The immunoproteasome and thymoproteasome: functions, evolution and human disease

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Evolution of Alternative Adaptive Immune Systems in Vertebrates

(2018) Thomas Boehm et al.   Annual Review of Immunology

Regulation of the Cell Biology of Antigen Cross-Presentation

(2018) J. Magarian Blander   Annual Review of Immunology

The immunoproteasome‐specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis

(2018) Nadine Althof et al.   EMBO Molecular Medicine

Structure-based design of human immuno- and constitutive proteasomes inhibitors

(2018) Nicolas Richy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation

(2018) Jun Li et al.   KIDNEY INTERNATIONAL

Immunoribosomes: Where’s there’s fire, there’s fire

(2018) Jiajie Wei et al.   MOLECULAR IMMUNOLOGY

Peptide splicing by the proteasome

(2017) Nathalie Vigneron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 20S immunoproteasome and constitutive proteasome bind with the same affinity to PA28αβ and equally degrade FAT10

(2017) Gunter Schmidtke et al.   MOLECULAR IMMUNOLOGY

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α 4 β 3 Complex

(2017) Eva M. Huber et al.   STRUCTURE

The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy

(2017) Yong Tae Kwon et al.   TRENDS IN BIOCHEMICAL SCIENCES

Post-Translational Peptide Splicing and T Cell Responses

(2017) Michele Mishto et al.   TRENDS IN IMMUNOLOGY

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

(2017) Muhammad Myn Uddin et al.   Nature Communications

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice

(2017) Julia Koerner et al.   Oncotarget

Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7

(2017) Niyati Vachharajani et al.   Oncotarget

The role of the immunoproteasome in interferon-γ-mediated microglial activation

(2017) Kasey E. Moritz et al.   Scientific Reports

Structure-Driven Developments of 26S Proteasome Inhibitors

(2016) Paweł Śledź et al.   Annual Review of Pharmacology and Toxicology

Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla

(2016) Carlos E. Mayer et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Nowhere to hide: unconventional translation yields cryptic peptides for immune surveillance

(2016) Shelley R. Starck et al.   IMMUNOLOGICAL REVIEWS

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

(2016) Saulius Žuklys et al.   NATURE IMMUNOLOGY

Specialized proteasome subunits have an essential role in the thymic selection of CD8+ T cells

(2016) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for dynamic regulation of the human 26S proteasome

(2016) Shuobing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the human 26S proteasome at a resolution of 3.9 Å

(2016) Andreas Schweitzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice

(2016) Esilida Sula Karreci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A large fraction of HLA class I ligands are proteasome-generated spliced peptides

(2016) Juliane Liepe et al.   SCIENCE

An atomic structure of the human 26S proteasome

(2016) Xiuliang Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The transporter associated with antigen processing: a key player in adaptive immunity

(2015) Sabine Eggensperger et al.   BIOLOGICAL CHEMISTRY

What chickens would tell you about the evolution of antigen processing and presentation

(2015) Jim Kaufman   CURRENT OPINION IN IMMUNOLOGY

The nature of self for T cells—a systems-level perspective

(2015) Diana P Granados et al.   CURRENT OPINION IN IMMUNOLOGY

Evolution of Proteasome Regulators in Eukaryotes

(2015) Philippe Fort et al.   Genome Biology and Evolution

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

(2015) Anja Brehm et al.   JOURNAL OF CLINICAL INVESTIGATION

The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes

(2015) Alexander Marx et al.   Journal of Thoracic Oncology

TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8+ T cells

(2015) Kensuke Takada et al.   NATURE IMMUNOLOGY

Dysfunction in protein clearance by the proteasome: impact on autoinflammatory diseases

(2015) Anja Brehm et al.   Seminars in Immunopathology

Thymoproteasomes produce unique peptide motifs for positive selection of CD8+ T cells

(2015) Katsuhiro Sasaki et al.   Nature Communications

Adult Thymic Medullary Epithelium Is Maintained and Regenerated by Lineage-Restricted Cells Rather Than Bipotent Progenitors

(2015) Izumi Ohigashi et al.   Cell Reports

The immunoproteasome and viral infection: a complex regulator of inflammation

(2015) Mary K. McCarthy et al.   Frontiers in Microbiology

No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes

(2014) Sonja Erath et al.   IMMUNOGENETICS

Proteasome-associated autoinflammatory syndromes: advances in pathogeneses, clinical presentations, diagnosis, and management

(2014) Amelia McDermott et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Re-examining class-I presentation and the DRiP hypothesis

(2014) Kenneth L. Rock et al.   TRENDS IN IMMUNOLOGY

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Defense genes missing from the flight division

(2013) Katharine E. Magor et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Expression of thymoproteasome subunit β5t in type AB thymoma

(2013) Yosuke Yamada et al.   JOURNAL OF CLINICAL PATHOLOGY

Thymoproteasome subunit- 5T generates peptide-MHC complexes specialized for positive selection

(2013) Y. Xing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aire-expressing thymic medullary epithelial cells originate from  5t-expressing progenitor cells

(2013) I. Ohigashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The unique functions of tissue-specific proteasomes

(2013) Andrea Kniepert et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Ubiquitin System, an Immense Realm

(2012) Alexander Varshavsky   Annual Review of Biochemistry

VLR-Based Adaptive Immunity

(2012) Thomas Boehm et al.   Annual Review of Immunology

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

The immunoproteasome in antigen processing and other immunological functions

(2012) Michael Basler et al.   CURRENT OPINION IN IMMUNOLOGY

Immunoproteasome Subunit LMP7 Deficiency and Inhibition Suppresses Th1 and Th17 but Enhances Regulatory T Cell Differentiation

(2012) K. W. Kalim et al.   JOURNAL OF IMMUNOLOGY

Molecular Model of the Human 26S Proteasome

(2012) Paula C.A. da Fonseca et al.   MOLECULAR CELL

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach

(2012) K. Lasker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of Proteasome Subunit β5t in Thymic Epithelial Tumors

(2011) Yosuke Yamada et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity

(2011) Yin Liu et al.   ARTHRITIS AND RHEUMATISM

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

(2011) H. Travis Ichikawa et al.   ARTHRITIS AND RHEUMATISM

Insights into the processing of MHC class I ligands gained from the study of human tumor epitopes

(2011) Nathalie Vigneron et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo

(2011) Natascha de Graaf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t

(2011) Adiratna Mat Ripen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes

(2011) Yoichi Sutoh et al.   IMMUNOGENETICS

A mutation in the immunoproteasome subunit PSMB8 causes autoinflammation and lipodystrophy in humans

(2011) Akiko Kitamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Mice completely lacking immunoproteasomes show major changes in antigen presentation

(2011) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome

(2011) K. Arima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DRiPs solidify: progress in understanding endogenous MHC class I antigen processing

(2011) Jonathan W. Yewdell   TRENDS IN IMMUNOLOGY

PSMB8 Encoding the β5i Proteasome Subunit Is Mutated in Joint Contractures, Muscle Atrophy, Microcytic Anemia, and Panniculitis-Induced Lipodystrophy Syndrome

(2010) Anil K. Agarwal et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t

(2010) Bogdan I. Florea et al.   CHEMISTRY & BIOLOGY

Differences in the production of spliced antigenic peptides by the standard proteasome and the immunoproteasome

(2010) Alexandre Dalet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

(2010) Jacqueline Moebius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

(2010) Takeshi Nitta et al.   IMMUNITY

Prevention of Experimental Colitis by a Selective Inhibitor of the Immunoproteasome

(2010) M. Basler et al.   JOURNAL OF IMMUNOLOGY

Two abundant proteasome subtypes that uniquely process some antigens presented by HLA class I molecules

(2010) B. Guillaume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of thymic cortex-specific self-peptides in positive selection of T cells

(2010) Yousuke Takahama et al.   SEMINARS IN IMMUNOLOGY

Exclusive expression of proteasome subunit  5t in the human thymic cortex

(2009) U. Tomaru et al.   BLOOD

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

Origin and evolution of the adaptive immune system: genetic events and selective pressures

(2009) Martin F. Flajnik et al.   NATURE REVIEWS GENETICS

Molecular mechanisms of proteasome assembly

(2009) Shigeo Murata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thymoproteasome: probable role in generating positively selecting peptides

(2008) Shigeo Murata et al.   CURRENT OPINION IN IMMUNOLOGY

Modest cortex and promiscuous medulla for thymic repertoire formation

(2008) Yousuke Takahama et al.   TRENDS IN IMMUNOLOGY