Article
Biochemistry & Molecular Biology
Lais Ramos Monteiro Lima, Everton Lucas de Lima Ramos, Maria Francilene Souza Silva, Fabio de Oliveira Silva Ribeiro, Jeanlex S. Sousa, Claudia Pessoa, Durcilene Alves Silva, Judith P. A. Feitosa, Haroldo C. B. Paula, Regina Celia Monteiro de Paula
Summary: In this study, aminated poly(N-isopropylacrylamide) was successfully grafted onto oxidized galactomannan polysaccharide from Delonix regia via Schiff base reaction. The self-organizing ability of the obtained nanoparticle copolymers was investigated, showing promising potential for drug delivery with good cell viability and transition temperature close to human body temperature. The use of free aldehyde groups in the oxidized polysaccharide for pro-drug formation with substances possessing NH2 groups was also highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Kai Wang, Guoqi Chen, Sen Weng, Linxi Hou, Dezhan Ye, Xiancai Jiang
Summary: A thermo-responsive PNIPAM/HPMC hydrogel was prepared using a simple one-step low-temperature polymerization method, achieving high transmittance, high solar modulation, low phase-transition temperature, and excellent high-temperature thermal stability simultaneously. The hydrogel exhibited high light transmittance (90.82%) and good mechanical properties and thermal stability. It also showed a low phase-transition temperature (about 32 degrees C) and high solar modulation (81.52%), making it an ideal material for thermochromic smart windows.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Qichen Tang, Shanhua Qian, Weiwei Chen, Xiaofei Song, Jianfeng Huang
Summary: In this study, Ca-alginate/PNIPAm hydrogels were prepared through physical crosslinking and chemical crosslinking, and their properties were characterized. The results showed that the pure PNIPAm hydrogel obtained using thermal initiation polymerization exhibited better swelling and temperature-responsive properties compared to the hydrogel using ultraviolet polymerization. The mechanical properties of the Ca/PNIPAm hydrogel were enhanced when the SA concentration exceeded 8 wt%.
POLYMER INTERNATIONAL
(2023)
Review
Chemistry, Multidisciplinary
Jia-Qi Zhu, Han Wu, Zhen-Li Li, Xin-Fei Xu, Hao Xing, Ming-Da Wang, Hang-Dong Jia, Lei Liang, Chao Li, Li-Yang Sun, Yu-Guang Wang, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: This article summarizes the synthesis methods and applications of nanocomposite responsive hydrogels, which can respond to external or internal physiological stimuli and be used for responsive drug delivery.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Masud Hassan, Ravi Naidu, Jianhua Du, Fangjie Qi, Md Ariful Ahsan, Yanju Liu
Summary: Mesoporous biopolymer hydrogel beads synthesized via ionic polymerization route exhibited high adsorption capacity for heavy metal ions. The adsorption mechanism involved both chemosorption and physisorption processes. The adsorbent showed selectivity and adsorption trends for different heavy metals. Pore filling and intra-particle diffusion played a significant role in the removal of heavy metals.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Junta Sano, Shigeki Habaue
Summary: Novel interpenetrating polymer networks (IPNs) composed of poly(N-isopropylacrylamide) (poly-NIPAM) and polyethers, including polyethylene glycol (PEG) and poly(tetramethylene oxide), were synthesized with the presence of polysiloxane. A novel one-step method was developed for constructing the IPN structure using end-capped polyethers containing trimethoxysilyl moieties. The synthesized IPNs exhibited temperature-responsive volume changes in water and specific color-change responses to chemical stimuli when both poly-NIPAM and PEG components were present in gel form.
Article
Polymer Science
Yerin Shin, Jongseon Choi, Jun-Hee Na, So Yeon Kim
Summary: The study successfully synthesized temperature-responsive hydrogel soft actuators with a bilayer structure using gamma ray radiation, allowing for controllable temperature and shape transformation. This new strategy provides potential applications in biomimetic robotics, medical devices, and other fields.
Review
Pharmacology & Pharmacy
Amr Elsherbeny, Hulya Bayraktutan, Umut Can Oz, Cara Moloney, Jennifer C. Ashworth, Anna M. Grabowska, Cameron Alexander
Summary: Pancreatic cancer treatment is hindered by the complex tumor microenvironment, but the emergence of stimuli-responsive nanomaterials presents a promising avenue for targeted drug delivery. These nanomaterials can intelligently and selectively respond to external and internal stimuli, promoting drug accumulation and release in pancreatic cancer tissue for enhanced therapeutic efficacy.
ADVANCED THERAPEUTICS
(2023)
Article
Polymer Science
Bingxin Liu, Jianzhi Liu, Yueqin Yu
Summary: The research team developed a smart window system based on PNIPAM thermo-responsive hydrogel, which exhibited a smooth thermo-response and comfortable indoor temperature/lightness balance through additional cross-linking materials. This method not only continuously shields dazzling sunlight, but also allows for personalized adjustment of response degree and response temperature, promising a broad prospect for the development of smart windows.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Parvaneh Gheysoori, Azin Paydayesh, Maryam Jafari, Hamed Peidayesh
Summary: This study focuses on the development of thermoresponsive nanocomposite hydrogels for minimally invasive drug delivery. Gelatin-based hydrogels with poly (N-isopropylacrylamide) (PNIPAM) were prepared using response surface methodology. The PNIPAM nanoparticles showed successful polymerization and a reversible sol-gel transition close to body temperature. These nanocomposite hydrogels demonstrated antibacterial activity and good potential for targeted drug delivery.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Bing-Zi Yang, Shu-Ya Zhang, Ping -Hua Wang, Chun-Hua Liu, Yuan -Yuan Zhu
Summary: The organic-inorganic hydrogels doped with silicon nanoparticles exhibit enhanced mechanical strength and rapid response properties. The study demonstrates that SiNPs doping can increase the rigidity of hydrogel networks and improve water diffusion, leading to faster response rates.
Article
Biochemistry & Molecular Biology
Zewen Shi, Fang Yang, Qian Pang, Yiwei Hu, Haijian Wu, Xueqiang Yu, Xianjun Chen, Lin Shi, Bowen Wen, Rui Xu, Ruixia Hou, Dan Liu, Qingjiang Pang, Yabin Zhu
Summary: With the development of minimally invasive orthopedics, injectable materials for bone repair are attracting more attention. In this study, a hydrogel called FHCS was designed and fabricated, which showed thermo-responsiveness, degradability, and injectability. The FHCS hydrogel enhanced the ALP activity and extracellular matrix calcification of MC3T3-E1 cells, promoting new bone formation and maturation in a rat calvarial bone defect model. The upregulation of osteogenic genes and proteins through the BMP/Smad signaling pathway suggested promising applications for the FHCS-5 hydrogel in non-loading bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Analytical
Jung Gi Choi, Hocheol Gwac, Yongwoo Jang, Christopher Richards, Holly Warren, Geoffrey Spinks, Seon Jeong Kim
Summary: The diving and surfacing device fabricated from thermo-sensitive poly(N-isopropylacrylamide) or a poly(N-isopropylacrylamide)-containing hydrogel can exhibit fast and reversible diving/surfacing cycles in response to changing temperature. Modulation of the interaction between poly(N-isopropylacrylamide) chains and water molecules at different temperatures allows for control of gel density through swelling and de-swelling, enabling the gel to surface in water when heated and sink when cooled. Reversible diving/surfacing cycles of the device can also be achieved when exposed to electrical and ultrasonic stimuli.
Article
Polymer Science
Yi-Cheng Huang, Chia-Tien Lee, Trong-Ming Don
Summary: The gelatin/CMCS/P(NI-co-AA) membranes prepared in this study exhibited good biocompatibility, appropriate swelling ratio and water vapor transmission rate, as well as antibacterial and thermo-responsive properties.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Yingying Zhang, Guanglin Fan, Jinqiang Jiang, Zhaotie Liu, Zhongwen Liu, Guo Li
Summary: This study reports the development and regulation of gradient structures of hydrogels for programmable thermally responsive actuating behaviors. The shapes and actuation amplitudes of the hydrogel actuators can be independently regulated by controlling the formation and photodissociation of Fe3+-carboxylate coordination in the formed gradient networks. Some interesting applications have been realized, demonstrating the potential for extending this method to other hydrogel actuators with different compositions and stimuli-responsive behaviors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Laila C. Roudsari, Sydney E. Jeffs, Jennifer L. West
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Materials Science, Biomaterials
Laila C. Roudsari, Sydney E. Jeffs, Jennifer L. West
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Review
Biochemical Research Methods
Joshua A. Hammer, Jennifer L. West
BIOCONJUGATE CHEMISTRY
(2018)
Article
Urology & Nephrology
Samit D. Soni, Weitao Song, Jennifer L. West, Mohit Khera
JOURNAL OF SEXUAL MEDICINE
(2013)
Article
Multidisciplinary Sciences
Jeffrey R. Ashton, Darin P. Clark, Everett J. Moding, Ketan Ghaghada, David G. Kirsch, Jennifer L. West, Cristian T. Badea
Article
Chemistry, Multidisciplinary
Andrew J. Coughlin, Jeyarama S. Ananta, Nanfu Deng, Irina V. Larina, Paolo Decuzzi, Jennifer L. West
Article
Biochemistry & Molecular Biology
Joshua A. Hammer, Anna Ruta, Aidan M. Therien, Jennifer L. West
Review
Biochemical Research Methods
Asli Z. Unal, Jennifer L. West
BIOCONJUGATE CHEMISTRY
(2020)
Article
Biochemical Research Methods
Joshua A. Hammer, Jennifer L. West
BIOCONJUGATE CHEMISTRY
(2020)
Article
Materials Science, Biomaterials
Rachel Chapla, Joshua A. Hammer, Jennifer L. West
Summary: This study developed a genetically encoded method for reversible biochemical signaling to accurately model tissue regeneration. By connecting specific proteins and peptides, reversible adhesion between cells and matrices can be achieved to mimic tissue processes. This system is significant for studying tissue behavior and improving therapeutic outcomes.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Oncology
Rachel R. Katz, Jennifer L. West
Summary: The tumor microenvironment (TME) plays a crucial role in tumor progression and drug resistance. In vitro models that can replicate the cell-cell and cell-matrix interactions in situ are essential for studying tumor behavior and selecting effective drugs. While naturally derived polymers can maintain the dimensionality of the native TME, they lack tunability and batch-to-batch consistency. Therefore, synthetic polymer systems have been widely used to create physiologically relevant TME cultures. In this review, we discuss the current state and future directions of tumor microenvironment models in synthetic hydrogels.
Article
Materials Science, Biomaterials
Rachel R. Katz, Jennifer L. West
Summary: Increased extracellular matrix (ECM) density in the tumor microenvironment influences tumor progression, and the effect varies between different tumor cell lines of epithelial and mesenchymal origin. Epithelial origin cell line proliferates more and forms more mature focal complexes in response to an increase in matrix adhesion sites, while mesenchymal origin cell line proliferates more in 2D culture but less in 3D culture, invades less, and forms more mature focal complexes in response to an increase in matrix stiffness.
Article
Engineering, Biomedical
V. Suresh, J. L. West
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2019)
Article
Engineering, Biomedical
E. M. Moore, J. L. West
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2019)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)