N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca2+ signaling

Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms

(2014) Z Yu et al.   GENES AND IMMUNITY

Lck Availability during Thymic Selection Determines the Recognition Specificity of the T Cell Repertoire

(2013) François Van Laethem et al.   CELL

Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants

(2013) Carey F. Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Themis sets the signal threshold for positive and negative selection in T-cell development

(2013) Guo Fu et al.   NATURE

Interleukin-2, Interleukin-7, T cell-mediated autoimmunity, and N-glycosylation

(2012) Ani Grigorian et al.   Annals of the New York Academy of Sciences

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling

(2012) Di Wang et al.   NATURE IMMUNOLOGY

Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation

(2012) Ani Grigorian et al.   Seminars in Immunopathology

Dampening of death pathways by schnurri-2 is essential for T-cell development

(2011) Tracy L. Staton et al.   NATURE

Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis

(2011) Haik Mkhikian et al.   Nature Communications

Immunodeficiency due to mutations in ORAI1 and STIM1

(2010) Stefan Feske et al.   CLINICAL IMMUNOLOGY

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

MGAT5 alters the severity of multiple sclerosis

(2010) B. Brynedal et al.   JOURNAL OF NEUROIMMUNOLOGY

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

(2010) M. N. Artyomov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

Restoring the Association of the T Cell Receptor with CD8 Reverses Anergy in Human Tumor-Infiltrating Lymphocytes

(2008) Nathalie Demotte et al.   IMMUNITY

Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1

(2008) Y. Gwack et al.   MOLECULAR AND CELLULAR BIOLOGY