang, Weifei Zhang, Shuo Feng, Jin-Ming Lin
Summary: Cell adhesion is crucial for cellular behaviors and life processes, but studying specific cells is challenging due to adhesion deficiencies or interference from surrounding cells. This study presents an open microfluidic system for culturing adherent single cells, offering high versatility and compatibility for various assaying methods.
Article
Biochemistry & Molecular Biology
Tianyu Duan, Qingyuan Bian, Hongbin Li
Summary: Fluorescent polymeric hydrogels are promising information storage media that can generate fluorescent patterns in a light-controlled and spatially defined manner. Grayscale patterning allows the generation of multi-dimensional fluorescent images. This method opens up new possibilities for developing protein-based smart materials for information storage and anti-counterfeit applications.
Article
Chemistry, Applied
Mariana I. Neves, Mariana Magalhaes, Silvia J. Bidarra, Lorenzo Moroni, Cristina C. Barrias
Summary: This study explored the use of a biocompatible and bio-orthogonal click chemistry reaction to graft cyclooctyne-modified alginate with bi-azide-functionalized PVGLIG peptides, creating artificial extracellular matrices for tissue engineering applications.
CARBOHYDRATE POLYMERS
(2023)
Review
Materials Science, Biomaterials
Kanishka Fernando, Leng Gek Kwang, Joanne Tze Chin Lim, Eliza Li Shan Fong
Summary: Hydrogel-based three-dimensional tumor models have become increasingly mainstream in cancer research, focusing on the importance of cell interactions in the TME and proposing future directions.
BIOMATERIALS SCIENCE
(2021)
Article
Polymer Science
Yoshinori Arisaka, Asato Tonegawa, Atsushi Tamura, Nobuhiko Yui
Summary: Polyrotaxane hydrogels, prepared without additional monomers via redox polymerization, demonstrate unique structural features and dynamic viscoelasticity. They show suitable potential as new supramolecular biomaterials.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Multidisciplinary Sciences
Thomas B. H. Schroeder, Joanna Aizenberg
Summary: The authors demonstrate area-selective activation of thermoresponsive processes by exothermic crystallization of sodium acetate into trihydrate crystals within a patterned polyacrylamide hydrogel.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Shabir Hassan, Berivan Cecen, Ramon Pena-Garcia, Fernanda Roberta Marciano, Amir K. Miri, Ali Fattahi, Christina Karavasili, Shikha Sebastian, Hamza Zaidi, Anderson Oliveira Lobo
Summary: This study introduces the use of calcium peroxide encapsulated in polycaprolactone as oxygen releasing microparticles, which can sustainably release oxygen without causing stress to encapsulated cells. Incorporating these microparticles in gelatin methacryloyl hydrogels promotes survival and proliferation of skeletal myoblasts. This oxygen releasing and delivery platform has potential for cell-based therapeutic approaches in treating diseases caused by ischemic conditions and enhancing implant survival under severe hypoxic conditions.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Zheng Xiong, Arun Poudel, Ameya R. Narkar, Zhe Zhang, Puskal Kunwar, James H. Henderson, Pranav Soman
Summary: In this study, the authors propose a new method called femtosecond (fs) laser-induced densification to generate diffractive gratings within hydrogel materials. By controlling the parameters of the fs laser, custom volume gratings can be fabricated within the hydrogel. The method is also demonstrated to be applicable to pH-responsive hydrogels.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Sicong Ren, Xiaoduo Tang, Lijun Liu, Fanrong Meng, Xudong Yang, Nuo Li, Zhiying Zhang, Maierhaba Aimaijiang, Manxuan Liu, Xinchen Liu, Hanchi Wang, Huimin Huangfu, Huan Wang, Junhu Zhang, Daowei Li, Yanmin Zhou
Summary: Physiological microenvironment engineering has great potential in combating diseases. This study presents a rational design of reinforced and injectable blood-derived protein hydrogels, which can act as dual-level regulators to engineer the microenvironment for personalized bone regeneration with high efficacy.
Article
Chemistry, Multidisciplinary
Patricia Monks, Jacek K. Wychowaniec, Eoin McKiernan, Shane Clerkin, John Crean, Brian J. Rodriguez, Emmanuel G. Reynaud, Andreas Heise, Dermot F. Brougham
Summary: This study demonstrates the use of multifunctional nanocomposites based on magnetic hydrogels for heat generation under alternating magnetic field irradiation, as well as the manipulation of spatial heat distribution through 3D printing. The research discusses the dependence of heat induction on various factors, such as particle concentration, gel volume, exposed surface area, and environmental conditions, and explores the potential applications in responsive scaffold remodeling and cargo release for regenerative medicine.
Article
Biochemistry & Molecular Biology
Jiaxi Song, Christos Michas, Christopher S. Chen, Alice E. White, Mark W. Grinstaff
Summary: DLW-fabricated hydrogel microstructures with alternating soft and stiff regions enable precise control over cell alignment and selective adhesion of human mesenchymal stem cells. Additionally, DLW patterning allows cell alignment on flat surfaces as well as irregular and curved 3D microstructures, which are typically challenging to pattern with cells.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jinhu Wang, Mingyuzhi Sun, Changle Liu, Yuchuan Ye, Mengshan Chen, Zhemeng Zhao, Yongcai Zhang, Xiaohu Wu, Kaiwen Wang, Yingtang Zhou
Summary: This study presents the design of a solar vaporization device based on organic-inorganic hybrid nanocomposites, which is capable of catalyzing wastewater and desalination simultaneously. The device achieves high water-vapor generation rate and efficient pollutant removal. The study also demonstrates the durability and adaptability of the device in multiple real-life scenarios.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jinhu Wang, Mingyuzhi Sun, Changle Liu, Yuchuan Ye, Mengshan Chen, Zhemeng Zhao, Yongcai Zhang, Xiaohu Wu, Kaiwen Wang, Yingtang Zhou
Summary: This study presents the design of fully functional solar vaporization devices (SVD) based on organic-inorganic hybrid nanocomposites (CCMs-x). These devices exhibit efficient photothermal properties that facilitate multitargeted interfacial reactions, enabling simultaneous catalysis of sewage and desalination. The exceptional photothermal conversion rate of wastewater for environmental remediation and water capture is attributed to customized microenvironments within the system.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Alicja Jagiello, Qingda Hu, Ulysses Castillo, Elliot Botvinick
Summary: Cells constantly interact with their extracellular matrix (ECM) and respond to biochemical and mechanical cues. However, understanding cell-ECM interactions has been challenging. This study presents a cell-safe method of patterned photocrosslinking to study mechanotransduction in 3D hydrogels. Photocrosslinking induces localized stiffness increase and fiber alignment, promoting directed cell migration. The usefulness of this method is validated through experiments with human breast cancer cells. The study emphasizes the importance of studying cell-ECM interactions in a more natural environment.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Jing Zhang, Yipeng Qin, Yangteng Ou, Yu Shen, Bao Tang, Xiaoyun Zhang, Ziyi Yu
Summary: In this study, a new type of printable ink called photonic granular hydrogel was developed for constructing customized structural colored objects. This ink exhibits dynamic properties and can be used for direct writing of macroscopic structural colored patterns by extrusion 3D printing. It also allows additive color mixing, simplifying the process of nano-synthesis and expanding the color variety of structural colored materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Biomaterials
Laila C. Roudsari, Sydney E. Jeffs, Jennifer L. West
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Laila C. Roudsari, Sydney E. Jeffs, Jennifer L. West
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Review
Biochemical Research Methods
Joshua A. Hammer, Jennifer L. West
BIOCONJUGATE CHEMISTRY
(2018)
Article
Cell Biology
Joseph C. Hoffmann, Jennifer L. West
INTEGRATIVE BIOLOGY
(2013)
Article
Chemistry, Multidisciplinary
Laura E. Strong, Shreyas N. Dahotre, Jennifer L. West
JOURNAL OF CONTROLLED RELEASE
(2014)
Article
Multidisciplinary Sciences
Jeffrey R. Ashton, Darin P. Clark, Everett J. Moding, Ketan Ghaghada, David G. Kirsch, Jennifer L. West, Cristian T. Badea
Article
Chemistry, Multidisciplinary
Andrew J. Coughlin, Jeyarama S. Ananta, Nanfu Deng, Irina V. Larina, Paolo Decuzzi, Jennifer L. West
Article
Biochemistry & Molecular Biology
Joshua A. Hammer, Anna Ruta, Aidan M. Therien, Jennifer L. West
Review
Biochemical Research Methods
Asli Z. Unal, Jennifer L. West
BIOCONJUGATE CHEMISTRY
(2020)
Article
Biochemical Research Methods
Joshua A. Hammer, Jennifer L. West
BIOCONJUGATE CHEMISTRY
(2020)
Article
Materials Science, Biomaterials
Rachel Chapla, Joshua A. Hammer, Jennifer L. West
Summary: This study developed a genetically encoded method for reversible biochemical signaling to accurately model tissue regeneration. By connecting specific proteins and peptides, reversible adhesion between cells and matrices can be achieved to mimic tissue processes. This system is significant for studying tissue behavior and improving therapeutic outcomes.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Oncology
Rachel R. Katz, Jennifer L. West
Summary: The tumor microenvironment (TME) plays a crucial role in tumor progression and drug resistance. In vitro models that can replicate the cell-cell and cell-matrix interactions in situ are essential for studying tumor behavior and selecting effective drugs. While naturally derived polymers can maintain the dimensionality of the native TME, they lack tunability and batch-to-batch consistency. Therefore, synthetic polymer systems have been widely used to create physiologically relevant TME cultures. In this review, we discuss the current state and future directions of tumor microenvironment models in synthetic hydrogels.
Article
Materials Science, Biomaterials
Rachel R. Katz, Jennifer L. West
Summary: Increased extracellular matrix (ECM) density in the tumor microenvironment influences tumor progression, and the effect varies between different tumor cell lines of epithelial and mesenchymal origin. Epithelial origin cell line proliferates more and forms more mature focal complexes in response to an increase in matrix adhesion sites, while mesenchymal origin cell line proliferates more in 2D culture but less in 3D culture, invades less, and forms more mature focal complexes in response to an increase in matrix stiffness.
Article
Engineering, Biomedical
V. Suresh, J. L. West
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2019)
Article
Engineering, Biomedical
E. M. Moore, J. L. West
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2019)
